Detailed information for compound 285309

Basic information

Technical information
  • TDR Targets ID: 285309
  • Name: (2S)-2-amino-4-(4,4-diphenylbutyl)pentanedioi c acid
  • MW: 355.428 | Formula: C21H25NO4
  • H donors: 3 H acceptors: 4 LogP: 1.37 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](C(=O)O)CC(C(=O)O)CCCC(c1ccccc1)c1ccccc1
  • InChi: 1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17?,19-/m0/s1
  • InChiKey: DWLOVDOPFJPWNE-NNBQYGFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-azanyl-4-(4,4-diphenylbutyl)pentanedioic acid
  • (2S)-2-amino-4-(4,4-diphenylbutyl)glutaric acid
  • (2S)-2-amino-4-[4,4-di(phenyl)butyl]pentanedioic acid
  • (2S)-2-amino-4-[4,4-di(phenyl)butyl]glutaric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Metabotropic glutamate receptor   915 aa 852 aa 21.4 %
Drosophila melanogaster metabotropic Glutamate Receptor Metabotropic glutamate receptor   915 aa 895 aa 47.0 %
Schistosoma mansoni metabotropic glutamate receptor Metabotropic glutamate receptor   915 aa 908 aa 27.4 %
Onchocerca volvulus Golgi-associated plant pathogenesis-related protein 1 homolog Metabotropic glutamate receptor   915 aa 837 aa 34.0 %
Drosophila melanogaster mangetout Metabotropic glutamate receptor   915 aa 822 aa 42.5 %
Loa Loa (eye worm) hypothetical protein Metabotropic glutamate receptor   915 aa 877 aa 33.8 %
Brugia malayi Metabotropic glutamate receptor precursor. Metabotropic glutamate receptor   915 aa 891 aa 38.0 %
Onchocerca volvulus Cell death abnormality protein 8 homolog Metabotropic glutamate receptor   915 aa 872 aa 39.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0175 0.3063 0.3063
Brugia malayi GnHR receptor homolog 0.0158 0.273 0.2724
Schistosoma mansoni myosin xvIII 0.0158 0.273 0.273
Loa Loa (eye worm) pyruvate kinase 0.0041 0.0364 0.0356
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus multilocularis nmda type glutamate receptor 0.0023 0.0011 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.0165 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.273 0.273
Schistosoma mansoni metabotropic glutamate receptor 0.0071 0.0978 0.0978
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0392 0.0392
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0158 0.273 0.2724
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus granulosus glutamate NMDA receptor subunit 0.0061 0.0767 0.0767
Schistosoma mansoni biogenic amine receptor 0.0158 0.273 0.273
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.1229 0.1229
Echinococcus multilocularis lamin 0.0024 0.0032 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.006 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0364 0.0356
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.273 0.273
Schistosoma mansoni glutamate receptor kainate 0.0061 0.0767 0.0767
Echinococcus granulosus nmda type glutamate receptor 0.0051 0.0577 0.0577
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0354 0.6671 0.6671
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0378 0.0378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0032 0.0023
Giardia lamblia Pyruvate kinase 0.0041 0.0364 0.9628
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0094 0.1429 0.1429
Brugia malayi RE15519p 0.0158 0.273 0.2724
Entamoeba histolytica acyl-coA synthetase, putative 0.0044 0.0441 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0441 1
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0011
Schistosoma mansoni opsin-like receptor 0.0158 0.273 0.273
Onchocerca volvulus 0.0158 0.273 0.2722
Brugia malayi Pyruvate kinase, M2 isozyme 0.0041 0.0364 0.0356
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0158 0.273 0.273
Onchocerca volvulus 0.0158 0.273 0.2722
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Trypanosoma brucei prolyl endopeptidase 0.0041 0.0378 0.1208
Echinococcus granulosus metabotropic glutamate receptor 2 0.0068 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0118 0.0109
Onchocerca volvulus 0.0158 0.273 0.2722
Leishmania major oligopeptidase b 0.0041 0.0378 0.1208
Onchocerca volvulus Prolyl endopeptidase homolog 0.0041 0.0378 0.0367
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0158 0.273 0.273
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0441 1
Echinococcus granulosus neuropeptide receptor 0.0158 0.273 0.273
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0158 0.273 0.273
Schistosoma mansoni amine GPCR 0.0158 0.273 0.273
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0378 0.8541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Onchocerca volvulus 0.0158 0.273 0.2722
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0207
Brugia malayi Dopamine receptor protein 1 0.0158 0.273 0.2724
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0175 0.3063 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.273 0.273
