Detailed information for compound 314487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.502 | Formula: C23H30FN3O
  • H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1nc2CC[C@@H](O)CCCc2c(c1)c1ccc(cc1)F
  • InChi: 1S/C23H30FN3O/c1-2-26-12-14-27(15-13-26)23-16-21(17-6-8-18(24)9-7-17)20-5-3-4-19(28)10-11-22(20)25-23/h6-9,16,19,28H,2-5,10-15H2,1H3/t19-/m0/s1
  • InChiKey: FLPVFOMJIXWGPC-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0024 0.005 0.0029
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0223 0.0203
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0053 0.0223 0.0203
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0027 0.0009
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0347 0.0829
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0122 0.0101
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0108 0.0551 0.1314
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0103 0.0524 0.0504
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0044 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Echinococcus multilocularis neuropeptides capa receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0055 0.0231 0.0211
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0021 0.0027 0.0007
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0443 0.0423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni neuropeptide F-like receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis dro:myosuppressin receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0195 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) beta-lactamase 0.0036 0.0122 0.0103
Schistosoma mansoni adenoreceptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0399 0.2304 0.229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0031 0.001
Echinococcus multilocularis G protein coupled receptor 139 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0074 0.0347 0.033
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0399 0.2304 0.2288
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1695 0.1678
Echinococcus granulosus neuropeptide receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) adenylyl cyclase 3 0.0186 0.102 0.1004
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Onchocerca volvulus 0.0712 0.419 1
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1695 0.1678
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0737 0.072
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi Dihydrofolate reductase 0.1676 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0751 0.0732
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0077 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0036 0.0122 0.0131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1302 0.1286
Echinococcus granulosus serotonin receptor 0.0399 0.2304 0.2288
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1611 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0021 0.0049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.0049
Echinococcus granulosus neuropeptide FF receptor 2 0.0399 0.2304 0.2288
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0195 0.0175
Echinococcus multilocularis neuropeptide FF receptor 2 0.0399 0.2304 0.2288
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.005 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0399 0.2304 0.2288
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0151 0.036
Brugia malayi ORL1-like opioid receptor 0.0399 0.2304 0.2288
Brugia malayi G-protein coupled receptor 0.0399 0.2304 0.2288
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.03 0.1707 0.169
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0223 0.0533
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Echinococcus granulosus importin subunit beta 1 0.0029 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.3927 0.3915
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Plasmodium falciparum importin beta, putative 0.0029 0.0077 0.0058
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Onchocerca volvulus 0.0399 0.2304 0.5424
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0231 0.0211
Toxoplasma gondii hypothetical protein 0.0048 0.0192 0.0174
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1206 0.7166 0.716
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0031 0.0012
Entamoeba histolytica hypothetical protein 0.0023 0.0044 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0423 0.0403
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0159 0.0862 0.0843
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus multilocularis musashi 0.0027 0.0068 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0231 0.0552
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0002
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0074 0.0347 0.0327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0122 0.0101
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.367 0.3658
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0122 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0159 0.0862 0.2057
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Onchocerca volvulus 0.0075 0.0356 0.0698
Schistosoma mansoni lamin 0.0027 0.0068 0.0047
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0416 0.2411 0.2397
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0074 0.0347 0.0327
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0021 0.0027 0.0009
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0211
Brugia malayi RNA, U transporter 1 0.0082 0.0398 0.0378
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0012
Mycobacterium leprae Probable lipase LipE 0.0036 0.0122 0.0103
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1676 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Echinococcus multilocularis g-protein coupled receptor 0.0399 0.2304 0.2288
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1676 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0399 0.2304 0.2288
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0328 0.1932
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0122 0.0103
Echinococcus granulosus adenylate cyclase type IX 0.011 0.0567 0.0548
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0748 0.0729
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Brugia malayi RE15519p 0.0399 0.2304 0.2288
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.4868 0.4858
Echinococcus granulosus biogenic amine 5HT receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0122 0.029
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.3927 0.3915
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni myosin xvIII 0.0399 0.2304 0.2288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.0561 0.134
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Echinococcus granulosus snurportin 1 0.0309 0.1762 0.1745
Brugia malayi neuropeptide F receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0063
Echinococcus multilocularis adenylate cyclase type IX 0.011 0.0567 0.0548
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0751 0.0732
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0122 0.0101
