Detailed information for compound 315660

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.502 | Formula: C23H30FN3O
  • H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1nc2CC[C@H](O)CCCc2c(c1)c1ccc(cc1)F
  • InChi: 1S/C23H30FN3O/c1-2-26-12-14-27(15-13-26)23-16-21(17-6-8-18(24)9-7-17)20-5-3-4-19(28)10-11-22(20)25-23/h6-9,16,19,28H,2-5,10-15H2,1H3/t19-/m1/s1
  • InChiKey: FLPVFOMJIXWGPC-LJQANCHMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0044 0.0104
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0103 0.0524 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0122 0.0101
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0347 0.0829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0053 0.0223 0.0203
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0027 0.0009
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0223 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0211
Echinococcus granulosus neuropeptide Y receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0024 0.005 0.0029
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0195 0.0177
Echinococcus multilocularis dro:myosuppressin receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) beta-lactamase 0.0036 0.0122 0.0103
Schistosoma mansoni neuropeptide F-like receptor 0.0399 0.2304 0.2288
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0399 0.2304 0.2288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0443 0.0423
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0021 0.0027 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0055 0.0231 0.0211
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis neuropeptides capa receptor 0.0399 0.2304 0.2288
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0751 0.0732
Brugia malayi Dihydrofolate reductase 0.1676 1 1
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0737 0.072
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1695 0.1678
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0712 0.419 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus neuropeptide receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) adenylyl cyclase 3 0.0186 0.102 0.1004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1695 0.1678
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0031 0.001
Schistosoma mansoni adenoreceptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0074 0.0347 0.033
Echinococcus multilocularis G protein coupled receptor 139 0.0399 0.2304 0.2288
Brugia malayi ORL1-like opioid receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0151 0.036
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.03 0.1707 0.169
Brugia malayi G-protein coupled receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis neuropeptide receptor A26 0.0399 0.2304 0.2288
Echinococcus multilocularis neuropeptide FF receptor 2 0.0399 0.2304 0.2288
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.005 0.0029
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0195 0.0175
Echinococcus granulosus serotonin receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1302 0.1286
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0399 0.2304 0.2288
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1611 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.0049
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0021 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0036 0.0122 0.0131
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0077 0.0058
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Entamoeba histolytica hypothetical protein 0.0023 0.0044 0.0145
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0031 0.0012
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1206 0.7166 0.716
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0231 0.0211
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Onchocerca volvulus 0.0399 0.2304 0.5424
Toxoplasma gondii hypothetical protein 0.0048 0.0192 0.0174
Plasmodium falciparum importin beta, putative 0.0029 0.0077 0.0058
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.3927 0.3915
Echinococcus granulosus importin subunit beta 1 0.0029 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0053 0.0223 0.0533
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0122 0.0101
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.367 0.3658
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0231 0.0552
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0122 0.0101
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0074 0.0347 0.0327
Echinococcus multilocularis musashi 0.0027 0.0068 0.0047
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0159 0.0862 0.0843
Onchocerca volvulus 0.0399 0.2304 0.5424
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0423 0.0403
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0399 0.2304 0.2288
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1676 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1676 1 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0122 0.0103
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0012
Brugia malayi RNA, U transporter 1 0.0082 0.0398 0.0378
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0021 0.0027 0.0009
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0074 0.0347 0.0327
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0416 0.2411 0.2397
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Onchocerca volvulus 0.0075 0.0356 0.0698
Schistosoma mansoni lamin 0.0027 0.0068 0.0047
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0159 0.0862 0.2057
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus snurportin 1 0.0309 0.1762 0.1745
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0109 0.0561 0.134
Schistosoma mansoni myosin xvIII 0.0399 0.2304 0.2288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0122 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.3927 0.3915
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus biogenic amine 5HT receptor 0.0399 0.2304 0.2288
Brugia malayi RE15519p 0.0399 0.2304 0.2288
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.4868 0.4858
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0748 0.0729
