TDR Targets

Basic information

Technical information

TDR Targets ID: 302129
Name: 1,3-dimethyl-5-[4-(3-propan-2-ylphenyl)-2-thi ophen-2-yl-1H-imidazol-5-yl]benzimidazol-2-on e
MW: 428.549 | Formula: C25H24N4OS
H donors: 1 H acceptors: 2 LogP: 4.9 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1cccc(c1)c1[nH]c(nc1c1ccc2c(c1)n(C)c(=O)n2C)c1cccs1)C
InChi: 1S/C25H24N4OS/c1-15(2)16-7-5-8-17(13-16)22-23(27-24(26-22)21-9-6-12-31-21)18-10-11-19-20(14-18)29(4)25(30)28(19)3/h5-15H,1-4H3,(H,26,27)
InChiKey: VLZWWLJWKCJAEF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[4-(3-isopropylphenyl)-2-(2-thienyl)-1H-imidazol-5-yl]-1,3-dimethyl-benzimidazol-2-one
5-[4-(3-isopropylphenyl)-2-(2-thienyl)-1H-imidazol-5-yl]-1,3-dimethyl-2-benzimidazolone
5-[4-m-cumenyl-2-(2-thienyl)-1H-imidazol-5-yl]-1,3-dimethyl-benzimidazol-2-one
1,3-dimethyl-5-[5-(3-propan-2-ylphenyl)-2-thiophen-2-yl-3H-imidazol-4-yl]benzimidazol-2-one
5-[5-(3-isopropylphenyl)-2-(2-thienyl)-3H-imidazol-4-yl]-1,3-dimethyl-benzimidazol-2-one
5-[5-(3-isopropylphenyl)-2-(2-thienyl)-3H-imidazol-4-yl]-1,3-dimethyl-2-benzimidazolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0056	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0268	0.0358
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0056	0.0268	0.0515
Echinococcus granulosus	thioredoxin glutathione reductase	0.0607	0.5202	0.8228
Schistosoma mansoni	phosphoglucomutase	0.0047	0.0185	0.0185
Plasmodium falciparum	glutathione reductase	0.021	0.1651	0.3061
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.021	0.1651	1
Leishmania major	hypothetical protein, conserved	0.0056	0.0268	0.0358
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0058	0.0284	0.0449
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0085	0.0707
Mycobacterium ulcerans	dehydrogenase	0.0056	0.0268	0.1168
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0056	0.0268	0.0424
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.021	0.1651	0.3174
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0056	0.0268	0.0515
Plasmodium falciparum	thioredoxin reductase	0.0607	0.5202	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.021	0.1651	0.2612
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0395	0.0395
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0056	0.0268	0.0515
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.0221	0.0266
Trichomonas vaginalis	ribonuclease H1, putative	0.0047	0.0185	0.1119
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.0221	0.035
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0056	0.0268	0.0424
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Echinococcus granulosus	glutamate synthase	0.0056	0.0268	0.0424
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0056	0.0268	0.1168
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0607	0.5202	0.8228
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0607	0.5202	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Echinococcus granulosus	pyruvate kinase	0.0035	0.0085	0.0135
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0056	0.0268	0.0515
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0268	0.0515
Echinococcus multilocularis	microtubule associated protein 2	0.0733	0.6322	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Loa Loa (eye worm)	thioredoxin reductase	0.0607	0.5202	1
Onchocerca volvulus		0.0056	0.0268	0.2227
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0056	0.0268	0.1623
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0056	0.0268	0.0515
Echinococcus multilocularis	pyruvate kinase	0.0028	0.0018	0.0029
Onchocerca volvulus	Ribonuclease H1 homolog	0.0047	0.0185	0.1535
Trypanosoma brucei	unspecified product	0.0072	0.0417	0.0417
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0395	0.076
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0284	0.0389
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1128	0.2169
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0056	0.0268	0.0568
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.1128	0.1128
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0056	0.0268	0.1168
Brugia malayi	hypothetical protein	0.016	0.1203	0.2313
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0056	0.0268	0.0515
Plasmodium vivax	ferrodoxin reductase, putative	0.0056	0.0268	0.0358
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0056	0.0268	0.1623
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.0221	0.035
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0056	0.0268	0.0358
Mycobacterium ulcerans	ferredoxin reductase	0.0056	0.0268	0.1168
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0058	0.0284	0.0449
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0056	0.0268	0.1168
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0056	0.0268	0.0358
Trypanosoma brucei	RNA helicase, putative	0.1144	1	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.007	0.0395	0.0625
Trypanosoma cruzi	trypanothione reductase, putative	0.0607	0.5202	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.021	0.1651	0.3174
