Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Cathepsin D | Starlite/ChEMBL | References |
Sus scrofa | Pepsin A | Starlite/ChEMBL | References |
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG31926 gene product from transcript CG31926-RB | Pepsin A | 385 aa | 332 aa | 40.4 % |
Plasmodium falciparum | plasmepsin VI | Pepsin A | 385 aa | 397 aa | 31.5 % |
Plasmodium knowlesi | plasmepsin V, putative | Pepsin A | 385 aa | 418 aa | 21.5 % |
Plasmodium berghei | plasmepsin X | Cathepsin D | 390 aa | 354 aa | 27.7 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Pepsin A | 385 aa | 358 aa | 30.7 % |
Babesia bovis | aspartyl protease, putative | Cathepsin D | 390 aa | 339 aa | 31.3 % |
Onchocerca volvulus | Pepsin A | 385 aa | 382 aa | 33.0 % | |
Brugia malayi | aspartic protease BmAsp-1, identical | Pepsin A | 385 aa | 385 aa | 33.0 % |
Plasmodium vivax | plasmepsin IV, putative | Pepsin A | 385 aa | 323 aa | 30.0 % |
Candida albicans | secretory aspartyl proteinase SAP3p | Pepsin A | 385 aa | 368 aa | 27.4 % |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | Pepsin A | 385 aa | 382 aa | 33.5 % |
Schistosoma mansoni | cathepsin D (A01 family) | Pepsin A | 385 aa | 373 aa | 43.7 % |
Candida albicans | secretory aspartyl proteinase SAP1p | Pepsin A | 385 aa | 331 aa | 31.1 % |
Candida albicans | secretory aspartyl proteinase SAP9p, related to SAP10 | Cathepsin D | 390 aa | 315 aa | 25.1 % |
Plasmodium knowlesi | eukaryotic aspartyl protease, putative | Cathepsin D | 390 aa | 350 aa | 29.1 % |
Dictyostelium discoideum | hypothetical protein | Pepsin A | 385 aa | 377 aa | 29.2 % |
Candida albicans | secretory aspartyl proteinase SAP8p | Pepsin A | 385 aa | 358 aa | 30.7 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Pepsin A | 385 aa | 342 aa | 27.5 % |
Neospora caninum | Pepsinogen A1, related | Pepsin A | 385 aa | 380 aa | 33.9 % |
Candida albicans | secretory aspartyl proteinase SAP1p | Pepsin A | 385 aa | 331 aa | 31.1 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Pepsin A | 385 aa | 378 aa | 27.2 % |
Plasmodium falciparum | plasmepsin VII | Pepsin A | 385 aa | 423 aa | 27.7 % |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | Pepsin A | 385 aa | 363 aa | 25.3 % |
Plasmodium falciparum | plasmepsin II | Pepsin A | 385 aa | 323 aa | 31.6 % |
Neospora caninum | Renin, related | Pepsin A | 385 aa | 355 aa | 29.3 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Pepsin A | 385 aa | 361 aa | 26.9 % |
Candida albicans | secretory aspartyl proteinase SAP10p, related to SAP9p | Pepsin A | 385 aa | 378 aa | 27.2 % |
Plasmodium berghei | plasmepsin IV | Pepsin A | 385 aa | 369 aa | 31.7 % |
Dictyostelium discoideum | hypothetical protein | Cathepsin D | 390 aa | 374 aa | 24.9 % |
Babesia bovis | aspartyl protease, putative | Pepsin A | 385 aa | 327 aa | 28.7 % |
Candida albicans | secretory aspartyl proteinase SAP3p | Pepsin A | 385 aa | 368 aa | 27.4 % |
Plasmodium vivax | aspartyl protease, putative | Pepsin A | 385 aa | 365 aa | 27.7 % |
Schistosoma mansoni | memapsin-2 (A01 family) | Pepsin A | 385 aa | 434 aa | 21.4 % |
Plasmodium falciparum | plasmepsin III | Pepsin A | 385 aa | 363 aa | 26.2 % |
Plasmodium falciparum | plasmepsin I | Pepsin A | 385 aa | 366 aa | 30.3 % |
Schistosoma japonicum | Cathepsin D precursor, putative | Pepsin A | 385 aa | 328 aa | 37.8 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Pepsin A | 385 aa | 332 aa | 28.9 % |
