TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 689.624 | Formula: C31H36F5N3O9
H donors: 5 H acceptors: 7 LogP: 5.26 Rotable bonds: 21
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCNC(=O)[C@H](Cc1ccc(cc1)OC(C(=O)O)C(=O)O)NC(=O)[C@H](Cc1c(F)c(F)c(c(c1F)F)F)NC(=O)OC(C)(C)C
InChi: 1S/C31H36F5N3O9/c1-5-6-7-12-37-26(40)18(13-15-8-10-16(11-9-15)47-25(28(42)43)29(44)45)38-27(41)19(39-30(46)48-31(2,3)4)14-17-20(32)22(34)24(36)23(35)21(17)33/h8-11,18-19,25H,5-7,12-14H2,1-4H3,(H,37,40)(H,38,41)(H,39,46)(H,42,43)(H,44,45)/t18-,19-/m0/s1
InChiKey: VBBUBJVPGNFYPL-OALUTQOASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0011	0.0361	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0011	0.0361	0.4601
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0004	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Brugia malayi	hypothetical protein	0.0009	0.0289	0.054
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0665	0.1248
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0004	0.0101	0.019
Schistosoma mansoni	neurotransmitter gated ion channel	0.0009	0.0289	0.0543
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0019	0.0665	0.1247
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0004	0.0101	0.0286
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0174	0.26
Schistosoma mansoni	hypothetical protein	0.0006	0.0174	0.0328
Trypanosoma cruzi	hypothetical protein, conserved	0.0097	0.3476	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0019	0.0665	0.184
Entamoeba histolytica	hypothetical protein	0.0009	0.0302	0.3558
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0004	0.0101	0.0101
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0006	0.0174	0.26
Echinococcus granulosus	serine protein kinase ATM	0.0011	0.0361	0.0361
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0011	0.0361	0.0678
Leishmania major	phosphatidylinositol kinase, putative	0.0004	0.0101	0.0275
Entamoeba histolytica	hypothetical protein	0.0009	0.0302	0.3558
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0004	0.0101	0.0275
Echinococcus granulosus	SAM domain containing protein	0.0006	0.0174	0.0174
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0004	0.0101	0.1496
Plasmodium falciparum	protein kinase, putative	0.0007	0.0204	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Brugia malayi	WGR domain containing protein	0.0009	0.0302	0.0565
Onchocerca volvulus		0.0019	0.0665	0.2858
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0001	0.0002	0.00000033869
Echinococcus multilocularis	epidermal growth factor receptor	0.0079	0.2841	0.2841
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0665	0.125
Entamoeba histolytica	hypothetical protein	0.0009	0.0302	0.3558
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0019	0.0665	0.0665
Echinococcus granulosus	liprin beta 1	0.0006	0.0174	0.0174
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0004	0.0101	0.019
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.001	0.0343	0.0642
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0004	0.0101	0.1516
Loa Loa (eye worm)	phosphatidylinositol 3	0.0004	0.0101	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0174	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0004	0.0101	0.1496
Onchocerca volvulus		0.0006	0.0174	0.0371
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0009	0.0302	0.0864
Trichomonas vaginalis	ankyrin, putative	0.0001	0.0002	0.00000033869
Brugia malayi	WGR domain containing protein	0.0009	0.0302	0.0565
Onchocerca volvulus		0.0019	0.0665	0.2858
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Brugia malayi	hypothetical protein	0.0009	0.0289	0.054
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0148	0.5317	1
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0001	0.0002	0.00000033869
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0009	0.0289	0.0539
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0019	0.0665	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0019	0.0665	0.0665
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0004	0.0101	0.1496
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0004	0.0101	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0006	0.0174	0.0328
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Schistosoma mansoni	ankyrin 23/unc44	0.0001	0.0002	0.0003
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Giardia lamblia	Kinase, NEK	0.0001	0.0002	0.0024
Brugia malayi	Liprin-alpha 2	0.0006	0.0174	0.0325
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0004	0.0101	0.0286
Schistosoma mansoni	tankyrase	0.0065	0.2318	0.4359
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0343	0.0642
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0226	0.3383
Echinococcus multilocularis	liprin alpha 2	0.0006	0.0174	0.0174
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0019	0.0665	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0004	0.0101	0.0101
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0271	0.0507
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Schistosoma mansoni	tyrosine kinase	0.0079	0.2841	0.5344
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0019	0.0665	0.125
Brugia malayi	Cation transporter family protein	0.0019	0.0665	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0008	0.0271	0.0271
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0174	0.26
Toxoplasma gondii	FATC domain-containing protein	0.0011	0.0361	0.4601
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0004	0.0101	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0047	0.1676	0.315
Schistosoma mansoni	hypothetical protein	0.0004	0.0101	0.019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0004	0.0101	0.0101
Loa Loa (eye worm)	phosphatidylinositol 3	0.0004	0.0101	0.0186
Echinococcus multilocularis	SAM domain containing protein	0.0006	0.0174	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Echinococcus granulosus	tankyrase	0.0065	0.2314	0.2314
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0406	0.6087
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0271	0.4061
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0004	0.0101	0.1496
Echinococcus multilocularis	Ankyrin	0.0001	0.0002	0.0002
Schistosoma mansoni	tyrosine kinase	0.0079	0.2811	0.5287
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Schistosoma mansoni	sarm1	0.0006	0.0174	0.0328
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0007	0.0226	0.0646
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Schistosoma mansoni	nAChR subunit	0.0009	0.0289	0.0543
