Detailed information for compound 263674

Basic information

Technical information
  • TDR Targets ID: 263674
  • Name: (5Z)-N-methoxy-1-methyl-3,6-dihydro-2H-pyridi ne-5-carboximidoyl cyanide
  • MW: 179.219 | Formula: C9H13N3O
  • H donors: 0 H acceptors: 1 LogP: 0.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/N=C(/C1=CCCN(C1)C)\C#N
  • InChi: 1S/C9H13N3O/c1-12-5-3-4-8(7-12)9(6-10)11-13-2/h4H,3,5,7H2,1-2H3/b11-9+
  • InChiKey: CBOPDFIRBQHXIG-PKNBQFBNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2Z)-2-methoxyimino-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)acetonitrile
  • (2Z)-2-methoxyimino-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)ethanenitrile
  • (2Z)-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-2-methyloximino-acetonitrile
  • N-methoxy-1-methyl-5,6-dihydro-2H-pyridine-3-carboximidoyl cyanide
  • (2Z)-2-methoxyimino-2-(1-methyl-5,6-dihydro-2H-pyridin-3-yl)acetonitrile
  • (2Z)-2-methoxyimino-2-(1-methyl-5,6-dihydro-2H-pyridin-3-yl)ethanenitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Muscarinic acetylcholine receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Muscarinic acetylcholine receptor   466 aa 461 aa 23.9 %
Loa Loa (eye worm) TYRA-2 protein Muscarinic acetylcholine receptor   466 aa 497 aa 24.7 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 484 aa 24.4 %
Echinococcus multilocularis alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 21.1 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 463 aa 24.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Muscarinic acetylcholine receptor   466 aa 493 aa 34.7 %
Schistosoma mansoni growth hormone secretagogue receptor Muscarinic acetylcholine receptor   466 aa 462 aa 19.9 %
Schistosoma japonicum Octopamine receptor, putative Muscarinic acetylcholine receptor   466 aa 462 aa 26.8 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Muscarinic acetylcholine receptor   466 aa 461 aa 26.0 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Muscarinic acetylcholine receptor   466 aa 505 aa 26.9 %
Schistosoma japonicum Octopamine receptor 1, putative Muscarinic acetylcholine receptor   466 aa 412 aa 22.6 %
Onchocerca volvulus Muscarinic acetylcholine receptor   466 aa 472 aa 24.6 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Muscarinic acetylcholine receptor   466 aa 510 aa 29.8 %
Echinococcus granulosus g protein coupled receptor Muscarinic acetylcholine receptor   466 aa 480 aa 18.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 20.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1218 0.1218
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.1758 0.1979
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0423 0.4246
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Echinococcus granulosus hypothetical protein 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Onchocerca volvulus Peroxidasin homolog 0.0077 0.2271 0.238
Echinococcus granulosus protein cereblon 0.0294 0.9408 1
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1218 0.1295
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.1218 0.1295
Trichomonas vaginalis esterase, putative 0.0035 0.0882 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Schistosoma mansoni myosin xvIII 0.0046 0.1218 0.1295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0882 0.0937
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1218 0.1295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0045
Echinococcus granulosus somatostatin receptor 0.0046 0.1218 0.1295
Schistosoma mansoni peroxidasin 0.0077 0.2271 0.2414
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0045
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0042
Echinococcus granulosus neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi G-protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.1218 0.1295
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0882 0.4505
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0042 0.0045
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.1218 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0042
Brugia malayi GnHR receptor homolog 0.0046 0.1218 0.1295
Echinococcus granulosus peroxidasin 0.0077 0.2271 0.2414
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus fmrfamide receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0272 0.8676 0.8676
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0423 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0042 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0042 0.0045
Echinococcus granulosus allatostatin A receptor 0.0046 0.1218 0.1295
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.1218 0.1256
Onchocerca volvulus 0.0035 0.0882 0.0896
Onchocerca volvulus 0.0046 0.1218 0.1256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.1218 0.1295
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0042 0.0045
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1855 0.1855
Brugia malayi hypothetical protein 0.012 0.3661 0.3891
Onchocerca volvulus 0.0046 0.1218 0.1256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Onchocerca volvulus 0.0046 0.1218 0.1256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0017 0.0266 0.0266
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.1218 0.1218
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis sex peptide receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Plasmodium falciparum glutathione reductase 0.0062 0.1758 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.2271 0.2271
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.1218 0.1295
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.1758 0.1869
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.1758 0.1758
Brugia malayi follicle stimulating hormone receptor 0.0272 0.8676 0.9222
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.4124 0.4383
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0423 0.4246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0042 0.0045
Brugia malayi Peroxidasin 0.0077 0.2271 0.2414
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0042 0.0045
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1218 0.1295
Schistosoma mansoni hypothetical protein 0.0124 0.3796 0.4035
Loa Loa (eye worm) beta-lactamase 0.0035 0.0882 0.0882
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0882 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0882 0.4505
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Brugia malayi Melatonin receptor type 1A 0.0046 0.1218 0.1295
Echinococcus granulosus sex peptide receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.1218 0.1295
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Trypanosoma brucei trypanothione reductase 0.0062 0.1758 0.9457
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0042 0.0045
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0423 0.2404
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0294 0.9408 0.9408
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0045
Brugia malayi putative neuropeptide receptor 0.0046 0.1218 0.1295
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1855 0.1899
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0423 0.2404
Brugia malayi G protein-coupled receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0882 0.0882
Onchocerca volvulus 0.0046 0.1218 0.1256
Brugia malayi G-protein coupled receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.1218 0.1295
