Detailed information for compound 334641

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.541 | Formula: C27H32O3
  • H donors: 2 H acceptors: 2 LogP: 5.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/[C@@]1(O)CCC2[C@@]1(C)CCC1C2CCc2c1ccc(c2)O
  • InChi: 1S/C27H32O3/c1-26-14-12-23-22-10-6-20(28)17-19(22)5-9-24(23)25(26)13-16-27(26,29)15-11-18-3-7-21(30-2)8-4-18/h3-4,6-8,10-11,15,17,23-25,28-29H,5,9,12-14,16H2,1-2H3/b15-11-/t23?,24?,25?,26-,27-/m0/s1
  • InChiKey: CMHYUFRDMXRNOT-SYSICWMVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0222 0.0232
Loa Loa (eye worm) melatonin receptor type 1A 0.0128 0.1311 0.2554
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Trypanosoma cruzi cruzipain precursor, putative 0.0156 0.1668 0.3234
Plasmodium vivax vivapain-1 0.003 0.0065 0.0103
Echinococcus multilocularis mitogen activated protein kinase 11 0.0426 0.5088 0.6064
Trypanosoma brucei carbonic anhydrase-like protein 0.0412 0.492 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0151 0.1597 1
Echinococcus granulosus lactate dehydrogenase a 0.0266 0.3061 0.3041
Echinococcus granulosus cytosolic malate dehydrogenase 0.0151 0.1597 0.1574
Brugia malayi G protein-coupled receptor F59B2.13 0.0128 0.1311 0.1806
Schistosoma mansoni growth hormone secretagogue receptor 0.0128 0.1311 0.2664
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0151 0.1597 0.3094
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.038 0.1144
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0128 0.1311 0.1537
Echinococcus multilocularis lactate dehydrogenase protein 0.0266 0.3061 0.3635
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0059 0.0426 0.2175
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) TYRA-2 protein 0.0128 0.1311 0.2554
Trypanosoma brucei cytosolic malate dehydrogenase 0.0151 0.1597 0.3094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis g-protein coupled receptor 0.0128 0.1311 0.1537
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Loa Loa (eye worm) CYP4Cod1 0.006 0.0448 0.0853
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1537
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0144 0.151 0.2922
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0128 0.1311 0.1537
Echinococcus granulosus neuropeptide FF receptor 2 0.0128 0.1311 0.1286
Echinococcus granulosus lactate dehydrogenase a 0.0266 0.3061 0.3041
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.1311 0.2554
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trichomonas vaginalis malate dehydrogenase, putative 0.0061 0.046 0.2723
Chlamydia trachomatis malate dehydrogenase 0.0151 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0065 0.0062
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.4318 0.8478
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0065 0.0037
Schistosoma mansoni myosin xvIII 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0426 0.5088 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) intermediate filament protein 0.0057 0.04 0.0759
Brugia malayi larval opioid receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Echinococcus granulosus lamin 0.0057 0.04 0.0373
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Echinococcus granulosus peptide allatostatin:somatostatin 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Echinococcus multilocularis conserved hypothetical protein 0.0684 0.8371 1
Plasmodium vivax vivapain-2 0.0059 0.0426 0.1295
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0128 0.1311 0.2554
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0144 0.151 0.2922
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni neuropeptide f receptor 76f 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0151 0.1597 0.2212
Echinococcus multilocularis neuropeptide FF receptor 2 0.0128 0.1311 0.1537
Schistosoma mansoni patched 1 0.0042 0.0215 0.0437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.0426 0.1295
Loa Loa (eye worm) carbonic anhydrase 3 0.0412 0.492 0.9669
Echinococcus granulosus tumor protein p63 0.0343 0.4036 0.4019
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0126 0.1278 0.4111
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Schistosoma mansoni malate dehydrogenase 0.0266 0.3061 0.6222
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0112 0.011
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0426 0.2175
Loa Loa (eye worm) ctsf protein 0.0059 0.0426 0.0809
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Schistosoma mansoni malate dehydrogenase 0.0151 0.1597 0.3247
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0223 0.2518 0.3514
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0128 0.1311 0.1286
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0215 0.0187
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.022 0.0614
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0426 0.1295
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0128 0.1311 0.2664
Brugia malayi RE15519p 0.0128 0.1311 0.1806
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus neuropeptide receptor A26 0.0128 0.1311 0.1286
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0222 0.0407
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Echinococcus multilocularis lamin 0.0057 0.04 0.0445
Schistosoma mansoni lamin 0.0057 0.04 0.0813
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Loa Loa (eye worm) hypothetical protein 0.0057 0.04 0.0759