Schistosoma mansoni	tyrosine kinase	0.0079	0.2811	0.5287
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0665	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0001	0.0002	0.00000033869
Brugia malayi	Cation transporter family protein	0.0019	0.0665	0.1248
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0006	0.0174	0.0328
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0019	0.0665	0.184
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0001	0.0002	0.00000033869
Brugia malayi	Cation transporter family protein	0.0019	0.0665	0.1248
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0011	0.0361	0.5409
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Loa Loa (eye worm)	GABA receptor subunit	0.001	0.0343	0.0641
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0019	0.0665	0.1247
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0019	0.0665	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0665	0.1248
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0665	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0009	0.0302	0.3558
Brugia malayi	Neurabin protein 1	0.0006	0.0174	0.0325
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0019	0.0665	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0004	0.0101	0.1496
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0665	0.0665
Giardia lamblia	GTOR	0.0019	0.0665	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0004	0.0101	0.1496
Leishmania major	hypothetical protein, unknown function	0.0004	0.0101	0.0275
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0019	0.0665	0.184
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Loa Loa (eye worm)	phosphatidylinositol 3	0.0004	0.0101	0.0186
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Echinococcus granulosus	nAChR subunit	0.001	0.0343	0.0343
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.0361	0.0675
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0004	0.0101	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0001	0.0002	0.00000033869
Echinococcus multilocularis	stromal interaction molecule 1	0.0006	0.0174	0.0174
Schistosoma mansoni	tyrosine kinase	0.0079	0.2811	0.5287
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0047	0.1676	0.1676
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0011	0.0361	0.0361
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0009	0.0289	0.054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0665	0.0665
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0019	0.0665	0.0665
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0665	0.125
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0007	0.0204	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0148	0.5317	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus multilocularis	nAChR subunit	0.001	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0004	0.0101	0.0101
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0004	0.0101	0.0275
Schistosoma mansoni	nAChR subunit	0.0009	0.0289	0.0543
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0665	0.1247
Entamoeba histolytica	hypothetical protein	0.0009	0.0302	0.3558
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0007	0.0226	0.3383
Echinococcus granulosus	liprin alpha 2	0.0006	0.0174	0.0174
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0009	0.0302	0.0302
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0009	0.0302	0.0302
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0009	0.0289	0.0289
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0009	0.0302	0.0564
Onchocerca volvulus		0.0019	0.0665	0.2858
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0665	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	acetylcholine receptor protein	0.0009	0.0289	0.0539
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0019	0.0665	0.1252
Entamoeba histolytica	hypothetical protein	0.001	0.0343	0.4283
Echinococcus multilocularis		0.0004	0.0101	0.0101
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0019	0.0665	0.1252
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Brugia malayi	hypothetical protein	0.0009	0.0289	0.054
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0009	0.0302	0.0302
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0006	0.0174	0.0174
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0004	0.0101	0.019
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0004	0.0101	0.1496
Echinococcus granulosus	Sterile alpha motif SAM	0.0006	0.0174	0.0174
Entamoeba histolytica	zinc finger protein, putative	0.0009	0.0302	0.3558
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0665	0.1248
Loa Loa (eye worm)	phosphatidylinositol 3	0.0004	0.0101	0.0186
Onchocerca volvulus		0.0006	0.0174	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0001	0.0002	0.0002
Onchocerca volvulus		0.001	0.0343	0.1225
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Schistosoma mansoni	neurotransmitter gated ion channel	0.0009	0.0289	0.0543
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0004	0.0101	0.1516
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Echinococcus granulosus	poly adp ribose polymerase 2	0.0009	0.0302	0.0302
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0011	0.0361	0.0361
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0019	0.0665	0.0665
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0665	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0665	0.0665
Echinococcus granulosus	nAChR subunit	0.0019	0.0665	0.0665
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0665	0.0665
Echinococcus multilocularis	insulin receptor	0.0047	0.1676	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0101	0.0186
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0004	0.0101	0.0286
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0009	0.0289	0.054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Brugia malayi	hypothetical protein	0.0006	0.0174	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0361	0.0675
Loa Loa (eye worm)	tnks protein	0.0059	0.211	0.3966
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Onchocerca volvulus		0.0019	0.0665	0.2858
Schistosoma mansoni	hypothetical protein	0.0006	0.0174	0.0328
Brugia malayi	Tnks protein	0.0065	0.2304	0.4333
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0004	0.0101	0.0286
Onchocerca volvulus		0.0019	0.0665	0.2858
Onchocerca volvulus		0.0019	0.0665	0.2858
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0012	0.0406	0.5399
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.001	0.0343	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0174	0.26