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Onchocerca volvulus 0.0158 0.273 0.2722
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0011 0.0003
Toxoplasma gondii pyruvate kinase PyK1 0.0041 0.0364 0.1163
Echinococcus granulosus neuropeptide s receptor 0.0158 0.273 0.273
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0041 0.0378 0.8541
Schistosoma mansoni smad1 5 8 and 0.0033 0.0204 0.0204
Echinococcus granulosus metabotropic glutamate receptor 5 0.0117 0.1891 0.1891
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0441 1
Trypanosoma cruzi extracellular receptor, putative 0.0023 0.0011 0.0009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0158 0.273 0.273
Trypanosoma brucei pyruvate kinase 1 0.0041 0.0364 0.1163
Onchocerca volvulus Pyruvate kinase homolog 0.0041 0.0364 0.0353
Echinococcus multilocularis NMDA receptor 0.006 0.075 0.075
Toxoplasma gondii prolyl endopeptidase 0.0041 0.0378 0.1208
Schistosoma mansoni neuropeptide receptor 0.0158 0.273 0.273
Plasmodium vivax acyl-CoA synthetase, putative 0.0033 0.0216 0.5602
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0378 0.0378
Brugia malayi AKH receptor 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0799 0.0799
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0041 0.0378 0.1208
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.273 0.2724
Trypanosoma brucei pyruvate kinase 1, putative 0.0041 0.0364 0.1163
Echinococcus multilocularis dro:myosuppressin receptor 0.0158 0.273 0.273
Brugia malayi G-protein coupled receptor 0.0158 0.273 0.2724
Echinococcus multilocularis smad 0.0033 0.0204 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0378 0.0369
Echinococcus granulosus neuropeptide receptor A26 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni adenoreceptor 0.0158 0.273 0.273
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.273 0.273
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.273 0.273
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0011 0.0003
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus multilocularis G protein coupled receptor 139 0.0158 0.273 0.273
Brugia malayi Metabotropic glutamate receptor precursor. 0.0088 0.1323 0.1316
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0212
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.273 0.273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0121 0.1978 0.1978
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0121 0.1978 0.1978
Echinococcus multilocularis prolyl endopeptidase 0.0041 0.0378 0.0378
Echinococcus multilocularis acylamino acid releasing enzyme 0.0041 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.0062 0.0799 0.0799
Trypanosoma brucei oligopeptidase b 0.0041 0.0378 0.1208
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus tyrosine kinase 0.0023 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0392 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0378 0.1208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0799 0.0791
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0044 0.0441 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0041 0.0378 0.8541
Echinococcus granulosus dro:myosuppressin receptor 0.0158 0.273 0.273
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0378 0.1208
Echinococcus granulosus acylamino acid releasing enzyme 0.0041 0.0378 0.0378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0378 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0061 0.0767 0.0767
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0158 0.273 0.2724
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus granulosus lamin 0.0024 0.0032 0.0032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0121 0.1978 0.1978
Onchocerca volvulus 0.0158 0.273 0.2722
Loa Loa (eye worm) hypothetical protein 0.0041 0.0378 0.0369
Brugia malayi MH1 domain containing protein 0.0033 0.0204 0.0195
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Plasmodium falciparum peptidase, putative 0.0041 0.0378 1
Echinococcus granulosus hypothetical protein 0.0158 0.273 0.273
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0023 0.0011 0.0003
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0023 0.0011 0.0003
Brugia malayi Glutamate receptor 2 precursor 0.0061 0.0767 0.0759
Loa Loa (eye worm) glutamate receptor 1 0.0061 0.0767 0.0759
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus pyruvate kinase 0.0041 0.0364 0.0364
Echinococcus multilocularis sex peptide receptor 0.0158 0.273 0.273
Echinococcus multilocularis serotonin receptor 0.0158 0.273 0.273
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0799 0.0791
Schistosoma mansoni neuropeptide f receptor 76f 0.0158 0.273 0.273
Mycobacterium ulcerans pyruvate kinase 0.0041 0.0364 0.8224
