TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.221 | Formula: C10H14N5O7P
H donors: 6 H acceptors: 9 LogP: -3.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: O[C@H]1[C@H](O)C(OC1n1cnc2c1nc(N)nc2O)CP(=O)(O)O
InChi: 1S/C10H14N5O7P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(22-9)1-23(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3?,5-,6?,9?/m0/s1
InChiKey: WXQSIZSBZUXYQW-MVOICYSSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0019	0.0548	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0464	0.0438
Schistosoma mansoni	cpg binding protein	0.0025	0.0792	0.0772
Plasmodium falciparum	nitric oxide synthase, putative	0.0169	0.6502	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1943	0.296
Toxoplasma gondii	flavodoxin domain-containing protein	0.0084	0.3117	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.379	0.3777
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.1503	0.1485
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0467	0.0441
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0169	0.6502	1
Echinococcus granulosus	Ankyrin	0.0017	0.0464	0.0444
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0169	0.6502	1
Treponema pallidum	flavodoxin	0.0064	0.2354	1
Leishmania major	importin beta-1 subunit, putative	0.0019	0.056	0.0324
Schistosoma mansoni	glutamate receptor AMPA	0.0069	0.2534	0.2518
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0064	0.2354	0.3245
Schistosoma mansoni	cpg binding protein	0.0025	0.0792	0.0772
Schistosoma mansoni	hypothetical protein	0.0026	0.0802	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0458	0.0432
Mycobacterium ulcerans	oxidoreductase	0.0019	0.0548	0.0304
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Trypanosoma cruzi	reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	protein patched	0.0043	0.1503	0.1485
Toxoplasma gondii	HEAT repeat-containing protein	0.0024	0.0741	0.2311
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0741	0.0619
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0019	0.0548	0.0804
Schistosoma mansoni	hypothetical protein	0.0042	0.1441	0.1423
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0051	0.1806	0.1789
Brugia malayi	RNA, U transporter 1	0.0068	0.2505	0.3828
Brugia malayi	FAD binding domain containing protein	0.0169	0.6502	1
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0802	0.0782
Mycobacterium ulcerans	electron transfer protein FdxB	0.0019	0.0548	0.0304
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Loa Loa (eye worm)	histone methyltransferase	0.0007	0.0079	0.0052
Loa Loa (eye worm)	hypothetical protein	0.001	0.0195	0.0168
Echinococcus granulosus	expressed conserved protein	0.0094	0.3547	0.3534
Schistosoma mansoni	netrin receptor unc5	0.0017	0.0458	0.0438
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0802	0.0782
Brugia malayi	Niemann-Pick C1 protein precursor	0.0101	0.379	0.5812
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.2255	0.7208
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1943	0.296
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.2534	0.2518
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0017	0.0458	0.0438
Trypanosoma brucei	oxidoreductase-protein, putative	0.0019	0.0548	0.0304
Brugia malayi	Death domain containing protein	0.0017	0.0458	0.0666
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0467	0.068
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0019	0.0548	0.0304
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0104	0.3932	0.3919
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0467	0.0447
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.2255	0.3084
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0737	0.0712
Trichomonas vaginalis	sulfite reductase, putative	0.0169	0.6502	1
Trypanosoma brucei	nitrate reductase, putative	0.0019	0.0548	0.0304
Leishmania major	reductase, putative	0.0019	0.0548	0.0304
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0737	0.1097
Schistosoma mansoni	hypothetical protein	0.0017	0.0467	0.0447
Toxoplasma gondii	flavodoxin domain-containing protein	0.0084	0.3117	1
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0169	0.6502	1
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.1503	0.1485
Brugia malayi	diaphorase	0.0019	0.0548	0.0804
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.2534	0.2518
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Mycobacterium ulcerans	flavodoxin reductase Hmp	0.0019	0.0548	0.0304
Loa Loa (eye worm)	glutamate receptor 2	0.0069	0.2534	0.2513
Leishmania major	cytochrome P450 reductase, putative	0.0149	0.5738	0.8756
Leishmania major	hypothetical protein, conserved	0.0064	0.2354	0.3245
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0467	0.068
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0467	0.0447
Schistosoma mansoni	hypothetical protein	0.0017	0.0467	0.0447
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.5509	0.55
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.1503	0.148
Giardia lamblia	Hypothetical protein	0.0149	0.5738	1
