Detailed information for compound 286830

Basic information

Technical information
  • TDR Targets ID: 286830
  • Name: 2,5-dimethyl-3-oxopyrido[3,4-b][1,4]benzothia zine-4-carbonitrile
  • MW: 269.322 | Formula: C14H11N3OS
  • H donors: 0 H acceptors: 2 LogP: 1.58 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c2c(sc3c(n2C)cccc3)cn(c1=O)C
  • InChi: 1S/C14H11N3OS/c1-16-8-12-13(9(7-15)14(16)18)17(2)10-5-3-4-6-11(10)19-12/h3-6,8H,1-2H3
  • InChiKey: KWJIGHUTNKKWNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,5-dimethyl-3-oxo-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile
  • 2,5-dimethyl-3-oxo-4-pyrido[3,4-b][1,4]benzothiazinecarbonitrile
  • 3-keto-2,5-dimethyl-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile
  • 2,5-dimethyl-3-oxopyrido[5,4-b][1,4]benzothiazine-4-carbonitrile
  • 2,5-dimethyl-3-oxo-pyrido[5,4-b][1,4]benzothiazine-4-carbonitrile
  • 2,5-dimethyl-3-oxo-4-pyrido[5,4-b][1,4]benzothiazinecarbonitrile
  • 3-keto-2,5-dimethyl-pyrido[5,4-b][1,4]benzothiazine-4-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0037 0.0081 0.0028
Leishmania major calcium-translocating P-type ATPase 0.0115 0.2854 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0073 0.1366 0.4785
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.0021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0037 0.0081 0.0028
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0227 0.684 0.6823
Entamoeba histolytica heat shock protein 90, putative 0.0057 0.0796 0.2653
Brugia malayi MH2 domain containing protein 0.0188 0.5435 0.541
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0038 0.0113 0.0215
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Brugia malayi Protein kinase domain containing protein 0.0057 0.077 0.072
Mycobacterium ulcerans heat shock protein 90 0.0054 0.0671 0.2207
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0161
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0055 0.0724 0.0675
Giardia lamblia Kinase, CDC7 0.0057 0.077 0.2558
Entamoeba histolytica hypothetical protein 0.0052 0.0603 0.1963
Loa Loa (eye worm) endoplasmin 0.0057 0.0796 0.0747
Entamoeba histolytica heat shock protein 90, putative 0.0057 0.0796 0.2653
Loa Loa (eye worm) hypothetical protein 0.0173 0.4921 0.4894
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0042 0.025 0.0875
Schistosoma mansoni transcription factor LCR-F1 0.0052 0.0603 0.081
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0502 0.176
Loa Loa (eye worm) heat shock protein 75 0.0038 0.0113 0.006
Onchocerca volvulus 0.0173 0.4921 1
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0092 0.2037 0.7082
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0115 0.2854 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0092 0.2037 0.2867
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Echinococcus multilocularis GPCR, family 2 0.0039 0.0162 0.0158
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0115 0.2854 0.4128
Toxoplasma gondii P-type ATPase4, putative 0.0115 0.2854 0.4363
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0092 0.2037 0.2923
Trypanosoma brucei calcium-translocating P-type ATPase 0.0092 0.2037 0.7082
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Plasmodium falciparum calcium-transporting ATPase 0.0092 0.2037 0.309
Schistosoma mansoni hypothetical protein 0.0212 0.6287 0.9185
Trypanosoma cruzi hexose transporter, putative 0.0064 0.1027 0.3599
Trypanosoma brucei heat shock protein 84, putative 0.0038 0.0113 0.0215
Giardia lamblia Heat shock protein HSP 90-alpha 0.0057 0.0796 0.2653
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.1027 0.3478
Giardia lamblia Grp94/Hsp90 0.0054 0.0671 0.2207
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.1027 0.3478
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0092 0.2037 0.2923
Brugia malayi calcium ATPase 0.005 0.0549 0.0498
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Leishmania major P-type H -ATPase, putative 0.0073 0.1366 0.4686
Plasmodium vivax heat shock protein 90, putative 0.0038 0.0113 0.0094
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0115 0.2854 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.077 0.1191
Brugia malayi Na,K-ATPase alpha subunit 0.0115 0.2854 0.2816
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0081 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0085 0.1788 0.1744
Toxoplasma gondii P-type ATPase PMA1 0.0073 0.1366 0.2045
Loa Loa (eye worm) E1-E2 ATPase 0.0073 0.1366 0.132
Echinococcus multilocularis endoplasmin 0.0054 0.0671 0.0893
Trypanosoma cruzi Heat shock protein 83, putative 0.0057 0.0796 0.279
