Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0023 | 0.0758 | 0.085 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.0475 | 0.0392 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0049 | 0.2508 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0475 | 0.0525 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0.2508 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.0475 | 0.0392 |
Mycobacterium ulcerans | mycolic acid synthase UmaA | 0.015 | 0.9384 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.4025 | 0.4559 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.1246 | 0.1411 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Schistosoma mansoni | lamin | 0.003 | 0.1246 | 0.1411 |
Treponema pallidum | NADH oxidase | 0.0049 | 0.2508 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.0475 | 0.0392 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0025 | 0.093 | 0.1048 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0037 | 0.1719 | 0.189 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.1246 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0057 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0057 | 0.0045 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0049 | 0.2508 | 0.2605 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.1246 | 0.1411 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0013 | 0.0086 | 0.0404 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Plasmodium falciparum | thioredoxin reductase | 0.014 | 0.8726 | 0.8715 |
Schistosoma mansoni | sulfide quinone reductase | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0013 | 0.0086 | 0.0404 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0035 | 0.1564 | 0.1776 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0193 | 0.0202 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.1246 | 0.1411 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.2803 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0013 | 0.0086 | 0.0404 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0049 | 0.2508 | 0.2803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Loa Loa (eye worm) | glutathione reductase | 0.014 | 0.8726 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0017 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0086 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.4025 | 0.4559 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0475 | 0.0525 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.4025 | 0.4559 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0475 | 0.0449 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0475 | 0.0525 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Toxoplasma gondii | cathepsin CPL | 0.0019 | 0.0475 | 0.0449 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0013 | 0.0086 | 0.0344 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0013 | 0.0086 | 0.0344 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0475 | 0.0525 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0404 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0301 | 0.0326 |
Echinococcus multilocularis | nervana 2 | 0.0023 | 0.0758 | 0.085 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0086 | 0.0344 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0301 | 0.0326 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0023 | 0.0775 | 0.087 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0012 | 0.0057 | 0.0045 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0023 | 0.0758 | 0.085 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0057 | 0.0226 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0049 | 0.2508 | 0.2803 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0475 | 0.0449 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0013 | 0.0086 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0057 | 0.0226 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0049 | 0.2508 | 0.2443 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0013 | 0.0086 | 0.0079 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0036 | 0.1633 | 0.1855 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0156 | 0.0159 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0049 | 0.2508 | 0.2803 |
Brugia malayi | intermediate filament protein | 0.003 | 0.1246 | 0.1411 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.014 | 0.8726 | 0.9292 |
Trypanosoma brucei | trypanothione reductase | 0.014 | 0.8726 | 1 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0475 | 0.0449 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0013 | 0.0086 | 0.0079 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0475 | 0.2686 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.0475 | 0.2686 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.2508 | 0.2443 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0013 | 0.0086 | 0.0079 |
Echinococcus granulosus | lamin | 0.003 | 0.1246 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1209 | 0.1368 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0023 | 0.0758 | 0.085 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0025 | 0.093 | 0.5363 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0013 | 0.0086 | 0.0079 |
Entamoeba histolytica | protein kinase 2, putative | 0.0023 | 0.0775 | 0.4453 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0012 | 0.0057 | 0.0232 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0049 | 0.2508 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0025 | 0.093 | 0.1048 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0025 | 0.093 | 0.1048 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0023 | 0.0758 | 0.085 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0193 | 0.0202 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0023 | 0.0775 | 0.087 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.4025 | 0.4559 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0049 | 0.2508 | 0.2605 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0013 | 0.0086 | 0.0344 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Echinococcus multilocularis | nervana 2 | 0.0023 | 0.0758 | 0.085 |
Mycobacterium ulcerans | methyltransferase | 0.015 | 0.9384 | 1 |
Plasmodium falciparum | glutathione reductase | 0.014 | 0.8726 | 0.8715 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.014 | 0.8726 | 1 |
Schistosoma mansoni | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0049 | 0.2508 | 0.2443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0049 | 0.2508 | 0.2605 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0049 | 0.2508 | 0.2605 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0049 | 0.2508 | 0.2605 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Leishmania major | cysteine peptidase A (CPA) | 0.0019 | 0.0475 | 0.0449 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0475 | 0.3513 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.2605 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0049 | 0.2508 | 0.2443 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0.2508 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1246 | 0.1411 |
Leishmania major | trypanothione reductase | 0.014 | 0.8726 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.0475 | 0.0449 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Plasmodium vivax | glutathione reductase, putative | 0.014 | 0.8726 | 0.8715 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0475 | 0.0392 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0057 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0475 | 0.0525 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0475 | 0.0525 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0065 | 0.3607 | 0.4075 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Brugia malayi | glutathione reductase | 0.014 | 0.8726 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Mycobacterium tuberculosis | Possible mycolic acid synthase UmaA | 0.015 | 0.9384 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0475 | 0.2686 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0049 | 0.2508 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Giardia lamblia | Kinase, AGC PKA | 0.0023 | 0.0775 | 0.2845 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0156 | 0.0159 |