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0053 0.0223 0.0533
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.021 0.0189
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0027 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.1275
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0151 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0151 0.0133
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0108 0.0551 0.0531
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0053 0.0223 0.0533
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0122 0.0103
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0047
Brugia malayi Adenylyl cyclase protein 0.0079 0.0376 0.0356
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0416 0.2411 0.2395
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0399 0.2304 0.2288
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.013 0.0112
Brugia malayi hypothetical protein 0.0166 0.0902 0.0883
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0077 0.0056
Onchocerca volvulus 0.0399 0.2304 0.5424
Giardia lamblia Hypothetical protein 0.0055 0.0231 0.1325
Echinococcus granulosus orexin receptor type 2 0.0399 0.2304 0.2288
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus fmrfamide receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis neuropeptides capa receptor 0.0399 0.2304 0.2288
Entamoeba histolytica hypothetical protein 0.0127 0.0666 0.4057
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis neuropeptide Y receptor 0.0399 0.2304 0.2288
Echinococcus granulosus dihydrofolate reductase 0.1676 1 1
Onchocerca volvulus 0.0079 0.0376 0.0747
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0021 0.0027 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1762 0.1747
Toxoplasma gondii hypothetical protein 0.0053 0.0222 0.0204
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0088 0.0435 0.1037
Trichomonas vaginalis ran, putative 0.0021 0.0031 0.0073
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0044 0.0104
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.005 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0376 0.0358
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Brugia malayi G protein-coupled receptor 0.0399 0.2304 0.2288
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0751 0.0732
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0399 0.2304 0.229
Mycobacterium ulcerans lipase LipD 0.0036 0.0122 0.0103
Schistosoma mansoni hypothetical protein 0.0172 0.094 0.0921
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0151 0.036
Schistosoma mansoni histamine h1 receptor 0.0399 0.2304 0.2288
Echinococcus granulosus 7TM GPCR rhodopsin 0.0399 0.2304 0.2288
Schistosoma mansoni growth hormone secretagogue receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Echinococcus multilocularis dihydrofolate reductase 0.1676 1 1
Brugia malayi Serotonin receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1206 0.7166 0.716
Echinococcus granulosus 7tm_1 domain containing protein 0.0399 0.2304 0.2288
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Echinococcus multilocularis G-protein coupled receptor, putative 0.0399 0.2304 0.2288
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0053 0.0223 0.0203
Echinococcus multilocularis neuropeptide Y receptor 0.0399 0.2304 0.2288
Brugia malayi Tachykinin-like peptides receptor 99D 0.0399 0.2304 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0551 0.1314
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Echinococcus granulosus somatostatin receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0159 0.0862 0.2057
Echinococcus granulosus neuropeptide s receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0021 0.0027 0.0007
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0123 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0416 0.2411 0.2397
Onchocerca volvulus 0.0399 0.2304 0.5424
Loa Loa (eye worm) G-protein coupled receptor 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) neuropeptide F receptor 0.0399 0.2304 0.229
Brugia malayi sulfakinin receptor protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0122 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0032
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) dihydrofolate reductase 0.1676 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.1206 0.7166 0.716
Echinococcus granulosus neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Onchocerca volvulus 0.0036 0.0122 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0712 0.419 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni neuropeptide f receptor 76f 0.0399 0.2304 0.2288
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0151 0.0133
Brugia malayi Importin beta-1 subunit 0.0029 0.0077 0.0056
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0108 0.0551 0.0531
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0123 0.0103
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0443 0.0425
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0031 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0399 0.2304 0.2288
Brugia malayi follicle stimulating hormone receptor 0.0632 0.3712 0.3699
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0047
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1611 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0211
Chlamydia trachomatis dihydrofolate reductase 0.1676 1 0.5
Echinococcus multilocularis serotonin receptor 0.0399 0.2304 0.2288
Brugia malayi putative neuropeptide receptor NPR1 0.0399 0.2304 0.2288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0399 0.2304 0.2288
Brugia malayi Dopamine receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0055 0.0231 0.0211
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Echinococcus multilocularis Zinc finger, PHD finger 0.0021 0.0027 0.0007
Echinococcus granulosus hypothetical protein 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0037 0.0127 0.0668
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1695 0.1678
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0122 0.0101
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0032
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0159 0.0862 0.0843
Onchocerca volvulus 0.0399 0.2304 0.5424
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0079 0.0376 0.0747
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis allatostatin A receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Mycobacterium ulcerans hypothetical protein 0.0157 0.0847 0.083
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0122 0.0101
Onchocerca volvulus 0.0037 0.0123 0.0134
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0824 0.0808
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0399 0.2304 0.2288
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0443 0.0423
Brugia malayi Serotonin receptor 0.0399 0.2304 0.2288
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0079 0.0376 0.0747
Brugia malayi Pre-SET motif family protein 0.0625 0.367 0.3657
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0021 0.0002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trichomonas vaginalis esterase, putative 0.0036 0.0122 0.029