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0019	0.0548	0.0304
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0064	0.2354	0.3245
Schistosoma mansoni	cpg binding protein	0.0024	0.0737	0.0718
Schistosoma mansoni	hypothetical protein	0.0042	0.1441	0.1423
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.1503	0.1485
Echinococcus multilocularis	importin subunit beta 1	0.0024	0.0741	0.0722
Plasmodium vivax	hypothetical protein, conserved	0.0064	0.2354	0.3593
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0019	0.0548	0.0304
Schistosoma mansoni	ATP-binding cassette transporter	0.0069	0.2534	0.2518
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	expressed conserved protein	0.0094	0.3547	0.3534
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0361	0.0335
Loa Loa (eye worm)	flavodoxin family protein	0.0064	0.2354	0.2333
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0741	0.0619
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0104	0.3932	0.3916
Schistosoma mansoni	hypothetical protein	0.0017	0.0467	0.0447
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus granulosus	importin subunit beta 1	0.0024	0.0741	0.0722
Echinococcus granulosus	netrin receptor unc 5	0.0017	0.0458	0.0438
Entamoeba histolytica	type A flavoprotein, putative	0.0064	0.2354	0.5553
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1943	0.1921
Leishmania major	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0169	0.6502	0.6494
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0026	0.0802	0.0782
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0079	0.0058
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0019	0.0548	0.0528
Echinococcus multilocularis	glutamate receptor 2	0.0043	0.1516	0.1498
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0169	0.6502	0.6492
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0169	0.6502	0.6494
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.2255	0.3084
Trypanosoma cruzi	nitrate reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	protein dispatched 1	0.0049	0.1746	0.1729
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0064	0.2354	0.362
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.379	0.3777
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0169	0.6502	1
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0361	0.0516
Brugia malayi	FAD binding domain containing protein	0.0104	0.3932	0.6031
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0169	0.6502	0.6494
Schistosoma mansoni	hypothetical protein	0.0017	0.0458	0.0438
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0026	0.0802	0.0782
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0256	1	1
Leishmania major	cytochrome-b5 reductase, putative	0.0019	0.0548	0.0304
Schistosoma mansoni	patched 1	0.0043	0.1503	0.1485
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0069	0.2534	0.2518
Onchocerca volvulus		0.0024	0.0737	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0169	0.6502	0.6492
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0464	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0741	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0053	0.189	0.1868
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.2255	0.2238
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0087	0.3237	0.3223
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	netrin receptor unc 5	0.0017	0.0458	0.0438
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0064	0.2354	0.362
Mycobacterium ulcerans	monooxygenase	0.0019	0.0548	0.0304
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.2534	0.2518
Entamoeba histolytica	type A flavoprotein, putative	0.0064	0.2354	0.5553
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0361	0.0335
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0169	0.6502	1
Chlamydia trachomatis	sulfite reductase	0.0104	0.3932	1
Echinococcus multilocularis	methionine synthase reductase	0.0104	0.3932	0.3919
Entamoeba histolytica	type A flavoprotein, putative	0.0064	0.2354	0.5553
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0169	0.6502	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0169	0.6502	1
Entamoeba histolytica	type A flavoprotein, putative	0.0064	0.2354	0.5553
Onchocerca volvulus		0.0019	0.0548	0.7333
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0087	0.3237	0.3223
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0458	0.0432
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0019	0.0548	0.0528
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0069	0.2534	0.2518
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.126	0.1905
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0079	0.0058
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.2255	0.3084
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0467	0.0447
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.2255	0.3084
Mycobacterium ulcerans	oxygenase	0.0019	0.0548	0.0304
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0019	0.0548	0.1685
