TDR Targets

Basic information

Technical information

TDR Targets ID: 306845
Name: 2-[2,6-dihydroxy-4-[[(1R,2R)-1-[(4-hydroxyben zoyl)amino]-2,3-dihydro-1H-inden-2-yl]oxycarb onyl]benzoyl]-3-hydroxybenzoic acid
MW: 569.515 | Formula: C31H23NO10
H donors: 6 H acceptors: 9 LogP: 4.38 Rotable bonds: 9
Rule of 5 violations (Lipinski): 3
SMILES: Oc1ccc(cc1)C(=O)N[C@H]1[C@H](OC(=O)c2cc(O)c(c(c2)O)C(=O)c2c(O)cccc2C(=O)O)Cc2c1cccc2
InChi: 1S/C31H23NO10/c33-18-10-8-15(9-11-18)29(38)32-27-19-5-2-1-4-16(19)14-24(27)42-31(41)17-12-22(35)26(23(36)13-17)28(37)25-20(30(39)40)6-3-7-21(25)34/h1-13,24,27,33-36H,14H2,(H,32,38)(H,39,40)/t24-,27-/m1/s1
InChiKey: NNVINYYJNCKGRA-SHQCIBLASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2,6-dihydroxy-4-[(1R,2R)-1-[(4-hydroxybenzoyl)amino]indan-2-yl]oxycarbonyl-benzoyl]-3-hydroxy-benzoic acid
2-[[2,6-dihydroxy-4-[[(1R,2R)-1-[[(4-hydroxyphenyl)-oxomethyl]amino]-2-indanyl]oxy-oxomethyl]phenyl]-oxomethyl]-3-hydroxybenzoic acid
2-[2,6-dihydroxy-4-[[(1R,2R)-1-[(4-hydroxyphenyl)carbonylamino]-2,3-dihydro-1H-inden-2-yl]oxycarbonyl]phenyl]carbonyl-3-hydroxy-benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	protein kinase c iota type	0.011	0.0221	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0768	0.3909	0.8183
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0376	0.1711	0.1711
Onchocerca volvulus		0.0454	0.2151	1
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.0957
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.011	0.0221	0.0221
Echinococcus granulosus	protein kinase c epsilon type	0.0284	0.1198	0.2457
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0454	0.2151	0.4411
Giardia lamblia	Rab geranylgeranyltransferase	0.0241	0.0957	0.1449
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.161
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0454	0.2151	0.4411
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Loa Loa (eye worm)	fli-1 protein	0.0215	0.0807	0.0807
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0278	0.1161	0.1161
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0768	0.3909	1
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Loa Loa (eye worm)	hypothetical protein	0.0499	0.2404	0.2404
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0957	0.0957
Loa Loa (eye worm)	hypothetical protein	0.011	0.0221	0.0221
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Echinococcus granulosus	protein kinase C gamma type	0.0215	0.0809	0.1659
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0092	0.0117	0.024
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0496	0.2382	0.2382
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Schistosoma mansoni	peptidylglycine monooxygenase	0.0499	0.2404	0.493
Loa Loa (eye worm)	matrixin family protein	0.0087	0.009	0.009
Brugia malayi	Protein kinase c protein 2	0.0197	0.0711	0.0711
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0768	0.3909	0.8066
Trypanosoma cruzi	hypothetical protein, conserved	0.0454	0.2151	0.331
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.161
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0241	0.0957	0.2405
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.4044
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0154	0.0315
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Echinococcus multilocularis	protein kinase c epsilon type	0.0284	0.1198	0.2457
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0957	0.0957
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Schistosoma mansoni	neprilysin-2 (M13 family)	0.019	0.0667	0.1368
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0268	0.1104	0.2265
Loa Loa (eye worm)	hypothetical protein	0.0268	0.1104	0.1104
Schistosoma mansoni	atypical protein kinase C	0.011	0.0221	0.0453
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0496	0.2382	0.4726
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331
Brugia malayi	Fli-1 protein	0.0215	0.0807	0.0807
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0152	0.0455	0.0455
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0454	0.2151	0.4411
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.019	0.0667	0.1368
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0261	0.1065	0.2183
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0278	0.1161	0.1161
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0768	0.3909	0.7695
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0231	0.09	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0454	0.2151	0.4411
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.0405	0.083
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0768	0.3909	0.8183
Toxoplasma gondii	peptidase family M13 protein	0.0376	0.1711	0.4345
Echinococcus granulosus	Protein patched homolog 1	0.011	0.0221	0.0454
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0925	0.4792	0.4792
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0246	0.0983	0.0983
Echinococcus multilocularis	protein dispatched 1	0.011	0.0221	0.0454
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0925	0.4792	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0376	0.1711	0.3509
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0768	0.3909	0.3909
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0284	0.1198	0.1198
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.1065	0.2183
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0768	0.3909	0.3909
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Toxoplasma gondii	hypothetical protein	0.0471	0.2245	0.5719
Echinococcus multilocularis	sterol regulatory element binding protein	0.011	0.0221	0.0454
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Trypanosoma brucei	hypothetical protein, conserved	0.0454	0.2151	0.331
Echinococcus granulosus	endothelin converting enzyme 1	0.0376	0.1711	0.3509
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0925	0.4792	0.4792
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Echinococcus granulosus	protein kinase c iota type	0.011	0.0221	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Schistosoma mansoni	ets-related	0.0215	0.0807	0.1655
Brugia malayi	Matrixin family protein	0.0087	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Brugia malayi	CHE-14 protein	0.011	0.0221	0.0221
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0092	0.0117	0.0117
Echinococcus granulosus	sterol regulatory element binding protein	0.011	0.0221	0.0454
Echinococcus multilocularis	serine threonine protein kinase	0.0215	0.0809	0.1659
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0496	0.2382	0.4323
Giardia lamblia	Rab geranylgeranyltransferase	0.0454	0.2151	0.411
