TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 441.323 | Formula: C20H12FN3O8
H donors: 3 H acceptors: 8 LogP: 2.53 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1NC(=O)c1nccc(c1)[N+](=O)[O-])Oc1ccc(c(c1)C(=O)O)C(=O)O
InChi: 1S/C20H12FN3O8/c21-14-2-1-3-16(32-11-4-5-12(19(26)27)13(9-11)20(28)29)17(14)23-18(25)15-8-10(24(30)31)6-7-22-15/h1-9H,(H,23,25)(H,26,27)(H,28,29)
InChiKey: PDSGSWUNDWJOFE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References
Homo sapiens	phosphorylase, glycogen	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0454	0.9905	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Schistosoma mansoni	hypothetical protein	0.0165	0.3397	0.341
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Echinococcus multilocularis	geminin	0.0165	0.3397	0.3377
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	0.1432
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0083	0.1545	0.156
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0083	0.1545	0.1535
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0566	0.0544
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.003	0.0353	0.1321
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0083	0.1545	0.152
Onchocerca volvulus		0.005	0.0806	0.0552
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.2478	0.4091
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2957	0.2985
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0033	0.0423	0.0395
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0083	0.1545	0.152
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0776	0.0783
Loa Loa (eye worm)	ACC-1 protein	0.0083	0.1545	0.156
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0077	0.1419	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0454	0.9905	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0091	0.0092
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.2478	1
Brugia malayi	Cation transporter family protein	0.0083	0.1545	0.156
Brugia malayi	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0124	0.2478	0.2155
Echinococcus multilocularis	nAChR subunit	0.005	0.0806	0.0779
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.1419	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.0091	0.0092
Brugia malayi	hypothetical protein	0.0019	0.0102	0.0103
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0124	0.2478	0.5
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0077	0.1419	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0083	0.1545	0.152
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.003	0.0001
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0438	0.2943
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2957	0.2985
Entamoeba histolytica	hypothetical protein	0.0041	0.0608	0.0492
Echinococcus granulosus	Glycosyl transferase family 35	0.0261	0.5548	0.5535
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0083	0.1545	0.1535
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0438	0.0165
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0454	0.9905	1
Brugia malayi	hypothetical protein	0.0077	0.1419	0.1432
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0033	0.0423	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.003	0.0353	0.2328
Onchocerca volvulus		0.0083	0.1545	0.1319
Loa Loa (eye worm)	glycogen phosphorylase	0.0261	0.5548	0.5601
Loa Loa (eye worm)	hypothetical protein	0.0454	0.9905	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0274	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0029	0.0029
Entamoeba histolytica	glycogenphosphorylase, putative	0.0113	0.2219	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Schistosoma mansoni	nAChR subunit	0.0033	0.0423	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0124	0.2478	1
Loa Loa (eye worm)	hypothetical protein	0.0363	0.784	0.7915
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0077	0.1419	0.1394
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Onchocerca volvulus		0.0077	0.1419	0.1188
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Entamoeba histolytica	hypothetical protein	0.0041	0.0608	0.0492
Onchocerca volvulus		0.005	0.0806	0.0552
Echinococcus granulosus	lamin	0.0026	0.0274	0.0246
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.0423	0.0427
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.2478	0.4091
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0091	0.0092
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2957	0.2936
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.2219	0.3592
Schistosoma mansoni	neurotransmitter gated ion channel	0.005	0.0806	0.0787
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.2478	0.2502
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0439	0.0165
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0083	0.1545	0.156
Brugia malayi	hypothetical protein	0.0033	0.0423	0.0427
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0033	0.0423	0.0395
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0033	0.0423	0.0395
Loa Loa (eye worm)	serotonin transporter b	0.0454	0.9905	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0083	0.1545	0.156
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Echinococcus multilocularis	serotonin transporter	0.0454	0.9905	0.9905
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Trypanosoma brucei	cytochrome P450, putative	0.0018	0.0091	0.0249
Echinococcus multilocularis	glycine receptor subunit beta	0.0083	0.1545	0.152
Entamoeba histolytica	hypothetical protein	0.005	0.0806	0.0872
