TDR Targets

Basic information

Technical information

TDR Targets ID: 312122
Name: (2-oxo-4,6-dihydrofuro[3,2-c]pyran-4-yl) 3-br omobenzoate
MW: 337.122 | Formula: C14H9BrO5
H donors: 0 H acceptors: 2 LogP: 1.94 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OC2=CCOC(C2=C1)OC(=O)c1cccc(c1)Br
InChi: 1S/C14H9BrO5/c15-9-3-1-2-8(6-9)13(17)20-14-10-7-12(16)19-11(10)4-5-18-14/h1-4,6-7,14H,5H2
InChiKey: ATJCYQYBPLMJQS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-bromobenzoic acid (2-oxo-4,6-dihydrofuro[3,2-c]pyran-4-yl) ester
3-bromobenzoic acid (2-keto-4,6-dihydrofuro[3,2-c]pyran-4-yl) ester
AIDS-293002
AIDS293002
Benzoic acid, 3-bromo-, 2,6-dihydro-2-oxo-4H-furo[3,2-c]pyran-4-yl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS3 protease/helicase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium vivax	RNA helicase-1, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Theileria parva	RNA helicase-1, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Treponema pallidum	ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium berghei	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium knowlesi	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus granulosus	eukaryotic initiation factor 4A III	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania braziliensis	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania donovani	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Candida albicans	similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	Get druggable targets OG5_126984	All targets in OG5_126984
Babesia bovis	eukaryotic translation initiation factor 4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma japonicum	Eukaryotic initiation factor 4A-III, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus multilocularis	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Giardia lamblia	Translation initiation factor eIF-4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	Get druggable targets OG5_126984	All targets in OG5_126984
Cryptosporidium parvum	eukaryotic initiation factor 4A (eIF4A) (eIF-4A)	Get druggable targets OG5_126984	All targets in OG5_126984
Brugia malayi	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania infantum	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Cryptosporidium hominis	eukaryotic initiation factor 4A (eIF4A) (eIF-4A)	Get druggable targets OG5_126984	All targets in OG5_126984
Candida albicans	similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus granulosus	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma congolense	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium yoelii	RNA helicase-1	Get druggable targets OG5_126984	All targets in OG5_126984
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126984	All targets in OG5_126984
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma japonicum	ATP-dependent RNA helicase eIF4A, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma japonicum	Eukaryotic initiation factor 4A-II, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania major	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Echinococcus multilocularis	eukaryotic initiation factor 4A III	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania major	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania mexicana		Get druggable targets OG5_126984	All targets in OG5_126984
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	Get druggable targets OG5_126984	All targets in OG5_126984
Neospora caninum	DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related	Get druggable targets OG5_126984	All targets in OG5_126984
Entamoeba histolytica	DEAD/DEAH box helicase, putative	Get druggable targets OG5_126984	All targets in OG5_126984
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	Get druggable targets OG5_126984	All targets in OG5_126984
Plasmodium falciparum	eukaryotic initiation factor 4A	Get druggable targets OG5_126984	All targets in OG5_126984
Leishmania infantum	eukaryotic initiation factor 4a, putative	Get druggable targets OG5_126984	All targets in OG5_126984

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.003	0.0261	0.0244
Loa Loa (eye worm)	hypothetical protein	0.002	0.0139	0.0361
Brugia malayi	hypothetical protein	0.0019	0.0132	0.0529
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0132	0.0529
Onchocerca volvulus		0.0053	0.0554	0.1942
Echinococcus multilocularis	RUN	0.002	0.0139	0.0122
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.003	0.0261	0.1808
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0365	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Schistosoma mansoni	hypothetical protein	0.0011	0.0029	0.003
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0365	1
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0132	0.0237
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0666	0.131
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0365	0.1279
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0197	0.2562
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.014	0.0056
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.014	0.35
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0273	0.052
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0014	0.0072	0.0117
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0027	0.0232	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0132	0.0237
Brugia malayi	ecdysone receptor	0.0013	0.0053	0.0212
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0119	0.1381	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0033	0.03	0.8134
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0365	0.2536
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0132	0.0237
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0273	0.052
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0027	0.0232	0.093
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0365	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.003	0.0261	0.049
Echinococcus multilocularis	geminin	0.0169	0.2005	0.1991
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.014	0.0491
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0119	0.1381	0.1366
Echinococcus multilocularis	lamin	0.0053	0.0554	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0275	0.3318	0.3306