Echinococcus granulosus adenylate cyclase type IX 0.011 0.0567 0.0548
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0122 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0328 0.1932
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0151 0.0133
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.1275
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0027 0.0007
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0151 0.0133
Onchocerca volvulus 0.0399 0.2304 0.5424
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.021 0.0189
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0053 0.0223 0.0533
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0108 0.0551 0.1314
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0122 0.0101
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis adenylate cyclase type IX 0.011 0.0567 0.0548
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0063
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0751 0.0732
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi neuropeptide F receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus fmrfamide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus orexin receptor type 2 0.0399 0.2304 0.2288
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0077 0.0056
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Giardia lamblia Hypothetical protein 0.0055 0.0231 0.1325
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0416 0.2411 0.2395
Brugia malayi Adenylyl cyclase protein 0.0079 0.0376 0.0356
Brugia malayi hypothetical protein 0.0166 0.0902 0.0883
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.013 0.0112
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0399 0.2304 0.2288
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0047
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0122 0.0103
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0053 0.0223 0.0533
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0108 0.0551 0.0531
Brugia malayi G protein-coupled receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0376 0.0358
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.005 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0399 0.2304 0.2288
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0088 0.0435 0.1037
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0044 0.0104
Trichomonas vaginalis ran, putative 0.0021 0.0031 0.0073
Onchocerca volvulus 0.0079 0.0376 0.0747
Toxoplasma gondii hypothetical protein 0.0053 0.0222 0.0204
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1762 0.1747
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0021 0.0027 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0399 0.2304 0.2288
Entamoeba histolytica hypothetical protein 0.0127 0.0666 0.4057
Echinococcus multilocularis neuropeptides capa receptor 0.0399 0.2304 0.2288
Echinococcus granulosus dihydrofolate reductase 0.1676 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0399 0.2304 0.2288
Echinococcus granulosus 7tm_1 domain containing protein 0.0399 0.2304 0.2288
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1206 0.7166 0.716
Brugia malayi Serotonin receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Echinococcus multilocularis dihydrofolate reductase 0.1676 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0399 0.2304 0.2288
Echinococcus granulosus 7TM GPCR rhodopsin 0.0399 0.2304 0.2288
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0151 0.036
Schistosoma mansoni histamine h1 receptor 0.0399 0.2304 0.2288
Schistosoma mansoni hypothetical protein 0.0172 0.094 0.0921
Mycobacterium ulcerans lipase LipD 0.0036 0.0122 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0399 0.2304 0.229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0751 0.0732
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0551 0.1314
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Echinococcus multilocularis neuropeptide Y receptor 0.0399 0.2304 0.2288
Brugia malayi Tachykinin-like peptides receptor 99D 0.0399 0.2304 0.2288
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0053 0.0223 0.0203
Echinococcus multilocularis G-protein coupled receptor, putative 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0399 0.2304 0.2288
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0032
Loa Loa (eye worm) dihydrofolate reductase 0.1676 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.1206 0.7166 0.716
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0122 0.0101
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0416 0.2411 0.2397
Loa Loa (eye worm) G-protein coupled receptor 0.0399 0.2304 0.229
Onchocerca volvulus 0.0399 0.2304 0.5424
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) neuropeptide F receptor 0.0399 0.2304 0.229
Brugia malayi sulfakinin receptor protein 0.0399 0.2304 0.2288
Echinococcus granulosus neuropeptide s receptor 0.0399 0.2304 0.2288
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0123 0.0103
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0021 0.0027 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0159 0.0862 0.2057
Echinococcus granulosus somatostatin receptor 0.0399 0.2304 0.2288
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0399 0.2304 0.2288
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0031 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0443 0.0425
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0108 0.0551 0.0531
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0123 0.0103
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0151 0.0133
Brugia malayi Importin beta-1 subunit 0.0029 0.0077 0.0056
Schistosoma mansoni neuropeptide f receptor 76f 0.0399 0.2304 0.2288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Onchocerca volvulus 0.0036 0.0122 0.0131
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis set domain proteins, putative 0.0712 0.419 1
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0399 0.2304 0.2288
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0037 0.0127 0.0668
Onchocerca volvulus 0.0399 0.2304 0.5424
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Echinococcus granulosus hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis Zinc finger, PHD finger 0.0021 0.0027 0.0007
