Detailed information for compound 256212

Basic information

Technical information
  • TDR Targets ID: 256212
  • Name: (2S)-2-(2-benzoylanilino)-3-[4-[(2,3,5,6-tetr amethylphenyl)methoxy]phenyl]propanoic acid
  • MW: 507.619 | Formula: C33H33NO4
  • H donors: 2 H acceptors: 3 LogP: 8.31 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](Nc1ccccc1C(=O)c1ccccc1)Cc1ccc(cc1)OCc1c(C)c(C)cc(c1C)C
  • InChi: 1S/C33H33NO4/c1-21-18-22(2)24(4)29(23(21)3)20-38-27-16-14-25(15-17-27)19-31(33(36)37)34-30-13-9-8-12-28(30)32(35)26-10-6-5-7-11-26/h5-18,31,34H,19-20H2,1-4H3,(H,36,37)/t31-/m0/s1
  • InChiKey: MSODZZFKIHFHQF-HKBQPEDESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[2-(phenylcarbonyl)phenyl]amino]-3-[4-[(2,3,5,6-tetramethylphenyl)methoxy]phenyl]propanoic acid
  • (2S)-2-(2-benzoylanilino)-3-[4-(2,3,5,6-tetramethylbenzyl)oxyphenyl]propionic acid
  • (2S)-2-[[2-(benzoyl)phenyl]amino]-3-[4-[(2,3,5,6-tetramethylphenyl)methoxy]phenyl]propanoic acid
  • (2S)-2-[[2-(oxo-phenylmethyl)phenyl]amino]-3-[4-[(2,3,5,6-tetramethylphenyl)methoxy]phenyl]propanoic acid
  • (2S)-2-[[2-(benzoyl)phenyl]amino]-3-[4-(2,3,5,6-tetramethylbenzyl)oxyphenyl]propionic acid
  • (2S)-2-[(2-phenylcarbonylphenyl)amino]-3-[4-[(2,3,5,6-tetramethylphenyl)methoxy]phenyl]propanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calpain family protein 1 0.0031 0.0022 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Giardia lamblia Alanyl dipeptidyl peptidase 0.0203 0.0488 0.5669
Loa Loa (eye worm) aspartyl protease 6 0.0287 0.0714 0.1377
Brugia malayi Angiotensin-converting enzyme family protein 0.1853 0.4951 0.9544
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0051 0.0076 0.0147
Trypanosoma cruzi oligopeptidase b 0.0771 0.2026 0.3904
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0018
Plasmodium vivax aspartyl protease, putative 0.0367 0.0932 0.3693
Plasmodium falciparum plasmepsin VIII, putative 0.0287 0.0714 0.2832
Echinococcus granulosus acylamino acid releasing enzyme 0.0203 0.0488 0.0941
Loa Loa (eye worm) hypothetical protein 0.0109 0.0231 0.0446
Echinococcus multilocularis snurportin 1 0.0334 0.0842 0.1623
Schistosoma mansoni histone deacetylase 4 5 0.037 0.094 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0072 0.0139
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0771 0.2026 0.3904
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0006 0.0025
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0186 0.0359
Plasmodium falciparum plasmepsin IX 0.0367 0.0932 0.3693
Plasmodium vivax plasmepsin V, putative 0.0287 0.0714 0.2832
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Echinococcus multilocularis histone deacetylase 0.037 0.094 0.1811
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0536 0.1389 0.2678
Brugia malayi CHE-14 protein 0.0221 0.0535 0.1032
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0203 0.0488 0.0925
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0203 0.0488 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0488 0.1936
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.194 0.5188 0.5188
Schistosoma mansoni memapsin-2 (A01 family) 0.1108 0.2937 0.2937
Toxoplasma gondii hypothetical protein 0.0203 0.0488 0.0941
Echinococcus multilocularis tissue type plasminogen activator 0.0037 0.0038 0.0073
Trypanosoma cruzi histone deacetylase, putative 0.0161 0.0375 0.0722
Toxoplasma gondii histone deacetylase HDAC1 0.037 0.094 0.1811
Brugia malayi gamma-secretase subunit aph-1 0.0498 0.1286 0.2478
Onchocerca volvulus 0.0287 0.0714 0.1362
Schistosoma mansoni hypothetical protein 0.0092 0.0187 0.0187
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0771 0.2026 0.3904
Loa Loa (eye worm) hypothetical protein 0.0161 0.0375 0.0722
Leishmania major histone deacetylase, putative 0.037 0.094 0.1811
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0343 0.0866 0.167
Trypanosoma brucei histone deacetylase 2 0.0161 0.0375 0.0722