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Brugia malayi	Doublecortin family protein	0.002	0.0139	0.0556
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.003	0.0261	0.7005
Brugia malayi	PXA domain containing protein	0.0019	0.0132	0.0529
Toxoplasma gondii	exonuclease III APE	0.0038	0.0365	0.2566
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0365	0.0949
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0019	0.0137
Loa Loa (eye worm)	hypothetical protein	0.002	0.0139	0.0361
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0132	0.023
Loa Loa (eye worm)	steroid hormone receptor	0.0027	0.0232	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	ap endonuclease	0.0038	0.0365	0.0705
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0013	0.0053	0.0078
Trichomonas vaginalis	rotamase, putative	0.0033	0.0309	0.1084
Onchocerca volvulus		0.002	0.0139	0.0486
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0027	0.0232	0.0215
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0132	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Leishmania major	hypothetical protein, conserved	0.0024	0.0197	0.1301
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0027	0.0232	0.0603
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0027	0.0232	0.0603
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0132	0.0343
Onchocerca volvulus		0.002	0.0139	0.0486
Leishmania major	eukaryotic initiation factor 4a, putative	0.003	0.0261	0.1775
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.003	0.0261	0.0244
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0132	0.0115
Schistosoma mansoni	nuclear receptor	0.0013	0.0053	0.0078
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0132	0.0237
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0014	0.0072	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0025	0.02	0.052
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0212	0.0551
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0027	0.0232	0.0432
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0251	0.047
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0132	0.0115
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0232	0.093
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.003	0.0261	0.0916
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0132	0.0115
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.3318	0.6638
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0197	0.5138
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0132	0.0529
Brugia malayi	tailless protein	0.0013	0.0053	0.0212
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0027	0.0232	0.093
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0365	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0132	0.3358
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0029	0.0024
Echinococcus multilocularis	expressed protein	0.0373	0.4545	0.4536
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Brugia malayi	Pre-SET motif family protein	0.003	0.0273	0.1094
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.014	0.0921
Loa Loa (eye worm)	hypothetical protein	0.002	0.014	0.0364
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0027	0.0232	0.0432
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0132	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0232	0.093
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0212	0.0195
Loa Loa (eye worm)	nuclear hormone receptor	0.0013	0.0053	0.0138
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0027	0.0232	0.0603
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0232	0.093
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0188
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1381	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Brugia malayi	hypothetical protein	0.0013	0.0053	0.0212
Brugia malayi	hypothetical protein	0.0014	0.0072	0.0289
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0013	0.0053	0.0071
Brugia malayi	hypothetical protein	0.0122	0.141	0.5652
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0019	0.0035
Schistosoma mansoni	cpg binding protein	0.0029	0.0251	0.0476
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0053	0.0036
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0139	0.0244
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0232	0.093
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.003	0.0261	0.0497
Echinococcus granulosus	nuclear receptor nhr 48	0.0013	0.0053	0.0071
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0132	0.023
Onchocerca volvulus		0.0029	0.0251	0.088
Loa Loa (eye worm)	DR-78	0.0013	0.0053	0.0138
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0132	0.0529
Onchocerca volvulus	Protein ultraspiracle homolog	0.0027	0.0232	0.0813
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0326	0.0621
Schistosoma mansoni	lamin	0.0053	0.0554	0.1085
Schistosoma mansoni	hypothetical protein	0.0035	0.0326	0.0628
Echinococcus multilocularis	nuclear receptor nhr 48	0.0013	0.0053	0.0036
Plasmodium vivax	SET domain protein, putative	0.003	0.0273	0.7376
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0554	0.144
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0013	0.0053	0.0036
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0132	0.0115
Brugia malayi	nuclear receptor NHR-67	0.0013	0.0053	0.0212
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0132	0.023
Brugia malayi	nuclear hormone receptor	0.0013	0.0053	0.0212
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0232	0.0432
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.003	0.0261	0.049
Schistosoma mansoni	loxhd1	0.002	0.0139	0.025
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0053	0.0078
Echinococcus multilocularis	lamin dm0	0.0053	0.0554	0.0538
Entamoeba histolytica	hypothetical protein	0.0019	0.0132	0.3358
Schistosoma mansoni	cpg binding protein	0.003	0.0271	0.0517
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0132	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1381	0.2747
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0013	0.0053	0.0138
Echinococcus granulosus	expressed protein	0.0373	0.4545	0.9104
Schistosoma mansoni	retinoic acid receptor RXR	0.0027	0.0232	0.0438