Schistosoma mansoni glucose transport protein 0.0206 0.6068 0.8863
Schistosoma mansoni heat shock protein 0.0038 0.0113 0.0089
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0238 0.0308
Echinococcus granulosus nervana 2 0.0173 0.4921 0.7035
Echinococcus granulosus Na:K ATPase alpha subunit 0.0092 0.2037 0.2867
Onchocerca volvulus 0.0173 0.4921 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0217 0.6474 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 0.4657
Plasmodium falciparum hexose transporter 0.0206 0.6068 0.9368
Toxoplasma gondii heat shock protein 90, putative 0.0057 0.0796 0.1157
Leishmania major calcium-transporting ATPase, putative 0.0092 0.2037 0.7082
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0671 0.1028
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 0.4657
Loa Loa (eye worm) sugar transporter 0.0206 0.6068 0.6047
Leishmania major heat shock protein, putative 0.0038 0.0113 0.0215
Echinococcus multilocularis General substrate transporter 0.0177 0.5041 0.7207
Entamoeba histolytica hypothetical protein 0.0052 0.0603 0.1963
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0173 0.4921 0.7173
Plasmodium vivax hexose transporter 0.0206 0.6068 0.9368
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0115 0.2854 0.4048
Plasmodium falciparum endoplasmin, putative 0.0042 0.0238 0.0288
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Echinococcus granulosus calcium transporting atpase 0.0092 0.2037 0.2867
Brugia malayi Hsp90 protein 0.0038 0.0113 0.006
Echinococcus granulosus c-Jun N-terminal kinases 0.0227 0.684 0.9807
Loa Loa (eye worm) hypothetical protein 0.0055 0.0724 0.0675
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.6973 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0092 0.2037 0.309
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Echinococcus granulosus heat shock protein 0.0057 0.0796 0.1074
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0078 0.1542 1
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.005 0.0549 0.1922
Brugia malayi Endoplasmin precursor 0.0057 0.0796 0.0747
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0092 0.2037 0.7137
Echinococcus multilocularis geminin 0.0212 0.6287 0.9009
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0054 0.0671 0.5
Echinococcus granulosus General substrate transporter 0.0177 0.5041 0.7207
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0161
Trypanosoma brucei glucose transporter 2A 0.0064 0.1027 0.3478
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0065 0.1067 0.362
Trichomonas vaginalis sugar transporter, putative 0.0064 0.1027 0.162
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0049 0.0502 0.0649
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 0.4657
Plasmodium vivax endoplasmin, putative 0.0057 0.0796 0.1157
Trichomonas vaginalis cation-transporting ATPase, putative 0.0115 0.2854 0.4657
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0092 0.2037 0.2923
Toxoplasma gondii heat shock protein 75, putative 0.0038 0.0113 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0162 0.011
Trichomonas vaginalis cation-transporting ATPase, putative 0.0115 0.2854 0.4657
Trypanosoma cruzi P-type H+-ATPase, putative 0.0073 0.1366 0.4785
Leishmania major glucose transporter, lmgt2 0.0064 0.1027 0.3478
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.1027 0.3478
Echinococcus multilocularis nervana 2 0.0173 0.4921 0.7035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0052 0.0603 0.0795
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0115 0.2854 0.4048
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0081 0.0041
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0036 0.0053 0.0186
Echinococcus granulosus GPCR family 2 0.0039 0.0162 0.0158
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0065 0.1067 0.1019
Loa Loa (eye worm) hypothetical protein 0.0115 0.2854 0.2816
Echinococcus multilocularis heat shock protein 0.0057 0.0796 0.1074
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0092 0.2037 0.2867
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.005 0.0549 0.0498
Schistosoma mansoni endoplasmin 0.0057 0.0796 0.1095
Loa Loa (eye worm) RNA binding protein 0.0037 0.0081 0.0028
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Toxoplasma gondii facilitative glucose transporter GT1 0.0206 0.6068 0.9368
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0092 0.2037 0.2867
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0161
Echinococcus multilocularis CDC7 cell division cycle 7 0.0057 0.077 0.1035
Loa Loa (eye worm) hypothetical protein 0.0042 0.025 0.0198