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0004	0.0101	0.0286
Schistosoma mansoni	tyrosine kinase	0.0148	0.5317	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0019	0.0665	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0665	0.1247
Plasmodium falciparum	tyrosine kinase-like protein	0.0007	0.0204	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0665	0.1248
Giardia lamblia	Hypothetical protein	0.0004	0.0101	0.1516
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0019	0.0665	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Brugia malayi	FAT domain containing protein	0.0008	0.0271	0.0507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0226	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0406	0.076
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0665	0.0665
Echinococcus granulosus	insulin receptor	0.0047	0.1676	0.1676
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0012	0.0406	0.6087
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0343	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0004	0.0101	0.1516
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0019	0.0665	1
Brugia malayi	hypothetical protein	0.0009	0.0289	0.054
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0009	0.0289	0.0539
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0004	0.0101	0.0101
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.0021	0.029
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0665	0.1248
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0004	0.0101	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Brugia malayi	coiled-coil like protein 1	0.0006	0.0174	0.0325
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0174	0.0324
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0665	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Schistosoma mansoni	tyrosine kinase	0.0047	0.1676	0.3152
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0009	0.0289	0.0289
Onchocerca volvulus	Putative nachr subunit	0.0019	0.0665	0.2858
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0004	0.0101	0.1496
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0006	0.0174	0.1299
Echinococcus granulosus	Ankyrin	0.0001	0.0002	0.0002
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0009	0.0302	0.3558
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.001	0.0343	0.0642
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0009	0.0289	0.0289
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0004	0.0101	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0004	0.0101	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0174	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0004	0.0101	0.0286
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0004	0.0101	0.0275
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0665	0.1248
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0004	0.0101	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0665	0.0665
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0009	0.0302	0.4522
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Echinococcus multilocularis	serine protein kinase ATM	0.0011	0.0361	0.0361
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0008	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0302	0.0564
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0004	0.0101	0.1496
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0004	0.0101	0.0286
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0079	0.2841	0.2841
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0019	0.0665	0.1247
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0004	0.0101	0.1496
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0004	0.0101	0.1496
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0665	0.0665
Schistosoma mansoni	tyrosine kinase	0.0047	0.1676	0.3152
Echinococcus multilocularis		0.0046	0.1622	0.1622
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0001	0.0002	0.00000033869
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0047	0.1676	0.1676
Trypanosoma cruzi	target of rapamycin kinase 3	0.0019	0.0665	0.1911
Giardia lamblia	Kinase, NEK	0.0001	0.0002	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0406	0.6087
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0009	0.0302	0.0568
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0006	0.0174	0.0325
Echinococcus multilocularis	nAChR subunit	0.0019	0.0665	0.0665
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0019	0.0665	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0001	0.0002	0.00000033869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0004	0.0101	0.0101
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0004	0.0101	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0174	0.0324
Loa Loa (eye worm)	hypothetical protein	0.001	0.0343	0.0641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0004	0.0101	0.0275
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0019	0.0665	0.0665
Loa Loa (eye worm)	LGC-31 protein	0.0019	0.0665	0.1247
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0665	0.1249
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0271	0.051
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0019	0.0665	0.125
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0289	0.054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Trichomonas vaginalis	ankyrin, putative	0.0001	0.0002	0.0005
Schistosoma mansoni	tyrosine kinase	0.0079	0.2841	0.5344
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0018	0.0241
Schistosoma mansoni	hypothetical protein	0.0006	0.0174	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0174	0.0324
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.001	0.0343	0.0644
Loa Loa (eye worm)	phosphatidylinositol 3	0.0004	0.0101	0.0186
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0009	0.0302	0.0864
Schistosoma mansoni	acetylcholine receptor-related	0.0009	0.0289	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Schistosoma mansoni	neurotransmitter gated ion channel	0.001	0.0343	0.0644
Echinococcus granulosus	stromal interaction molecule 1	0.0006	0.0174	0.0174
Echinococcus multilocularis	tankyrase	0.0065	0.2314	0.2314
Schistosoma mansoni	hypothetical protein	0.0006	0.0174	0.0328
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0019	0.0665	0.184
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0665	0.1248
Onchocerca volvulus	Tankyrase homolog	0.0058	0.2074	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0665	0.1248
Onchocerca volvulus		0.001	0.0343	0.1225