Echinococcus multilocularis histone deacetylase 1 0.0341 0.0861 0.166
Echinococcus granulosus sodium channel protein 0.004 0.0045 0.0087
Leishmania major histone deacetylase, putative 0.0341 0.0861 0.166
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.0488 0.0941
Trypanosoma brucei histone deacetylase, putative 0.037 0.094 0.1811
Plasmodium falciparum plasmepsin VI 0.0955 0.2523 1
Leishmania major histone deacetylase, putative 0.037 0.094 0.1811
Echinococcus granulosus gamma secretase subunit aph 1 0.0498 0.1286 0.2478
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0488 0.0941
Plasmodium falciparum plasmepsin VII 0.0287 0.0714 0.2832
Brugia malayi aspartic protease BmAsp-2, identical 0.0287 0.0714 0.1377
Toxoplasma gondii kringle domain-containing protein 0.0037 0.0038 0.0073
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0186 0.0359
Trypanosoma cruzi histone deacetylase, putative 0.0161 0.0375 0.0722
Echinococcus granulosus sterol regulatory element binding protein 0.0221 0.0535 0.1032
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0203 0.0488 0.0488
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Plasmodium vivax aspartyl protease, putative 0.0287 0.0714 0.2832
Trypanosoma cruzi histone deacetylase, putative 0.037 0.094 0.1811
Echinococcus multilocularis sodium channel protein 0.004 0.0045 0.0087
Loa Loa (eye worm) histone deacetylase 1 0.0341 0.0861 0.166
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0203 0.0488 0.1936
Brugia malayi Importin beta-1 subunit 0.0031 0.0022 0.0043
Plasmodium vivax aspartyl protease, putative 0.0367 0.0932 0.3693
Brugia malayi Latrophilin receptor protein 2 0.0109 0.0231 0.0446
Brugia malayi Calcitonin receptor-like protein seb-1 0.0343 0.0866 0.167
Trypanosoma brucei histone deacetylase 4 0.037 0.094 0.1811
Plasmodium falciparum cysteine repeat modular protein 1 0.0037 0.0038 0.015
Echinococcus granulosus importin subunit beta 1 0.0031 0.0022 0.0043
Brugia malayi proteasome subunit beta type 1 0.0051 0.0076 0.0147
Loa Loa (eye worm) hypothetical protein 0.0203 0.0488 0.0941
Toxoplasma gondii prolyl endopeptidase 0.194 0.5188 1
Echinococcus granulosus histone deacetylase 6 0.037 0.094 0.1811
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0051 0.0076 0.0076
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.194 0.5188 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0109 0.0231 0.0446
Schistosoma mansoni cathepsin D (A01 family) 0.2754 0.7391 0.7391
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0252 0.0619 0.7183
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1736 0.4637 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0109 0.0231 0.0446
Echinococcus granulosus GPCR family 2 0.0109 0.0231 0.0446
Trypanosoma brucei histone deacetylase 1 0.0341 0.0861 0.166
Trypanosoma brucei prolyl endopeptidase 0.194 0.5188 1
Echinococcus multilocularis calpain A 0.0044 0.0058 0.0112
Loa Loa (eye worm) hypothetical protein 0.0042 0.0053 0.0101
Plasmodium falciparum plasmepsin V 0.0287 0.0714 0.2832
Onchocerca volvulus Histone deacetylase 10 homolog 0.0161 0.0375 0.0706
Trypanosoma cruzi histone deacetylase, putative 0.037 0.094 0.1811
Trypanosoma brucei prolyl oligopeptidase, putative 0.0771 0.2026 0.3904
Loa Loa (eye worm) hypothetical protein 0.0536 0.1389 0.2678
Trypanosoma cruzi prolyl endopeptidase 0.194 0.5188 1
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0536 0.1389 0.1389
Schistosoma mansoni importin beta-1 0.0031 0.0022 0.0022
Echinococcus multilocularis prolyl endopeptidase 0.194 0.5188 1
Plasmodium falciparum plasmepsin IV 0.0955 0.2523 1
Leishmania major oligopeptidase b 0.0771 0.2026 0.3904
Toxoplasma gondii aspartyl protease ASP1 0.0955 0.2523 0.4863
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0287 0.0714 0.1377
Plasmodium falciparum histone deacetylase 2 0.037 0.094 0.3724
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0109 0.0231 0.0446