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0055 0.0231 0.0211
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0399 0.2304 0.2288
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0399 0.2304 0.2288
Brugia malayi Dopamine receptor 0.0399 0.2304 0.2288
Brugia malayi putative neuropeptide receptor NPR1 0.0399 0.2304 0.2288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Chlamydia trachomatis dihydrofolate reductase 0.1676 1 0.5
Echinococcus multilocularis serotonin receptor 0.0399 0.2304 0.2288
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0211
Brugia malayi follicle stimulating hormone receptor 0.0632 0.3712 0.3699
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0047
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1611 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0021 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0399 0.2304 0.229
Brugia malayi Pre-SET motif family protein 0.0625 0.367 0.3657
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0079 0.0376 0.0747
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0122 0.0101
Mycobacterium ulcerans hypothetical protein 0.0157 0.0847 0.083
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Brugia malayi Serotonin receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0443 0.0423
Onchocerca volvulus 0.0037 0.0123 0.0134
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0824 0.0808
Echinococcus multilocularis allatostatin A receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0159 0.0862 0.0843
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0079 0.0376 0.0747
Onchocerca volvulus 0.0399 0.2304 0.5424
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0032
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1695 0.1678
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0122 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0108 0.0551 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0021 0.0027 0.0065
Brugia malayi intermediate filament protein 0.0027 0.0068 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0109 0.0561 0.134
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Echinococcus multilocularis lamin 0.0027 0.0068 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0399 0.2304 0.2288
Echinococcus granulosus adenylate cyclase 9 0.0079 0.0376 0.0356
Schistosoma mansoni lamin 0.0027 0.0068 0.0047
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Entamoeba histolytica Ran family GTPase 0.0021 0.0031 0.0063
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0027 0.0009
Plasmodium vivax SET domain protein, putative 0.009 0.0443 0.0425
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0847 0.083
Loa Loa (eye worm) hypothetical protein 0.0075 0.0356 0.0338
Echinococcus multilocularis fmrfamide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus dro:myosuppressin receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0632 0.3712 0.3701
Leishmania major GTP-binding protein, putative 0.0021 0.0031 0.001
Trichomonas vaginalis esterase, putative 0.0036 0.0122 0.029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0155 0.0134
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0399 0.2304 0.2288
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0122 0.0103
Echinococcus multilocularis neuropeptide receptor 0.0399 0.2304 0.2288
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0416 0.2411 0.2395
Echinococcus granulosus alpha 1A adrenergic receptor 0.0399 0.2304 0.2288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.0524 0.0504
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.001
Loa Loa (eye worm) melatonin receptor type 1A 0.0399 0.2304 0.229
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0416 0.2411 0.2397
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0122 0.0103
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis sex peptide receptor 0.0399 0.2304 0.2288
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.03 0.1707 0.169
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0399 0.2304 0.2288
Onchocerca volvulus Neuropeptide F receptor homolog 0.0399 0.2304 0.5424
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0055 0.0231 0.0211
Schistosoma mansoni hypothetical protein 0.0172 0.094 0.0921
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Brugia malayi larval opioid receptor 0.0399 0.2304 0.2288
Echinococcus granulosus single minded 2 0.0037 0.0123 0.0103
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Echinococcus multilocularis snurportin 1 0.0309 0.1762 0.1745
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0122 0.0103
Schistosoma mansoni ran 0.0021 0.0031 0.001
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis adenylate cyclase 9 0.0079 0.0376 0.0356
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0748 0.0729
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0347 0.0829
Onchocerca volvulus 0.0036 0.0122 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0443 0.0423
Leishmania major cAMP-specific phosphodiesterase, putative 0.0055 0.0231 0.0211
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0347 0.0829
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0166 0.0902 0.0885
Echinococcus granulosus tachykinin peptides receptor 99D 0.0399 0.2304 0.2288
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Echinococcus granulosus tm gpcr rhodopsin 0.0399 0.2304 0.2288
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) TYRA-2 protein 0.0399 0.2304 0.229
Echinococcus granulosus microtubule associated protein 2 0.0668 0.3927 0.3915
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0399 0.2304 0.2288
Brugia malayi Dopamine receptor protein 2 0.0399 0.2304 0.2288
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus neuropeptides capa receptor 0.0399 0.2304 0.2288
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1611 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0055 0.0231 0.0213
Schistosoma mansoni neuropeptide F-like receptor 0.0399 0.2304 0.2288
Brugia malayi PAS domain containing protein 0.0049 0.02 0.018
Leishmania major importin beta-1 subunit, putative 0.0023 0.0044 0.0023