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0019	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0132	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0188
Echinococcus multilocularis	tumor protein p63	0.0326	0.3964	0.3954
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0027	0.0232	0.0438
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0132	0.0343
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0019	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0273	0.052
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0284	0.3433	0.3421
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Schistosoma mansoni	cpg binding protein	0.003	0.0271	0.0517
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0013	0.0053	0.0078
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0132	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Schistosoma mansoni	aldehyde dehydrogenase	0.0119	0.1381	0.2747
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.001	0.002	0.0019
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0132	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0132	0.0237
Brugia malayi	PXA domain containing protein	0.0019	0.0132	0.0529
Brugia malayi	nuclear hormone receptor family member odr-7	0.0013	0.0053	0.0212
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0251	0.0652
Echinococcus multilocularis	FTZ F1 alpha	0.0027	0.0232	0.0215
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0132	0.023
Echinococcus multilocularis	bloom syndrome protein	0.002	0.014	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Brugia malayi	nuclear hormone receptor	0.0027	0.0232	0.093
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0273	0.1893
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0027	0.0232	0.0432
Schistosoma mansoni	hypothetical protein	0.0169	0.2005	0.4
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0489	0.1271
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.03	0.8108
Trichomonas vaginalis	rotamase, putative	0.0033	0.03	0.105
Entamoeba histolytica	recQ family helicase, putative	0.002	0.014	0.3589
Schistosoma mansoni	hypothetical protein	0.0169	0.2005	0.4
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0027	0.0232	0.0438
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.2853	1
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0033	0.03	0.2056
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0132	0.023
Brugia malayi	orphan nuclear receptor NR2E1	0.0013	0.0053	0.0212
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0139	0.0122
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0132	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0554	0.144
Plasmodium falciparum	eukaryotic initiation factor 4A	0.003	0.0261	0.5419
Onchocerca volvulus		0.003	0.0273	0.0956
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0542	0.1409
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.014	0.3487
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0129	0.1503	0.2987
Schistosoma mansoni	lipoxygenase	0.002	0.0139	0.025
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0365	0.0699
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0197	0.5128
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0139	0.3552
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0129	0.1503	0.1488
Schistosoma mansoni	hypothetical protein	0.0247	0.2979	0.5957
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0251	0.1006
Onchocerca volvulus		0.0027	0.0232	0.0813
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.014	0.0364
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0365	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0027	0.0232	0.093
Brugia malayi	nuclear receptor RXR	0.0014	0.0072	0.0289
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0247	0.0991
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.001	0.002	0.004
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0273	0.0256
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0013	0.0053	0.0138
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0365	0.2642
Loa Loa (eye worm)	RecQ helicase	0.002	0.014	0.0364
Brugia malayi	eukaryotic initiation factor 4A	0.003	0.0261	0.1048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0027	0.0232	0.0603
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0027	0.0232	0.093
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0027	0.0232	0.0438
Brugia malayi	hypothetical protein	0.0016	0.0089	0.0357
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0132	0.0529
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0489	0.0954
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.014	0.0561
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0029	0.0012
Schistosoma mansoni	zinc finger protein	0.0013	0.0053	0.0078
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0273	0.052
Echinococcus granulosus	bloom syndrome protein	0.002	0.014	0.0246
Echinococcus granulosus	intermediate filament protein	0.0053	0.0554	0.1079
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0014	0.0072	0.0117
Schistosoma mansoni	lamin	0.0053	0.0554	0.1085
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.014	0.3837
Brugia malayi	Cache domain containing protein	0.0057	0.0606	0.2428
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0132	0.0115
Toxoplasma gondii	aldehyde dehydrogenase	0.0119	0.1381	1
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.003	0.0261	0.7046
Schistosoma mansoni	nuclear receptor	0.0013	0.0053	0.0078
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0132	0.0237
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0027	0.0232	0.0603
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.014	0.0884
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0232	0.093
Onchocerca volvulus	Bile acid receptor homolog	0.0027	0.0232	0.0813
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0132	0.0343
Treponema pallidum	methyl-accepting chemotaxis protein (mcp2-1)	0.0263	0.3171	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0212	0.0391
Echinococcus granulosus	tumor protein p63	0.0326	0.3964	0.7935
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0132	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0027	0.0232	0.0438
Entamoeba histolytica	hypothetical protein	0.0035	0.0326	0.8903