Onchocerca volvulus		0.0077	0.1419	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Plasmodium falciparum	flap endonuclease 1	0.003	0.0353	0.2328
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.2478	0.4091
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.0806	0.0814
Brugia malayi	phosphofructokinase	0.0124	0.2478	0.2502
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0091	0.0092
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0261	0.5548	0.5535
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0033	0.0423	0.0427
Loa Loa (eye worm)	acetylcholine receptor protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Echinococcus granulosus	serotonin transporter	0.0454	0.9905	0.9905
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.2478	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.1545	0.156
Onchocerca volvulus	Putative nachr subunit	0.0083	0.1545	0.1319
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0083	0.1545	0.156
Brugia malayi	6-phosphofructokinase	0.0124	0.2478	0.2502
Loa Loa (eye worm)	phosphofructokinase	0.0124	0.2478	0.2502
Treponema pallidum	sodium- and chloride- dependent transporter	0.0454	0.9905	1
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.5548	0.5535
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Brugia malayi	Cation transporter family protein	0.0083	0.1545	0.156
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0083	0.1545	0.152
Brugia malayi	hypothetical protein	0.0033	0.0423	0.0427
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0492	0.0464
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.015	0.305	0.3079
Echinococcus granulosus	intermediate filament protein	0.0026	0.0274	0.0246
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0438	0.2943
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Onchocerca volvulus		0.0077	0.1419	0.1188
Echinococcus multilocularis	flap endonuclease 1	0.003	0.0353	0.0325
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0083	0.1545	0.152
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0083	0.1545	0.156
Onchocerca volvulus		0.0083	0.1545	0.1319
Echinococcus multilocularis	lamin	0.0026	0.0274	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Echinococcus granulosus	6 phosphofructokinase	0.0124	0.2478	0.2456
Echinococcus multilocularis	serotonin receptor	0.015	0.305	0.303
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	0.1432
Mycobacterium ulcerans	6-phosphofructokinase	0.0124	0.2478	1
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0438	0.2943
Leishmania major	ATP-dependent phosphofructokinase	0.0124	0.2478	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0083	0.1545	0.156
Toxoplasma gondii	hypothetical protein	0.0077	0.1419	1
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Schistosoma mansoni	biogenic amine (5HT) receptor	0.015	0.305	0.3059
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0608	0.0581
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0077	0.1419	0.1407
Echinococcus multilocularis	serotonin receptor	0.015	0.305	0.303
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.2478	0.248
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0332	0.2173
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.0423	0.0427
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.2478	0.4091
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.005	0.0806	0.0787
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0492	0.0496
Schistosoma mansoni	flap endonuclease-1	0.0027	0.0289	0.0263
Plasmodium vivax	amine transporter, putative	0.0077	0.1419	1
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.5548	0.5535
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0077	0.1419	0.1432
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0438	0.2943
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.043	0.0434
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Echinococcus multilocularis	lamin dm0	0.0026	0.0274	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0264	0.0266
Echinococcus granulosus	nAChR subunit	0.005	0.0806	0.0779
Entamoeba histolytica	glycogen phosphorylase, putative	0.0113	0.2219	0.3592
Loa Loa (eye worm)	GABA receptor subunit	0.005	0.0806	0.0814
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.003	0.0001
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	0.1432
Schistosoma mansoni	glycogen phosphorylase	0.0113	0.2219	0.2217
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.2478	0.4091
Echinococcus granulosus	sodium and chloride dependent glycine	0.0077	0.1419	0.1394
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.003	0.0353	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.5548	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0083	0.1545	0.156
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.5548	0.5588
Onchocerca volvulus		0.0083	0.1545	0.1319
Echinococcus multilocularis	nAChR subunit	0.0083	0.1545	0.152
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0077	0.1419	0.1407
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0083	0.1545	0.152
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0608	0.0587
Plasmodium vivax	flap endonuclease 1, putative	0.003	0.0353	0.2328
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.005	0.0806	0.0787
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.003	0.0001
Onchocerca volvulus		0.0083	0.1545	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0083	0.1545	0.156
Onchocerca volvulus		0.0083	0.1545	0.1319
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.1545	0.1535