Plasmodium falciparum phosphodiesterase delta, putative 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0103 0.0524 0.0506
Loa Loa (eye worm) neuropeptide F receptor 0.0399 0.2304 0.229
Onchocerca volvulus 0.0399 0.2304 0.5424
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0044 0.0104
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0047
Brugia malayi AKH receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1676 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0155 0.0834 0.5111
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0737 0.072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0181 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0443 0.0423
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0074 0.0347 0.0327
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0103
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0031 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0724 0.0705
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.03 0.1707 0.169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0123 0.0105
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.0049
Schistosoma mansoni opsin-like receptor 0.0399 0.2304 0.2288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1206 0.7166 0.716
Mycobacterium tuberculosis Conserved protein 0.0036 0.0122 0.0103
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0021 0.0027 0.0007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0399 0.2304 0.5424
Echinococcus granulosus neuropeptide receptor A26 0.0399 0.2304 0.2288
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0122 0.029
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.0203
Leishmania major hypothetical protein, conserved 0.0036 0.0122 0.0101
Schistosoma mansoni amine GPCR 0.0399 0.2304 0.2288
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0108 0.0551 0.0531
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.014 0.0748 0.0728
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0122 0.0103
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0021 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0416 0.2411 0.2395
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0748 0.0729
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0399 0.2304 0.2288
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0074 0.0347 0.0327
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.02 0.018
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0055 0.0231 0.0213
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0151 0.0131
Leishmania major hypothetical protein, conserved 0.0055 0.0231 0.0211
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.013 0.069
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0127 0.0666 0.4057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.1511 0.1495
Loa Loa (eye worm) hypothetical protein 0.009 0.0443 0.0425
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0122 0.029
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Schistosoma mansoni hypothetical protein 0.0399 0.2304 0.2288
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0399 0.2304 0.2288
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1695 0.1678
Brugia malayi G protein-coupled receptor F59B2.13 0.0399 0.2304 0.2288
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0077 0.0056
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0416 0.2411 0.2395
Schistosoma mansoni dihydrofolate reductase 0.1676 1 1
Onchocerca volvulus 0.0399 0.2304 0.5424
Echinococcus granulosus G protein coupled receptor 139 0.0399 0.2304 0.2288
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Brugia malayi beta-lactamase 0.0036 0.0122 0.0101
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0055 0.0231 0.0552
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1676 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0159 0.0862 0.5289
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0077 0.0365 0.2168
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0213
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0108 0.0551 0.1314
Onchocerca volvulus 0.0399 0.2304 0.5424
Echinococcus granulosus g-protein coupled receptor 0.0399 0.2304 0.2288
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0021 0.0002
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0055 0.0231 0.0211
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0159 0.0862 0.2057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0443 0.0423
Plasmodium vivax phosphodiesterase gamma, putative 0.0055 0.0231 0.0213
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0231 0.0552
Brugia malayi putative neuropeptide receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Onchocerca volvulus 0.0399 0.2304 0.5424
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Schistosoma mansoni importin beta-1 0.0029 0.0077 0.0056
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0021 0.0027 0.0007
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0021 0.0027 0.0009
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1676 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0737 0.072
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0021 0.0027 0.0009
Echinococcus multilocularis geminin 0.0172 0.094 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0181 0.0163
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus multilocularis orexin receptor type 2 0.0399 0.2304 0.2288
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0155 0.0134
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0088 0.0435 0.0415
Schistosoma mansoni single-minded 0.0049 0.02 0.018
Brugia malayi hypothetical protein 0.0399 0.2304 0.2288
Echinococcus multilocularis g protein coupled receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.0002
Brugia malayi beta-lactamase family protein 0.0036 0.0122 0.0101
Brugia malayi beta-lactamase family protein 0.0036 0.0122 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0021 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0122 0.0103
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Schistosoma mansoni ran 0.0021 0.0031 0.001
Giardia lamblia hypothetical protein 0.0055 0.0231 0.1325