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	ap endonuclease	0.0038	0.0365	0.0705
Schistosoma mansoni	RAR-like nuclear receptor	0.0027	0.0232	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0053	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0232	0.093
Brugia malayi	intermediate filament protein	0.0053	0.0554	0.2221
Brugia malayi	Nuclear hormone receptor-like 1	0.0014	0.0072	0.0289
Echinococcus multilocularis	dnaJ subfamily B	0.0409	0.4991	0.4982
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.014	0.0246
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0139	0.0122
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0365	1
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0139	0.0244
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0132	0.0237
Echinococcus granulosus	FTZ F1 alpha	0.0027	0.0232	0.0432
Schistosoma mansoni	hypothetical protein	0.002	0.0139	0.025
Echinococcus granulosus	lamin	0.0053	0.0554	0.1079
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0132	0.023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0188
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.003	0.0261	0.7161
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.003	0.0261	0.1892
Schistosoma mansoni	nuclear receptor nhr-48	0.0013	0.0053	0.0078
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0309	0.0804
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0247	0.2979	0.5954
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0132	0.0115
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.003	0.0261	0.0497
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0309	0.1084
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.014	0.0491
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0585	0.4174
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	0.0261	0.0916
Echinococcus granulosus	expressed protein	0.0033	0.0309	0.0587
Onchocerca volvulus		0.0237	0.2853	1
Echinococcus granulosus	RUN	0.002	0.0139	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0188
Brugia malayi	ecdysteroid receptor	0.0027	0.0232	0.093
Echinococcus multilocularis	musashi	0.0053	0.0554	0.0538
Echinococcus granulosus	lamin dm0	0.0053	0.0554	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Schistosoma mansoni	polycystin 1-related	0.002	0.0139	0.025
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0132	0.0462
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1381	1
Brugia malayi	Steroid receptor seven-up type 2	0.0027	0.0232	0.093
Echinococcus granulosus	dnaJ subfamily B	0.0409	0.4991	1
Schistosoma mansoni	DNA helicase recq5	0.002	0.014	0.0253
Brugia malayi	hypothetical protein	0.002	0.0139	0.0556
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0554	0.2221
Brugia malayi	nuclear receptor RXR	0.0013	0.0053	0.0212
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.014	0.0246
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.0581	0.0565
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.014	0.0561
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0119	0.1381	0.2742
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0013	0.0053	0.0036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0027	0.0232	0.0603
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0013	0.0053	0.0212
Brugia malayi	hypothetical protein	0.0019	0.0132	0.0529
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0132	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Echinococcus multilocularis	ecdysone induced protein 78C	0.0027	0.0232	0.0215
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0132	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0027	0.0232	0.0438
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0365	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0139	0.0244
Brugia malayi	hypothetical protein	0.0035	0.0326	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Onchocerca volvulus		0.0053	0.0554	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0013	0.0053	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0053	0.0138
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0013	0.0053	0.0186
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0013	0.0053	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Brugia malayi	hypothetical protein	0.0014	0.0072	0.0289
Entamoeba histolytica	hypothetical protein	0.0035	0.0326	0.8903
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0027	0.0232	0.093
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0554	0.1085
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0119	0.1381	1
Brugia malayi	hypothetical protein	0.0013	0.0053	0.0212
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.3318	0.6638
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0132	0.0115
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0013	0.0053	0.0036
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0132	0.023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0606	0.1574
Treponema pallidum	ATP-dependent RNA helicase	0.003	0.0261	0.0769
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0365	1
Toxoplasma gondii	peptidylprolyl isomerase	0.0033	0.03	0.2087
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0326	0.0628
Loa Loa (eye worm)	hypothetical protein	0.003	0.0273	0.0709
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0027	0.0232	0.0438
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0132	0.0529
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0197	0.2562
Onchocerca volvulus		0.0013	0.0053	0.0186
Plasmodium vivax	RNA helicase-1, putative	0.003	0.0261	0.7046
Onchocerca volvulus		0.0013	0.0053	0.0186
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	0.0261	0.0916
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0232	0.0438
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0139	0.0361
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.03	0.8108
Echinococcus granulosus	geminin	0.0169	0.2005	0.3996
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0273	0.0256
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.014	0.0123
Brugia malayi	hypothetical protein	0.002	0.0139	0.0556
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0309	0.124
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.014	0.0491
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0027	0.0232	0.0813
