Detailed information for compound 28665

Basic information

Technical information
  • TDR Targets ID: 28665
  • Name: methyl (Z)-4-hydroxy-4-(4-methylphenyl)-2-oxo but-3-enoate
  • MW: 220.221 | Formula: C12H12O4
  • H donors: 1 H acceptors: 3 LogP: 2.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(=O)/C=C(\c1ccc(cc1)C)/O
  • InChi: 1S/C12H12O4/c1-8-3-5-9(6-4-8)10(13)7-11(14)12(15)16-2/h3-7,13H,1-2H3/b10-7-
  • InChiKey: KAQIFZRTEIWJID-YFHOEESVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (Z)-4-hydroxy-2-oxo-4-(p-tolyl)but-3-enoate
  • (Z)-4-hydroxy-2-oxo-4-(p-tolyl)-3-butenoic acid methyl ester
  • methyl (Z)-4-hydroxy-4-(4-methylphenyl)-2-oxo-but-3-enoate
  • (Z)-4-hydroxy-2-keto-4-(p-tolyl)but-3-enoic acid methyl ester
  • methyl 4-hydroxy-4-(4-methylphenyl)-2-oxobut-3-enoate
  • methyl 4-hydroxy-4-(4-methylphenyl)-2-oxo-but-3-enoate
  • 4-hydroxy-4-(4-methylphenyl)-2-oxobut-3-enoic acid methyl ester
  • (Z)-4-hydroxy-4-(4-methylphenyl)-2-oxobut-3-enoic acid methyl ester
  • (Z)-4-hydroxy-2-keto-4-(4-methylphenyl)but-3-enoic acid methyl ester
  • 4-hydroxy-2-keto-4-(4-methylphenyl)but-3-enoic acid methyl ester
  • ZINC03888451
  • CBMicro_002025
  • TOS-BB-1263
  • methyl (2Z)-2-hydroxy-4-(4-methylphenyl)-4-oxobut-2-enoate
  • ST5033454

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1116 0.3537
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.1103
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0167 0.4481 0.4481
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0272 0.0272
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0272 0.0272
Onchocerca volvulus 0.0018 0.0239 0.0759
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0386 0.1198
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0239 0.0239
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0239 0.0239
Entamoeba histolytica Ran family GTPase 0.0022 0.0348 0.1103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0181 0.1573
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.1091 0.1091
Schistosoma mansoni glycogen phosphorylase 0.0121 0.3154 0.3154
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0239 0.0239
Entamoeba histolytica glycogen phosphorylase, putative 0.0052 0.1205 0.382
Onchocerca volvulus Putative nachr subunit 0.0018 0.0239 0.0759
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0272 0.0272
Loa Loa (eye worm) glycogen phosphorylase 0.0121 0.3154 0.3154
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0272 0.0861
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Brugia malayi nuclear hormone receptor 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Schistosoma mansoni ap endonuclease 0.0018 0.024 0.024
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0348 0.0348
Echinococcus multilocularis Glycosyl transferase, family 35 0.0121 0.3154 0.3154
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0674 0.2137
Brugia malayi hypothetical protein 0.001 0.0012 0.0037
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0272 0.0272
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0239 0.0759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1005 0.1005
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Onchocerca volvulus 0.0018 0.0239 0.0759
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.1049 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Brugia malayi RNA binding protein 0.0062 0.15 0.4756
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.0562
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Brugia malayi glutathione reductase 0.0047 0.1049 0.3325
Entamoeba histolytica glycogen phosphorylase, putative 0.0121 0.3154 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0272 0.0861
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0272 0.0272
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0239 0.0759
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0052 0.1205 1
Schistosoma mansoni hypothetical protein 0.0167 0.4481 0.4481
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Trypanosoma brucei trypanothione reductase 0.0047 0.1049 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0501 0.1078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Leishmania major GTP-binding protein, putative 0.0022 0.0348 0.3197
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.3089 1
Schistosoma mansoni cytochrome P450 0.001 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0272 0.0272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Schistosoma mansoni importin beta-1 0.0034 0.0683 0.0683
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0239 0.0239
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0265 0.0265
Plasmodium falciparum importin beta, putative 0.0034 0.0683 0.5789
Echinococcus granulosus glycogen phosphorylase 0.0121 0.3154 0.3154
Chlamydia trachomatis glycogen phosphorylase 0.0121 0.3154 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0272 0.0861
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1005 0.1005
Echinococcus granulosus nAChR subunit 0.0018 0.0239 0.0239
Leishmania major cytochrome p450-like protein 0.0019 0.0265 0.2389
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus multilocularis tar DNA binding protein 0.0062 0.15 0.15
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0162 0.0513
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0348 0.1927
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0181 0.1573
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0265 0.2389
Loa Loa (eye worm) glutathione reductase 0.0047 0.1049 0.1049
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0239 0.0239
Onchocerca volvulus 0.0018 0.0239 0.0759
Brugia malayi Thioredoxin reductase 0.0047 0.1049 0.3325
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0272 0.0861
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0272 0.0272
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0386 0.1198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0181 0.1573
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0239 0.0239
Entamoeba histolytica glycogen phosphorylase, putative 0.0121 0.3154 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0272 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1573
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0386 0.31
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1116 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0272 0.0861
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0386 0.1198
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1005 0.1005
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0272 0.0272
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0683 0.6451
Loa Loa (eye worm) hypothetical protein 0.0049 0.1116 0.1116
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.024 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.024 0.0686
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) RNA binding protein 0.0062 0.15 0.15
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0272 0.0272
Entamoeba histolytica hypothetical protein 0.0027 0.0501 0.1589
Mycobacterium tuberculosis Probable reductase 0.0106 0.2751 0.8899
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2751 0.8899