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.1311 0.2664
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0065 0.0044
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0271 0.0552
Brugia malayi follicle stimulating hormone receptor 0.0128 0.1311 0.1806
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Onchocerca volvulus 0.0128 0.1311 1
Plasmodium falciparum L-lactate dehydrogenase 0.0266 0.3061 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Leishmania major carbonic anhydrase-like protein 0.0412 0.492 0.9668
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Onchocerca volvulus 0.0128 0.1311 1
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0151 0.1597 0.1881
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0412 0.492 0.9668
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0128 0.1311 0.2664
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Echinococcus granulosus 7tm_1 domain containing protein 0.0128 0.1311 0.1286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.018 0.0482
Schistosoma mansoni intermediate filament proteins 0.0057 0.04 0.0813
Mycobacterium ulcerans malate dehydrogenase 0.0151 0.1597 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0065 0.0062
Toxoplasma gondii malate dehydrogenase MDH 0.0266 0.3061 1
Brugia malayi Serotonin receptor 0.0584 0.7104 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.1062 0.2033
Echinococcus multilocularis cysteine protease 0.0059 0.0426 0.0476
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0128 0.1311 0.1806
Trypanosoma cruzi malate dehydrogenase, putative 0.0126 0.1278 0.2463
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni L-lactate dehydrogenase 0.0126 0.1278 0.2598
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Onchocerca volvulus 0.0059 0.0426 0.2175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0335 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Onchocerca volvulus 0.0128 0.1311 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0311 0.0392
Loa Loa (eye worm) hypothetical protein 0.0365 0.4318 0.8483
Toxoplasma gondii lactate dehydrogenase LDH1 0.0266 0.3061 1
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Leishmania major malate dehydrogenase, putative 0.0126 0.1278 0.2463
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0448 0.0853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus granulosus neuropeptide receptor 0.0128 0.1311 0.1286
Echinococcus granulosus L lactate dehydrogenase 0.014 0.1464 0.144
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) fibroinase 0.0059 0.0426 0.0809
Echinococcus granulosus G protein coupled receptor 139 0.0128 0.1311 0.1286
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Brugia malayi ORL1-like opioid receptor 0.0128 0.1311 0.1806
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0144 0.151 0.2089
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.0426 0.2506
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0426 0.0775
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.1311 0.1286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.0426 0.0809
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0412 0.492 0.9668
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1511 0.2089
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.018 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.4318 0.606
Entamoeba histolytica cysteine proteinase 2 0.003 0.0065 0.0103
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.1311 0.2554
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0616 0.1924
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0412 0.492 0.9669
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.0418
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0412 0.492 1
Brugia malayi Serotonin receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis G protein coupled receptor 139 0.0248 0.2837 0.3367
Brugia malayi Dopamine receptor protein 2 0.0128 0.1311 0.1806
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.0426 0.1295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0128 0.1311 0.1537
Echinococcus granulosus cathepsin l1 0.0059 0.0426 0.0398
Onchocerca volvulus 0.0074 0.0616 0.3859
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0128 0.1311 0.1537
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0222 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0175 0.0466
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.1311 0.1286
Echinococcus granulosus mitogen activated protein kinase 11 0.0426 0.5088 0.5074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0311 0.0583
Brugia malayi G-protein coupled receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis mitogen activated protein kinase 11 0.0426 0.5088 0.6064
Mycobacterium ulcerans hypothetical protein 0.0074 0.0616 0.194
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0426 0.0476
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Schistosoma mansoni neuropeptide receptor 0.0248 0.2837 0.5767
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Entamoeba histolytica malate dehydrogenase, putative 0.0151 0.1597 0.5165
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0924 0.2941
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Echinococcus granulosus lactate dehydrogenase protein 0.0266 0.3061 0.3041
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Onchocerca volvulus 0.0059 0.0426 0.2175
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Trichomonas vaginalis malate dehydrogenase, putative 0.0126 0.1278 0.7959