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1611 0.3845
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0399 0.2304 0.2288
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0021 0.0027 0.0065
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0074 0.0347 0.0327
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0223 0.1275
Echinococcus multilocularis somatostatin receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0021 0.0027 0.0043
Toxoplasma gondii ABC1 family protein 0.0036 0.0122 0.0103
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0027 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0222 0.0529
Onchocerca volvulus 0.009 0.0443 0.091
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0122 0.0101
Leishmania major hypothetical protein, conserved 0.0055 0.0231 0.0211
Echinococcus multilocularis neuropeptide receptor 0.0399 0.2304 0.2288
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0055 0.0231 0.1325
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Schistosoma mansoni biogenic amine receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Echinococcus granulosus Solute carrier family 22 5 0.1026 0.6087 0.6079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0399 0.2304 0.2288
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Loa Loa (eye worm) hypothetical protein 0.0056 0.024 0.0223
Echinococcus multilocularis fmrfamide receptor 0.0399 0.2304 0.2288
Brugia malayi neuropeptide F receptor 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0862 0.0843
Brugia malayi Dopamine receptor protein 1 0.0399 0.2304 0.2288
Mycobacterium ulcerans beta-lactamase 0.0036 0.0122 0.0103
Echinococcus granulosus sex peptide receptor 0.0399 0.2304 0.2288
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0044 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0231 0.0213
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0231 0.0552
Echinococcus granulosus neuropeptides capa receptor 0.0399 0.2304 0.2288
Echinococcus multilocularis neuropeptide s receptor 0.0399 0.2304 0.2288
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0181 0.016
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0108 0.0551 0.0531
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.005 0.0032
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0027 0.0007
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0108 0.0551 0.0531
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0122 0.0103
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0021 0.0027 0.0043
Echinococcus granulosus geminin 0.0172 0.094 0.0921
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Brugia malayi G-protein coupled receptor 0.0399 0.2304 0.2288
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0435 0.1037
Loa Loa (eye worm) PDE1B protein 0.1206 0.7166 0.7161
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0055 0.0231 0.0213
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0108 0.0551 0.1314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0399 0.2304 0.2288
Echinococcus granulosus peptide allatostatin:somatostatin 0.0399 0.2304 0.2288
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0103 0.0524 0.0504
Schistosoma mansoni biogenic amine (5HT) receptor 0.0399 0.2304 0.2288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0181 0.016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0399 0.2304 0.2288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0399 0.2304 0.2288
Onchocerca volvulus 0.0399 0.2304 0.5424
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.013 0.069
Mycobacterium ulcerans hypothetical protein 0.0036 0.0122 0.0103
Plasmodium vivax importin-beta 2, putative 0.0029 0.0077 0.0058
Brugia malayi Pre-SET motif family protein 0.009 0.0443 0.0423
Echinococcus granulosus allatostatin A receptor 0.0399 0.2304 0.2288
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0231 0.0211
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0399 0.2304 0.2288
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0122 0.0103
Onchocerca volvulus 0.0399 0.2304 0.5424
Brugia malayi GnHR receptor homolog 0.0399 0.2304 0.2288
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0399 0.2304 0.2288
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0231 0.0211
Leishmania major hypothetical protein, conserved 0.0024 0.005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Loa Loa (eye worm) acetyltransferase 0.014 0.0748 0.0731
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0231 0.0213
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0122 0.0103
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0055 0.0231 0.0211
Echinococcus granulosus g protein coupled receptor 0.0399 0.2304 0.2288
Loa Loa (eye worm) G-protein coupled receptor 0.0399 0.2304 0.229
Echinococcus granulosus lamin 0.0027 0.0068 0.0047
Echinococcus multilocularis serotonin receptor 0.0399 0.2304 0.2288
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1611 0.5
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0231 0.0213
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0021 0.0027 0.0065
Brugia malayi Melatonin receptor type 1A 0.0399 0.2304 0.2288
Schistosoma mansoni alpha-1 adrenergic receptor 0.0399 0.2304 0.2288
Brugia malayi hypoxia-induced factor 1 0.0153 0.0824 0.0806
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0181 0.016
Loa Loa (eye worm) hypothetical protein 0.0399 0.2304 0.229
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0032
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0231 0.0211
Schistosoma mansoni hypothetical protein 0.0309 0.1762 0.1745
Schistosoma mansoni neuropeptide receptor 0.0399 0.2304 0.2288

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.6 nM In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes ChEMBL. 15686911
Ki (binding) = 3.6 nM In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes ChEMBL. 15686911
Ki (binding) = 9.67 nM In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes ChEMBL. 15686911
Ki (binding) = 9.67 nM In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes ChEMBL. 15686911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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