Echinococcus granulosus glutamate receptor 2 0.0084 0.1229 0.1229
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0011 0.0003
Entamoeba histolytica hypothetical protein 0.0033 0.0212 0.47
Echinococcus granulosus glutamate receptor ionotropic kainate 0.006 0.075 0.075
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0033 0.0216 0.4785
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.273 0.273
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.225 0.2243
Echinococcus multilocularis GPCR, family 2 0.0062 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Trichomonas vaginalis pyruvate kinase, putative 0.0041 0.0364 0.9628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0158 0.273 0.2724
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0158 0.273 0.273
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0032 0.0023
Schistosoma mansoni glutamate receptor AMPA 0.0061 0.0767 0.0767
Entamoeba histolytica hypothetical protein 0.0033 0.0212 0.47
Onchocerca volvulus 0.0158 0.273 0.2722
Schistosoma mansoni glutamate receptor kainate 0.0098 0.1516 0.1516
Echinococcus granulosus intermediate filament protein 0.0024 0.0032 0.0032
Echinococcus multilocularis G-protein coupled receptor, putative 0.0158 0.273 0.273
Mycobacterium tuberculosis Probable peptidase 0.0041 0.0378 0.8541
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.273 0.273
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Echinococcus granulosus nmda type glutamate receptor 0.0023 0.0011 0.0011
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0378 0.0369
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0158 0.273 0.273
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0158 0.273 0.273
Brugia malayi ORL1-like opioid receptor 0.0158 0.273 0.2724
Brugia malayi MH2 domain containing protein 0.0033 0.0204 0.0195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.273 0.273
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.273 0.273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.273 0.273
Entamoeba histolytica hypothetical protein 0.0033 0.0212 0.47
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.273 0.273
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.273 0.2724
Echinococcus multilocularis fmrfamide receptor 0.0158 0.273 0.273
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0033 0.0216 0.4785
Plasmodium vivax pyruvate kinase, putative 0.0041 0.0364 0.9628
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0014
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0378 0.0378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0392 0.0392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis somatostatin receptor 0.0158 0.273 0.273
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0041 0.0378 0.0378
Schistosoma mansoni pyruvate kinase 0.0041 0.0364 0.0364
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0204 0.0204
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.3063 0.3057
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0441 0.0432
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0441 0.0432
Brugia malayi intermediate filament protein 0.0024 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Trypanosoma brucei PAB1-binding protein , putative 0.0031 0.0165 0.0512
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0041 0.0378 0.1208
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0378 1
Schistosoma mansoni amine GPCR 0.0158 0.273 0.273
Schistosoma mansoni smad1 5 8 and 0.0033 0.0204 0.0204
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0204 0.0204
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0158 0.273 0.273
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Onchocerca volvulus 0.0158 0.273 0.2722
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0041 0.0378 0.1208
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0441 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni smad 0.0033 0.0204 0.0204
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0175 0.3063 1
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.273 0.273
Leishmania major pyruvate kinase 0.0041 0.0364 0.1163
Brugia malayi Glutamate receptor 1 precursor 0.0061 0.0767 0.0759
Schistosoma mansoni hypothetical protein 0.0158 0.273 0.273
Brugia malayi Tachykinin-like peptides receptor 99D 0.0158 0.273 0.2724
Schistosoma mansoni opsin-like receptor 0.0158 0.273 0.273
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.273 0.273
Echinococcus multilocularis g-protein coupled receptor 0.0158 0.273 0.273
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0044 0.0441 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.273 0.273
Brugia malayi metabotropic glutamate receptor type 2 0.0071 0.0978 0.097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0207
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus granulosus serotonin receptor 0.0158 0.273 0.273
