Detailed information for compound 261089

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.806 | Formula: C18H17ClN4O3
  • H donors: 1 H acceptors: 4 LogP: 4.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc2ncnc(c2cc1[N+](=O)[O-])NCCc1ccc(cc1)Cl
  • InChi: 1S/C18H17ClN4O3/c1-2-26-17-10-15-14(9-16(17)23(24)25)18(22-11-21-15)20-8-7-12-3-5-13(19)6-4-12/h3-6,9-11H,2,7-8H2,1H3,(H,20,21,22)
  • InChiKey: FMCGYKGTQLFPMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1844 0.6701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0018 0.0064
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0153 0.1783 0.1783
Echinococcus granulosus neuropeptide receptor A26 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni loxhd1 0.0035 0.0259 0.0337
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0333 0.0333
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0036 0.0668
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0018 0.0329
Echinococcus multilocularis neuropeptide s receptor 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0028 0.0176 0.0527
Loa Loa (eye worm) hypothetical protein 0.0339 0.4197 0.4705
Echinococcus granulosus intermediate filament protein 0.0028 0.0176 0.0176
Echinococcus multilocularis lipoxygenase domain containing protein 0.0035 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus lipoxygenase domain containing protein 0.0035 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Echinococcus multilocularis sex peptide receptor 0.0273 0.3344 0.3344
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0705 0.0705
Loa Loa (eye worm) G-protein coupled receptor 0.0273 0.3344 0.3748
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0463 0.0463
Loa Loa (eye worm) neuropeptide F receptor 0.0273 0.3344 0.3748
Echinococcus granulosus serotonin receptor 0.0273 0.3344 0.3344
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0333 0.0433
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0333 0.0557
Plasmodium falciparum glutathione reductase 0.0051 0.0463 1
Brugia malayi Dopamine receptor protein 1 0.0273 0.3344 0.5605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0065 0.3473
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0085
Schistosoma mansoni axis inhibition protein axin 0.004 0.0333 0.0433
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0304 0.567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0018 0.003
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0333 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Schistosoma mansoni hypothetical protein 0.0273 0.3344 0.4357
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0018 0.002
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0333 0.0333
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0036 0.0773
Loa Loa (eye worm) carboxylesterase 0.0069 0.0705 0.0791
Schistosoma mansoni neuropeptide receptor 0.0273 0.3344 0.4357
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0479 0.0625
Schistosoma mansoni growth hormone secretagogue receptor 0.0273 0.3344 0.4357
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0273 0.51
Brugia malayi neuropeptide F receptor 0.0273 0.3344 0.5605
Echinococcus granulosus microtubule associated protein 2 0.0608 0.7674 0.7674
Schistosoma mansoni regulator of G protein signaling 0.004 0.0333 0.0433
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0065 0.0065
Schistosoma mansoni microtubule-associated protein tau 0.0608 0.7674 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Schistosoma mansoni jumonji domain containing protein 0.0052 0.0479 0.0625
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0065 0.1214
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0104 0.1155 0.2545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0213 0.0773
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0333 0.0433
Loa Loa (eye worm) hypothetical protein 0.0143 0.1658 0.1858
Echinococcus granulosus sex peptide receptor 0.0273 0.3344 0.3344
Echinococcus granulosus lipoxygenase domain containing protein 0.0035 0.0259 0.0259
Brugia malayi jmjC domain containing protein 0.0052 0.0479 0.0804
Schistosoma mansoni neuropeptide F-like receptor 0.0273 0.3344 0.4357
Trypanosoma brucei trypanothione reductase 0.0051 0.0463 0.8591
Echinococcus multilocularis serotonin receptor 0.0273 0.3344 0.3344
Schistosoma mansoni neuropeptide F-like receptor 0.0273 0.3344 0.4357
Toxoplasma gondii exonuclease III APE 0.002 0.0065 0.1405
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1844 0.6701
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0273 0.3344 0.4357
Schistosoma mansoni neuropeptide receptor 0.0273 0.3344 0.4357
Schistosoma mansoni regulator of G protein signaling 0.004 0.0333 0.0433
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0226 0.0821
Loa Loa (eye worm) hypothetical protein 0.0028 0.0169 0.019
Onchocerca volvulus 0.0035 0.0259 0.0773
Schistosoma mansoni hypothetical protein 0.0342 0.4229 0.5511
Echinococcus multilocularis neuropeptide receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.034 0.1235
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0333 0.0333
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0463 0.0463
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0067 0.0959
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0273 0.3344 0.5605
Schistosoma mansoni histamine h1 receptor 0.0273 0.3344 0.4357
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0333 0.0433
Echinococcus multilocularis microtubule associated protein 2 0.0608 0.7674 0.7674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1103
Plasmodium falciparum LCCL domain-containing protein 0.0035 0.0259 0.5583
Echinococcus multilocularis neuropeptide Y receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0259 0.029
