Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0594 | 0.6275 | 1 |
Brugia malayi | lactate dehydrogenase. | 0.0573 | 0.5919 | 0.5919 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0226 | 0.0052 | 0.0052 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Giardia lamblia | Malate dehydrogenase | 0.0223 | 0 | 0.5 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0573 | 0.5919 | 0.9432 |
Schistosoma mansoni | malate dehydrogenase | 0.0573 | 0.5919 | 0.5919 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0814 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0814 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0573 | 0.5919 | 0.5919 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0573 | 0.5919 | 0.5919 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0594 | 0.6275 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0573 | 0.5919 | 0.5919 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0573 | 0.5919 | 0.5919 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0573 | 0.5919 | 0.5919 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0573 | 0.5919 | 0.9432 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.035 | 0.2155 | 0.2155 |
Echinococcus granulosus | dihydrofolate reductase | 0.0814 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0594 | 0.6275 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0573 | 0.5919 | 0.5919 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0573 | 0.5919 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0814 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0573 | 0.5919 | 0.5919 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0602 | 0.641 | 0.641 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0226 | 0.0052 | 0.0052 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0594 | 0.6275 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0814 | 1 | 1 |
Echinococcus granulosus | L lactate dehydrogenase | 0.035 | 0.2155 | 0.2155 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0814 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0573 | 0.5919 | 0.5919 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0573 | 0.5919 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0594 | 0.6275 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Plasmodium vivax | lactate dehydrogenase | 0.0573 | 0.5919 | 0.9432 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0602 | 0.641 | 0.641 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0594 | 0.6275 | 1 |
Brugia malayi | thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0226 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0573 | 0.5919 | 0.5919 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0573 | 0.5919 | 0.5919 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0814 | 1 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0573 | 0.5919 | 0.9432 |
Schistosoma mansoni | dihydrofolate reductase | 0.0814 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0602 | 0.641 | 0.641 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0223 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0421 | 0.3349 | 0.3349 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0814 | 1 | 1 |
Plasmodium falciparum | malate dehydrogenase | 0.0573 | 0.5919 | 0.9432 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0573 | 0.5919 | 0.5919 |
Onchocerca volvulus | 0.0226 | 0.0052 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 92 nM | Binding affinity against Adenosine A2a receptor determined using [3H]-ZM-241,385 as radioligand | ChEMBL. | 15341934 |
Ki (binding) | = 92 nM | Binding affinity against Adenosine A2a receptor determined using [3H]-ZM-241,385 as radioligand | ChEMBL. | 15341934 |
Ki (binding) | > 500 nM | Binding affinity against Adenosine A1 receptor from rat cerebral cortex was determined using [3H]-DPCPX as radioligand | ChEMBL. | 15341934 |
Ki (binding) | > 500 nM | Binding affinity against Adenosine A1 receptor from rat cerebral cortex was determined using [3H]-DPCPX as radioligand | ChEMBL. | 15341934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.