Echinococcus multilocularis orexin receptor type 2 0.0158 0.273 0.273
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0378 0.8541
Plasmodium vivax ataxin-2 like protein, putative 0.0031 0.0165 0.4234
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Entamoeba histolytica hypothetical protein 0.0033 0.0212 0.47
Echinococcus multilocularis receptor type guanylyl cyclase 0.0023 0.0011 0.0011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0121 0.1978 0.1978
Brugia malayi MH1 domain containing protein 0.0033 0.0204 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.273 0.273
Echinococcus multilocularis neuropeptide receptor 0.0158 0.273 0.273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus multilocularis nmda type glutamate receptor 0.0051 0.0577 0.0577
Brugia malayi MH2 domain containing protein 0.0478 0.9151 0.915
Schistosoma mansoni lamin 0.0024 0.0032 0.0032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0799 0.0799
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0032 0.0023
Echinococcus granulosus neuropeptide receptor 0.0158 0.273 0.273
Brugia malayi neuropeptide F receptor 0.0158 0.273 0.2724
Schistosoma mansoni lamin 0.0024 0.0032 0.0032
Echinococcus granulosus pyruvate kinase 0.0041 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.0134 0.225 0.2243
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) Smad1 0.0033 0.0204 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0207
Echinococcus granulosus g protein coupled receptor 0.0158 0.273 0.273
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0354 0.6671 0.6671
Trypanosoma cruzi oligopeptidase b 0.0041 0.0378 0.1208
Echinococcus multilocularis glutamate receptor 2 0.0061 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0041 0.0378 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0392 0.0392
Echinococcus granulosus g protein coupled receptor 0.0158 0.273 0.273
Echinococcus multilocularis g protein coupled receptor 0.0158 0.273 0.273
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.0378 1
Trichomonas vaginalis pyruvate kinase, putative 0.0041 0.0364 0.9628
Schistosoma mansoni pyruvate kinase 0.0041 0.0364 0.0364
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0378 0.0369
Loa Loa (eye worm) glutamate receptor 2 0.0061 0.0767 0.0759
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0041 0.0364 0.8224
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0158 0.273 0.273
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0118 0.2519
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0212 0.0212
Onchocerca volvulus 0.0024 0.0032 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0378 0.0369
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0207
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0011
Schistosoma mansoni biogenic amine receptor 0.0158 0.273 0.273
Mycobacterium ulcerans hypothetical protein 0.0044 0.0441 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0799 0.0791
Trypanosoma cruzi oligopeptidase b 0.0041 0.0378 0.1208
Echinococcus granulosus somatostatin receptor 0.0158 0.273 0.273
Schistosoma mansoni neuropeptide receptor 0.0158 0.273 0.273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Brugia malayi follicle stimulating hormone receptor 0.0158 0.273 0.2724
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.1229 0.1229
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.052 1 1
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus granulosus tachykinin peptides receptor 99D 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0117 0.1891 0.1884
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0043 0.041 0.0402
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0204 0.0204
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0441 1
Brugia malayi hypothetical protein 0.0023 0.0011 0.0003
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0175 0.3063 0.3063
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus granulosus 7TM GPCR rhodopsin 0.0158 0.273 0.273
Loa Loa (eye worm) pyruvate kinase 0.0041 0.0364 0.0356
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0158 0.273 0.273
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0175 0.3063 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0158 0.273 0.273
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.006 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0044 0.0441 0.0432
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0165 0.0156
Echinococcus multilocularis glutamate receptor 2 0.0084 0.1229 0.1229
Echinococcus multilocularis neuropeptide s receptor 0.0158 0.273 0.273
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0041 0.0378 0.1208
Loa Loa (eye worm) prolyl oligopeptidase 0.052 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.273 0.273