Onchocerca volvulus 0.0081 0.0861 0.2575
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0333 0.0333
Echinococcus multilocularis lysine specific demethylase 5A 0.0052 0.0479 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0431 0.1565
Brugia malayi Cytochrome P450 family protein 0.0035 0.0263 0.0441
Echinococcus multilocularis fmrfamide receptor 0.0273 0.3344 0.3344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0656
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0065 0.0915
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0333 0.0433
Echinococcus granulosus lamin dm0 0.0028 0.0176 0.0176
Echinococcus multilocularis serotonin receptor 0.0273 0.3344 0.3344
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0273 0.3344 0.3344
Brugia malayi putative neuropeptide receptor NPR1 0.0273 0.3344 0.5605
Echinococcus granulosus dro:myosuppressin receptor 0.0273 0.3344 0.3344
Plasmodium vivax glutathione reductase, putative 0.0051 0.0463 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0069 0.0705 0.0791
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0273 0.3344 0.4357
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1301 0.8837
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Echinococcus granulosus biogenic amine 5HT receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis G protein coupled receptor 139 0.0273 0.3344 0.3344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Echinococcus multilocularis small conductance calcium activated potassium 0.0342 0.4229 0.4229
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0273 0.3344 0.3344
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0536 1
Mycobacterium tuberculosis Probable reductase 0.0115 0.1301 0.8837
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus biogenic amine 5HT receptor 0.0273 0.3344 0.3344
Echinococcus granulosus alpha 1A adrenergic receptor 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0028 0.0176 0.0527
Schistosoma mansoni amine GPCR 0.0273 0.3344 0.4357
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0018 0.0329
Brugia malayi Cation transporter family protein 0.0081 0.0861 0.1444
Loa Loa (eye worm) hypothetical protein 0.0076 0.0789 0.0884
Schistosoma mansoni biogenic amine receptor 0.0273 0.3344 0.4357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.3344 0.3344
Echinococcus granulosus orexin receptor type 2 0.0273 0.3344 0.3344
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0065 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0018 0.0329
Loa Loa (eye worm) G-protein coupled receptor 0.0273 0.3344 0.3748
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1468 1
Onchocerca volvulus 0.0273 0.3344 1
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.012 0.2241
Onchocerca volvulus 0.0273 0.3344 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Brugia malayi Dopamine receptor protein 2 0.0273 0.3344 0.5605
Brugia malayi Tachykinin-like peptides receptor 99D 0.0273 0.3344 0.5605
Loa Loa (eye worm) melatonin receptor type 1A 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni amine GPCR 0.0273 0.3344 0.4357
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1301 0.8837
Echinococcus multilocularis G-protein coupled receptor, putative 0.0273 0.3344 0.3344
Echinococcus granulosus axis inhibition protein axin 0.004 0.0333 0.0333
Brugia malayi jmjC domain containing protein 0.0052 0.0479 0.0804
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0273 0.3344 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0656
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0273 0.3344 0.4357
Trypanosoma brucei membrane transporter protein, putative 0.0036 0.0273 0.4933
Onchocerca volvulus 0.0273 0.3344 1
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Brugia malayi Serotonin receptor 0.0273 0.3344 0.5605
Brugia malayi larval opioid receptor 0.0273 0.3344 0.5605
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.1405
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0273 0.3344 0.3344
Brugia malayi Carboxylesterase family protein 0.0069 0.0705 0.1182
Echinococcus granulosus neuropeptides capa receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0431 0.0483
Echinococcus granulosus g protein coupled receptor 0.0273 0.3344 0.3344
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0273 0.3344 0.3344
Giardia lamblia DNA repair protein RAD52 0.0366 0.454 1
Echinococcus granulosus G protein coupled receptor 139 0.0273 0.3344 0.3344
Schistosoma mansoni amine GPCR 0.0273 0.3344 0.4357
Echinococcus granulosus 7TM GPCR rhodopsin 0.0273 0.3344 0.3344
Entamoeba histolytica hypothetical protein 0.004 0.0333 0.0732
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0273 0.3344 0.3344
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0273 0.3344 0.4357
Trypanosoma brucei MATE efflux family protein, putative 0.0036 0.0273 0.4933
Schistosoma mansoni biogenic amine receptor 0.0273 0.3344 0.4357
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0065 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0273 0.3344 0.4357
Schistosoma mansoni hypothetical protein 0.0178 0.2115 0.2756
Brugia malayi G-protein coupled receptor 0.0273 0.3344 0.5605
Onchocerca volvulus 0.0081 0.0861 0.2575
Leishmania major trypanothione reductase 0.0051 0.0463 0.8637
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0473 0.8824
Echinococcus multilocularis g protein coupled receptor 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0273 0.3344 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0333 0.0333
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.3344 0.4357
Trypanosoma brucei membrane transporter protein, putative 0.0036 0.0273 0.4933