Echinococcus multilocularis | lamin | 0.003 | 0.1246 | 0.1411 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.1246 | 0.1411 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0049 | 0.2508 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0057 | 0.0045 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0475 | 0.0449 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0025 | 0.093 | 0.1048 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.1564 | 0.909 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0475 | 0.0525 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0036 | 0.1633 | 0.1855 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0475 | 0.0392 |
Echinococcus granulosus | nervana 2 | 0.0023 | 0.0758 | 0.085 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0023 | 0.0775 | 0.087 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0475 | 0.3513 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0086 | 0.0079 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0012 | 0.0057 | 0.0045 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0017 | 0.0069 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0475 | 0.0525 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0193 | 0.0202 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.286 |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.0475 | 0.3513 |
Schistosoma mansoni | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.4025 | 0.4559 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0475 | 0.0525 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0475 | 0.0525 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0025 | 0.093 | 0.5363 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0013 | 0.0086 | 0.0079 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.1246 | 0.1411 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0023 | 0.0775 | 0.0797 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Onchocerca volvulus | 0.0013 | 0.0086 | 0.0247 | |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.1719 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.2803 |
Echinococcus granulosus | cathepsin l1 | 0.0012 | 0.0057 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.1246 | 0.1411 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0013 | 0.0086 | 0.0344 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0475 | 0.0525 |
Plasmodium vivax | thioredoxin reductase, putative | 0.014 | 0.8726 | 0.8715 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0013 | 0.0086 | 0.0079 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0023 | 0.0775 | 0.0695 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0023 | 0.0775 | 0.0695 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0475 | 0.0525 |
Brugia malayi | Protein kinase domain containing protein | 0.0037 | 0.1719 | 0.1954 |
Brugia malayi | Thioredoxin reductase | 0.014 | 0.8726 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.014 | 0.8726 | 1 |
Mycobacterium tuberculosis | Possible methyltransferase (methylase) | 0.015 | 0.9384 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.2508 | 0.2803 |
Echinococcus multilocularis | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0035 | 0.1564 | 0.1776 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Toxoplasma gondii | thioredoxin reductase | 0.014 | 0.8726 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.1719 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.286 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0475 | 0.0525 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0013 | 0.0086 | 0.0404 |
Echinococcus granulosus | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0049 | 0.2508 | 0.2803 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0013 | 0.0086 | 0.0404 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0013 | 0.0086 | 0.0079 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Trichomonas vaginalis | AGC family protein kinase | 0.0037 | 0.1719 | 0.6853 |
Echinococcus multilocularis | musashi | 0.003 | 0.1246 | 0.1411 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.2508 | 0.2443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Schistosoma mansoni | lamin | 0.003 | 0.1246 | 0.1411 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0475 | 0.0525 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0475 | 0.0525 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0071 | 0.4025 | 0.4559 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0475 | 0.0525 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0013 | 0.0086 | 0.0344 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Trichomonas vaginalis | AGC family protein kinase | 0.0014 | 0.0172 | 0.0687 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0049 | 0.2508 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0475 | 0.0525 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Echinococcus granulosus | nervana 2 | 0.0023 | 0.0758 | 0.085 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0017 | 0.0069 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0049 | 0.2508 | 0.286 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0475 | 0.0449 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Brugia malayi | cathepsin L-like precursor | 0.0012 | 0.0057 | 0.0045 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0056 | 0.2995 | 0.3366 |
Trypanosoma cruzi | Protein kinase B | 0.0025 | 0.093 | 0.0977 |
Onchocerca volvulus | 0.003 | 0.1246 | 1 | |
Onchocerca volvulus | 0.003 | 0.1246 | 1 | |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0049 | 0.2508 | 0.2605 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0013 | 0.0086 | 0.0344 |
Onchocerca volvulus | 0.0019 | 0.0475 | 0.3513 | |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0025 | 0.093 | 0.0977 |
Schistosoma mansoni | sulfide quinone reductase | 0.0013 | 0.0086 | 0.0079 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0049 | 0.2508 | 0.2803 |
Brugia malayi | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0475 | 0.0525 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.4025 | 0.4559 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0049 | 0.2508 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0049 | 0.2508 | 0.286 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0037 | 0.1719 | 0.1954 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.014 | 0.8726 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0013 | 0.0086 | 0.0404 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0475 | 0.0525 |
Toxoplasma gondii | AGC kinase | 0.0035 | 0.1564 | 0.1711 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0013 | 0.0086 | 0.0344 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0049 | 0.2508 | 0.2443 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0013 | 0.0086 | 0.0079 |
Plasmodium vivax | phosphoethanolamine N-methyltransferase | 0.0159 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0475 | 0.1892 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.4025 | 0.4559 |
Loa Loa (eye worm) | thioredoxin reductase | 0.014 | 0.8726 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0049 | 0.2508 | 0.2803 |
Schistosoma mansoni | glutamate synthase | 0.0013 | 0.0086 | 0.0079 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0057 | 0.0045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -8 % | Percent change in high-density lipoprotein cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = -7 % | Percent change in triglycerides in hypercholesterolemic rats at a dose of 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = 37 % | Percent change in total plasma cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.