Detailed information for compound 275481

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 238.67 | Formula: C11H11ClN2O2
  • H donors: 0 H acceptors: 2 LogP: 1.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)N1C(=O)CN(C1=O)C)C
  • InChi: 1S/C11H11ClN2O2/c1-7-3-4-8(12)5-9(7)14-10(15)6-13(2)11(14)16/h3-5H,6H2,1-2H3
  • InChiKey: BZKDFVWNEFIZNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.2508 0.2443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis AGC family protein kinase 0.0014 0.0172 0.0687
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.4025 0.4559
Leishmania major cathepsin L-like protease 0.0019 0.0475 0.0449
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0086 0.0079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.093 0.5363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0475 0.0525
Entamoeba histolytica cysteine protease, putative 0.0019 0.0475 0.2686
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.093 0.1048
Brugia malayi Thioredoxin reductase 0.014 0.8726 1
Toxoplasma gondii AGC kinase 0.0035 0.1564 0.1711
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0057 0.0045
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0301 0.0326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.1719 0.1954
Plasmodium falciparum thioredoxin reductase 0.0049 0.2508 0.2443
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0193 0.0202
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.2508 0.2605
Loa Loa (eye worm) intermediate filament protein 0.003 0.1246 0.1411
Echinococcus multilocularis nervana 2 0.0023 0.0758 0.085
Leishmania major cathepsin L-like protease 0.0071 0.4025 0.4559
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0475 0.3513
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.8726 1
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0086 0.0344
Giardia lamblia Kinase, AGC PKA 0.0023 0.0775 0.2845
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.093 0.1048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.2508 0.2803
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.3607 0.4075
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.2995 0.3366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.2508 1
Leishmania major cathepsin L-like protease 0.0019 0.0475 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.2508 0.2443
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0475 0.0525
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.2508 0.2443
Echinococcus multilocularis musashi 0.003 0.1246 0.1411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0475 0.3513
Onchocerca volvulus 0.0019 0.0475 0.3513
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.093 0.5363
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.2508 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0156 0.0159
Brugia malayi glutamate synthase 0.0013 0.0086 0.0079
Echinococcus granulosus lamin 0.003 0.1246 0.1411
Brugia malayi cathepsin L-like precursor 0.0012 0.0057 0.0045
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0023 0.0758 0.085
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0086 0.0079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.2508 0.286
Schistosoma mansoni glutamate synthase 0.0013 0.0086 0.0079
Brugia malayi glutathione reductase 0.014 0.8726 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Leishmania major trypanothione reductase 0.014 0.8726 1
Echinococcus granulosus Glutaredoxin protein 5 0.0023 0.0758 0.085
Echinococcus granulosus cathepsin l1 0.0019 0.0475 0.0525
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.1246 0.1411
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0475 0.0525
Echinococcus multilocularis lamin 0.003 0.1246 0.1411
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0049 0.2508 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Leishmania major cathepsin L-like protease 0.0071 0.4025 0.4559
Echinococcus granulosus cathepsin l1 0.0012 0.0057 0.0045
Onchocerca volvulus 0.0019 0.0475 0.3513
Brugia malayi intermediate filament protein 0.003 0.1246 0.1411
Schistosoma mansoni glutamate synthase 0.0013 0.0086 0.0079
Trypanosoma brucei rac serine-threonine kinase, putative 0.0037 0.1719 0.189
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.2508 0.2803
Schistosoma mansoni lamin 0.003 0.1246 0.1411
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.2508 0.286
Plasmodium vivax vivapain-2 0.0019 0.0475 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0086 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0017 0.0069
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0045
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.2508 1
Onchocerca volvulus 0.0019 0.0475 0.3513
Treponema pallidum NADH oxidase 0.0049 0.2508 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.2508 0.286
Onchocerca volvulus 0.003 0.1246 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0086 0.0404
Plasmodium vivax phosphoethanolamine N-methyltransferase 0.0159 1 1
Echinococcus granulosus intermediate filament protein 0.003 0.1246 0.1411
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0775 0.0797
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0475 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0017 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0079
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.2508 0.2803
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.0775 0.087
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.093 0.1048
Loa Loa (eye worm) fibroinase 0.0019 0.0475 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.1246 0.1411
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0086 0.0079
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0086 0.0079
Entamoeba histolytica protein kinase, putative 0.0037 0.1719 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0086 0.0344
Echinococcus multilocularis glutamate synthase 0.0013 0.0086 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.093 0.0977
Plasmodium vivax thioredoxin reductase, putative 0.014 0.8726 0.8715
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0086 0.0079
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0086 0.0344
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.0775 0.0695
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0086 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0475 0.2686
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0086 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0086 0.0344
Plasmodium falciparum glutathione reductase 0.0049 0.2508 0.2443
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0086 0.0404
Entamoeba histolytica protein kinase 2, putative 0.0023 0.0775 0.4453
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.2508 0.2605
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Echinococcus multilocularis cysteine protease 0.0019 0.0475 0.0525
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0045
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.1633 0.1855
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0475 0.0525
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0086 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Mycobacterium tuberculosis Probable oxidoreductase 0.0049 0.2508 0.2605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0086 0.0344
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0035 0.1564 0.1776
Loa Loa (eye worm) cysteine protease 0.0019 0.0475 0.0525
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.0775 0.0695
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.2508 1
Echinococcus multilocularis nervana 2 0.0023 0.0758 0.085
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.015 0.9384 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Onchocerca volvulus 0.003 0.1246 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Loa Loa (eye worm) hypothetical protein 0.0029 0.1209 0.1368