Schistosoma mansoni	cytochrome B5	0.0019	0.0548	0.0528
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.2534	0.2518
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0085	0.3168	0.3154
Plasmodium vivax	importin-beta 2, putative	0.0024	0.0741	0.1103
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0069	0.2534	0.2518
Schistosoma mansoni	hypothetical protein	0.0017	0.0467	0.0447
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0064	0.2354	0.362
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0019	0.0548	0.0304
Echinococcus granulosus	cytochrome b5 reductase 4	0.0019	0.0548	0.0528
Leishmania major	oxidoreductase-like protein	0.0019	0.0548	0.0304
Trypanosoma cruzi	p450 reductase, putative	0.0169	0.6502	1
Echinococcus granulosus	glutamate receptor 2	0.0069	0.2534	0.2518
Echinococcus granulosus	death domain containing protein	0.0017	0.0458	0.0438
Echinococcus multilocularis	NMDA receptor	0.0026	0.0802	0.0782
Loa Loa (eye worm)	diaphorase	0.0019	0.0548	0.0522
Echinococcus multilocularis	glutamate receptor 2	0.0069	0.2534	0.2518
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.2255	0.2238
Schistosoma mansoni	cytochrome P450 reductase	0.0169	0.6502	0.6494
Schistosoma mansoni	glutamate receptor NMDA	0.0069	0.2534	0.2518
Brugia malayi	flavodoxin family protein	0.0064	0.2354	0.3593
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Giardia lamblia	Nitric oxide synthase, inducible	0.0149	0.5738	1
Echinococcus granulosus	cpg binding protein	0.0025	0.0792	0.0772
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0169	0.6502	1
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus multilocularis	cpg binding protein	0.0025	0.0792	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0037	0.126	0.1236
Schistosoma mansoni	glutamate receptor kainate	0.0069	0.2534	0.2518
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0169	0.6502	0.6494
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0069	0.2534	0.2518
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0026	0.0802	0.0782
Echinococcus multilocularis	Ankyrin	0.0017	0.0464	0.0444
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0045	0.159	0.5057
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0019	0.056	0.0324
Mycobacterium ulcerans	flavodoxin oxidoreductase	0.0019	0.0548	0.0304
Leishmania major	cytochrome-b5 reductase, putative	0.0019	0.0548	0.0304
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0017	0.0458	0.0438
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0019	0.0548	0.0804
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0169	0.6502	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Brugia malayi	Glutamate receptor 1 precursor	0.0069	0.2534	0.3872
Trypanosoma cruzi	p450 reductase, putative	0.0019	0.0548	0.0304
Brugia malayi	Importin beta-1 subunit	0.0024	0.0741	0.1103
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0064	0.2354	0.3593
Schistosoma mansoni	hypothetical protein	0.0037	0.126	0.1242
Leishmania major	p450 reductase, putative	0.0169	0.6502	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Plasmodium falciparum	importin beta, putative	0.0024	0.0741	0.1103
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0064	0.2354	0.3245
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0458	0.0666
Trichomonas vaginalis	importin beta-1, putative	0.0019	0.056	0.0861
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0019	0.056	0.0861
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1503	0.2312
Schistosoma mansoni	hypothetical protein	0.0042	0.1441	0.1423
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0019	0.0548	0.0804
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0019	0.0548	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1943	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0101	0.379	0.3773
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0467	0.0447
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0019	0.0548	0.0304
Schistosoma mansoni	glutamate receptor kainate	0.0069	0.2534	0.2518
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.2255	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.5509	0.55
Brugia malayi	flavodoxin family protein	0.0169	0.6502	1
Schistosoma mansoni	glutamate receptor kainate	0.0069	0.2534	0.2518
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0019	0.0548	0.0528
Echinococcus granulosus	glutamate receptor 2	0.0043	0.1516	0.1498
Brugia malayi	CHE-14 protein	0.0043	0.1503	0.228
Echinococcus granulosus	cytochrome b5 reductase 4	0.0019	0.0548	0.0528
Loa Loa (eye worm)	glutamate receptor 1	0.0069	0.2534	0.2513
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.2255	0.2238
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0467	0.0447
Schistosoma mansoni	ankyrin 23/unc44	0.0017	0.0458	0.0438
Schistosoma mansoni	glutamate receptor NMDA	0.0069	0.2534	0.2518
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0361	0.0516
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0149	0.5738	0.8825
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0458	0.0666