Schistosoma mansoni hypothetical protein 0.0167 0.5208 0.5536
Mycobacterium ulcerans hypothetical protein 0.0035 0.0882 1
Schistosoma mansoni hypothetical protein 0.0294 0.9408 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.1218 0.1295
Echinococcus multilocularis allatostatin A receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Plasmodium falciparum thioredoxin reductase 0.0021 0.0423 0.2404
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0423 0.1913
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.1218 0.1295
Schistosoma mansoni thyroid hormone receptor 0.0134 0.4124 0.4383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0077 0.2271 0.238
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.3796 0.4035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.1218 0.1295
Brugia malayi beta-lactamase family protein 0.0035 0.0882 0.0937
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Onchocerca volvulus 0.0077 0.2271 0.238
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.1218 0.1295
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0077 0.2271 0.238
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0045
Onchocerca volvulus 0.0035 0.0882 0.0896
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.1218 0.1295
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0423 0.1913
Echinococcus granulosus serotonin receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Mycobacterium ulcerans beta-lactamase 0.0035 0.0882 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.1218 0.1218
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0423 0.1913
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.1218 0.1295
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0423 0.2404
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0042 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0045
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0882 1
Brugia malayi neuropeptide F receptor 0.0046 0.1218 0.1295
Onchocerca volvulus Protein cereblon homolog 0.0294 0.9408 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Brugia malayi RE15519p 0.0046 0.1218 0.1295
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Brugia malayi Dopamine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Onchocerca volvulus Peroxidase homolog 0.0077 0.2271 0.238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0882 0.4438
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1855 0.1971
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0042 0.0045
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.1218 0.1295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0042 0.0045
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Echinococcus multilocularis geminin 0.0167 0.5208 0.5536
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Echinococcus granulosus bloom syndrome protein 0.0021 0.0406 0.0432
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0045
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.1218 0.1295
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0045
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1855 0.1971
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0882 0.0937
Brugia malayi steroid hormone receptor 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0882 0.068
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1218 0.1218
Brugia malayi ecdysteroid receptor 0.001 0.0042 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0423 0.1913
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis protein cereblon 0.0294 0.9408 1
Schistosoma mansoni coup transcription factor 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Entamoeba histolytica hypothetical protein, conserved 0.0294 0.9408 1
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Mycobacterium ulcerans lipase LipD 0.0035 0.0882 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0235 0.0249
Echinococcus granulosus g-protein coupled receptor 0.0046 0.1218 0.1295
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0882 0.0937
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.1218 0.1218
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.7172 1
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0423 0.1913
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.1218 0.1295
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0042 0.0045
Onchocerca volvulus Peroxidasin homolog 0.0077 0.2271 0.238
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1218 0.1295
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0423 0.5
Plasmodium falciparum glutathione reductase 0.0021 0.0423 0.2404
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Brugia malayi nuclear receptor NHR-88 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.1218 0.1295
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1855 0.1971
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.1218 0.1295
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.3796 0.4035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Onchocerca volvulus 0.0035 0.0882 0.0896
Onchocerca volvulus Peroxidase homolog 0.0077 0.2271 0.238
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0045
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0261 0.0277
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Brugia malayi beta-lactamase family protein 0.0035 0.0882 0.0937
Schistosoma mansoni adenoreceptor 0.0046 0.1218 0.1295
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0882 1
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus multilocularis orexin receptor type 2 0.0046 0.1218 0.1295
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0953 0.1013
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0882 0.0937
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Schistosoma mansoni thyroid hormone receptor 0.0134 0.4124 0.4383
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus FTZ F1 alpha 0.001 0.0042 0.0045
Plasmodium falciparum thioredoxin reductase 0.0062 0.1758 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0042 0.0045
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0045
Brugia malayi ORL1-like opioid receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1855 0.1971
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi Serotonin receptor 0.0046 0.1218 0.1295
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0423 0.5
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0042 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0406 0.4039
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.2271 0.238
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Brugia malayi beta-lactamase 0.0035 0.0882 0.0937
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0042 0.0045
Echinococcus multilocularis peroxidasin 0.0077 0.2271 0.2414
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.1218 0.1218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0042 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0423 0.1526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0882 0.068
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Echinococcus multilocularis somatostatin receptor 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Plasmodium vivax glutathione reductase, putative 0.0062 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.1218 0.1295
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1218 0.1295
Brugia malayi larval opioid receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.1758 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.1218 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0042
