Detailed information for compound 227994

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.494 | Formula: C26H25N3O4
  • H donors: 3 H acceptors: 4 LogP: 3.94 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H](NC(=O)[C@@H](Nc1ccccc1)Cc1ccccc1)COCc1cccc(c1)C(=O)O
  • InChi: 1S/C26H25N3O4/c27-16-23(18-33-17-20-10-7-11-21(14-20)26(31)32)29-25(30)24(15-19-8-3-1-4-9-19)28-22-12-5-2-6-13-22/h1-14,23-24,28H,15,17-18H2,(H,29,30)(H,31,32)/t23-,24+/m1/s1
  • InChiKey: MCJNEOXSKWPBMT-RPWUZVMVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0015 0.0193 0.0444
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0919 0.0919
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0635 0.3836
Brugia malayi hypothetical protein 0.0013 0.0142 0.017
Brugia malayi Protein kinase domain containing protein 0.0044 0.0919 0.147
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0193 0.0444
Echinococcus granulosus cysteine protease 0.0033 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0018 0.0265 0.037
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0015 0.0193 0.0444
Echinococcus granulosus cpg binding protein 0.003 0.0578 0.0578
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0193 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Echinococcus multilocularis cpg binding protein 0.003 0.0578 0.0578
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0919 0.6044
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0919 0.0919
Echinococcus granulosus cyclin G2 0.0013 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0059 0.1284 0.2077
Echinococcus multilocularis cyclin y 0.0013 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.1284 0.2077
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0193 0.0255
Plasmodium falciparum serine repeat antigen 2 0.0015 0.0193 0.0444
Echinococcus granulosus cyclin B 0.0053 0.1147 0.1147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Echinococcus multilocularis cyclin b3 0.0053 0.1147 0.1147
Brugia malayi cathepsin L precursor 0.0015 0.0193 0.0255
Echinococcus granulosus cyclin 0.0013 0.0142 0.0142
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0193 0.0193
Schistosoma mansoni cathepsin B (C01 family) 0.0015 0.0193 0.0193
Echinococcus multilocularis cysteine protease 0.0059 0.1284 0.1284
Loa Loa (eye worm) cyclin domain-containing protein 0.025 0.6016 1
Plasmodium falciparum serine repeat antigen 8 0.0015 0.0193 0.0444
Schistosoma mansoni cyclin k 0.0013 0.0142 0.0142
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0193 0.0394
Plasmodium falciparum serine repeat antigen 4 0.0015 0.0193 0.0444
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0193 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0635 0.3836
Echinococcus granulosus cyclin G2 0.0013 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0015 0.0193 0.0444
Onchocerca volvulus 0.0059 0.1284 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0015 0.0193 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Giardia lamblia Cathepsin L-like protease 0.0015 0.0193 0.0394
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0919 0.6044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0193 0.025
Giardia lamblia Cysteine protease 0.0015 0.0193 0.0394
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0015 0.0193 0.0444
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Trichomonas vaginalis cyclin B, putative 0.0053 0.1147 0.7821
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0015 0.0193 0.0444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.1427 0.1427
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0193 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0193 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0015 0.0193 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Giardia lamblia Cathepsin L-like protease 0.0015 0.0193 0.0394
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Trichomonas vaginalis cyclins, putative 0.0053 0.1147 0.7821
Echinococcus granulosus cyclin A3 4 0.0013 0.0142 0.0142
Brugia malayi cell division control protein 2 homolog 0.0044 0.0919 0.147
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Echinococcus granulosus cathepsin b 0.0176 0.4185 0.4185
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1284 0.1284
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0015 0.0193 0.0444
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0635 0.4318
Echinococcus granulosus cyclins 0.0053 0.1147 0.1147
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0635 0.122
Giardia lamblia Cathepsin B precursor 0.0065 0.1427 1
Loa Loa (eye worm) fibroinase 0.0059 0.1284 0.2077
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1284 0.2824
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1284 1
Echinococcus granulosus cyclins 0.0053 0.1147 0.1147
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.4185 0.4185
Giardia lamblia Cysteine protease 0.0015 0.0193 0.0394
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1284 0.2824
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0013 0.0142 0.0142
Brugia malayi Cathepsin L-like precursor 0.0041 0.0842 0.134