Schistosoma mansoni	sodium/chloride dependent transporter	0.0077	0.1419	0.1407
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.005	0.0806	0.0814
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.003	0.0001
Loa Loa (eye worm)	flap endonuclease-1	0.003	0.0353	0.0356
Echinococcus multilocularis	neuropeptide receptor A26	0.0459	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0077	0.1419	0.1394
Echinococcus multilocularis	neuropeptide s receptor	0.0459	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.1545	0.1535
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0113	0.2219	0.8915
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.003	0.0001
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.1545	0.156
Onchocerca volvulus		0.0083	0.1545	0.1319
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0091	0.0249
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.003	0.0001
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.2478	0.4091
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0077	0.1419	0.1394
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0083	0.1545	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0274	0.0277
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0274	0.0277
Brugia malayi	Flap endonuclease-1	0.003	0.0353	0.0356
Echinococcus granulosus	biogenic amine 5HT receptor	0.015	0.305	0.303
Brugia malayi	hypothetical protein	0.0139	0.2813	0.284
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Schistosoma mansoni	sodium/chloride dependent transporter	0.0454	0.9905	1
Leishmania major	cytochrome p450-like protein	0.0018	0.0091	0.0249
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.0806	0.0814
Entamoeba histolytica	glycogen phosphorylase, putative	0.0261	0.5548	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0438	0.2943
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0083	0.1545	0.156
Brugia malayi	excitatory GABA receptor EXP-1A	0.0083	0.1545	0.156
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0608	0.0581
Schistosoma mansoni	lamin	0.0026	0.0274	0.0248
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0332	0.1233
Brugia malayi	intermediate filament protein	0.0026	0.0274	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0033	0.043	0.0434
Echinococcus multilocularis	glycogen phosphorylase	0.0261	0.5548	0.5535
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0033	0.0423	0.0427
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0029	0.0029
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0083	0.1545	0.152
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0113	0.2219	0.8942
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.0454	0.9905	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0332	0.0335
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0438	0.0165
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0083	0.1545	0.152
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Schistosoma mansoni	sodium/chloride dependent transporter	0.0077	0.1419	0.1407
Plasmodium falciparum	transporter, putative	0.0077	0.1419	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0492	0.0496
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0091	0.0092
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0492	0.0464
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0033	0.0423	0.0427
Brugia malayi	hypothetical protein	0.0041	0.0608	0.0614
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0776	0.0783
Echinococcus granulosus	lamin dm0	0.0026	0.0274	0.0246
Toxoplasma gondii	hypothetical protein	0.0077	0.1419	1
Schistosoma mansoni	nAChR subunit	0.0033	0.0423	0.0399
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0083	0.1545	0.152
Loa Loa (eye worm)	hypothetical protein	0.015	0.305	0.3079
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.2478	0.2502
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	0.1432
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	ACC-1 protein	0.0083	0.1545	0.156
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0438	0.2943
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0077	0.1419	0.1407
Schistosoma mansoni	hypothetical protein	0.0041	0.0608	0.0587
Brugia malayi	hypothetical protein	0.0033	0.0423	0.0427
Brugia malayi	Muscleblind-like protein	0.0146	0.2957	0.2985
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0033	0.0423	0.0395
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0332	0.2173
Echinococcus granulosus	flap endonuclease 1	0.003	0.0353	0.0325
Onchocerca volvulus		0.0454	0.9905	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0274	0.0277
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.003	0.0353	0.1321
Loa Loa (eye worm)	LGC-31 protein	0.0083	0.1545	0.156
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0083	0.1545	0.156
Schistosoma mansoni	acetylcholine receptor-related	0.0033	0.0423	0.0399
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0776	0.0783
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.5548	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.003	0.003
Giardia lamblia	Glycogen phosphorylase	0.0261	0.5548	1
Echinococcus multilocularis	6 phosphofructokinase	0.0124	0.2478	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0566	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0332	0.2173
Onchocerca volvulus		0.0033	0.0423	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Brugia malayi	6-phosphofructokinase	0.0124	0.2478	0.2502
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0083	0.1545	0.152
