TDR Targets

Basic information

Technical information

TDR Targets ID: 335716
Name: 1-pentylimidazo[4,5-c]quinolin-4-amine
MW: 254.33 | Formula: C15H18N4
H donors: 1 H acceptors: 2 LogP: 3.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCn1cnc2c1c1ccccc1nc2N
InChi: 1S/C15H18N4/c1-2-3-6-9-19-10-17-13-14(19)11-7-4-5-8-12(11)18-15(13)16/h4-5,7-8,10H,2-3,6,9H2,1H3,(H2,16,18)
InChiKey: QMWNFUBKQDOJAI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-pentyl-4-imidazo[4,5-c]quinolinamine
(1-amylimidazo[4,5-c]quinolin-4-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Bromodomain containing protein	0.0087	0.0684	0.1206
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0045	0.0105	0.0105
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0134	0.1317	0.2322
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0109	0.0977	0.193
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0109	0.0977	0.193
Brugia malayi	hypothetical protein	0.0454	0.5672	1
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0045	0.0105	0.0041
Brugia malayi	Adenine phosphoribosyltransferase	0.0044	0.0097	0.017
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0044	0.0097	0.0097
Echinococcus multilocularis	microtubule associated protein 2	0.0773	1	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1317	0.2189
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0044	0.0097	0.0097
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0281	0.3314	0.7053
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0219	0.247	0.247
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0617	0.0933
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0109	0.0977	0.193
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0281	0.3314	0.7053
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Schistosoma mansoni	bromodomain containing protein	0.0074	0.0499	0.0499
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0219	0.247	0.247
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.0357	0.0357
Onchocerca volvulus		0.0053	0.0218	0.0218
Echinococcus granulosus	solute carrier family 5	0.0045	0.0105	0.0105
Schistosoma mansoni	lozenge	0.0057	0.0273	0.0273
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0045	0.0105	0.0105
Brugia malayi	Sodium:solute symporter family protein	0.0045	0.0105	0.0184
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0195	0.0343
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0045	0.0105	0.0105
Schistosoma mansoni	single-minded	0.0071	0.046	0.046
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0105	0.0014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0195	0.0195
Brugia malayi	GH02984p	0.0404	0.4994	0.8804
Onchocerca volvulus		0.0045	0.0105	0.0014
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0097	0.0097
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.038	0.4659	1
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0.0977	0.4501
Loa Loa (eye worm)	hypothetical protein	0.0454	0.5672	1
Schistosoma mansoni	microtubule-associated protein tau	0.0773	1	1
Echinococcus multilocularis	high affinity choline transporter 1	0.0404	0.4994	0.4994
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0045	0.0105	0.0105
Loa Loa (eye worm)	mbt repeat family protein	0.0056	0.0253	0.028
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0109	0.0977	0.1906
Onchocerca volvulus		0.0188	0.2053	0.3509
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.0253	0.0253
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.0212	0.2379	0.5004
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0188	0.2053	0.4288
Onchocerca volvulus		0.0454	0.5672	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0056	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0454	0.5672	1
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	1
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0109	0.0977	0.193
Echinococcus granulosus	single minded 2	0.0052	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0404	0.4994	0.8784
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0044	0.0097	0.0097
Schistosoma mansoni	hypothetical protein	0.0337	0.4083	0.4083
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0281	0.3314	0.7053
Echinococcus multilocularis	polycomb protein SCMH1	0.0056	0.0253	0.0253
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0097	0.0097
Loa Loa (eye worm)	MBCTL1	0.0063	0.0357	0.0467
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0188	0.2053	0.3619
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0105	0.0015
Echinococcus granulosus	sodium:glucose cotransporter	0.0045	0.0105	0.0105
Treponema pallidum	penicillin-binding protein (pbp-3)	0.0212	0.2379	0.4941
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0153	0.1575	0.1575
Onchocerca volvulus		0.0056	0.0253	0.028
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0045	0.0105	0.0105
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0384	0.4717	1
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0056	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0253	0.028
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0143	0.0083
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0067	0.0067
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0195	0.0195
Schistosoma mansoni	inositol transporter	0.0045	0.0105	0.0105
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.0357	0.0357
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0188	0.2053	1
Entamoeba histolytica	hypothetical protein	0.0037	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1567	0.2637
Echinococcus granulosus	polycomb protein SCMH1	0.0056	0.0253	0.0253
Schistosoma mansoni	inositol transporter	0.0045	0.0105	0.0105
Brugia malayi	Bromodomain containing protein	0.0045	0.0104	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0195	0.0195
Schistosoma mansoni	high-affinity choline transporter	0.0404	0.4994	0.4994
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.0097	0.0097
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.0357	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1325	0.2203
Entamoeba histolytica	hypothetical protein	0.0037	0	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0067	0.0067
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0195	0.0195
Echinococcus granulosus	SAM and MBT domain containing protein	0.0056	0.0253	0.0253
Chlamydia trachomatis	transglycolase/transpeptidase	0.0384	0.4717	1
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.0253	0.0253
Echinococcus multilocularis	Protein lozenge	0.0057	0.0273	0.0273
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0109	0.0977	0.193
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Loa Loa (eye worm)	hypothetical protein	0.005	0.0173	0.0137
Echinococcus multilocularis	solute carrier family 5	0.0045	0.0105	0.0105
Echinococcus multilocularis	transfer RNA-Lys	0.0052	0.021	0.021
Schistosoma mansoni	aryl hydrocarbon receptor	0.0205	0.2286	0.2286
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0056	0.0253	0.028
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0384	0.4717	1
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.038	0.4659	1
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0044	0.0097	0.0097
Echinococcus granulosus	aryl hydrocarbon receptor	0.0153	0.1575	0.1575
Schistosoma mansoni	sodium/solute symporter	0.0045	0.0105	0.0105
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0188	0.2053	0.2053
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0195	0.0195
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0144	0.1455	0.2977
Entamoeba histolytica	hypothetical protein	0.0037	0	0.5
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0442	0.0442
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0045	0.0105	0.0105
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.0097	0.0097
Brugia malayi	PAS domain containing protein	0.0071	0.046	0.0811
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0044	0.0097	0.0097
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0195	0.0195
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.0357	0.0357
Brugia malayi	mbt repeat family protein	0.0056	0.0253	0.0445
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0188	0.2053	1
Brugia malayi	mbt repeat family protein	0.0056	0.0253	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0357	0.0467
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0195	0.0195
Leishmania major	xanthine phosphoribosyltransferase	0.0188	0.2053	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.0357	0.0357
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0044	0.0097	0.017
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0195	0.0176
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0044	0.0097	0.0097
Loa Loa (eye worm)	runx1	0.0057	0.0273	0.0316
Giardia lamblia	Guanine phosphoribosyltransferase	0.0188	0.2053	1
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0188	0.2053	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0442	0.0442
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0144	0.1455	0.2977
Echinococcus granulosus	high affinity choline transporter 1	0.0404	0.4994	0.4994
Mycobacterium ulcerans	putative regulatory protein	0.0052	0.021	0.0249
Brugia malayi	bHLH-PAS transcription factor	0.0052	0.021	0.037
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.038	0.4659	1
Entamoeba histolytica	hypothetical protein	0.0037	0	0.5
Onchocerca volvulus		0.0152	0.1567	0.2637

Activities

Activity type	Activity value	Assay description	Source	Reference
MEC (functional)	= 0.5 ug ml-1	Minimum effective concentration required to induce interferon (IFN) production in human peripheral blood mononuclear cells (hPBMC)	ChEMBL.	15887957

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11196114

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 335716