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0019	0.0665	0.1247
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0302	0.4522
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0011	0.0361	0.1033
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0019	0.0665	0.125
Brugia malayi	Protein kinase domain containing protein	0.0047	0.1676	0.315
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.0665	0.1911
Mycobacterium leprae	conserved hypothetical protein	0.0004	0.0101	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0665	0.1247
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0009	0.0289	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Onchocerca volvulus		0.0009	0.0289	0.0951
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0004	0.0101	0.019
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0004	0.0101	0.019
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0009	0.0302	0.0302
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0277	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0011	0.0361	0.1033
Brugia malayi	hypothetical protein	0.0009	0.0289	0.054
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0004	0.0101	0.0187
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0009	0.0289	0.054
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0665	0.0665
Echinococcus granulosus	epidermal growth factor receptor	0.0079	0.2841	0.2841
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0665	0.1249
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0174	0.26
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0004	0.0101	0.0101
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0004	0.0101	0.0286
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0001	0.0002	0.00000033869
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0011	0.0361	0.0678
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0006	0.0174	0.0174
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0665	0.1248
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0665	0.125
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Leishmania major	hypothetical protein, conserved	0.0101	0.361	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.0005
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0004	0.0101	0.1496
Onchocerca volvulus		0.0009	0.0289	0.0951
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0004	0.0101	0.0101
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0004	0.0101	0.1496
Brugia malayi	hypothetical protein	0.0006	0.0174	0.0325
Echinococcus multilocularis	epidermal growth factor receptor	0.0148	0.5317	0.5317
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0004	0.0101	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0004	0.0101	0.019
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0019	0.0665	1
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0004	0.0101	0.1496
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0002	0.00000033869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0361	0.5409
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0009	0.0289	0.0289
Echinococcus multilocularis	liprin beta 1	0.0006	0.0174	0.0174
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0289	0.054
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0665	0.0665
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.0361	0.0675
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0019	0.0665	1
Onchocerca volvulus		0.0009	0.0289	0.0951
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0019	0.0665	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0001	0.0017	0.0236
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0006	0.0174	0.0324
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0004	0.0101	0.019
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0665	0.1248
Echinococcus granulosus	epidermal growth factor receptor	0.0148	0.5317	0.5317
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0019	0.0665	0.184
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0019	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.0665	0.1911
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0665	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0665	0.1247
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0009	0.0289	0.0289
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0009	0.0289	0.054
Entamoeba histolytica	protein kinase rad3, putative	0.0011	0.0361	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0665	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0101	0.0186
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0009	0.0302	0.0568
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0004	0.0101	0.0187
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0019	0.0665	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0289	0.0539
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0665	0.0665
Schistosoma mansoni	nAChR subunit	0.0019	0.0665	0.125
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0004	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1742	0.3275

Activities

Activity type	Activity value	Assay description	Source	Reference
Control Uptake (functional)	= 100 %	Uptake of 2-DOG (2-deoxyglucose) into L6 myocytes in the presence of half-maximal concentration of insulin at 100 microM.	ChEMBL.	12617932
Inhibition (binding)	= 0 %	Inhibition of recombinant human phosphatase (SHP-2) at a concentration of 100 microM	ChEMBL.	12617932
Inhibition (binding)	= 0 %	Inhibition of recombinant human phosphatase (SHP-2) at a concentration of 100 microM	ChEMBL.	12617932
Inhibition (binding)	= 5 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 1 microM	ChEMBL.	12617932
Inhibition (binding)	= 5 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 1 microM	ChEMBL.	12617932
Inhibition (binding)	= 8 %	Inhibitory activity against phosphatase (LAR) at a concentration of 100 microM.	ChEMBL.	12617932
Inhibition (binding)	= 8 %	Inhibitory activity against phosphatase (LAR) at a concentration of 100 microM.	ChEMBL.	12617932
Inhibition (binding)	= 25 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 10 microM	ChEMBL.	12617932
Inhibition (binding)	= 25 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 10 microM	ChEMBL.	12617932
Inhibition (binding)	= 80 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 100 microM	ChEMBL.	12617932
Inhibition (binding)	= 80 %	Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) at a concentration of 100 microM	ChEMBL.	12617932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL414653

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 312028