Schistosoma mansoni	hypothetical protein	0.0033	0.043	0.0406
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0077	0.1419	0.1394
Echinococcus granulosus	glycogen phosphorylase	0.0261	0.5548	0.5535
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.2478	0.4091
Echinococcus multilocularis	musashi	0.0026	0.0274	0.0246
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0077	0.1419	0.1918
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0077	0.1419	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0776	0.0783
Brugia malayi	hypothetical protein	0.0029	0.0332	0.0335
Trypanosoma cruzi	cytochrome P450, putative	0.0018	0.0091	0.0249
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0083	0.1545	0.156
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0083	0.1545	0.152
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0274	0.0248
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0077	0.1419	0.1394
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0083	0.1545	0.156
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0332	0.1233
Brugia malayi	isocitrate dehydrogenase	0.0015	0.003	0.003
Onchocerca volvulus		0.0033	0.0423	0.0154
Chlamydia trachomatis	glycogen phosphorylase	0.0261	0.5548	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0083	0.1545	0.152
Schistosoma mansoni	lamin	0.0026	0.0274	0.0248
Schistosoma mansoni	neurotransmitter gated ion channel	0.0033	0.0423	0.0399
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	0.1432
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0332	0.2173
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0438	0.0165
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0385	0.0389
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0261	0.5548	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.005	0.0806	0.0814
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0029	0.0029
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Entamoeba histolytica	hypothetical protein	0.0041	0.0608	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0439	0.0165
Schistosoma mansoni	hypothetical protein	0.0165	0.3397	0.341
Leishmania major	hypothetical protein, conserved	0.0029	0.0332	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0083	0.1545	0.1535
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0083	0.1545	0.156
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1419	0.1432
Plasmodium falciparum	amino acid transporter, putative	0.0077	0.1419	1
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.2478	0.248
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0438	0.2943
Schistosoma mansoni	nAChR subunit	0.0083	0.1545	0.1535
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0033	0.0423	0.0395
Echinococcus granulosus	muscleblind protein	0.0146	0.2957	0.2936
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Schistosoma mansoni	neurotransmitter gated ion channel	0.0033	0.0423	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Brugia malayi	Cation transporter family protein	0.0083	0.1545	0.156
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0423	0.0427
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0454	0.9905	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0608	0.0492
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0083	0.1545	0.156
Echinococcus granulosus	neuropeptide receptor A26	0.0459	1	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1545	0.156
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.003	0.003
Schistosoma mansoni	glycogen phosphorylase	0.0261	0.5548	0.5588
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0033	0.0423	0.0427
Echinococcus granulosus	geminin	0.0165	0.3397	0.3377
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0261	0.5548	0.5476
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Echinococcus granulosus	glycine receptor subunit beta	0.0083	0.1545	0.152
Echinococcus multilocularis	muscleblind protein	0.0146	0.2957	0.2936
Onchocerca volvulus		0.0033	0.0423	0.0154
Echinococcus granulosus	nAChR subunit	0.0083	0.1545	0.152
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0077	0.1419	0.1394
Echinococcus granulosus	glycine receptor subunit beta	0.0083	0.1545	0.152
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0332	0.1233
Echinococcus granulosus	sodium and chloride dependent glycine	0.0077	0.1419	0.1394
Loa Loa (eye worm)	norepinephrine transporter	0.0454	0.9905	1
Brugia malayi	carbohydrate phosphorylase	0.0261	0.5548	0.5601
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0077	0.1419	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0806	0.0814
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0077	0.1419	0.1394
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0438	0.0165
Echinococcus multilocularis	glycine receptor subunit beta	0.0083	0.1545	0.152

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibitory activity against HLGP(human liver glycogen phosphorylase)	ChEMBL.	14592521
IC50 (binding)	= 1 nM	Inhibitory activity against HLGP(human liver glycogen phosphorylase)	ChEMBL.	14592521
IC50 (binding)	= 9 nM	Inhibitory activity against HMGP(human muscle glycogen phosphorylase)	ChEMBL.	14592521
IC50 (binding)	= 9 nM	Inhibitory activity against HMGP(human muscle glycogen phosphorylase)	ChEMBL.	14592521
Ratio (binding)	= 9	Ratio of HMGP to that of HLGP was determined	ChEMBL.	14592521
Ratio (binding)	= 9	Ratio of HMGP to that of HLGP was determined	ChEMBL.	14592521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL133911

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 229496