Plasmodium falciparum plasmepsin X 0.0367 0.0932 0.3693
Brugia malayi hypothetical protein 0.0287 0.0714 0.1377
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0037 0.0038 0.015
Schistosoma mansoni histone deacetylase hda2 0.0161 0.0375 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.0235 0.0572 0.1103
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0955 0.2523 0.4863
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0186 0.0359
Echinococcus granulosus Dipeptidyl peptidase 9 0.0203 0.0488 0.0941
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.0488 0.0941
Schistosoma mansoni hypothetical protein 0.0109 0.0231 0.0231
Echinococcus multilocularis histone deacetylase 8 0.0161 0.0375 0.0722
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0109 0.0231 0.0446
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0043
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0044 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0037 0.0038 0.0038
Brugia malayi calpain family protein 1 0.0042 0.0053 0.0101
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0203 0.0488 0.0941
Entamoeba histolytica histone deacetylase, putative 0.0341 0.0861 1
Echinococcus multilocularis protein patched 0.0221 0.0535 0.1032
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0341 0.0861 0.3414
Giardia lamblia Proteasome subunit beta type 1 0.0051 0.0076 0.0885
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0072 0.0139
Brugia malayi RNA, U transporter 1 0.0089 0.0179 0.0344
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Schistosoma mansoni histone deacetylase 1 2 3 0.0161 0.0375 0.0375
Toxoplasma gondii histone deacetylase HDAC5 0.0161 0.0375 0.0722
Brugia malayi prolyl oligopeptidase family protein 0.194 0.5188 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0022 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0072 0.0139
Schistosoma mansoni gamma-secretase subunit aph-1 0.0498 0.1286 0.1286
Plasmodium vivax histone deacetylase 2, putative 0.037 0.094 0.3724
Echinococcus granulosus histone deacetylase 0.037 0.094 0.1811
Trypanosoma cruzi histone deacetylase 1, putative 0.0341 0.0861 0.166
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0536 0.1389 0.2678
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0051 0.0076 0.0885
Echinococcus granulosus Niemann Pick C1 protein 0.0221 0.0535 0.1032
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0203 0.0488 0.0941
Brugia malayi hypothetical protein 0.0287 0.0714 0.1377
Loa Loa (eye worm) hypothetical protein 0.0955 0.2523 0.4863
Echinococcus multilocularis histone deacetylase 6 0.037 0.094 0.1811
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0771 0.2026 0.3904
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0203 0.0488 0.0941
Plasmodium vivax plasmepsin IV, putative 0.0955 0.2523 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Trypanosoma brucei oligopeptidase b 0.0771 0.2026 0.3904
Brugia malayi Histone deacetylase family protein 0.037 0.094 0.1811
Leishmania major calcium channel protein, putative,ion transporter, putative 0.004 0.0045 0.0087
Schistosoma mansoni histone deacetylase hda2 0.0376 0.0956 0.0956
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0051 0.0076 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0038 0.0073
Echinococcus multilocularis sterol regulatory element binding protein 0.0221 0.0535 0.1032
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0955 0.2523 0.4863
Trypanosoma cruzi hypothetical protein, conserved 0.0203 0.0488 0.0941
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0006 0.0025
Entamoeba histolytica prolyl oligopeptidase family protein 0.0203 0.0488 0.5669
Schistosoma mansoni histone deacetylase 0.0341 0.0861 0.0861
Loa Loa (eye worm) latrophilin receptor protein 2 0.0109 0.0231 0.0446
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0203 0.0488 0.0941