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.021	0.1651	1
Treponema pallidum	NADH oxidase	0.021	0.1651	1
Giardia lamblia	Thioredoxin reductase	0.0056	0.0268	0.1623
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0056	0.0268	0.1168
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1128	0.2169
Loa Loa (eye worm)	programmed cell death 8	0.0056	0.0268	0.0358
Echinococcus multilocularis	ribonuclease H1	0.0047	0.0185	0.0292
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0035	0.0085	0.0163
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0056	0.0268	0.0424
Brugia malayi	RNase H family protein	0.0047	0.0185	0.0355
Onchocerca volvulus		0.0051	0.0221	0.1839
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.021	0.1651	1
Echinococcus granulosus	pyruvate kinase	0.0035	0.0085	0.0135
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3061
Toxoplasma gondii	thioredoxin reductase	0.0607	0.5202	1
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0056	0.0268	0.0424
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0035	0.0085	0.0163
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1128	0.1785
Schistosoma mansoni	sulfide quinone reductase	0.0056	0.0268	0.0268
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.007	0.0395	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0345	0.0345
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0058	0.0284	0.0449
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0417	0.0417
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.021	0.1651	0.1651
Brugia malayi	mbt repeat family protein	0.0051	0.0221	0.0425
Schistosoma mansoni	glutamate synthase	0.0056	0.0268	0.0268
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0056	0.0268	0.0515
Trypanosoma brucei	NADH dehydrogenase	0.0056	0.0268	0.0268
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0345	0.1659
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.0221	0.035
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0056	0.0268	0.0515
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0056	0.0268	0.0358
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0056	0.0268	0.0515
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0005	0.0005
Trypanosoma brucei	pyruvate kinase 1, putative	0.0035	0.0085	0.0085
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1128	0.1785
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0085	0.0515
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0056	0.0268	0.1168
Mycobacterium tuberculosis	Probable dehydrogenase	0.0056	0.0268	0.0515
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.1128	0.1785
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0056	0.0268	0.0515
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0056	0.0268	0.0358
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.0221	0.035
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0085	0.0135
Schistosoma mansoni	hypothetical protein	0.0056	0.0268	0.0268
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Schistosoma mansoni	glutamate synthase	0.0056	0.0268	0.0268
Leishmania major	trypanothione reductase	0.0607	0.5202	1
Onchocerca volvulus		0.016	0.1203	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0085	0.0707
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0056	0.0268	0.1168
Giardia lamblia	Glutamate synthase	0.0056	0.0268	0.1623
Mycobacterium ulcerans	hypothetical protein	0.0056	0.0268	0.1168
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0056	0.0268	0.1168
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0345	0.0508
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.021	0.1651	0.3174
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0056	0.0268	0.0424
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0056	0.0268	0.0424
Giardia lamblia	NADH oxidase lateral transfer candidate	0.021	0.1651	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.021	0.1651	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.007	0.0395	0.0625
Schistosoma mansoni	sulfide quinone reductase	0.0056	0.0268	0.0268
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.1128	0.2039
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0056	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.018	0.1377	0.1377
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.0221	0.1839
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.007	0.0395	0.0606
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0345	0.0546
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.021	0.1651	0.1651
Loa Loa (eye worm)	hypothetical protein	0.016	0.1203	0.2185
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.021	0.1651	0.3061
Trichomonas vaginalis	glutamate synthase, putative	0.0056	0.0268	0.1623
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0056	0.0268	0.0424
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0056	0.0268	0.0515
Loa Loa (eye worm)	MBCTL1	0.0058	0.0284	0.0389
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3174