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0221	0.0454
Schistosoma mansoni	serine/threonine protein kinase	0.0284	0.1198	0.2457
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.4221
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.094	0.4876	1
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0526	0.2555	0.5309
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0768	0.3909	0.8183
Mycobacterium leprae	probable zinc metalloprotease	0.0376	0.1711	0.5
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.094	0.4876	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Leishmania major	farnesyltransferase beta subunit	0.0768	0.3909	1
Brugia malayi	Peptidase family M13 containing protein	0.0376	0.1711	0.1711
Leishmania major	lanosterol synthase, putative	0.0643	0.321	0.7633
Echinococcus granulosus	serine:threonine protein kinase N2	0.0168	0.0546	0.1119
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.013	0.0335	0.0687
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0768	0.3909	0.8066
Echinococcus multilocularis	endothelin converting enzyme 1	0.0376	0.1711	0.3509
Loa Loa (eye worm)	matrixin family protein	0.008	0.005	0.005
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.019	0.0667	0.1368
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0268	0.1104	0.0408
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.094	0.4876	0.4876
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.0405	0.083
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0454	0.2151	0.4411
Loa Loa (eye worm)	hypothetical protein	0.094	0.4876	0.4876
Giardia lamblia	Rab geranylgeranyltransferase	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0405	0.0405
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0268	0.1104	0.0408
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0241	0.0957	0.1963
Brugia malayi	protein kinase C II.	0.0284	0.1198	0.1198
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Brugia malayi	peptidase family M13 containing protein	0.0092	0.0117	0.0117
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0499	0.2404	0.493
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Onchocerca volvulus		0.0167	0.0538	0.2323
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0268	0.1104	0.0408
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.1065	0.2183
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0221	0.0454
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0092	0.0117	0.024
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0454	0.2151	0.4462
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0499	0.2404	0.2404
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0241	0.0957	0.196
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0648	0.0648
Mycobacterium ulcerans	zinc metalloprotease	0.0376	0.1711	1
Trypanosoma cruzi	lanosterol synthase, putative	0.0885	0.4564	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0925	0.4792	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.0405	0.083
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0241	0.0957	0.1963
Schistosoma mansoni	endothelin-converting enzyme-related	0.0092	0.0117	0.024
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0508	0.2452	0.5029
Trypanosoma brucei	lanosterol synthase	0.0885	0.4564	1
Toxoplasma gondii	hypothetical protein	0.0454	0.2151	0.5477
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.013	0.0335	0.0687
Echinococcus granulosus	tm gpcr rhodopsin	0.0508	0.2452	0.5029
Loa Loa (eye worm)	hypothetical protein	0.0925	0.4792	0.4792
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.019	0.0667	0.1368
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0768	0.3909	0.8066
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0454	0.2151	0.2151
Loa Loa (eye worm)	hypothetical protein	0.0231	0.09	0.09
Trypanosoma cruzi	lanosterol synthase, putative	0.0885	0.4564	1
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0885	0.4564	1
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0768	0.3909	0.7919
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0496	0.2382	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0188	0.066	0.066
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.1854	1	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.019	0.0667	0.1368
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0241	0.0957	0.0969
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0221	0.0454
Plasmodium vivax	geranylgeranyltransferase, putative	0.0241	0.0957	0.196
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0253	0.1025	0.1025
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.094	0.4876	1
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0471	0.2245	0.4427
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Echinococcus granulosus	Protein kinase C brain isozyme	0.0261	0.1065	0.2183
Trypanosoma cruzi	hypothetical protein, conserved	0.0454	0.2151	0.331
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0241	0.0957	0.2405
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0454	0.2151	0.378
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0454	0.2151	0.2151
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0268	0.1104	0.1104
Onchocerca volvulus		0.0186	0.0648	0.2845
Giardia lamblia	Prenyltransferase	0.0768	0.3909	0.8029
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0268	0.1104	0.2265
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0268	0.1104	0.2265
Echinococcus multilocularis	protein patched	0.011	0.0221	0.0454
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0268	0.1104	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0454	0.2151	0.3112
Schistosoma mansoni	neprilysin	0.0098	0.0154	0.0315
Schistosoma mansoni	patched 1	0.011	0.0221	0.0454
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0768	0.3909	0.8147

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 32 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	= 32 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	= 32 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	= 32 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	= 35 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 35 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 39 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	= 39 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C beta 1	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C beta 1	ChEMBL.	No reference
IC50 (binding)	> 50 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL444877
PubChem: 10460643

Bibliographic References

No literature references available for this target.

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Detailed information for compound 306845