Plasmodium falciparum malate dehydrogenase 0.0266 0.3061 1
Loa Loa (eye worm) malate dehydrogenase 0.0144 0.151 0.2948
Schistosoma mansoni hypothetical protein 0.0223 0.2518 0.5119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Onchocerca volvulus 0.005 0.0319 0.1232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus neuropeptide s receptor 0.0128 0.1311 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni hypothetical protein 0.0128 0.1311 0.2664
Echinococcus granulosus serotonin receptor 0.0128 0.1311 0.1286
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0065 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1457 0.1433
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0223 0.2518 0.4935
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0426 0.5088 1
Onchocerca volvulus 0.0128 0.1311 1
Schistosoma mansoni adenoreceptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0394
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0616 0.194
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Brugia malayi AKH receptor 0.0128 0.1311 0.1806
Echinococcus granulosus somatostatin receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis cathepsin L 0.003 0.0065 0.0044
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1511 0.3071
Echinococcus multilocularis mitogen activated protein kinase 14 0.0426 0.5088 0.6064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.04 0.0518
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0426 0.1295
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.1311 0.1537
Echinococcus granulosus cathepsin L 0.003 0.0065 0.0037
Onchocerca volvulus 0.0128 0.1311 1
Schistosoma mansoni lamin 0.0057 0.04 0.0813
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.1311 0.2554
Echinococcus multilocularis L lactate dehydrogenase 0.014 0.1464 0.1721
Echinococcus multilocularis dro:myosuppressin receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis protein patched 0.0042 0.0215 0.0224
Schistosoma mansoni malate dehydrogenase 0.0151 0.1597 0.3247
Schistosoma mansoni hypothetical protein 0.0034 0.0112 0.0227
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) malate dehydrogenase 0.0151 0.1597 0.3119
Brugia malayi sulfakinin receptor protein 0.0128 0.1311 0.1806
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0065 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1286
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0426 0.0809
Loa Loa (eye worm) hypothetical protein 0.0223 0.2518 0.4935
Echinococcus multilocularis carbonic anhydrase II 0.0412 0.492 0.5863
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Echinococcus granulosus carbonic anhydrase 0.0223 0.2518 0.2497
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0144 0.151 0.2922
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0616 0.194
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Echinococcus multilocularis neuropeptide receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0128 0.1311 0.1537
Giardia lamblia Malate dehydrogenase 0.0151 0.1597 1
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Schistosoma mansoni histamine h1 receptor 0.0128 0.1311 0.2664
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0187 0.2052 0.4015
Loa Loa (eye worm) hypothetical protein 0.0266 0.3061 0.6004
Brugia malayi GnHR receptor homolog 0.0128 0.1311 0.1806
Brugia malayi putative neuropeptide receptor NPR1 0.0128 0.1311 0.1806
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0065 0.0103
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Brugia malayi putative neuropeptide receptor 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0059 0.0426 0.0809
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus granulosus intermediate filament protein 0.0057 0.04 0.0373
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0065 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0412 0.492 0.6911
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0448 0.0853
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0128 0.1311 0.2664
Brugia malayi Dopamine receptor 0.0128 0.1311 0.1806
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.022 0.1188
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1286
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.022 0.1188
Echinococcus granulosus fmrfamide receptor 0.0128 0.1311 0.1286
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.0426 0.1295
Echinococcus multilocularis orexin receptor type 2 0.0128 0.1311 0.1537
Toxoplasma gondii cathepsin CPL 0.0059 0.0426 0.1295
Onchocerca volvulus Cathepsin F homolog 0.0059 0.0426 0.2175
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.0426 0.0398
Onchocerca volvulus 0.0057 0.04 0.1948
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0175 0.0901
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Echinococcus multilocularis sex peptide receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis neuropeptide receptor A26 0.0128 0.1311 0.1537
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus carbonic anhydrase II 0.0412 0.492 0.4905
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0616 0.194
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Onchocerca volvulus 0.0059 0.0426 0.2175
Echinococcus granulosus malate dehydrogenase 0.0144 0.151 0.1486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Plasmodium vivax unspecified product 0.003 0.0065 0.0103