Brugia malayi Smad1 0.0033 0.0204 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0478 0.9151 0.915
Echinococcus multilocularis pyruvate kinase 0.0041 0.0364 0.0364
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0158 0.273 0.273
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0041 0.0378 0.1208
Schistosoma mansoni Smad4 0.0033 0.0204 0.0204
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0378 0.8541
Loa Loa (eye worm) melatonin receptor type 1A 0.0158 0.273 0.2724
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0441 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Schistosoma mansoni hypothetical protein 0.0062 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.0441 1
Brugia malayi Melatonin receptor type 1A 0.0158 0.273 0.2724
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0378 0.8541
Onchocerca volvulus Pyruvate kinase homolog 0.0041 0.0364 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Schistosoma mansoni biogenic amine receptor 0.0158 0.273 0.273
Onchocerca volvulus 0.0158 0.273 0.2722
Schistosoma mansoni ATP-binding cassette transporter 0.0061 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis Smad4 0.0033 0.0204 0.0204
Loa Loa (eye worm) TYRA-2 protein 0.0158 0.273 0.2724
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.0441 0.1415
Schistosoma mansoni alpha-1 adrenergic receptor 0.0158 0.273 0.273
Echinococcus granulosus prolyl endopeptidase 0.0041 0.0378 0.0378
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0378 0.0369
Echinococcus granulosus allatostatin A receptor 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0197 0.35 0.3494
Brugia malayi sulfakinin receptor protein 0.0158 0.273 0.2724
Echinococcus granulosus smad 0.0033 0.0204 0.0204
Brugia malayi MH2 domain containing protein 0.0033 0.0204 0.0195
Schistosoma mansoni intermediate filament proteins 0.0024 0.0032 0.0032
Brugia malayi hypothetical protein 0.0134 0.2235 0.2228
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.273 0.273
Echinococcus granulosus Dipeptidyl peptidase 9 0.0175 0.3063 0.3063
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0029 0.0127 0.2733
Echinococcus multilocularis neuropeptide receptor 0.0158 0.273 0.273
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0204 0.0195
Trypanosoma cruzi prolyl endopeptidase 0.0041 0.0378 0.1208
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni protein kinase 0.0023 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.273 0.273
Echinococcus multilocularis fmrfamide receptor 0.0158 0.273 0.273
Schistosoma mansoni glutamate receptor kainate 0.0098 0.1516 0.1516
Brugia malayi Serotonin receptor 0.0158 0.273 0.2724
Brugia malayi Serotonin receptor 0.0158 0.273 0.2724
Onchocerca volvulus 0.0024 0.0032 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0799 0.0799
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0158 0.273 0.273
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0068 0.0925 0.0925
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Schistosoma mansoni amine GPCR 0.0158 0.273 0.273
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.273 0.2724
Brugia malayi G-protein coupled receptor 0.0158 0.273 0.2724
Echinococcus multilocularis tyrosine kinase 0.0023 0.0011 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0158 0.273 0.273
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0354 0.6671 0.6668
Schistosoma mansoni glutamate receptor AMPA 0.0061 0.0767 0.0767
Loa Loa (eye worm) glutamate receptor 0.0048 0.0516 0.0507
Echinococcus granulosus g-protein coupled receptor 0.0158 0.273 0.273
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.273 0.273
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0088 0.1327 0.1327
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0175 0.3063 1
Schistosoma mansoni histamine h1 receptor 0.0158 0.273 0.273
Schistosoma mansoni hypothetical protein 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.273 0.273
Echinococcus granulosus GPCR family 2 0.0062 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0044 0.0441 0.0432
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0158 0.273 0.273
Loa Loa (eye worm) glutamate receptor 0.0088 0.1323 0.1316
Echinococcus multilocularis neuropeptide FF receptor 2 0.0158 0.273 0.273
Echinococcus granulosus g protein coupled receptor 0.0158 0.273 0.273
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.273 0.2724
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0029 0.0127 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0041 0.0378 0.1789
Brugia malayi Guanylyl cyclase protein 23 0.0023 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Onchocerca volvulus 0.0158 0.273 0.2722
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0158 0.273 0.2724
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0799 0.0791