Cryptosporidium parvum | secreted pepsinogen like aspartyl protease having a signal peptide | Cathepsin D | 390 aa | 387 aa | 24.0 % |
Plasmodium falciparum | plasmepsin IX | Cathepsin D | 390 aa | 410 aa | 26.3 % |
Neospora caninum | Cathepsin D enzyme (EC 3.4.23.5), related | Pepsin A | 385 aa | 353 aa | 28.3 % |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | Pepsin A | 385 aa | 330 aa | 44.5 % |
Candida albicans | potential aspartic protease, weakly similar to C terminus of S. cerevisiae YPS1 (YLR120C), GPI-anchored protease | Pepsin A | 385 aa | 336 aa | 22.6 % |
Plasmodium knowlesi | aspartyl protease, putative | Pepsin A | 385 aa | 391 aa | 31.5 % |
Plasmodium berghei | plasmepsin IX, putative | Cathepsin D | 390 aa | 403 aa | 25.8 % |
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Plasmodium yoelii | aspartyl protease-like | Pepsin A | 385 aa | 419 aa | 21.0 % |
Plasmodium vivax | aspartyl proteinase, putative | Pepsin A | 385 aa | 380 aa | 32.1 % |
Candida albicans | secretory aspartyl proteinase SAP7p | Pepsin A | 385 aa | 361 aa | 26.9 % |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | Pepsin A | 385 aa | 406 aa | 29.3 % |
Schistosoma mansoni | cathepsin D (A01 family) | Pepsin A | 385 aa | 375 aa | 43.7 % |
Toxoplasma gondii | aspartyl protease ASP1 | Pepsin A | 385 aa | 410 aa | 29.5 % |
Schistosoma japonicum | ko:K01379 cathepsin D [EC3.4.23.5], putative | Pepsin A | 385 aa | 376 aa | 43.1 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Pepsin A | 385 aa | 341 aa | 27.9 % |
Toxoplasma gondii | aspartyl protease | Pepsin A | 385 aa | 409 aa | 31.5 % |
Onchocerca volvulus | Sphingomyelin phosphodiesterase 1 homolog | Pepsin A | 385 aa | 386 aa | 42.0 % |
Candida albicans | potential aspartic protease, weakly similar to C terminus of S. cerevisiae YPS1 (YLR120C), GPI-anchored protease | Pepsin A | 385 aa | 336 aa | 22.6 % |
Plasmodium berghei | plasmepsin VII | Pepsin A | 385 aa | 410 aa | 28.5 % |
Candida albicans | secretory aspartyl proteinase SAP6p | Pepsin A | 385 aa | 342 aa | 27.5 % |
Candida albicans | vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) | Pepsin A | 385 aa | 325 aa | 42.8 % |
Cryptosporidium parvum | membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain | Pepsin A | 385 aa | 346 aa | 31.8 % |
Candida albicans | vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) | Pepsin A | 385 aa | 325 aa | 42.8 % |
Plasmodium vivax | aspartyl protease, putative | Cathepsin D | 390 aa | 350 aa | 28.9 % |
Plasmodium knowlesi | plasmepsin IV, putative | Pepsin A | 385 aa | 323 aa | 31.0 % |
Onchocerca volvulus | Pepsin A | 385 aa | 370 aa | 21.4 % | |
Plasmodium berghei | plasmepsin VI | Pepsin A | 385 aa | 351 aa | 31.9 % |
Babesia bovis | eukaryotic aspartyl protease family protein | Pepsin A | 385 aa | 365 aa | 32.3 % |
Cryptosporidium hominis | aspartyl protease precursor | Pepsin A | 385 aa | 345 aa | 31.9 % |
Onchocerca volvulus | Putative 6-pyruvoyl tetrahydrobiopterin synthase | Pepsin A | 385 aa | 386 aa | 31.9 % |
Plasmodium knowlesi | aspartyl protease, putative | Pepsin A | 385 aa | 366 aa | 27.9 % |
Candida albicans | secretory aspartyl proteinase SAP9p, related to SAP10 | Cathepsin D | 390 aa | 315 aa | 25.1 % |
Candida albicans | secretory aspartyl proteinase SAP2p | Pepsin A | 385 aa | 346 aa | 30.9 % |
Plasmodium berghei | plasmepsin V, putative | Pepsin A | 385 aa | 412 aa | 22.1 % |