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.1311 0.2664
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus cytosolic malate dehydrogenase 0.0151 0.1597 0.1574
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.0975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0426 0.0476
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0128 0.1311 0.2664
Echinococcus granulosus malate dehydrogenase 0.0144 0.151 0.1486
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Leishmania major malate dehydrogenase, putative 0.0266 0.3061 0.599
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0128 0.1311 0.2664
Loa Loa (eye worm) cysteine protease 0.0059 0.0426 0.0809
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0616 0.2185
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Onchocerca volvulus 0.0128 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0112 0.019
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0128 0.1311 0.2554
Brugia malayi intermediate filament protein 0.0057 0.04 0.0518
Brugia malayi CHE-14 protein 0.0042 0.0215 0.0256
Schistosoma mansoni L-lactate dehydrogenase 0.0266 0.3061 0.6222
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0128 0.1311 0.2554
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1459 0.1435
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0215 0.0187
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.0426 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0059 0.0426 0.2175
Loa Loa (eye worm) acetyltransferase 0.0144 0.1511 0.2948
Plasmodium vivax vivapain-3 0.003 0.0065 0.0103
Onchocerca volvulus 0.0128 0.1311 1
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.1311 0.1286
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0151 0.1597 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0426 0.5088 0.5074
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0924 0.1074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0223 0.2518 0.3514
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Trypanosoma cruzi malate dehydrogenase, putative 0.0144 0.151 0.2922
Onchocerca volvulus 0.0059 0.0426 0.2175
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.006 0.0448 0.0558
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.1311 0.2664
Brugia malayi Cytochrome P450 family protein 0.006 0.0448 0.0586
Echinococcus granulosus allatostatin A receptor 0.0128 0.1311 0.1286
Leishmania major cytochrome p450-like protein 0.006 0.0448 0.0819
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0128 0.1311 0.1286
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Onchocerca volvulus Cathepsin L homolog 0.0059 0.0426 0.2175
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.1311 0.1286
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0128 0.1311 0.1286
Brugia malayi Cathepsin L-like precursor 0.0039 0.018 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.1668 0.3234
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Onchocerca volvulus 0.0059 0.0426 0.2175
Echinococcus granulosus lamin dm0 0.0057 0.04 0.0373
Echinococcus multilocularis cysteine protease 0.0059 0.0426 0.0476
Loa Loa (eye worm) hypothetical protein 0.0056 0.0387 0.0733
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Loa Loa (eye worm) hypothetical protein 0.0098 0.0924 0.1792
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0426 0.0865
Echinococcus multilocularis neuropeptide receptor 0.0248 0.2837 0.3367
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.0324
Echinococcus multilocularis tumor protein p63 0.0343 0.4036 0.4804
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Brugia malayi P38 map kinase family protein 2 0.0426 0.5088 0.7149
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0128 0.1311 0.1806
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.1311 0.1537
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0266 0.3061 0.3635
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0266 0.3061 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0128 0.1311 0.2554
Leishmania major cytosolic malate dehydrogenase 0.0151 0.1597 0.3094
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0426 0.0554
Echinococcus multilocularis allatostatin A receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1511 0.1777
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0267
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Echinococcus granulosus neuropeptide receptor 0.0248 0.2837 0.2817
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.018 0.0933
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0311 0.0392
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0223 0.2518 0.3514
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.1185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0151 0.1597 0.3094
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0175 0.0466
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Toxoplasma gondii hypothetical protein 0.0223 0.2518 0.8208
Echinococcus multilocularis fmrfamide receptor 0.0128 0.1311 0.1537
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.0426 0.0398
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Brugia malayi Cathepsin L-like precursor 0.0039 0.018 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.018 0.0933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0426 0.0865
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Echinococcus multilocularis musashi 0.0057 0.04 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus granulosus tachykinin peptides receptor 99D 0.0128 0.1311 0.1286