Echinococcus multilocularis pyruvate kinase 0.0032 0.0192 0.0192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.0441 1
Onchocerca volvulus Pyruvate kinase homolog 0.0041 0.0364 0.0353
Toxoplasma gondii LsmAD domain-containing protein 0.0031 0.0165 0.0512
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0392 0.0392
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0179 0.3943
Brugia malayi Pyruvate kinase, muscle isozyme 0.0041 0.0364 0.0356
Brugia malayi putative neuropeptide receptor NPR1 0.0158 0.273 0.2724
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0009 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.0441 0.1415
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0041 0.0378 0.1208
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.052 1 1
Schistosoma mansoni opsin-like receptor 0.0158 0.273 0.273
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0378 0.8541
Schistosoma mansoni hypothetical protein 0.0158 0.273 0.273
Leishmania major hypothetical protein, conserved 0.0031 0.0165 0.0512
Chlamydia trachomatis pyruvate kinase 0.0041 0.0364 1
Brugia malayi hypothetical protein 0.0031 0.0165 0.0156
Echinococcus multilocularis musashi 0.0024 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0207
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0354 0.6671 0.6671
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0158 0.273 0.2724
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0011 0.0003
Trypanosoma brucei prolyl oligopeptidase, putative 0.0041 0.0378 0.1208
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0158 0.273 0.273
Schistosoma mansoni smad1 5 8 and 0.0033 0.0204 0.0204
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0158 0.273 0.273
Schistosoma mansoni hypothetical protein 0.0158 0.273 0.273
Schistosoma mansoni growth hormone secretagogue receptor 0.0158 0.273 0.273
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0478 0.9151 0.915
Brugia malayi neuropeptide F receptor 0.0158 0.273 0.2724
Echinococcus granulosus Smad4 0.0033 0.0204 0.0204
Onchocerca volvulus Neuropeptide F receptor homolog 0.0158 0.273 0.2722
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0065 0.0861 0.0853
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.273 0.273
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0033 0.0216 0.3738
Plasmodium falciparum pyruvate kinase 0.0041 0.0364 0.9628
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0158 0.273 0.273
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0041 0.0378 0.1208
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.052 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0023 0.0011 0.0011
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0441 0.0432
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0175 0.3063 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0204 0.0204
Brugia malayi G protein-coupled receptor 0.0158 0.273 0.2724
Schistosoma mansoni neuropeptide receptor 0.0158 0.273 0.273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.273 0.273
Schistosoma mansoni metabotropic glutamate receptor 0.0068 0.0925 0.0925
Onchocerca volvulus 0.0158 0.273 0.2722
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.041 0.0402
Brugia malayi larval opioid receptor 0.0158 0.273 0.2724
Loa Loa (eye worm) hypothetical protein 0.0043 0.041 0.0402
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.273 0.273
Echinococcus granulosus fmrfamide receptor 0.0158 0.273 0.273
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0354 0.6671 0.6668
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.35 0.3494
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0378 0.8541
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0121 0.1978 0.1978
Schistosoma mansoni amine GPCR 0.0158 0.273 0.273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus G protein coupled receptor 139 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0134 0.2235 0.2228
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.273 0.273
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0204 0.0195
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0158 0.273 0.273
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0009 0.0009
Echinococcus multilocularis glutamate receptor 2 0.0061 0.0778 0.0778
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus orexin receptor type 2 0.0158 0.273 0.273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0392 0.0392
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0158 0.273 0.2722
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0044 0.0441 1
Leishmania major pyruvate kinase 0.0041 0.0364 0.1163
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.273 0.273
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.0165 0.4234
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.273 0.273