Echinococcus granulosus cyclin B3 1 0.0053 0.1147 0.1147
Echinococcus multilocularis cyclin y 0.0013 0.0142 0.0142
Brugia malayi Cyclin C 0.0013 0.0142 0.017
Giardia lamblia Cathepsin B precursor 0.0015 0.0193 0.0394
Echinococcus multilocularis cyclin A3 4 0.0013 0.0142 0.0142
Brugia malayi Cyclin, N-terminal domain containing protein 0.0053 0.1147 0.1852
Loa Loa (eye worm) hypothetical protein 0.0013 0.0142 0.0165
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0193 0.0125
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0015 0.0193 0.0444
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0193 0.0255
Schistosoma mansoni cyclin B 0.0053 0.1147 0.1147
Schistosoma mansoni cyclin d 0.0013 0.0142 0.0142
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0919 0.0919
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0919 0.6044
Loa Loa (eye worm) cyclin domain-containing protein 0.0053 0.1147 0.1848
Trichomonas vaginalis cyclin B, putative 0.0053 0.1147 0.7821
Loa Loa (eye worm) hypothetical protein 0.0018 0.0265 0.037
Plasmodium falciparum serine repeat antigen 5 0.0015 0.0193 0.0444
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1284 0.1284
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0053 0.1147 0.1147
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0013 0.0142 0.0142
Echinococcus multilocularis cyclin B3 1 0.0053 0.1147 0.1147
Trichomonas vaginalis cyclins, putative 0.0053 0.1147 0.7821
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0193 0.0394
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0635 0.4318
Trichomonas vaginalis cyclin B3, putative 0.0053 0.1147 0.7821
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Brugia malayi fibroinase precursor 0.0015 0.0193 0.0255
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.1284 1
Brugia malayi cyclin fold protein 1 variant b 0.0013 0.0142 0.017
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0015 0.0193 0.0444
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0635 0.122
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0142 0.0165
Echinococcus multilocularis cysteine protease 0.0059 0.1284 0.1284
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1284 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1147 0.1848
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0193 0.0193
Onchocerca volvulus 0.0059 0.1284 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Plasmodium vivax unspecified product 0.0015 0.0193 0.0444
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0635 0.4318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0919 0.6804
Schistosoma mansoni hypothetical protein 0.0013 0.0142 0.0142
Plasmodium falciparum protein kinase 5 0.0044 0.0919 0.6804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Loa Loa (eye worm) cathepsin B 0.0065 0.1427 0.2317
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0635 0.4318
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1284 0.1284
Trypanosoma brucei mitotic cyclin 6 0.0053 0.1147 0.7821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.1427 0.3179
Loa Loa (eye worm) ctsf protein 0.0059 0.1284 0.2077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0193 0.0125
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0142 0.0165
Echinococcus granulosus cyclin y 0.0013 0.0142 0.0142
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0635 0.122
Brugia malayi Cyclin, N-terminal domain containing protein 0.025 0.6016 1
Echinococcus granulosus cyclins 0.0053 0.1147 0.1147
Schistosoma mansoni cyclin G 0.0013 0.0142 0.0142
Schistosoma mansoni cyclin G2 0.0013 0.0142 0.0142
Plasmodium falciparum serine repeat antigen 1 0.0015 0.0193 0.0444
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.4185 0.6935
Brugia malayi Cathepsin L-like precursor 0.0041 0.0842 0.134
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Onchocerca volvulus 0.0029 0.0537 0.3459
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0919 0.6044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.1427 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0919 0.6044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.4185 0.4185
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0919 0.0919
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0013 0.0142 0.0165
Onchocerca volvulus Cathepsin F homolog 0.0059 0.1284 1
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0842 0.0842
Trypanosoma cruzi CYC2-like cyclin, putative 0.0053 0.1147 0.2486
Schistosoma mansoni cathepsin C 0.0015 0.0193 0.0193
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1284 0.1284
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0394
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Giardia lamblia Cathepsin L precursor 0.0015 0.0193 0.0394
Plasmodium falciparum serine repeat antigen 7 0.0015 0.0193 0.0444
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0635 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Giardia lamblia Hypothetical protein 0.0015 0.0193 0.0394
Giardia lamblia Encystation-specific protease 0.0015 0.0193 0.0394
Echinococcus granulosus cathepsin L 0.0033 0.0635 0.0635