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0426 0.5088 1
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0034 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1311 0.2664
Echinococcus granulosus sex peptide receptor 0.0128 0.1311 0.1286
Onchocerca volvulus 0.0057 0.04 0.1948
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Brugia malayi Cytochrome P450 family protein 0.006 0.0448 0.0586
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Toxoplasma gondii lactate dehydrogenase LDH2 0.0266 0.3061 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0128 0.1311 0.1286
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus multilocularis malate dehydrogenase 0.0144 0.151 0.1776
Trypanosoma brucei glycosomal malate dehydrogenase 0.0144 0.151 0.2922
Onchocerca volvulus 0.0128 0.1311 1
Plasmodium vivax malate dehydrogenase, putative 0.0266 0.3061 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0215 0.0224
Leishmania major glycosomal malate dehydrogenase 0.0144 0.151 0.2922
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis carbonic anhydrase 0.0223 0.2518 0.2985
Brugia malayi neuropeptide F receptor 0.0128 0.1311 0.1806
Entamoeba histolytica cysteine protease, putative 0.003 0.0065 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0065 0.0199
Onchocerca volvulus 0.0128 0.1311 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0128 0.1311 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Brugia malayi Cathepsin L-like precursor 0.0059 0.0426 0.0554
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1457 0.1713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0065 0.0062
Schistosoma mansoni carbonic anhydrase-related 0.0223 0.2518 0.5119
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0616 0.0824
Plasmodium falciparum carbonic anhydrase 0.0223 0.2518 0.8208
Echinococcus multilocularis malate dehydrogenase 0.0144 0.151 0.1776
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0616 0.1152
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Echinococcus multilocularis serotonin receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0412 0.492 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0319 0.0649
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0151 0.1597 0.1881
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Brugia malayi cathepsin L-like precursor 0.0039 0.018 0.0206
Trypanosoma brucei cytochrome P450, putative 0.006 0.0448 0.0819
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0128 0.1311 0.1286
Schistosoma mansoni malate dehydrogenase 0.0144 0.151 0.307
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.0975
Echinococcus multilocularis neuropeptide s receptor 0.0128 0.1311 0.1537
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0065 0.0103
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0412 0.492 0.6911
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.022 0.0192
Echinococcus granulosus L lactate dehydrogenase B chain 0.0266 0.3061 0.3041
Schistosoma mansoni biogenic amine receptor 0.0128 0.1311 0.2664
Echinococcus granulosus cathepsin l1 0.0039 0.018 0.0152
Echinococcus multilocularis serotonin receptor 0.0128 0.1311 0.1537
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.04 0.0759
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0144 0.151 0.2922
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Onchocerca volvulus 0.0128 0.1311 1
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0065 0.0132
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis protein dispatched 1 0.0048 0.029 0.0314
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.1311 0.1537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Schistosoma mansoni neuropeptide receptor 0.0128 0.1311 0.2664
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0128 0.1311 0.1806
Trichomonas vaginalis malate dehydrogenase, putative 0.0086 0.0779 0.4764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Schistosoma mansoni amine GPCR 0.0128 0.1311 0.2664
Leishmania major cathepsin L-like protease 0.0059 0.0426 0.0775
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0616 0.1924
Echinococcus multilocularis mitogen activated protein kinase 14 0.0426 0.5088 0.6064
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.022 0.0614
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0128 0.1311 0.2664
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0616 0.2185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0065 0.0062
Leishmania major malate dehydrogenase 0.0144 0.151 0.2922
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.038 0.0304
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0924 0.1259
Echinococcus granulosus cysteine protease 0.003 0.0065 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Echinococcus granulosus orexin receptor type 2 0.0128 0.1311 0.1286
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0067 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.1311 0.2664
Brugia malayi hypothetical protein 0.0128 0.1311 0.1806
Brugia malayi Dopamine receptor protein 1 0.0128 0.1311 0.1806
Echinococcus granulosus flap endonuclease 1 0.0028 0.0034 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.1311 0.2664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0065 0.0199
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.018 0.0206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0616 0.194