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0131	0.0207
Chlamydia trachomatis	thioredoxin reductase	0.0056	0.0268	0.1168
Trypanosoma brucei	ingi protein (ORF1)	0.0072	0.0417	0.0417
Trichomonas vaginalis	mercuric reductase, putative	0.021	0.1651	1
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0056	0.0268	0.0268
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0056	0.0268	0.0358
Schistosoma mansoni	hypothetical protein	0.018	0.1377	0.1377
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.021	0.1651	0.1651
Toxoplasma gondii	selenide, water dikinase	0.0056	0.0268	0.0358
Schistosoma mansoni	microtubule-associated protein tau	0.0733	0.6322	0.6322
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1128	0.1785
Schistosoma mansoni	phosphoglucomutase	0.0047	0.0185	0.0185
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0345	0.1659
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.021	0.1651	0.3061
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0056	0.0268	0.1168
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0056	0.0268	0.0515
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0056	0.0268	0.0358
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.021	0.1651	0.1651
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0345	0.0663
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0085	0.0163
Mycobacterium ulcerans	monoxygenase	0.0056	0.0268	0.1168
Toxoplasma gondii	ribonuclease HI protein	0.0047	0.0185	0.0195
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.021	0.1651	0.3061
Trypanosoma brucei	pyruvate kinase 1	0.0035	0.0085	0.0085
Brugia malayi	RNase H family protein	0.0047	0.0185	0.0355
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0056	0.0268	0.0515
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0056	0.0268	0.1623
Trypanosoma brucei	ribonuclease H1	0.0047	0.0185	0.0185
Mycobacterium ulcerans	NADH dehydrogenase	0.0056	0.0268	0.1168
Schistosoma mansoni	disulfide oxidoreductase	0.0056	0.0268	0.0268
Echinococcus multilocularis	geminin	0.018	0.1377	0.2179
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.007	0.0395	0.0606
Schistosoma mansoni	glutamate synthase	0.0056	0.0268	0.0268
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.02	0.1553	0.2457
Leishmania major	hypothetical protein, conserved	0.0056	0.0268	0.0358
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0035	0.0085	0.0163
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.021	0.1651	0.3061
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0056	0.0268	0.1168
Plasmodium vivax	glutathione reductase, putative	0.0607	0.5202	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.021	0.1651	0.3061
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.021	0.1651	0.3174
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.021	0.1651	0.3061
Brugia malayi	Thioredoxin reductase	0.0607	0.5202	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.021	0.1651	0.1651
Toxoplasma gondii	NADPH-glutathione reductase	0.021	0.1651	0.3061
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0131	0.0207
Echinococcus granulosus	histone acetyltransferase MYST2	0.0058	0.0284	0.0449
Leishmania major	hypothetical protein, conserved	0.0056	0.0268	0.0358
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0085	0.0515
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0056	0.0268	0.0424
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.007	0.0395	0.076
Leishmania major	NADH dehydrogenase, putative	0.0056	0.0268	0.0358
Schistosoma mansoni	hypothetical protein	0.0308	0.2522	0.2522
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0155	0.1151	0.2213
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0345	0.0345
Trypanosoma brucei	trypanothione reductase	0.0607	0.5202	0.5202
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0085	0.0163
Echinococcus granulosus	geminin	0.018	0.1377	0.2179
Brugia malayi	glutathione reductase	0.0607	0.5202	1
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0056	0.0268	0.0358
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0056	0.0268	0.0424
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0056	0.0268	0.1623
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0056	0.0268	0.1623
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0085	0.0135
Trypanosoma brucei	hypothetical protein, conserved	0.0056	0.0268	0.0268
Trypanosoma cruzi	ribonuclease H1, putative	0.0047	0.0185	0.0355
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.02	0.1553	0.2457
Brugia malayi	glutamate synthase	0.0056	0.0268	0.0515
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0056	0.0268	0.0268
Plasmodium vivax	thioredoxin reductase, putative	0.0607	0.5202	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0345	0.1659
Giardia lamblia	Ribonuclease H	0.0047	0.0185	0.1119
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0056	0.0268	0.0515
Treponema pallidum	thioredoxin reductase (trxB)	0.0056	0.0268	0.0568
Brugia malayi	mbt repeat family protein	0.0051	0.0221	0.0425