Giardia lamblia Cyclin A 0.0053 0.1147 0.7821
Giardia lamblia Cathepsin B precursor 0.0015 0.0193 0.0394
Echinococcus granulosus cyclin k 0.0013 0.0142 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0919 0.6044
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0919 0.1466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Onchocerca volvulus 0.0041 0.0842 0.6126
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Entamoeba histolytica cysteine protease, putative 0.0059 0.1284 1
Brugia malayi Protein kinase domain containing protein 0.0169 0.4009 0.6641
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0919 0.6044
Schistosoma mansoni hypothetical protein 0.0013 0.0142 0.0142
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0193 0.0193
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0013 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0015 0.0193 0.0394
Echinococcus granulosus cathepsin L 0.0015 0.0193 0.0193
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0919 0.6044
Schistosoma mansoni cyclins 0.0053 0.1147 0.1147
Brugia malayi hypothetical protein 0.0013 0.0142 0.017
Entamoeba histolytica cyclin family protein 0.0053 0.1147 0.8803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Giardia lamblia Cathepsin B precursor 0.0015 0.0193 0.0394
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0193 0.0193
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0265 0.037
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0015 0.0193 0.0193
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0015 0.0193 0.0394
Plasmodium vivax vivapain-1 0.0033 0.0635 0.4318
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0193 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0919 0.0919
Giardia lamblia Cysteine protease 0.0015 0.0193 0.0394
Loa Loa (eye worm) cyclin C 0.0013 0.0142 0.0165
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0193 0.0444
Entamoeba histolytica cyclin family protein 0.0053 0.1147 0.8803
Giardia lamblia Cathepsin B precursor 0.0065 0.1427 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.1284 0.1284
Plasmodium falciparum serine repeat antigen 9 0.0015 0.0193 0.0444
Echinococcus multilocularis Cyclin L1 0.0013 0.0142 0.0142
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0265 0.0303
Echinococcus multilocularis cathepsin b 0.0176 0.4185 0.4185
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0193 0.0444
Schistosoma mansoni cathepsin S (C01 family) 0.0015 0.0193 0.0193
Echinococcus granulosus Cyclin L1 0.0013 0.0142 0.0142
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0142 0.0165
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.1284 1
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1338 0.1338
Trichomonas vaginalis cyclin D, putative 0.0053 0.1147 0.7821
Toxoplasma gondii cathepsin CPC1 0.0015 0.0193 0.0394
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0919 0.0919
Loa Loa (eye worm) CYL-1 protein 0.0013 0.0142 0.0165
Onchocerca volvulus 0.0015 0.0193 0.0444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Plasmodium falciparum serine repeat antigen 6 0.0015 0.0193 0.0444
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0193 0.0394
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1284 0.1284
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Plasmodium vivax vivapain-2 0.0059 0.1284 1
Echinococcus granulosus cyclin t1 0.0013 0.0142 0.0142
Trichomonas vaginalis cyclin B, putative 0.0053 0.1147 0.7821
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0635 0.0995
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0015 0.0193 0.0444
Entamoeba histolytica cyclin, putative 0.0053 0.1147 0.8803
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0919 0.6044
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.4009 0.4009
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0919 0.1922
Schistosoma mansoni cyclin l 0.0013 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0842 0.5442
Echinococcus multilocularis cathepsin L 0.0015 0.0193 0.0193
Plasmodium vivax unspecified product 0.0033 0.0635 0.4318
Echinococcus granulosus cathepsin l1 0.0059 0.1284 0.1284
Brugia malayi cathepsin L-like precursor 0.0041 0.0842 0.134
Trypanosoma cruzi cyclin, putative 0.0053 0.1147 0.2486
Echinococcus granulosus cathepsin b 0.0176 0.4185 0.4185
Plasmodium vivax vivapain-3 0.0033 0.0635 0.4318
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0015 0.0193 0.025
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0919 0.6044
Trichomonas vaginalis cyclins, putative 0.0053 0.1147 0.7821
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0193 0.0394
Onchocerca volvulus 0.0059 0.1284 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0193 0.0394
Echinococcus granulosus cyclin b3 0.0053 0.1147 0.1147
Echinococcus multilocularis cathepsin b 0.0176 0.4185 0.4185
Giardia lamblia G2/mitotic-specific cyclin B 0.0053 0.1147 0.7821
Schistosoma mansoni cpg binding protein 0.0029 0.0537 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0193 0.0394
Toxoplasma gondii preprocathepsin c precursor, putative 0.0015 0.0193 0.0394