Echinococcus multilocularis neuropeptide receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0122 0.0103
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0399 0.2304 0.2288
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0155 0.0134
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0632 0.3712 0.3701
Leishmania major GTP-binding protein, putative 0.0021 0.0031 0.001
Echinococcus granulosus dro:myosuppressin receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis fmrfamide receptor 0.0399 0.2304 0.2288
Plasmodium vivax SET domain protein, putative 0.009 0.0443 0.0425
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0027 0.0009
Entamoeba histolytica Ran family GTPase 0.0021 0.0031 0.0063
Loa Loa (eye worm) hypothetical protein 0.0075 0.0356 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0847 0.083
Schistosoma mansoni lamin 0.0027 0.0068 0.0047
Echinococcus granulosus adenylate cyclase 9 0.0079 0.0376 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0399 0.2304 0.2288
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Echinococcus multilocularis lamin 0.0027 0.0068 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0108 0.0551 0.0531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0021 0.0027 0.0065
Brugia malayi intermediate filament protein 0.0027 0.0068 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0109 0.0561 0.134
Brugia malayi larval opioid receptor 0.0399 0.2304 0.2288
Echinococcus granulosus single minded 2 0.0037 0.0123 0.0103
Schistosoma mansoni hypothetical protein 0.0172 0.094 0.0921
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0055 0.0231 0.0211
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0231 0.0211
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.03 0.1707 0.169
Onchocerca volvulus Neuropeptide F receptor homolog 0.0399 0.2304 0.5424
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0122 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0416 0.2411 0.2397
Echinococcus multilocularis sex peptide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Loa Loa (eye worm) melatonin receptor type 1A 0.0399 0.2304 0.229
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.0524 0.0504
Echinococcus granulosus alpha 1A adrenergic receptor 0.0399 0.2304 0.2288
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0416 0.2411 0.2395
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Echinococcus granulosus tachykinin peptides receptor 99D 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0166 0.0902 0.0885
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0347 0.0829
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0347 0.0829
Onchocerca volvulus 0.0036 0.0122 0.0131
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0748 0.0729
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Leishmania major cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0443 0.0423
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis adenylate cyclase 9 0.0079 0.0376 0.0356
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni ran 0.0021 0.0031 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0122 0.0103
Echinococcus multilocularis snurportin 1 0.0309 0.1762 0.1745
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Brugia malayi Dopamine receptor protein 2 0.0399 0.2304 0.2288
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0399 0.2304 0.2288
Echinococcus granulosus microtubule associated protein 2 0.0668 0.3927 0.3915
Loa Loa (eye worm) TYRA-2 protein 0.0399 0.2304 0.229
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0044 0.0104
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Onchocerca volvulus 0.0399 0.2304 0.5424
Brugia malayi AKH receptor 0.0399 0.2304 0.2288
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0399 0.2304 0.229
Leishmania major importin beta-1 subunit, putative 0.0023 0.0044 0.0023
Plasmodium falciparum phosphodiesterase delta, putative 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0103 0.0524 0.0506
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1611 1
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Plasmodium falciparum phosphodiesterase gamma, putative 0.0055 0.0231 0.0213
Brugia malayi PAS domain containing protein 0.0049 0.02 0.018
Schistosoma mansoni neuropeptide F-like receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Echinococcus granulosus neuropeptides capa receptor 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.0049
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0123 0.0105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0724 0.0705
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.03 0.1707 0.169
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0031 0.001
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0074 0.0347 0.0327
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0737 0.072
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0155 0.0834 0.5111
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0748 0.0729
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0416 0.2411 0.2395
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0122 0.0103
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0021 0.0049
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0399 0.2304 0.2288
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.014 0.0748 0.0728
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Leishmania major hypothetical protein, conserved 0.0036 0.0122 0.0101
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.0203
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0399 0.2304 0.5424
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Echinococcus granulosus neuropeptide receptor A26 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0021 0.0027 0.0007
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1206 0.7166 0.716
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Echinococcus granulosus G protein coupled receptor 139 0.0399 0.2304 0.2288
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.0056
Brugia malayi G protein-coupled receptor F59B2.13 0.0399 0.2304 0.2288
Schistosoma mansoni dihydrofolate reductase 0.1676 1 1
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0399 0.2304 0.2288
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1695 0.1678
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0122 0.029
Loa Loa (eye worm) hypothetical protein 0.009 0.0443 0.0425
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0666 0.4057
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.1511 0.1495
Leishmania major hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0151 0.0131
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0213
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.013 0.069
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0074 0.0347 0.0327
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.02 0.018
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0055 0.0231 0.0211