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Echinococcus granulosus CDC7 cell division cycle 7 0.0057 0.077 0.1035
Echinococcus multilocularis nervana 2 0.0173 0.4921 0.7035
Schistosoma mansoni glucose transport protein 0.0206 0.6068 0.8863
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0115 0.2854 0.4048
Brugia malayi RNA binding protein 0.0037 0.0081 0.0028
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0115 0.2854 0.4657
Treponema pallidum heat shock protein 90 0.0054 0.0671 1
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0796 0.1236
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Loa Loa (eye worm) calcium ATPase 0.0065 0.1067 0.1019
Trypanosoma cruzi heat shock protein 85, putative 0.0057 0.0796 0.279
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0092 0.2037 0.2923
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0161
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Plasmodium falciparum heat shock protein 90 0.0057 0.0796 0.1157
Echinococcus multilocularis nervana 2 0.0173 0.4921 0.7035
Plasmodium falciparum heat shock protein 90, putative 0.0217 0.6474 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Schistosoma mansoni endoplasmin 0.0057 0.0796 0.1095
Trypanosoma brucei heat shock protein 90, putative 0.0057 0.0796 0.2653
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.1027 0.3478
Trichomonas vaginalis glucose transporter, putative 0.0064 0.1027 0.162
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0081 0.0041
Chlamydia trachomatis metal transport ATPase 0.0036 0.0053 0.5
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Onchocerca volvulus 0.0057 0.077 0.1365
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.005 0.0549 0.1922
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0065 0.1067 0.362
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0039 0.0162 0.011
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0081 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0039 0.0162 0.011
Brugia malayi Stress-activated protein kinase jnk-1 0.0227 0.684 0.6823
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0092 0.2037 0.7082
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0115 0.2854 1
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.684 1
Trypanosoma cruzi hexose transporter, putative 0.0064 0.1027 0.3599
Plasmodium vivax heat shock protein 86, putative 0.0057 0.0796 0.1157
Echinococcus granulosus nervana 2 0.0173 0.4921 0.7035
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0092 0.2037 0.1994
Leishmania major P-type H -ATPase, putative 0.0073 0.1366 0.4686
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0078 0.1542 1
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0173 0.4921 0.7173
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Trypanosoma brucei Heat shock protein 83, putative 0.0057 0.0796 0.2653
Echinococcus granulosus heat shock protein 90 0.0049 0.0502 0.0649
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0092 0.2037 0.2867
Echinococcus granulosus tar DNA binding protein 0.0037 0.0081 0.0041
Giardia lamblia Heat shock protein HSP 90-alpha 0.0049 0.0502 0.1604
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0227 0.684 0.9807
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0115 0.2854 1
Onchocerca volvulus 0.0115 0.2854 0.5701
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0038 0.0113 0.0087
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0038 0.0113 0.0087
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Echinococcus multilocularis heat shock protein 90 0.0057 0.0796 0.1074
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0115 0.2854 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.0021
Trypanosoma cruzi cation-transporting ATPase, putative 0.0036 0.0053 0.0186
Trypanosoma brucei P-type H+-ATPase, putative 0.0073 0.1366 0.4686
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Trichomonas vaginalis sugar transporter, putative 0.0064 0.1027 0.162
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0173 0.4921 0.7035
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0115 0.2854 1
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0115 0.2854 1
Schistosoma mansoni glucose transport protein 0.0206 0.6068 0.8863
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Trypanosoma brucei heat shock protein 90, putative 0.0057 0.0796 0.2653
Trypanosoma brucei glucose transporter 1E 0.0064 0.1027 0.3478
Schistosoma mansoni heat shock protein 0.0057 0.0796 0.1095
Schistosoma mansoni hypothetical protein 0.0085 0.1788 0.2557