Echinococcus multilocularis glycogen phosphorylase 0.0121 0.3154 0.3154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0272 0.0272
Echinococcus multilocularis snurportin 1 0.0361 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Leishmania major trypanothione reductase 0.0047 0.1049 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0162 0.0162
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0239 0.0239
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0012 0.0012
Brugia malayi ecdysteroid receptor 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.0348
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0162 0.0162
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0239 0.0759
Echinococcus multilocularis 0.001 0.0019 0.0019
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0239 0.0239
Echinococcus multilocularis nAChR subunit 0.0018 0.0239 0.0239
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0181 0.1573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0272 0.0272
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Trichomonas vaginalis ran, putative 0.0022 0.0348 0.0562
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0239 0.0239
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0348 0.3197
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0272 0.0272
Echinococcus granulosus glycogen phosphorylase 0.0121 0.3154 0.3154
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0019 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3075 0.3075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0272 0.0861
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.024 0.2151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1005 0.3188
Brugia malayi hypothetical protein 0.001 0.0012 0.0037
Schistosoma mansoni glycogen phosphorylase 0.0052 0.1205 0.1205
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1366
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0265 0.2075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0033 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.024 0.2151
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.1049 0.1049
Brugia malayi Cytochrome P450 family protein 0.001 0.0019 0.0059
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0386 0.1225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0162 0.0162
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0272 0.0272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0218 0.1681
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0272 0.0861
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0272 0.0272
Brugia malayi MH2 domain containing protein 0.0118 0.3075 0.9747
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Onchocerca volvulus 0.0018 0.0239 0.0759
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0218 0.043
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0239 0.0239
Toxoplasma gondii thioredoxin reductase 0.0047 0.1049 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0272 0.0861
Brugia malayi RNA, U transporter 1 0.0096 0.2459 0.7794
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Entamoeba histolytica glycogenphosphorylase, putative 0.0052 0.1205 0.382
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.0034 0.0683 0.0683
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0272 0.0861
Brugia malayi Cytochrome P450 family protein 0.0048 0.1091 0.3458
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.1049 0.1049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0501 0.1078
Brugia malayi Importin beta-1 subunit 0.0034 0.0683 0.2166
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Schistosoma mansoni ap endonuclease 0.0018 0.024 0.024
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0683 0.0683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0272 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0272 0.0272
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0272 0.0272
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.024 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0272 0.0861
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0162 0.0513
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0386 0.31
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0272 0.0272
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0023 0.0386 0.0386
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.024 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0052 0.1205 0.3864
Trichomonas vaginalis glycogen phosphorylase, putative 0.0121 0.3154 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2751 0.8899
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0501 0.4684
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.1049 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0181 0.1366
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0239 0.0759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2751 0.8899
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0162 0.0162
Schistosoma mansoni coup transcription factor 0.0019 0.0272 0.0272
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Toxoplasma gondii exonuclease III APE 0.0018 0.024 0.2151
Loa Loa (eye worm) hypothetical protein 0.0033 0.0674 0.0674
Echinococcus multilocularis geminin 0.0167 0.4481 0.4481
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.024 0.0762
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.024 0.02
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0239 0.0239
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Echinococcus granulosus tar DNA binding protein 0.0062 0.15 0.15
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus GPCR family 2 0.0015 0.0162 0.0162
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0239 0.0759
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Onchocerca volvulus 0.0019 0.0272 0.0861
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.1049 0.3355
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0272 0.0861
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0239 0.0239
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Leishmania major importin beta-1 subunit, putative 0.0027 0.0501 0.4684
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0239 0.0759
Brugia malayi TAR-binding protein 0.0062 0.15 0.4756
Schistosoma mansoni ran 0.0022 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0272 0.0861
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0181 0.1573
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Loa Loa (eye worm) cytochrome P450 0.001 0.0019 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0272 0.0272
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0272 0.0861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.024 0.2151
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0265 0.2389
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0386 0.1225
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0348 0.3197
Trichomonas vaginalis glycogen phosphorylase, putative 0.0121 0.3154 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Plasmodium falciparum thioredoxin reductase 0.0047 0.1049 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0386 0.1225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0272 0.0861
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0012 0.0012