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0475 0.0449
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2508 0.2803
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0057 0.0232
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0086 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trypanosoma brucei trypanothione reductase 0.014 0.8726 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.2508 0.2605
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.2508 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0086 0.0079
Brugia malayi Cathepsin L-like precursor 0.0012 0.0057 0.0045
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0086 0.0404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0049 0.2508 0.2605
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0086 0.0344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0475 0.0525
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0086 0.0344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.093 0.1048
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.4025 0.4559
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.8726 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0086 0.0079
Onchocerca volvulus 0.0019 0.0475 0.3513
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0475 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0057 0.0226
Plasmodium vivax vivapain-2 0.0019 0.0475 0.0392
Plasmodium falciparum thioredoxin reductase 0.014 0.8726 0.8715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Onchocerca volvulus 0.0019 0.0475 0.3513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.2508 0.2803
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0057 0.0226
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0086 0.0079
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0086 0.0404
Toxoplasma gondii thioredoxin reductase 0.014 0.8726 1
Leishmania major cathepsin L-like protease 0.0019 0.0475 0.0449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.2508 0.2803
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0475 0.3513
Onchocerca volvulus 0.0019 0.0475 0.3513
Leishmania major cathepsin L-like protease 0.0071 0.4025 0.4559
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0193 0.0202
Loa Loa (eye worm) hypothetical protein 0.0019 0.0475 0.0525
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.2508 0.286
Entamoeba histolytica protein kinase, putative 0.0037 0.1719 1
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0301 0.0326
Toxoplasma gondii cathepsin CPL 0.0019 0.0475 0.0449
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.1246 0.1411
Echinococcus granulosus glutamate synthase 0.0013 0.0086 0.0079
Trypanosoma cruzi Protein kinase B 0.0025 0.093 0.0977
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0475 0.0525
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.2508 0.2803
Entamoeba histolytica protein kinase, putative 0.0035 0.1564 0.909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Loa Loa (eye worm) hypothetical protein 0.0014 0.0193 0.0202
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.0775 0.087
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.2508 0.2605
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Echinococcus multilocularis lamin dm0 0.003 0.1246 0.1411
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.2508 0.2803
Mycobacterium ulcerans methyltransferase 0.015 0.9384 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Echinococcus multilocularis cysteine protease 0.0019 0.0475 0.0525
Loa Loa (eye worm) hypothetical protein 0.0014 0.0156 0.0159
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0086 0.0079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0086 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0475 0.1892
Onchocerca volvulus 0.0019 0.0475 0.3513
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.2508 0.2803
Echinococcus multilocularis Glutaredoxin protein 5 0.0023 0.0758 0.085
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0475 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0086 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.4025 0.4559
Brugia malayi p70 ribosomal S6 kinase beta 0.0035 0.1564 0.1776
Plasmodium vivax glutathione reductase, putative 0.014 0.8726 0.8715
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.2508 1
Loa Loa (eye worm) ctsf protein 0.0019 0.0475 0.0525
Schistosoma mansoni glutamate synthase 0.0013 0.0086 0.0079
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.1633 0.1855
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0086 0.0079
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0475 0.0392
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.2508 0.2803
Mycobacterium ulcerans mycolic acid synthase UmaA 0.015 0.9384 1
Mycobacterium tuberculosis Possible methyltransferase (methylase) 0.015 0.9384 1
Leishmania major cathepsin L-like protease 0.0019 0.0475 0.0449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Loa Loa (eye worm) glutathione reductase 0.014 0.8726 1
Loa Loa (eye worm) thioredoxin reductase 0.014 0.8726 1
Leishmania major cathepsin L-like protease 0.0019 0.0475 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0475 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.2508 0.2803
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.0775 0.087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.8726 0.9292
Schistosoma mansoni lamin 0.003 0.1246 0.1411
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0086 0.0079
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0057 0.0045
Schistosoma mansoni intermediate filament proteins 0.003 0.1246 0.1411
Echinococcus granulosus nervana 2 0.0023 0.0758 0.085
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0023 0.0758 0.085
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0086 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.4025 0.4559
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0475 0.2686
Brugia malayi Protein kinase domain containing protein 0.0037 0.1719 0.1954
Trichomonas vaginalis AGC family protein kinase 0.0037 0.1719 0.6853
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0475 0.0392
Onchocerca volvulus 0.0013 0.0086 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0475 0.1892
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0049 0.2508 0.2605
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0475 0.0392
Brugia malayi Cathepsin L-like precursor 0.0019 0.0475 0.0525
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0086 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.4025 0.4559
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.8726 1
Echinococcus granulosus lamin dm0 0.003 0.1246 0.1411
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0017 0.0069
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0475 0.0525
Brugia malayi Cathepsin L-like precursor 0.0012 0.0057 0.0045
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0086 0.0404
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0086 0.0079
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.2508 0.2443
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.2508 0.2803
Plasmodium falciparum glutathione reductase 0.014 0.8726 0.8715
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0086 0.0079
Echinococcus granulosus nervana 2 0.0023 0.0758 0.085
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0475 0.0525

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -8 % Percent change in high-density lipoprotein cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days ChEMBL. 14736248
Change (functional) = -7 % Percent change in triglycerides in hypercholesterolemic rats at a dose of 100 mg/kg/day for 8 days ChEMBL. 14736248
Change (functional) = 37 % Percent change in total plasma cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days ChEMBL. 14736248

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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