Schistosoma mansoni	lipoxygenase	0.0055	0.0581	0.1139
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0014	0.0072	0.0055
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0053	0.0078
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0365	1
Brugia malayi	steroid hormone receptor	0.0027	0.0232	0.093
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0053	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.003	0.0261	0.0916
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0053	0.0071
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0273	0.0514
Brugia malayi	nuclear receptor NHR-88	0.0013	0.0053	0.0212
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.0581	0.1133
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0027	0.0232	0.093
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0247	0.0642
Schistosoma mansoni	hypothetical protein	0.0409	0.4991	1
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0132	0.0237
Echinococcus granulosus	cpg binding protein	0.003	0.0271	0.0511
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0124	0.1437	0.2859
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0132	0.0115
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0017	0.0045
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.014	0.0921
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.014	0.0561
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0062	0.0671	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0317	0.3847	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0027	0.0232	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0365	0.1279
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0232	0.093
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.014	0.0056
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0033	0.03	0.8105
Schistosoma mansoni	rab6-interacting	0.002	0.0139	0.025
Schistosoma mansoni	coup transcription factor	0.0027	0.0232	0.0438
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0197	0.5204
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0132	0.0115
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0132	0.023
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.003	0.0261	0.7
Brugia malayi	Pre-SET motif family protein	0.0209	0.2495	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0014	0.0072	0.0289
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0027	0.0232	0.0432
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0554	0.144
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.014	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.001	0.002	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0232	0.093
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0232	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0139	0.0122
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0197	0.5138
Entamoeba histolytica	hypothetical protein	0.0035	0.0326	0.8903
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0132	0.0343
Echinococcus multilocularis	cpg binding protein	0.003	0.0271	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0197	0.0511
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0365	0.2642
Loa Loa (eye worm)	hypothetical protein	0.003	0.0261	0.0679
Schistosoma mansoni	serine-rich repeat protein	0.0067	0.0724	0.1427
Onchocerca volvulus		0.0048	0.0489	0.1713
Echinococcus granulosus	thyroid hormone receptor alpha	0.0013	0.0053	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0025	0.02	0.052
Echinococcus multilocularis	expressed protein	0.0033	0.0309	0.0292
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0232	0.0432
Entamoeba histolytica	hypothetical protein	0.0019	0.0132	0.3358
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0027	0.0232	0.0432
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0027	0.0232	0.0215
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0197	0.1335
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0013	0.0053	0.0071
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0132	0.023
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.2495	0.6485
Schistosoma mansoni	rotamase	0.0033	0.0309	0.0593
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0119	0.1381	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.003	0.0261	0.7005
Brugia malayi	conserved hypotetical protein	0.0013	0.0053	0.0212
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0014	0.0072	0.011
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0188
Schistosoma mansoni	DNA helicase recq1	0.002	0.014	0.0253
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0232	0.0438
Brugia malayi	hypothetical protein	0.0024	0.0197	0.0788
Schistosoma mansoni	hypothetical protein	0.0067	0.0724	0.1427
Schistosoma mansoni	rab6-interacting	0.002	0.0139	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0027	0.0232	0.093
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0132	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0027	0.0232	0.093
Leishmania major	eukaryotic initiation factor 4a, putative	0.003	0.0261	0.1775
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0027	0.0232	0.0603
Brugia malayi	Nuclear hormone receptor E75	0.0013	0.0053	0.0212
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0232	0.0215
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0365	0.1463
Brugia malayi	Nuclear hormone receptor E75	0.0013	0.0053	0.0212
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0326	0.031
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0284	0.3433	0.6866
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0247	0.2979	0.2967
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0365	0.0348
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0016	0.0064
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0027	0.0232	0.0215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0232	0.0215
Entamoeba histolytica	hypothetical protein	0.0035	0.0326	0.8903

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12.6 uM	Inhibitory concentration of the compound against hepatitis C virus NS3 protease	ChEMBL.	15633995
IC50 (binding)	= 12.6 uM	Inhibitory concentration of the compound against hepatitis C virus NS3 protease	ChEMBL.	15633995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5278817

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 312122