Entamoeba histolytica cyclin, putative 0.0053 0.1147 0.8803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Trypanosoma cruzi cyclin 6, putative 0.0053 0.1147 0.2486
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0842 0.6126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.4185 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0842 0.1336
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0193 0.0255
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1284 0.8884
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0635 0.3836
Trichomonas vaginalis cyclin D, putative 0.0053 0.1147 0.7821
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.1427 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1284 0.1284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Echinococcus multilocularis G1:S specific cyclin D1 0.0013 0.0142 0.0142
Echinococcus multilocularis cathepsin L 0.0033 0.0635 0.0635
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Plasmodium vivax vivapain-2 0.0059 0.1284 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0193 0.0394
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0919 0.6804
Onchocerca volvulus 0.0059 0.1284 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Brugia malayi Cathepsin L-like precursor 0.0018 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0176 0.4185 0.6933
Echinococcus multilocularis cyclin 0.0013 0.0142 0.0142
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0193 0.0255
Loa Loa (eye worm) hypothetical protein 0.0053 0.1147 0.1848
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0169 0.4009 0.664
Trichomonas vaginalis cyclin B, putative 0.0053 0.1147 0.7821
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.1284 0.2081
Giardia lamblia Cathepsin B precursor 0.0015 0.0193 0.0394
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0919 0.1922
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1284 0.2077
Plasmodium vivax unspecified product 0.0018 0.0265 0.1074
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0635 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1147 0.7821
Toxoplasma gondii cathepsin CPC2 0.0015 0.0193 0.0394
Echinococcus granulosus G1:S specific cyclin D1 0.0013 0.0142 0.0142
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1284 0.2824
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0537 0.0826
Echinococcus granulosus cyclins 0.0053 0.1147 0.1147
Entamoeba histolytica cysteine protease, putative 0.0015 0.0193 0.0444
Loa Loa (eye worm) hypothetical protein 0.0018 0.0265 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0919 0.1466
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0142 0.0165
Loa Loa (eye worm) hypothetical protein 0.0041 0.0842 0.1336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0635 0.122
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1284 0.2824
Entamoeba histolytica hypothetical protein 0.0015 0.0193 0.0444
Plasmodium falciparum serine repeat antigen 3 0.0015 0.0193 0.0444
Trypanosoma cruzi cyclin, putative 0.0053 0.1147 0.2486
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0015 0.0193 0.0444
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0635 0.0635
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.4185 0.4185
Onchocerca volvulus 0.0059 0.1284 1
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0919 0.0919
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.1427 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0265 0.0375
Echinococcus multilocularis cyclin k 0.0013 0.0142 0.0142
Brugia malayi Cyclin, N-terminal domain containing protein 0.0053 0.1147 0.1852
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0635 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0015 0.0193 0.0394
Giardia lamblia Cathepsin B precursor 0.0065 0.1427 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0919 0.0919
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0193 0.025
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Echinococcus granulosus cyclin y 0.0013 0.0142 0.0142
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0193 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0842 0.5442
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Trichomonas vaginalis cyclin A, putative 0.0053 0.1147 0.7821
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0919 0.0919
Toxoplasma gondii cathepsin B 0.0065 0.1427 1
Echinococcus granulosus cyclins 0.0013 0.0142 0.0142
Echinococcus granulosus cyclins 0.0053 0.1147 0.1147
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Trichomonas vaginalis cyclins, putative 0.0053 0.1147 0.7821
Onchocerca volvulus 0.0053 0.1147 0.8803
Echinococcus multilocularis cyclin G2 0.0013 0.0142 0.0142
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0193 0.0255
Brugia malayi CXXC zinc finger family protein 0.0029 0.0537 0.0831
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0635 0.122
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Trichomonas vaginalis cyclins, putative 0.0053 0.1147 0.7821
Trichomonas vaginalis cyclin B, putative 0.0053 0.1147 0.7821
Giardia lamblia Hypothetical protein 0.0015 0.0193 0.0394