Trypanosoma brucei calcium-transporting ATPase, putative 0.0055 0.0724 0.2396
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0125 0.3189 0.3153
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0039 0.0162 0.0158
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0115 0.2854 1
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0502 0.0747
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0115 0.2854 1
Brugia malayi Membrane calcium atpase protein 3 0.0092 0.2037 0.1994
Brugia malayi hypothetical protein 0.0052 0.0603 0.0553
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0238 0.0308
Loa Loa (eye worm) CDC7 protein kinase 0.0057 0.077 0.072
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0115 0.2854 0.4048
Toxoplasma gondii heat shock protein HSP90 0.0057 0.0796 0.1157
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Trypanosoma cruzi heat shock protein, putative 0.0038 0.0113 0.0397
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0115 0.2854 0.4048
Schistosoma mansoni hypothetical protein 0.0206 0.6068 0.8863
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0115 0.2854 0.4363
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.005 0.0549 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1027 0.162
Echinococcus granulosus geminin 0.0212 0.6287 0.9009
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0115 0.2854 1
Trypanosoma cruzi hexose transporter, putative 0.0064 0.1027 0.3599
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0173 0.4921 0.7173
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0055 0.0724 0.2538
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 0.4657
Plasmodium vivax P-type ATPase4, putative 0.0115 0.2854 0.4363
Trichomonas vaginalis glucose transporter, putative 0.0064 0.1027 0.162
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.077 0.1056
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0173 0.4921 0.7173
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0036 0.0053 0.0186
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0115 0.2854 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0054 0.0671 0.4153
Echinococcus multilocularis nervana 2 0.0173 0.4921 0.7035
Plasmodium vivax heat shock protein, putative 0.0217 0.6474 1
Schistosoma mansoni hypothetical protein 0.0052 0.0603 0.081
Loa Loa (eye worm) MH2 domain-containing protein 0.0188 0.5435 0.541
Trypanosoma cruzi P-type H+-ATPase, putative 0.005 0.0549 0.1922
Loa Loa (eye worm) transcription factor SMAD2 0.0188 0.5435 0.541
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.6068 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0073 0.1366 0.2183
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0092 0.2037 0.2867
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.005 0.0549 0.1769
Brugia malayi E1-E2 ATPase family protein 0.0073 0.1366 0.132
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0092 0.2037 0.2923
Entamoeba histolytica hypothetical protein 0.0052 0.0603 0.1963
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Trichomonas vaginalis sugar transporter, putative 0.0064 0.1027 0.162
Trypanosoma brucei P-type H+-ATPase, putative 0.0073 0.1366 0.4686
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0092 0.2037 0.7082
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0078 0.1542 0.1496
Loa Loa (eye worm) hypothetical protein 0.005 0.0549 0.0498
Loa Loa (eye worm) hypothetical protein 0.0085 0.1788 0.1744
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0055 0.0724 0.0675
Echinococcus multilocularis tar DNA binding protein 0.0037 0.0081 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.6973 1
Brugia malayi RNA recognition motif domain containing protein 0.0037 0.0081 0.0028
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0502 0.176
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Loa Loa (eye worm) hypothetical protein 0.0316 1 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0115 0.2854 0.4048
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0115 0.2854 0.4363
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Trypanosoma cruzi hexose transporter 0.0064 0.1027 0.3599
Schistosoma mansoni heat shock protein 0.0057 0.0796 0.1095
Trypanosoma cruzi heat shock protein 85, putative 0.0057 0.0796 0.279
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0081 0.0041
Brugia malayi Sugar transporter family protein 0.0206 0.6068 0.6047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0039 0.0162 0.011
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.077 0.1191
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 1