Echinococcus multilocularis lamin dm0 0.0057 0.04 0.0445
Leishmania major mitochondrial malate dehydrogenase 0.0144 0.151 0.2922
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.022 0.0614
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.4318 0.8478
Brugia malayi neuropeptide F receptor 0.0128 0.1311 0.1806
Leishmania major cathepsin L-like protease 0.0156 0.1668 0.3234
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0067 0.0101
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0924 0.0898
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0222 0.0194
Brugia malayi Tachykinin-like peptides receptor 99D 0.0128 0.1311 0.1806
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0271 0.0552
Onchocerca volvulus 0.0128 0.1311 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.1311 0.1286
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0151 0.1597 0.5165
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.0055 0.038 0.0719
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.4318 0.8478
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0943 0.1917
Leishmania major cysteine peptidase A (CPA) 0.0059 0.0426 0.0775
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Echinococcus multilocularis fmrfamide receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0215 0.1158
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0065 0.0062
Schistosoma mansoni alpha-1 adrenergic receptor 0.0128 0.1311 0.2664
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.1311 0.1286
Plasmodium falciparum lactate dehydrogenase, putative 0.0126 0.1278 0.4111
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0128 0.1311 0.1537
Schistosoma mansoni opsin-like receptor 0.0128 0.1311 0.2664
Loa Loa (eye worm) hypothetical protein 0.005 0.0311 0.0583
Echinococcus multilocularis g protein coupled receptor 0.0128 0.1311 0.1537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0426 0.2506
Echinococcus granulosus g-protein coupled receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis expressed conserved protein 0.0092 0.0849 0.0983
Echinococcus granulosus alpha 1A adrenergic receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.1311 0.1537
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0137 0.1422 0.2747
Loa Loa (eye worm) hypothetical protein 0.0128 0.1311 0.2554
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0448 0.0819
Echinococcus multilocularis G-protein coupled receptor, putative 0.0128 0.1311 0.1537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.1311 0.2664
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0616 0.1924
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0215 0.0394
Echinococcus granulosus expressed conserved protein 0.0092 0.0849 0.0823
Brugia malayi G protein-coupled receptor 0.0128 0.1311 0.1806
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.0426 0.0476
Onchocerca volvulus 0.0128 0.1311 1
Trypanosoma brucei malate dehydrogenase-related 0.0126 0.1278 0.2463
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Entamoeba histolytica malate dehydrogenase, putative 0.0266 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0319 0.0599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Brugia malayi G-protein coupled receptor 0.0128 0.1311 0.1806
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.1597 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0034 0.0037
Schistosoma mansoni carbonic anhydrase 0.0223 0.2518 0.5119
Trypanosoma cruzi cysteine protease, putative 0.003 0.0065 0.0062
Onchocerca volvulus Neuropeptide F receptor homolog 0.0128 0.1311 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.0426 0.0476
Brugia malayi lactate dehydrogenase. 0.0266 0.3061 0.4282
Echinococcus multilocularis lactate dehydrogenase a 0.0266 0.3061 0.3635
Brugia malayi Melatonin receptor type 1A 0.0128 0.1311 0.1806
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0151 0.1597 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0128 0.1311 0.1537
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.038 0.1144
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0448 0.0819
Echinococcus granulosus g protein coupled receptor 0.0128 0.1311 0.1286
Plasmodium vivax lactate dehydrogenase 0.0266 0.3061 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1311 0.1286
Echinococcus granulosus dro:myosuppressin receptor 0.0128 0.1311 0.1286
Echinococcus multilocularis somatostatin receptor 0.0128 0.1311 0.1537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.1668 0.3234
Plasmodium vivax vivapain-2 0.0059 0.0426 0.1295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.1311 0.1537
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0128 0.1311 0.1537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.1311 0.1537

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) = 20 % Relative binding affinity of Z isomers to human ERalpha-HBD at 4C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 32 % Relative binding affinity of E isomers to human ERalpha-HBD at 25 degree C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 36 % Relative binding affinity of E isomers to human ERalpha-HBD at 4C compared to [3H]-estradiol ChEMBL. 15974584
RBA (binding) = 39 % Relative binding affinity of Z isomers to human ERalpha-HBD at 25 degree C compared to [3H]-estradiol ChEMBL. 15974584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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