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0181 0.1573
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0265 0.0265
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0239 0.0759
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0181 0.0528
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.024 0.02
Brugia malayi carbohydrate phosphorylase 0.0121 0.3154 1
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0162 0.0162
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0239 0.0239
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0218 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0181 0.1573
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Echinococcus multilocularis glycogen phosphorylase 0.0121 0.3154 0.3154
Onchocerca volvulus 0.0018 0.0239 0.0759
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3075 0.3075
Mycobacterium ulcerans hypothetical protein 0.0023 0.0386 0.31
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0239 0.0239
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.15 0.4756
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0386 0.1198
Loa Loa (eye worm) TAR-binding protein 0.0062 0.15 0.15
Brugia malayi nuclear receptor RXR 0.001 0.0012 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0218
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.024 0.0686
Brugia malayi cytochrome P450 0.001 0.0019 0.0059
Plasmodium falciparum glutathione reductase 0.0047 0.1049 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0272 0.0272
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0181 0.1366
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0348 0.1927
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0181 0.0181
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0181 0.0573
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0272 0.0272
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Schistosoma mansoni ran 0.0022 0.0348 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0239 0.0239
Onchocerca volvulus Glycogen phosphorylase homolog 0.0121 0.3154 1
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0272 0.0272
Giardia lamblia Glycogen phosphorylase 0.0121 0.3154 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0272 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2751 0.8899
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0239 0.0239
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0683 0.6451
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.3089 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0386 0.1225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0501 0.1078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0162 0.0162
Schistosoma mansoni glycogen phosphorylase 0.0121 0.3154 0.3154
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.001 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0361 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.024 0.2151
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0348 0.0348
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0012 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Echinococcus granulosus geminin 0.0167 0.4481 0.4481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1005 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0272 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0386 0.31
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.024 0.02
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.024 0.024
Echinococcus granulosus importin subunit beta 1 0.0034 0.0683 0.0683
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0239 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0062 0.15 0.15
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1116 0.3537
Loa Loa (eye worm) hypothetical protein 0.0019 0.0272 0.0272
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0272 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0239 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0191 0.0561
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2751 0.8899
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.024 0.024
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0265 0.2389
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0386 0.357
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1005 0.1005
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0239 0.0239
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0239 0.0759
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2751 0.8899
Onchocerca volvulus 0.0018 0.0239 0.0759
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0181 0.1573
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0218 0.065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0058 0.0185
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0239 0.0239
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0239 0.0759
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0272 0.0861
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.3089 1
Onchocerca volvulus 0.0023 0.0386 0.1225
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0037
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Brugia malayi Cation transporter family protein 0.0018 0.0239 0.0759
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0272 0.0861
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0386 0.31
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0272 0.0272
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0683 0.6451
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0181 0.1573
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0239 0.0239
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.024 0.0762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0272 0.0272
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0181 0.1573
Brugia malayi Cytochrome P450 family protein 0.0019 0.0265 0.0839
Brugia malayi Cytochrome P450 family protein 0.0019 0.0265 0.0839
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0386 0.31
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0239 0.0239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0272 0.0272
Brugia malayi steroid hormone receptor 0.0019 0.0272 0.0861
Echinococcus granulosus Glycosyl transferase family 35 0.0121 0.3154 0.3154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.15 0.15
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0265 0.0265
Schistosoma mansoni nAChR subunit 0.0018 0.0239 0.0239
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0239 0.0239
Entamoeba histolytica glycogen phosphorylase, putative 0.0052 0.1205 0.382
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0058 0.0185
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0218 0.043
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0239 0.0239
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.024 0.1868
Plasmodium vivax importin-beta 2, putative 0.0034 0.0683 0.5789
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.3089 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.1049 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 12 % Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver at 10 microM ChEMBL. 10633043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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