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.021	0.1651	0.3061
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0395	0.076
Mycobacterium tuberculosis	Probable oxidoreductase	0.021	0.1651	0.3174
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0056	0.0268	0.0358
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0056	0.0268	0.0515
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0221	0.0221
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0155	0.1151	0.2213
Echinococcus granulosus	microtubule associated protein 2	0.0733	0.6322	1
Trypanosoma cruzi	trypanothione reductase, putative	0.021	0.1651	0.3174
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0345	0.0508
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0056	0.0268	0.1623
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0056	0.0268	0.0424
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.021	0.1651	1
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0056	0.0268	0.0424
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0056	0.0268	0.0424
Echinococcus granulosus	ribonuclease H1	0.0047	0.0185	0.0292
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0056	0.0268	0.1623
Schistosoma mansoni	phosphoglucomutase	0.0047	0.0185	0.0185
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0058	0.0284	0.0284
Trypanosoma cruzi	ribonuclease H1, putative	0.0047	0.0185	0.0355
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0056	0.0268	0.0568
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0056	0.0268	0.0358
Mycobacterium tuberculosis	Probable reductase	0.0056	0.0268	0.0515
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0056	0.0268	0.0515
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0056	0.0268	0.1168
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0056	0.0268	0.0358
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1128	0.1785
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.021	0.1651	1
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0056	0.0268	0.0568
Trypanosoma brucei	ingi protein (ORF1)	0.0072	0.0417	0.0417
Loa Loa (eye worm)	glutathione reductase	0.0607	0.5202	1
Trichomonas vaginalis	glutathione reductase, putative	0.021	0.1651	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.0221	0.0221
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0056	0.0268	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0221	0.0266
Schistosoma mansoni	pyruvate kinase	0.0035	0.0085	0.0085
Schistosoma mansoni	pyruvate kinase	0.0035	0.0085	0.0085
Brugia malayi	RNase H family protein	0.0047	0.0185	0.0355
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0056	0.0268	0.1168
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.021	0.1651	0.3174
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0268	0.0515
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0056	0.0268	0.0515
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.0221	0.0221
Plasmodium falciparum	thioredoxin reductase	0.021	0.1651	0.3061
Giardia lamblia	Pyruvate kinase	0.0035	0.0085	0.0515
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0056	0.0268	0.0515
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0345	0.0546
Trichomonas vaginalis	glutamate synthase, putative	0.0056	0.0268	0.1623
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.021	0.1651	0.3061
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.021	0.1651	1
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0056	0.0268	0.1168
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0056	0.0268	0.0358
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0072	0.0417	0.0417
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.007	0.0395	0.0395
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.021	0.1651	0.2612
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0058	0.0284	0.0546
Treponema pallidum	oxidoreductase	0.0056	0.0268	0.0568
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.1128	0.2039
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.1128	0.1785
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0056	0.0268	0.0515
Plasmodium falciparum	glutathione reductase	0.0607	0.5202	1
Brugia malayi	P38 map kinase family protein 2	0.0152	0.1128	0.2169
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.021	0.1651	0.3174
Leishmania major	ribonuclease H1, putative	0.0047	0.0185	0.0195
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0056	0.0268	0.1168
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0056	0.0268	0.0358
Echinococcus multilocularis	glutamate synthase	0.0056	0.0268	0.0424
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0056	0.0268	0.0515
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0085	0.0707

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 32 uM	Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.	ChEMBL.	15012994
IC50 (binding)	> 32 uM	Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.	ChEMBL.	15012994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 23581662

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 302129