Brugia malayi Serotonin receptor 0.0046 0.1218 0.1295
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.1218 0.1295
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Brugia malayi hypothetical protein 0.0077 0.2271 0.2414
Schistosoma mansoni hypothetical protein 0.0167 0.5208 0.5536
Schistosoma mansoni peroxidasin 0.0077 0.2271 0.2414
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0953 0.1013
Brugia malayi glutathione reductase 0.0062 0.1758 0.1869
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0882 1
Toxoplasma gondii thioredoxin reductase 0.0062 0.1758 1
Echinococcus granulosus neuropeptide s receptor 0.0046 0.1218 0.1295
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Echinococcus granulosus orexin receptor type 2 0.0046 0.1218 0.1295
Onchocerca volvulus Dual oxidase homolog 0.0077 0.2271 0.238
Brugia malayi neuropeptide F receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.1218 0.1295
Leishmania major trypanothione reductase 0.0062 0.1758 0.9457
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1218 0.1295
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0423 1
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) glutathione reductase 0.0062 0.1758 0.1758
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.1758 0.9457
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Brugia malayi Dopamine receptor protein 2 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Brugia malayi AKH receptor 0.0046 0.1218 0.1295
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1218 0.1295
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0882 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.1218 0.1295
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0406 0.4039
Leishmania major hypothetical protein, conserved 0.0035 0.0882 0.4505
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1218 0.1218
Brugia malayi Dopamine receptor protein 1 0.0046 0.1218 0.1295
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0882 0.0937
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1218 0.1295
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.1218 0.1256
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.1758 0.1869
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0423 0.1913
Brugia malayi nuclear hormone receptor 0.001 0.0042 0.0045
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Mycobacterium leprae Probable lipase LipE 0.0035 0.0882 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0423 0.0449
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0042 0.0045
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.1218 0.1295
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0423 0.1913
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.1218 0.1295
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.1218 0.1295
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1218 0.1295
Echinococcus granulosus neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0406 0.0432
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0294 0.9408 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0322 0.1832
Brugia malayi Thioredoxin reductase 0.0062 0.1758 0.1869
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1218 0.1295
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) RecQ helicase 0.0021 0.0406 0.0406
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis serotonin receptor 0.0046 0.1218 0.1295
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0423 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0045
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.1218 0.1295
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.1218 0.1295
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0882 0.068
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0423 0.5
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0235 0.0249
Brugia malayi Blistered cuticle protein 3 0.0077 0.2271 0.2414
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000013006 0.00000000073963
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Echinococcus granulosus geminin 0.0167 0.5208 0.5536
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0423 0.1526
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1218 0.1218
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1855 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Treponema pallidum NADH oxidase 0.0021 0.0423 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Toxoplasma gondii ABC1 family protein 0.0035 0.0882 0.5014
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0882 0.4505
Echinococcus multilocularis serotonin receptor 0.0046 0.1218 0.1295
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0042 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0882 0.068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0423 0.2404
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0177 0.1005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1218 0.1295
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0882 1
Brugia malayi sulfakinin receptor protein 0.0046 0.1218 0.1295
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0406 0.0432
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni histamine h1 receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295

Activities

Activity type Activity value Assay description Source Reference
ED Arec (functional) = 0.16 mg kg-1 Dose required to induce a standard increase in rhythmical slow wave activity (RSA) in rats when administered intravenously ChEMBL. No reference
ED50 (functional) > 1 mg kg-1 Effective dose causing 50% decrease in mean blood pressure upon intravenous administration in rats ChEMBL. No reference
IC50 (binding) = 150 nM In vitro binding affinity against Muscarinic receptor in rat cerebral cortex using [3H]- oxotremorine-M (OXO-M) using as a radioligand; Value ranges from 120-220 ChEMBL. No reference
IC50 (binding) = 150 nM In vitro binding affinity against Muscarinic receptor in rat cerebral cortex using [3H]- oxotremorine-M (OXO-M) using as a radioligand; Value ranges from 120-220 ChEMBL. No reference
IC50 (binding) = 4500 nM In vitro binding affinity against Muscarinic receptor in rat cerebral cortex using [3H]- quinuclidinyl benzilate (QNB)using as a radioligand; Value ranges from 4300-9500 ChEMBL. No reference
IC50 (binding) = 4500 nM In vitro binding affinity against Muscarinic receptor in rat cerebral cortex using [3H]- quinuclidinyl benzilate (QNB)using as a radioligand; Value ranges from 4300-9500 ChEMBL. No reference
logD (ADMET) = 1.3 Log distribution coefficient value of the compound was calculated for pH=7.3 ChEMBL. No reference
logP (ADMET) = 1.76 Partition coefficient (logP) ChEMBL. No reference
pKa = 7.65 pKa value of the compound was measured ChEMBL. No reference
Ratio (binding) = 30 Selectivity is the ratio of inhibitory activities against muscarinic receptors, determined using radioligand [3H]-OXO-M and 3[H}-QND ChEMBL. No reference
Ratio (functional) > 6.3 Ratio of compound in rat rhythmical slow wave activity assay vs efficacy causing 50% decrease in BP in rats ChEMBL. No reference
Ratio (binding) = 30 Selectivity is the ratio of inhibitory activities against muscarinic receptors, determined using radioligand [3H]-OXO-M and 3[H}-QND ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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