Schistosoma mansoni transmemberane protein 0.0173 0.4921 0.7173
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0078 0.1542 0.5314
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0078 0.1542 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.077 0.1191
Echinococcus multilocularis calcium transporting atpase 0.0092 0.2037 0.2867
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Trichomonas vaginalis cation-transporting ATPase, putative 0.0115 0.2854 0.4657
Loa Loa (eye worm) hypothetical protein 0.0173 0.4921 0.4894
Echinococcus granulosus nervana 2 0.0173 0.4921 0.7035
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0054 0.0671 0.2207
Brugia malayi heat shock protein 90 0.0057 0.0796 0.0747
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0115 0.2854 0.2816
Schistosoma mansoni ATPase 0.0115 0.2854 0.4128
Echinococcus granulosus nervana 2 0.0173 0.4921 0.7035
Trypanosoma cruzi heat shock protein 90, putative 0.0057 0.0796 0.279
Brugia malayi Calcitonin receptor-like protein seb-1 0.0125 0.3189 0.3153
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0052 0.0603 0.0795
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 0.4657
Plasmodium vivax calcium-transporting ATPase, putative 0.0115 0.2854 0.4363
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0092 0.2037 0.7137
Echinococcus multilocularis heat shock protein 90 0.0049 0.0502 0.0649
Leishmania major calcium motive p-type ATPase, putative 0.0092 0.2037 0.7082
Trypanosoma cruzi heat shock protein 85, putative 0.0057 0.0796 0.279
Loa Loa (eye worm) hypothetical protein 0.0115 0.2854 0.2816
Onchocerca volvulus 0.0057 0.077 0.1365
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 1
Echinococcus granulosus heat shock protein 90 0.0057 0.0796 0.1074
Brugia malayi calcium ATPase 0.0042 0.025 0.0198
Trypanosoma brucei heat shock protein, putative 0.0057 0.0796 0.2653
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0115 0.2854 0.4363
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0671 0.1028
Loa Loa (eye worm) heat shock protein 90 0.0057 0.0796 0.0747
Leishmania major glucose transporter, lmgt1 0.0064 0.1027 0.3478
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0206 0.6068 0.8692
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0039 0.0162 0.0158
Entamoeba histolytica hypothetical protein 0.0052 0.0603 0.1963
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Leishmania major glucose transporter, lmgt3 0.0064 0.1027 0.3478
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0092 0.2037 0.3298
Leishmania major P-type ATPase, putative 0.0092 0.2037 0.7082
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.005 0.0549 0.0772
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0054 0.0671 0.4153
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0092 0.2037 0.2923
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0173 0.4921 0.7035
Schistosoma mansoni ATPase 0.0115 0.2854 0.4128
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0115 0.2854 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0173 0.4921 0.7035
Schistosoma mansoni hypothetical protein 0.0212 0.6287 0.9185
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0206 0.6068 0.8692
Brugia malayi TAR-binding protein 0.0037 0.0081 0.0028
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0115 0.2854 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.1027 0.3478
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1027 0.162
Echinococcus granulosus endoplasmin 0.0054 0.0671 0.0893
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653
Leishmania major heat shock protein 83-1 0.0057 0.0796 0.2653

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0001 M Inhibition of binding of tritiated 3[H]diazepam radioligand to rat brain homogenates ChEMBL. 6304314
IC50 (binding) = 0.0001 M Inhibition of binding of tritiated 3[H]diazepam radioligand to rat brain homogenates ChEMBL. 6304314
No. of mice protected (functional) = 0 Inhibition of pentylenetetrazole(PTZ) induced convulsions in mice at 4 mg/kg after 30 min; 0/10 ChEMBL. 6304314
No. of mice protected (functional) = 5 Inhibition of pentylenetetrazole(PTZ) induced convulsions in mice at 64 mg/kg after 30 min; 5/10 ChEMBL. 6304314
No. of mice protected (functional) = 0 Inhibition of pentylenetetrazole(PTZ) induced convulsions in mice at 4 mg/kg after 30 min; 0/10 ChEMBL. 6304314
No. of mice protected (functional) = 5 Inhibition of pentylenetetrazole(PTZ) induced convulsions in mice at 64 mg/kg after 30 min; 5/10 ChEMBL. 6304314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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