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.012 0.0135
Echinococcus multilocularis expressed protein 0.0788 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0431 0.7966
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0036 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0145 0.0526
Loa Loa (eye worm) jmjC domain-containing protein 0.0052 0.0479 0.0537
Brugia malayi Melatonin receptor type 1A 0.0273 0.3344 0.5605
Loa Loa (eye worm) hypothetical protein 0.0028 0.0176 0.0197
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0476 0.5966 0.6687
Brugia malayi Doublecortin family protein 0.0035 0.0259 0.0433
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0081 0.0861 0.1122
Schistosoma mansoni biogenic amine receptor 0.0273 0.3344 0.4357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0018 0.0064
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0103 0.1649
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus neuropeptide receptor 0.0273 0.3344 0.3344
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0333 0.0433
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0273 0.3344 0.3344
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0271 0.5861
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0463 0.8637
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0431 0.8033
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0536 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0052 0.0479 0.0479
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0431 0.0722
Schistosoma mansoni hypothetical protein 0.0178 0.2115 0.2756
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Leishmania major cytochrome p450-like protein 0.0024 0.012 0.2241
Echinococcus granulosus Polycystic kidney disease protein 0.0035 0.0259 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0144 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0144 0.0524
Brugia malayi intermediate filament protein 0.0028 0.0176 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0236
Schistosoma mansoni lipoxygenase 0.0153 0.1783 0.2323
Brugia malayi putative neuropeptide receptor 0.0273 0.3344 0.5605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0177 0.0643
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0033 0.0233 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0018 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0431 0.1565
Brugia malayi glutathione reductase 0.0051 0.0463 0.0776
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0036 0.006
Schistosoma mansoni rab6-interacting 0.0035 0.0259 0.0337
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0036 0.013
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.3344 0.3344
Schistosoma mansoni adenoreceptor 0.0273 0.3344 0.4357
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0036 0.0273 0.0273
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0273 0.3344 0.5605
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0273 0.51
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0705 0.0791
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Trypanosoma brucei cytochrome P450, putative 0.0024 0.012 0.1977
Schistosoma mansoni neuropeptide f receptor 76f 0.0273 0.3344 0.4357
Brugia malayi hypothetical protein 0.004 0.0333 0.0557
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Brugia malayi hypothetical protein 0.013 0.1493 0.2502
Echinococcus multilocularis lamin dm0 0.0028 0.0176 0.0176
Brugia malayi hypothetical protein 0.004 0.0333 0.0557
Echinococcus granulosus small conductance calcium activated potassium 0.0342 0.4229 0.4229
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Schistosoma mansoni hypothetical protein 0.0054 0.0506 0.0659
Onchocerca volvulus 0.0273 0.3344 1
Brugia malayi RE15519p 0.0273 0.3344 0.5605
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Leishmania major hypothetical protein, conserved 0.0036 0.0273 0.51
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0333 0.0333
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0273 0.3344 0.3344
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0704 0.8921 1
Brugia malayi G protein-coupled receptor 0.0273 0.3344 0.5605
Loa Loa (eye worm) glutathione reductase 0.0051 0.0463 0.0519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Echinococcus granulosus g-protein coupled receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.012 0.0135
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0705 0.0705
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Plasmodium falciparum thioredoxin reductase 0.0018 0.0036 0.0773
Brugia malayi Thioredoxin reductase 0.0051 0.0463 0.0776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Schistosoma mansoni multidrug resistance protein 0.0036 0.0273 0.0356
Loa Loa (eye worm) neuropeptide F receptor 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0342 0.4229 0.4741
Schistosoma mansoni rab6-interacting 0.0035 0.0259 0.0337
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0273 0.3344 0.4357
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0273 0.3344 0.5605
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Echinococcus granulosus axis inhibition protein axin 0.004 0.0333 0.0333
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0065 0.0205
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.3344 0.3344
Echinococcus multilocularis dro:myosuppressin receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis Polycystic kidney disease protein 0.0035 0.0259 0.0259
Loa Loa (eye worm) TYRA-2 protein 0.0273 0.3344 0.3748
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0273 0.3344 0.3344
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0018 0.0023
Schistosoma mansoni calcium-activated potassium channel 0.0271 0.3316 0.4321