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0443 0.0423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Plasmodium vivax phosphodiesterase gamma, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0159 0.0862 0.2057
Echinococcus granulosus g-protein coupled receptor 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0002
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1676 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0077 0.0365 0.2168
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0159 0.0862 0.5289
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi beta-lactamase 0.0036 0.0122 0.0101
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Schistosoma mansoni biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Brugia malayi beta-lactamase family protein 0.0036 0.0122 0.0101
Brugia malayi beta-lactamase family protein 0.0036 0.0122 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.0002
Schistosoma mansoni single-minded 0.0049 0.02 0.018
Echinococcus multilocularis orexin receptor type 2 0.0399 0.2304 0.2288
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0181 0.0163
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0088 0.0435 0.0415
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1676 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0737 0.072
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0021 0.0027 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.016
Echinococcus multilocularis geminin 0.0172 0.094 0.0921
Schistosoma mansoni importin beta-1 0.0029 0.0077 0.0056
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0021 0.0027 0.0009
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0021 0.0027 0.0007
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi putative neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0231 0.0552
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0027 0.0007
Toxoplasma gondii ABC1 family protein 0.0036 0.0122 0.0103
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0021 0.0027 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0044
Echinococcus multilocularis somatostatin receptor 0.0399 0.2304 0.2288
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0074 0.0347 0.0327
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.1275
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0021 0.0027 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Giardia lamblia hypothetical protein 0.0055 0.0231 0.1325
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0399 0.2304 0.2288
Schistosoma mansoni ran 0.0021 0.0031 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0122 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0021 0.0002
Onchocerca volvulus 0.0399 0.2304 0.5424
Brugia malayi Dopamine receptor protein 1 0.0399 0.2304 0.2288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0862 0.0843
Brugia malayi neuropeptide F receptor 0.0399 0.2304 0.2288
Mycobacterium ulcerans beta-lactamase 0.0036 0.0122 0.0103
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Echinococcus granulosus sex peptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus granulosus Solute carrier family 22 5 0.1026 0.6087 0.6079
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Echinococcus multilocularis fmrfamide receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0056 0.024 0.0223
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Onchocerca volvulus 0.009 0.0443 0.091
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0122 0.0101
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0055 0.0231 0.1325
Echinococcus multilocularis neuropeptide receptor 0.0399 0.2304 0.2288
Leishmania major hypothetical protein, conserved 0.0055 0.0231 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) PDE1B protein 0.1206 0.7166 0.7161
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0231 0.0211
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0435 0.1037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Brugia malayi G-protein coupled receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0122 0.0103
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0021 0.0027 0.0043
Echinococcus granulosus geminin 0.0172 0.094 0.0921
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0108 0.0551 0.0531
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0108 0.0551 0.0531
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.005 0.0032
Echinococcus multilocularis neuropeptide s receptor 0.0399 0.2304 0.2288
Echinococcus granulosus neuropeptides capa receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0231 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0181 0.016
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0044 0.0023
Brugia malayi GnHR receptor homolog 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0399 0.2304 0.2288
Leishmania major hypothetical protein, conserved 0.0024 0.005 0.0029
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Echinococcus granulosus allatostatin A receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0399 0.2304 0.2288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Plasmodium vivax importin-beta 2, putative 0.0029 0.0077 0.0058
Brugia malayi Pre-SET motif family protein 0.009 0.0443 0.0423
Onchocerca volvulus 0.0399 0.2304 0.5424
Mycobacterium ulcerans hypothetical protein 0.0036 0.0122 0.0103
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.013 0.069
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0122 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Echinococcus granulosus peptide allatostatin:somatostatin 0.0399 0.2304 0.2288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0103 0.0524 0.0504
Schistosoma mansoni hypothetical protein 0.0309 0.1762 0.1745
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni alpha-1 adrenergic receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.016
Brugia malayi hypoxia-induced factor 1 0.0153 0.0824 0.0806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Brugia malayi Melatonin receptor type 1A 0.0399 0.2304 0.2288
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0021 0.0027 0.0065
Echinococcus granulosus lamin 0.0027 0.0068 0.0047
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0047
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1611 0.5
Echinococcus multilocularis serotonin receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) G-protein coupled receptor 0.0399 0.2304 0.229
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0122 0.0103
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0055 0.0231 0.0211
Loa Loa (eye worm) acetyltransferase 0.014 0.0748 0.0731
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0231 0.0213

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 11.9 nM In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes ChEMBL. 15686911
Ki (binding) = 11.9 nM In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes ChEMBL. 15686911
Ki (binding) = 17.9 nM In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes ChEMBL. 15686911
Ki (binding) = 17.9 nM In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes ChEMBL. 15686911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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