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0193 0.0193
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0013 0.0142 0.0142
Schistosoma mansoni cyclin B3 0.0053 0.1147 0.1147
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0635 0.4318
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0842 0.134
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Echinococcus multilocularis dnaJ subfamily B 0.041 1 1
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0265 0.0303
Schistosoma mansoni hypothetical protein 0.041 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0193 0.0394
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0635 0.0635
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0142 0.017
Plasmodium falciparum cyclin 0.0053 0.1147 0.8803
Echinococcus multilocularis cyclin t1 0.0013 0.0142 0.0142
Brugia malayi Cyclin, N-terminal domain containing protein 0.0053 0.1147 0.1852
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0193 0.0255
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0919 0.1922
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0635 0.4318
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.1284 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0015 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Loa Loa (eye worm) hypothetical protein 0.0043 0.0885 0.1408
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0053 0.1147 0.7821
Schistosoma mansoni Cyclin fold protein 0.0013 0.0142 0.0142
Schistosoma mansoni cathepsin s 0.0018 0.0265 0.0265
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0053 0.1147 0.1147
Echinococcus multilocularis cyclin B 0.0053 0.1147 0.1147
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.1284 0.1284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.4185 0.4185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0013 0.0142 0.0142
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0142 0.0165
Loa Loa (eye worm) cysteine protease 0.0059 0.1284 0.2077
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0015 0.0193 0.0444
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1284 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0193 0.025
Giardia lamblia Hypothetical protein 0.0053 0.1147 0.7821
Echinococcus multilocularis cyclins 0.0053 0.1147 0.1147
Toxoplasma gondii hypothetical protein 0.0041 0.0828 0.5333
Loa Loa (eye worm) hypothetical protein 0.0041 0.0842 0.1336
Echinococcus multilocularis cyclin G2 0.0013 0.0142 0.0142
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1284 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Plasmodium vivax protein kinase Crk2 0.0044 0.0919 0.6804
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0919 0.1922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0919 0.0919
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1284 0.2824
Leishmania major cathepsin L-like protease 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1284 0.8884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1284 0.8884
Toxoplasma gondii cathepsin CPL 0.0059 0.1284 0.8884
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0635 0.4318
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0015 0.0193 0.0444
Onchocerca volvulus 0.0059 0.1284 1
Echinococcus granulosus cathepsin l1 0.0041 0.0842 0.0842
Leishmania major cysteine peptidase A (CPA) 0.0059 0.1284 0.8884
Onchocerca volvulus 0.0059 0.1284 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1176 0.8046
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0265 0.0375
Brugia malayi cathepsin L-like cysteine proteinase 0.0015 0.0193 0.0255
Schistosoma mansoni g1/s-specific cyclin C 0.0013 0.0142 0.0142
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0015 0.0193 0.0444
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0842 0.173
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0919 0.1466
Giardia lamblia Cysteine protease 0.0015 0.0193 0.0394
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Loa Loa (eye worm) hypothetical protein 0.0013 0.0142 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0193 0.0394
Entamoeba histolytica cysteine protease, putative 0.0033 0.0635 0.4318
Brugia malayi Cathepsin L-like precursor 0.0059 0.1284 0.2081
Leishmania major cyclin 0.0053 0.1147 0.7821
Giardia lamblia Cathepsin B precursor 0.0015 0.0193 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1284 0.8884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0635 0.3836
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0015 0.0193 0.0394

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 832 nM Inhibtitory activity against cathepsin B (catB) ChEMBL. 14592520
IC50 (binding) = 832 nM Inhibtitory activity against cathepsin B (catB) ChEMBL. 14592520
IC50 (binding) = 2600 nM Inhibtitory activity against cathepsin S (catS) ChEMBL. 14592520
IC50 (binding) = 2600 nM Inhibtitory activity against cathepsin S (catS) ChEMBL. 14592520
IC50 (binding) = 6100 nM Inhibtitory activity against cathepsin L (catL) ChEMBL. 14592520
IC50 (binding) = 6100 nM Inhibtitory activity against cathepsin L (catL) ChEMBL. 14592520

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.