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus lysine specific demethylase 5A 0.0052 0.0479 0.0479
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0333 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus multilocularis g protein coupled receptor 0.0273 0.3344 0.3344
Schistosoma mansoni lamin 0.0028 0.0176 0.023
Onchocerca volvulus 0.0081 0.0861 0.2575
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0333 0.0433
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0381 0.7098
Schistosoma mansoni regulator of G protein signaling 0.004 0.0333 0.0433
Loa Loa (eye worm) CYP4Cod1 0.0024 0.012 0.0135
Echinococcus multilocularis geminin 0.0178 0.2115 0.2115
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0273 0.3344 0.3344
Schistosoma mansoni axis inhibition protein axin 0.004 0.0333 0.0433
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0366 0.454 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0036 0.0773
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.0536 1
Schistosoma mansoni opsin-like receptor 0.0273 0.3344 0.4357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Schistosoma mansoni regulator of G protein signaling 0.004 0.0333 0.0433
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0176 0.0295
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0333 0.0557
Onchocerca volvulus 0.0035 0.0259 0.0773
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.0128 0.1468 0.1646
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0463 0.2985
Leishmania major cathepsin L-like protease 0.0056 0.0536 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.1405
Schistosoma mansoni lipoxygenase 0.009 0.0974 0.1269
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0431 0.0561
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.3344 0.3344
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0273 0.3344 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0036 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0144 0.0524
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1301 0.8837
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.3344 0.4357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0036 0.0773
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0273 0.3344 0.4357
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0273 0.3344 0.5605
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0036 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Onchocerca volvulus 0.0273 0.3344 1
Schistosoma mansoni amine GPCR 0.0273 0.3344 0.4357
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0036 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0273 0.3344 0.3344
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0065 0.1214
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Onchocerca volvulus Neuropeptide F receptor homolog 0.0273 0.3344 1
Loa Loa (eye worm) RGS-3 protein 0.004 0.0333 0.0373
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0705 0.0705
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0065 0.0143
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1301 0.8837
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.3344 0.3344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1103
Schistosoma mansoni myosin xvIII 0.0273 0.3344 0.4357
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Echinococcus granulosus hypothetical protein 0.0273 0.3344 0.3344
Brugia malayi Cytochrome P450 family protein 0.0024 0.012 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Onchocerca volvulus 0.0273 0.3344 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0065 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0065 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0273 0.3344 0.3344
Leishmania major cathepsin L-like protease 0.0056 0.0536 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0333 0.0373
Schistosoma mansoni biogenic amine (5HT) receptor 0.0273 0.3344 0.4357
Brugia malayi PXA domain containing protein 0.004 0.0333 0.0557
Echinococcus granulosus g protein coupled receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus neuropeptide Y receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis g protein coupled receptor 0.0273 0.3344 0.3344
Schistosoma mansoni regulator of G protein signaling 0.004 0.0333 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0145 0.0526
Onchocerca volvulus Glucosylceramidase homolog 0.0149 0.174 0.5205
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0036 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0273 0.3344 0.3344
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0036 0.0351
Schistosoma mansoni jumonji/arid domain-containing protein 0.0052 0.0479 0.0625
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0431 0.8033
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0081 0.0861 0.1122
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0431 0.7966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0018 0.0064
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0431 0.0949
Echinococcus granulosus 7tm_1 domain containing protein 0.0273 0.3344 0.3344
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0333 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0018 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Trypanosoma brucei membrane transporter protein, putative 0.0036 0.0273 0.4933
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1468 1
Echinococcus granulosus neuropeptide Y receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0333 0.0333
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0431 0.0949
Brugia malayi GnHR receptor homolog 0.0273 0.3344 0.5605
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0333 0.0333
Echinococcus granulosus acetylcholinesterase 0.0069 0.0705 0.0705