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0186 0.0359
Trypanosoma cruzi oligopeptidase b 0.0771 0.2026 0.3904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0072 0.0139
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0341 0.0861 0.3414
Echinococcus multilocularis histone deacetylase 7 0.037 0.094 0.1811
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0006 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0109 0.0231 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.0535 0.2122
Echinococcus multilocularis gamma secretase subunit aph 1 0.0498 0.1286 0.2478
Onchocerca volvulus 0.0037 0.0038 0.0055
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0221 0.0535 0.0535
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0203 0.0488 0.0941
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0955 0.2523 0.4863
Schistosoma mansoni histone deacetylase 0.0341 0.0861 0.0861
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0536 0.1389 0.2678
Brugia malayi histone deacetylase 1 (HD1) 0.0341 0.0861 0.166
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0022 0.0043
Schistosoma mansoni patched 1 0.0221 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0043
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0051 0.0076 0.0147
Brugia malayi Eukaryotic aspartyl protease family protein 0.0287 0.0714 0.1377
Plasmodium vivax histone deacetylase, putative 0.037 0.094 0.3724
Schistosoma mansoni hypothetical protein 0.0109 0.0231 0.0231
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Loa Loa (eye worm) hypothetical protein 0.0203 0.0488 0.0941
Loa Loa (eye worm) hypothetical protein 0.0287 0.0714 0.1377
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Loa Loa (eye worm) histone deacetylase 7A 0.037 0.094 0.1811
Plasmodium falciparum peptidase, putative 0.0203 0.0488 0.1936
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0252 0.0619 0.2453
Leishmania major importin beta-1 subunit, putative 0.0025 0.0006 0.0012
Plasmodium falciparum plasmepsin III 0.0287 0.0714 0.2832
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0006 0.0025
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0051 0.0076 0.0147
Loa Loa (eye worm) histone deacetylase 11 0.0161 0.0375 0.0722
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0203 0.0488 0.0941
Loa Loa (eye worm) prolyl oligopeptidase 0.0203 0.0488 0.0941
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0536 0.1389 0.2678
Plasmodium vivax aspartyl proteinase, putative 0.0287 0.0714 0.2832
Loa Loa (eye worm) prolyl oligopeptidase 0.0203 0.0488 0.0941
Trypanosoma brucei histone deacetylase 3 0.037 0.094 0.1811
Giardia lamblia Alanyl dipeptidyl peptidase 0.0203 0.0488 0.5669
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0051 0.0076 0.0302
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0022 0.0043
Toxoplasma gondii histone deacetylase HDAC2 0.0341 0.0861 0.166
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0771 0.2026 0.3904
Loa Loa (eye worm) hypothetical protein 0.0235 0.0572 0.1103
Trichomonas vaginalis histone deacetylase, putative 0.0341 0.0861 0.3414
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.194 0.5188 0.5188
Echinococcus multilocularis protein dispatched 1 0.0221 0.0535 0.1032
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0045 0.0087
Entamoeba histolytica prolyl oligopeptidase family protein 0.0203 0.0488 0.5669
Echinococcus granulosus histone deacetylase 8 0.0161 0.0375 0.0722
Brugia malayi Pepsin A precursor 0.0287 0.0714 0.1377
Echinococcus granulosus prolyl endopeptidase 0.194 0.5188 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.0842 0.1623
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.0186 0.0359
Entamoeba histolytica hypothetical protein, conserved 0.0203 0.0488 0.5669
Trypanosoma cruzi histone deacetylase 1, putative 0.0341 0.0861 0.166
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0252 0.0619 0.2453
