Detailed information for compound 305041

Basic information

Technical information
  • TDR Targets ID: 305041
  • Name: 5-ethyl-4-phenyl-1,3-thiazol-2-amine
  • MW: 204.291 | Formula: C11H12N2S
  • H donors: 1 H acceptors: 1 LogP: 3.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc(nc1c1ccccc1)N
  • InChi: 1S/C11H12N2S/c1-2-9-10(13-11(12)14-9)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,13)
  • InChiKey: JPFFDVPXYBZEPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-ethyl-4-phenyl-thiazol-2-amine
  • 5-ethyl-4-phenyl-2-thiazolamine
  • (5-ethyl-4-phenyl-thiazol-2-yl)amine
  • 34176-47-1
  • Oprea1_469578
  • SBB009363
  • ZINC00340510
  • 2-Thiazolamine, 5-ethyl-4-phenyl-
  • AI3-61619
  • AG-227/30749016
  • 5-Ethyl-4-phenyl-thiazol-2-ylamine
  • BAS 05277732
  • MLS000583659
  • SMR000197415

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0467 0.2804
Echinococcus granulosus snurportin 1 0.0372 0.1093 1
Plasmodium vivax adrenodoxin reductase, putative 0.0078 0.0158 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0452 0.4016
Toxoplasma gondii histone lysine-specific demethylase 0.0078 0.0158 1
Trypanosoma cruzi squalene monooxygenase, putative 0.3171 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1093 0.6737
Toxoplasma gondii electron transfer flavoprotein-ubiquinone oxidoreductase 0.0078 0.0158 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0154 0.0833
Onchocerca volvulus 0.0535 0.1612 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0154 0.0833
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0158 0.5
Brugia malayi TAR-binding protein 0.0076 0.0154 0.0833
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0074 0.388
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0858
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0074 0.0494
Echinococcus granulosus protoporphyrinogen oxidase 0.0078 0.0158 0.1274
Echinococcus multilocularis prenylcysteine oxidase 0.0078 0.0158 0.1274
Trypanosoma cruzi squalene monooxygenase, putative 0.3171 1 1
Mycobacterium tuberculosis Monooxygenase EthA 0.0078 0.0158 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0086 0.0606
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.006 0.2881
Mycobacterium tuberculosis Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase) 0.0078 0.0158 0.5
Loa Loa (eye worm) hypothetical protein 0.0535 0.1612 1
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0078 0.0158 0.0158
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0074 0.388
Mycobacterium tuberculosis Possible alanine rich dehydrogenase 0.0078 0.0158 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0154 0.0833
Schistosoma mansoni hypothetical protein 0.0078 0.0158 0.1274
Echinococcus multilocularis snurportin 1 0.0372 0.1093 1
Plasmodium vivax unspecified product 0.0078 0.0158 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0086 0.0606
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.006 1
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0078 0.0158 0.5
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0074 1
Echinococcus multilocularis Protein lozenge 0.0067 0.0124 0.0958
Mycobacterium tuberculosis Possible oxidoreductase 0.0078 0.0158 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0086 0.0606
Brugia malayi all-trans-13,14-dihydroretinol saturase 0.0078 0.0158 0.0858
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0086 0.0606
Plasmodium vivax unspecified product 0.0078 0.0158 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0078 0.0158 0.5
Brugia malayi RNA binding protein 0.0076 0.0154 0.0833
Toxoplasma gondii hypothetical protein 0.0078 0.0158 1
Brugia malayi RNA, U transporter 1 0.0099 0.0225 0.1284
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0078 0.0158 1
Brugia malayi hypothetical protein 0.0535 0.1612 1
Mycobacterium ulcerans dehydrogenase 0.0078 0.0158 0.5
Toxoplasma gondii prenylcysteine oxidase 0.0078 0.0158 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0467 0.4162
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0154 0.1237
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0154 0.1237
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0154 0.0833
Mycobacterium tuberculosis Probable monooxygenase (hydroxylase) 0.0078 0.0158 0.5
Mycobacterium leprae Probable monooxygenase EthA 0.0078 0.0158 0.5
Loa Loa (eye worm) hypothetical protein 0.0535 0.1612 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0086 0.0606
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0158 0.5
Trypanosoma cruzi UDP-galactopyranose mutase 0.0078 0.0158 0.0158
Trypanosoma brucei squalene monooxygenase, putative 0.3171 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0074 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0154 0.1237
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0078 0.0158 1
Leishmania major electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0078 0.0158 0.0158
Mycobacterium ulcerans monooxygenase EthA 0.0078 0.0158 0.5
Schistosoma mansoni amine oxidase 0.0078 0.0158 0.1274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0086 0.0606
Mycobacterium ulcerans oxidoreductase 0.0078 0.0158 0.5
Mycobacterium tuberculosis Unknown protein 0.0078 0.0158 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0154 0.1237
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0154 0.1237
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0078 0.0158 0.0158
Loa Loa (eye worm) lethal protein 721 0.0078 0.0158 0.0858
Schistosoma mansoni hypothetical protein 0.0372 0.1093 1
Echinococcus granulosus prenylcysteine oxidase 0.0078 0.0158 0.1274
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0078 0.0158 1
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0078 0.0158 0.5
Schistosoma mansoni lozenge 0.0067 0.0124 0.0958
Loa Loa (eye worm) runx1 0.0067 0.0124 0.0645
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0078 0.0158 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0086 0.0606
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0086 0.0408
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0467 0.4162
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.006 0.5
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0074 0.388
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0078 0.0158 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0154 0.1237
Plasmodium vivax unspecified product 0.0078 0.0158 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0086 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0154 0.1237
Mycobacterium ulcerans dehydrogenase 0.0078 0.0158 0.5
Loa Loa (eye worm) acetyltransferase 0.0175 0.0467 0.2804

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 ug ml-1 Inhibition the IL-6 secretion stimulated at a concentration of 10 ng/ml in osteoblastic MC3T3-E 1 cells. ChEMBL. 10230619
Potency (functional) 0.0077 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1477, AID1484] ChEMBL. No reference
Potency (functional) 0.4611 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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