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.012 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Brugia malayi Dopamine receptor 0.0273 0.3344 0.5605
Schistosoma mansoni amine GPCR 0.0273 0.3344 0.4357
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0273 0.3344 0.4357
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0431 0.0431
Leishmania major hypothetical protein, conserved 0.0036 0.0273 0.51
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0227 0.2753 0.4614
Echinococcus granulosus peptide allatostatin:somatostatin 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0273 0.3344 0.4357
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0065 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0273 0.3344 0.3344
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0273 0.3344 0.4357
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0333 0.0333
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0273 0.51
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0333 0.0557
Brugia malayi ORL1-like opioid receptor 0.0273 0.3344 0.5605
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Leishmania major cathepsin L-like protease 0.0056 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0036 0.0773
Onchocerca volvulus 0.0273 0.3344 1
Entamoeba histolytica hypothetical protein 0.004 0.0333 0.0732
Brugia malayi Carboxylesterase family protein 0.0069 0.0705 0.1182
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0333 0.0557
Echinococcus multilocularis fmrfamide receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0263 0.0295
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1468 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0236
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0463 1
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0273 0.3344 0.3748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1103
Echinococcus multilocularis neuropeptides capa receptor 0.0273 0.3344 0.3344
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0333 0.1208
Onchocerca volvulus 0.0273 0.3344 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0273 0.51
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0273 0.3344 0.3344
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0052 0.0479 0.0479
Echinococcus granulosus neuropeptide s receptor 0.0273 0.3344 0.3344
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0273 0.3344 0.5605
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Loa Loa (eye worm) hypothetical protein 0.0057 0.0542 0.0608
Brugia malayi G-protein coupled receptor 0.0273 0.3344 0.5605
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Onchocerca volvulus 0.0273 0.3344 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0176 0.0197
Echinococcus granulosus RUN 0.0035 0.0259 0.0259
Trypanosoma cruzi membrane transporter protein, putative 0.0036 0.0273 0.51
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Brugia malayi neuropeptide F receptor 0.0273 0.3344 0.5605
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0304 0.567
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Echinococcus granulosus acetylcholinesterase 0.0069 0.0705 0.0705
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Onchocerca volvulus 0.0273 0.3344 1
Onchocerca volvulus 0.0273 0.3344 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0333 0.0373
Toxoplasma gondii thioredoxin reductase 0.0051 0.0463 1
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0463 0.0519
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0273 0.3344 0.4357
Loa Loa (eye worm) doublecortin family protein 0.0035 0.0259 0.029
Entamoeba histolytica hypothetical protein 0.004 0.0333 0.0732
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0176 0.0197
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0333 0.0333
Schistosoma mansoni polycystin 1-related 0.0035 0.0259 0.0337
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0273 0.3344 1
Echinococcus granulosus fmrfamide receptor 0.0273 0.3344 0.3344
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0431 0.8033
Giardia lamblia GTOR 0.0048 0.0431 0.0877
Brugia malayi hypothetical protein 0.0035 0.0259 0.0433
Echinococcus granulosus somatostatin receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus granulosus neuropeptides capa receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis neuropeptide Y receptor 0.0273 0.3344 0.3344
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0036 0.0351
Schistosoma mansoni hypothetical protein 0.0273 0.3344 0.4357
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0273 0.51
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0431 0.8033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Onchocerca volvulus 0.0273 0.3344 1
Echinococcus multilocularis musashi 0.0028 0.0176 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0273 0.3344 0.4357
Brugia malayi G protein-coupled receptor F59B2.13 0.0273 0.3344 0.5605
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0036 0.0773
Brugia malayi AKH receptor 0.0273 0.3344 0.5605
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.012 0.2241
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0036 0.0351
Brugia malayi sulfakinin receptor protein 0.0273 0.3344 0.5605
Loa Loa (eye worm) hypothetical protein 0.004 0.0333 0.0373
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Schistosoma mansoni opsin-like receptor 0.0273 0.3344 0.4357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0177 0.0643
Brugia malayi Serotonin receptor 0.0273 0.3344 0.5605
Echinococcus multilocularis lipoxygenase domain containing protein 0.0035 0.0259 0.0259
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1468 1
Schistosoma mansoni neuropeptide receptor 0.0273 0.3344 0.4357