Candida albicans | secretory aspartyl proteinase SAP4p | Pepsin A | 385 aa | 341 aa | 27.9 % |
Plasmodium yoelii | plasmepsin | Pepsin A | 385 aa | 326 aa | 32.8 % |
Plasmodium falciparum | plasmepsin X | Cathepsin D | 390 aa | 351 aa | 28.8 % |
Candida albicans | secretory aspartyl proteinase SAP5p | Pepsin A | 385 aa | 332 aa | 28.9 % |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | Pepsin A | 385 aa | 330 aa | 43.9 % |
Theileria parva | cathepsin E, putative | Pepsin A | 385 aa | 390 aa | 33.3 % |
Drosophila melanogaster | CG6508 gene product from transcript CG6508-RA | Pepsin A | 385 aa | 379 aa | 41.4 % |
Schistosoma japonicum | Lysosomal aspartic protease precursor, putative | Pepsin A | 385 aa | 324 aa | 31.2 % |
Plasmodium falciparum | plasmepsin IV | Pepsin A | 385 aa | 323 aa | 32.2 % |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | Pepsin A | 385 aa | 385 aa | 44.2 % |
Plasmodium yoelii | Eukaryotic aspartyl protease, putative | Cathepsin D | 390 aa | 354 aa | 27.4 % |
Plasmodium yoelii | pepsinogen A-related | Cathepsin D | 390 aa | 387 aa | 25.8 % |
Candida albicans | secretory aspartyl proteinase SAP2p | Pepsin A | 385 aa | 346 aa | 30.9 % |
Neospora caninum | hypothetical protein | Cathepsin D | 390 aa | 345 aa | 32.5 % |
Plasmodium vivax | plasmepsin V, putative | Pepsin A | 385 aa | 410 aa | 22.9 % |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | Pepsin A | 385 aa | 332 aa | 42.5 % |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | Pepsin A | 385 aa | 377 aa | 30.0 % |
Toxoplasma gondii | aspartyl protease ASP3 | Cathepsin D | 390 aa | 345 aa | 32.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenylate cyclase type IX | 0.0804 | 0.6013 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.014 | 0.0075 | 1 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0532 | 0.3579 | 0.041 |
Brugia malayi | Adenylyl cyclase protein | 0.0532 | 0.3579 | 0.5 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0532 | 0.3579 | 0.5951 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0132 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0477 | 0.3086 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.014 | 0.0075 | 1 |
Onchocerca volvulus | 0.0532 | 0.3579 | 0.041 | |
Plasmodium vivax | aspartyl protease, putative | 0.014 | 0.0075 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.014 | 0.0075 | 1 |
Plasmodium falciparum | plasmepsin X | 0.014 | 0.0075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.115 | 0.9111 | 0.9111 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1178 | 0.9358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.3579 | 0.3579 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0477 | 0.3086 | 1 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0532 | 0.3579 | 0.5951 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0804 | 0.6013 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | In vitro inhibition of human renin. | ChEMBL. | 8120867 |
IC50 (binding) | = 16 nM | In vitro inhibition of human renin. | ChEMBL. | 8120867 |
IC50 (binding) | > 10000 nM | In vitro inhibition of porcine pepsin. | ChEMBL. | 8120867 |
IC50 (binding) | > 10000 nM | In vitro inhibition of bovine cathepsin D. | ChEMBL. | 8120867 |
IC50 (binding) | > 10000 nM | In vitro inhibition of porcine pepsin. | ChEMBL. | 8120867 |
IC50 (binding) | > 10000 nM | In vitro inhibition of bovine cathepsin D. | ChEMBL. | 8120867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.