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0064	0.2354	0.3593
Plasmodium falciparum	ferredoxin--NADP reductase	0.0019	0.0548	0.0804
Schistosoma mansoni	diflavin oxidoreductase	0.0084	0.3117	0.3103
Brugia malayi	Uncoordinated protein 44	0.0017	0.0458	0.0666
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0019	0.0548	0.0304
Echinococcus granulosus	methionine synthase reductase	0.0104	0.3932	0.3919
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.3852	0.3839
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.2534	0.2518
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0064	0.2354	0.362
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0101	0.379	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.2255	0.2238
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.2534	0.2518
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0361	0.0335
Schistosoma mansoni	glutamate receptor AMPA	0.0069	0.2534	0.2518
Leishmania major	nitrate reductase, putative	0.0019	0.0548	0.0304
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0169	0.6502	1
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0019	0.0548	0.0528
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0802	0.0782
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0026	0.0802	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1503	0.148
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Plasmodium vivax	flavodoxin domain containing protein	0.0149	0.5738	0.8821
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0019	0.0548	0.1685
Brugia malayi	Glutamate receptor 2 precursor	0.0069	0.2534	0.3872
Entamoeba histolytica	type A flavoprotein, putative	0.0064	0.2354	0.5553
Schistosoma mansoni	hypothetical protein	0.0256	1	1
Echinococcus multilocularis	glutamate receptor 2	0.0069	0.2534	0.2518
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0064	0.2354	0.3245
Echinococcus multilocularis	snurportin 1	0.0256	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0019	0.056	0.0861
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0019	0.0548	0.0304
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0019	0.0548	0.0304
Onchocerca volvulus	Netrin receptor homolog	0.0017	0.0458	0.6072
Schistosoma mansoni	importin beta-1	0.0024	0.0741	0.0722
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0026	0.0802	0.0782
Echinococcus granulosus	GPCR family 2	0.0017	0.0467	0.0447
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0075	0.0074
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0026	0.0802	0.0782
Schistosoma mansoni	hypothetical protein	0.0042	0.1441	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0467	0.0441
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0026	0.0802	0.0782

Activities

Activity type	Activity value	Assay description	Source	Reference
% nucleotide present (binding)	= 3 %	Percent of triphosphate forms of compound at 2 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
% nucleotide present (binding)	= 5 %	Percent of Monophosphate forms of compound at 2 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
% nucleotide present (binding)	= 8 %	Percent of Monophosphate forms of compound at 24 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
% nucleotide present (binding)	= 37 %	Percent of triphosphate forms of compound at 24 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
% nucleotide present (binding)	= 55 %	Percent of diphosphate forms of compound at 24 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
% nucleotide present (binding)	= 92 %	Percent of diphosphate forms of compound at 24 hr after phosphorylation by nucleoside monophosphate kinase	ChEMBL.	2542559
Activity (functional)	NA 0 uM	Antitumour activity at <=100 microM determined in a 3-5 days culture of L1210 murine leukemia; NA = no activity was shown	ChEMBL.	2542559
Activity (functional)	NA 0 uM	Antitumour activity at <=100 microM determined in a 3-5 days culture of WI-L2 (human B-ltmphoblast); NA = no activity was shown	ChEMBL.	2542559
Activity (functional)	NA 0 uM	Antitumour activity at <=100 microM determined in a 3-5 days culture of CCRF-CEM(human T cell leukemia) ; NA = no activity was shown	ChEMBL.	2542559
Activity (functional)	NA 0 uM	Antitumour activity at <=100 uM determined in a 3-5 days culture of LOVO/L (human colon carcinoma) ; NA = no activity was shown	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Parainfluenza virus type 3 ; IA = inactive	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Herpes simplex virus type 2 ; IA = inactive	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Adenovirus type 2 ; IA = inactive	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Rhinovirus type 1-A ; IA = inactive	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Influenza A; IA = inactive	ChEMBL.	2542559
Activity (functional)	0 uM	Antitviral activity at <=320 microM determined in a culture of Visna virus ; IA = inactive	ChEMBL.	2542559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 132962

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 31288