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0036 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0259 0.029
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0036 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0153 0.1783 0.1783
Echinococcus granulosus allatostatin A receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis g-protein coupled receptor 0.0273 0.3344 0.3344
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0081 0.0861 0.0965
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0006 0.0006
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0273 0.3344 0.4357
Echinococcus granulosus geminin 0.0178 0.2115 0.2115
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0227 0.2753 0.3086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1301 0.8837
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Schistosoma mansoni alpha-1 adrenergic receptor 0.0273 0.3344 0.4357
Loa Loa (eye worm) hypothetical protein 0.0704 0.8921 1
Echinococcus multilocularis neuropeptide receptor A26 0.0273 0.3344 0.3344
Trichomonas vaginalis glucosylceramidase, putative 0.0227 0.2753 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0036 0.0668
Schistosoma mansoni opsin-like receptor 0.0273 0.3344 0.4357
Echinococcus multilocularis lamin 0.0028 0.0176 0.0176
Echinococcus granulosus rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0333 0.0373
Brugia malayi Cytochrome P450 family protein 0.0024 0.012 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0145 0.0526
Brugia malayi hypothetical protein 0.0035 0.0259 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Loa Loa (eye worm) hypothetical protein 0.0081 0.0861 0.0965
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0536 1
Brugia malayi hypothetical protein 0.0273 0.3344 0.5605
Echinococcus granulosus tachykinin peptides receptor 99D 0.0273 0.3344 0.3344
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0333 0.0557
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0431 0.1565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1103
Echinococcus multilocularis neuropeptide FF receptor 2 0.0273 0.3344 0.3344
Echinococcus granulosus g protein coupled receptor 0.0273 0.3344 0.3344
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0705 0.0919
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0333 0.0433
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0333 0.0333
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0304 0.5523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0273 0.3344 0.3344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0036 0.0668
Plasmodium vivax multidomain scavenger receptor, putative 0.0035 0.0259 0.5583
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0273 0.3344 0.3748
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0705 0.0705
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0333 0.0333
Schistosoma mansoni calcium-activated potassium channel 0.0342 0.4229 0.5511
Loa Loa (eye worm) hypothetical protein 0.0069 0.0705 0.0791
Echinococcus granulosus lamin 0.0028 0.0176 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0536 1
Brugia malayi follicle stimulating hormone receptor 0.0476 0.5966 1
Brugia malayi PXA domain containing protein 0.004 0.0333 0.0557
Schistosoma mansoni intermediate filament proteins 0.0028 0.0176 0.023
Echinococcus granulosus neuropeptide receptor 0.0273 0.3344 0.3344
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0145 0.0526
Schistosoma mansoni lamin 0.0028 0.0176 0.023
Plasmodium falciparum glutathione reductase 0.0018 0.0036 0.0773
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0036 0.0668
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Echinococcus multilocularis somatostatin receptor 0.0273 0.3344 0.3344
Echinococcus multilocularis RUN 0.0035 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0149 0.174 0.6323
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Echinococcus multilocularis orexin receptor type 2 0.0273 0.3344 0.3344
Onchocerca volvulus 0.0273 0.3344 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0036 0.0351
Echinococcus granulosus neuropeptide FF receptor 2 0.0273 0.3344 0.3344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0333 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Echinococcus multilocularis allatostatin A receptor 0.0273 0.3344 0.3344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0065 0.1214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0036 0.013
Schistosoma mansoni neuropeptide receptor 0.0273 0.3344 0.4357
Onchocerca volvulus 0.0273 0.3344 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0273 0.3344 0.4357
Loa Loa (eye worm) hypothetical protein 0.0273 0.3344 0.3748
Plasmodium falciparum thioredoxin reductase 0.0051 0.0463 1
Schistosoma mansoni hypothetical protein 0.0273 0.3344 0.4357
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0018 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0271 0.0986
Entamoeba histolytica hypothetical protein 0.0104 0.1155 0.2545
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0273 0.3344 0.3344

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 uM Inhibitory concentration against T cell proliferation determined by MTS assay using concanavalin A (Con A)-stimulated mice spleen cells; NT = Not tested ChEMBL. 11229767
IC50 (functional) > 30 uM Inhibitory concentration against TNF-alpha production from human peripheral blood mononuclear cells stimulated by LPS ChEMBL. 11229767
IC50 (functional) > 30 uM Inhibitory concentration against growth of LPS stimulated human peripheral blood mononuclear cells ChEMBL. 11229767

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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