Loa Loa (eye worm) hypothetical protein 0.0287 0.0714 0.1377
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0044 0.0058 0.0112
Plasmodium falciparum histone deacetylase 1 0.0341 0.0861 0.3414
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0341 0.0861 0.3414
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0771 0.2026 1
Echinococcus granulosus calpain A 0.0044 0.0058 0.0112
Entamoeba histolytica prolyl oligopeptidase family protein 0.0203 0.0488 0.5669
Plasmodium vivax histone deacetylase 1, putative 0.0341 0.0861 0.3414
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0498 0.1286 0.2478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0072
Brugia malayi calpain family protein 1 0.0042 0.0053 0.0101
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0221 0.0535 0.1032
Loa Loa (eye worm) hypothetical protein 0.0215 0.0519 0.1001
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0203 0.0488 0.0488
Echinococcus multilocularis GPCR, family 2 0.0109 0.0231 0.0446
Echinococcus multilocularis histone deacetylase 3 0.0341 0.0861 0.166
Loa Loa (eye worm) hypothetical protein 0.0037 0.0038 0.0073
Loa Loa (eye worm) hypothetical protein 0.0343 0.0866 0.167
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1853 0.4951 0.9544
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0042 0.0053 0.0053
Plasmodium falciparum plasmepsin II 0.0955 0.2523 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0771 0.2026 0.5
Leishmania major histone deacetylase, putative 0.0341 0.0861 0.166
Plasmodium falciparum importin beta, putative 0.0031 0.0022 0.0089
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.0187 0.036
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0022 0.0043
Echinococcus granulosus histone deacetylase 6 0.0376 0.0956 0.1843
Onchocerca volvulus Prolyl endopeptidase homolog 0.194 0.5188 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0221 0.0535 0.1032
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.0488 0.0941
Echinococcus granulosus histone deacetylase 3 0.0341 0.0861 0.166
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0044 0.0058 0.0058
Brugia malayi Kringle domain containing protein 0.0037 0.0038 0.0073
Schistosoma mansoni hypothetical protein 0.0235 0.0572 0.0572
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0203 0.0488 0.0941
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0072
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0203 0.0488 0.0941
Trypanosoma brucei proteasome beta 6 subunit 0.0051 0.0076 0.0147
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0051 0.0076 0.0147
Brugia malayi histone deacetylase 3 (HD3) 0.0341 0.0861 0.166
Toxoplasma gondii histone deacetylase HDAC3 0.0341 0.0861 0.166
Schistosoma mansoni histone deacetylase 4 5 0.037 0.094 0.094
Brugia malayi prolyl oligopeptidase family protein 0.0203 0.0488 0.0941
Schistosoma mansoni hypothetical protein 0.0109 0.0231 0.0231
Toxoplasma gondii aspartyl protease ASP3 0.0367 0.0932 0.1796
Loa Loa (eye worm) hypothetical protein 0.0221 0.0535 0.1032
Trypanosoma cruzi histone deacetylase, putative 0.037 0.094 0.1811
Echinococcus multilocularis histone deacetylase 6 0.0376 0.0956 0.1843
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0536 0.1389 0.2678
Echinococcus granulosus snurportin 1 0.0334 0.0842 0.1623
Echinococcus granulosus tissue type plasminogen activator 0.0037 0.0038 0.0073
Echinococcus multilocularis calpain family protein 1, d 0.0031 0.0022 0.0043
Loa Loa (eye worm) proteasome subunit beta type 1 0.0051 0.0076 0.0147
Plasmodium vivax aspartyl proteinase, putative 0.0955 0.2523 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0955 0.2523 0.2523
Toxoplasma gondii histone deacetylase HDAC4 0.0161 0.0375 0.0722
Loa Loa (eye worm) hypothetical protein 0.194 0.5188 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Plasmodium vivax hypothetical protein, conserved 0.0203 0.0488 0.1936