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0158 0.273 0.2724
Brugia malayi Dopamine receptor 0.0158 0.273 0.2724
Onchocerca volvulus 0.0158 0.273 0.2722
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.1229 0.1229
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0175 0.3063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.273 0.273
Brugia malayi hypothetical protein 0.0033 0.0212 0.0203
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.35 0.3494
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0179 0.3943
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0041 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni neuropeptide receptor 0.0158 0.273 0.273
Echinococcus multilocularis g protein coupled receptor 0.0158 0.273 0.273
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0121 0.1978 0.1978
Schistosoma mansoni hypothetical protein 0.0062 0.0799 0.0799
Echinococcus granulosus glutamate receptor 2 0.0061 0.0778 0.0778
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0441 0.0432
Brugia malayi hypothetical protein 0.0158 0.273 0.2724
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0158 0.273 0.2724
Echinococcus granulosus sex peptide receptor 0.0158 0.273 0.273
Trypanosoma cruzi pyruvate kinase 2, putative 0.0041 0.0364 0.1163
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Leishmania major 4-coumarate:coa ligase-like protein 0.0044 0.0441 0.1415
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.052 1 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0041 0.0364 0.1163
Toxoplasma gondii hypothetical protein 0.0041 0.0378 0.1208
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.0165 0.4234
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0117 0.1891 0.1891
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.273 0.273
Onchocerca volvulus 0.0044 0.0441 0.043
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Brugia malayi Dopamine receptor protein 2 0.0158 0.273 0.2724
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.35 0.3494
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.273 0.273
Echinococcus granulosus neuropeptide FF receptor 2 0.0158 0.273 0.273
Echinococcus multilocularis serotonin receptor 0.0158 0.273 0.273
Echinococcus multilocularis g protein coupled receptor 0.0158 0.273 0.273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0212 0.0212
Brugia malayi G protein-coupled receptor F59B2.13 0.0158 0.273 0.2724
Plasmodium falciparum acyl-CoA synthetase 0.0033 0.0216 0.5602
Loa Loa (eye worm) pyruvate kinase 0.0041 0.0364 0.0356
Echinococcus granulosus alpha 1A adrenergic receptor 0.0158 0.273 0.273
Echinococcus granulosus atrial natriuretic peptide receptor 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0158 0.273 0.2724
Schistosoma mansoni hypothetical protein 0.0062 0.0799 0.0799
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0392 0.0383
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0441 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.0165 0.0512
Echinococcus granulosus 7tm_1 domain containing protein 0.0158 0.273 0.273
Echinococcus multilocularis pyruvate kinase 0.0041 0.0364 0.0364
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0179 0.3943
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0009 0.0009
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0029 0.0127 0.2733
Echinococcus multilocularis lamin dm0 0.0024 0.0032 0.0032
Echinococcus granulosus lamin dm0 0.0024 0.0032 0.0032
Leishmania major extracellular receptor, putative 0.0023 0.0011 0.0009
Echinococcus multilocularis allatostatin A receptor 0.0158 0.273 0.273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0179 0.3943
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0029 0.0127 1
Brugia malayi putative neuropeptide receptor 0.0158 0.273 0.2724
Schistosoma mansoni hypothetical protein 0.0134 0.225 0.225
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0043 0.041 0.0402
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0392 0.0383
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0044 0.0441 1
Schistosoma mansoni glutamate receptor NMDA 0.0061 0.0767 0.0767
Schistosoma mansoni amine GPCR 0.0158 0.273 0.273
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0158 0.273 0.2724
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0392 0.0392

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.2 uM Compound was tested for its ability to displace metabotropic glutamate binding to rat brain membranes using [3H]-glutamate radioligand. ChEMBL. 8632404
IC50 (binding) = 4.2 uM Compound was tested for its ability to displace metabotropic glutamate binding to rat brain membranes using [3H]-glutamate radioligand. ChEMBL. 8632404

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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