Entamoeba histolytica hypothetical protein 0.0025 0.0006 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0343 0.0866 0.167
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0076 0.0302
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0203 0.0488 0.1936
Plasmodium falciparum plasmepsin I 0.0955 0.2523 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0022 0.0043
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0536 0.1389 0.2678
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0203 0.0488 0.0941
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0287 0.0714 0.0714
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0252 0.0619 0.2453
Loa Loa (eye worm) hypothetical protein 0.0209 0.0503 0.0969
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0203 0.0488 0.5669
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0203 0.0488 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0072 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0072
Echinococcus granulosus Protein patched homolog 1 0.0221 0.0535 0.1032
Brugia malayi aspartic protease BmAsp-1, identical 0.0287 0.0714 0.1377
Onchocerca volvulus 0.0287 0.0714 0.1362
Giardia lamblia Histone deacetylase 0.0341 0.0861 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0203 0.0488 0.0941
Brugia malayi Protein kinase domain containing protein 0.0037 0.0038 0.0073
Plasmodium falciparum histone deacetylase, putative 0.037 0.094 0.3724
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0955 0.2523 0.4863
Echinococcus multilocularis histone deacetylase 6 0.037 0.094 0.1811
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0536 0.1389 0.2678
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0051 0.0076 0.0147
Trypanosoma cruzi Aph-1 protein, putative 0.0194 0.0463 0.0892
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0955 0.2523 1
Leishmania major hypothetical protein, conserved 0.0037 0.0038 0.0073
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0203 0.0488 0.0941
Plasmodium vivax proteasome subunit beta type-1, putative 0.0051 0.0076 0.0302
Toxoplasma gondii aspartyl protease 0.0287 0.0714 0.1377
Schistosoma mansoni cathepsin D (A01 family) 0.2754 0.7391 0.7391
Schistosoma mansoni hypothetical protein 0.0109 0.0231 0.0231
Brugia malayi Histone deacetylase family protein 0.037 0.094 0.1811
Loa Loa (eye worm) histone deacetylase 3 0.0341 0.0861 0.166
Trypanosoma cruzi Aph-1 protein, putative 0.0194 0.0463 0.0892
Brugia malayi Histone deacetylase 1 0.0341 0.0861 0.166
Loa Loa (eye worm) calpain family protein 1 0.0042 0.0053 0.0101
Loa Loa (eye worm) histone deacetylase 0.037 0.094 0.1811
Echinococcus multilocularis acylamino acid releasing enzyme 0.0203 0.0488 0.0941
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0044 0.0058 0.0112
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0676 0.1767 0.1767
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.0038 0.0073
Trypanosoma brucei Aph-1 protein, putative 0.0194 0.0463 0.0892
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0203 0.0488 0.5669
Schistosoma mansoni hypothetical protein 0.0334 0.0842 0.0842
Echinococcus granulosus histone deacetylase 1 0.0341 0.0861 0.166
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0287 0.0714 0.1377
Plasmodium vivax histone deacetylase, putative 0.0161 0.0375 0.1485
Echinococcus granulosus histone deacetylase 7 0.037 0.094 0.1811
Echinococcus granulosus histone deacetylase 6 0.037 0.094 0.1811
Brugia malayi histone deacetylase 11 0.0161 0.0375 0.0722
Loa Loa (eye worm) hypothetical protein 0.0341 0.0861 0.166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0072 0.0139

Activities

Activity type Activity value Assay description Source Reference
Log Ki (binding) 0 Inhibition of Peroxisome proliferator activated receptor gamma ChEMBL. 9836621

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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