Detailed information for compound 336150

Basic information

Technical information
  • TDR Targets ID: 336150
  • Name: cyclobutyl(diphosphonomethyl)azanium
  • MW: 246.115 | Formula: C5H14NO6P2+
  • H donors: 5 H acceptors: 6 LogP: -4.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=O)(C(P(=O)(O)O)[NH2+]C1CCC1)O
  • InChi: 1S/C5H13NO6P2/c7-13(8,9)5(14(10,11)12)6-4-2-1-3-4/h4-6H,1-3H2,(H2,7,8,9)(H2,10,11,12)/p+1
  • InChiKey: UNLQCNUHOMXEEC-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • cyclobutyl(diphosphonomethyl)ammonium
  • cyclobutyl-(diphosphonomethyl)azanium
  • cyclobutyl-(diphosphonomethyl)ammonium
  • AIDS-231618
  • AIDS231618
  • Phosphonic acid, [(cyclobutylamino)methylene]bis-, conjugate acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Echinococcus multilocularis cysteine protease 0.0078 0.0536 0.0536
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0252 0.0252
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.1097
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0036 0.0059 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0536 0.1551
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0036 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0124 0.1057 1
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0124 0.1057 0.3372
Loa Loa (eye worm) hypothetical protein 0.0908 1 1
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0031 0 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0252 0.4706
Giardia lamblia Cathepsin B precursor 0.0306 0.3133 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Onchocerca volvulus 0.0078 0.0536 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.0059 0.0556
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0059 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0252 0.4706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Onchocerca volvulus Dual oxidase homolog 0.0072 0.047 0.862
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0036 0.0059 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Brugia malayi cathepsin L precursor 0.0036 0.0059 0.0059
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0036 0.0059 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Plasmodium vivax unspecified product 0.0053 0.0252 0.2386
Toxoplasma gondii cathepsin CPC2 0.0036 0.0059 0.0188
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0306 0.3133 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0059 0.0059
Giardia lamblia Farnesyl diphosphate synthase 0.0124 0.1057 0.3246
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0252 0.0252
Brugia malayi cathepsin L-like cysteine proteinase 0.0036 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0536 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0908 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0124 0.1057 0.1057
Brugia malayi Cathepsin L-like cysteine proteinase 0.0061 0.0342 0.0342
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0036 0.0059 0.0556
Plasmodium vivax vivapain-2 0.0078 0.0536 0.5069
Loa Loa (eye worm) fibroinase 0.0078 0.0536 0.0536
Loa Loa (eye worm) cysteine protease 0.0078 0.0536 0.0536
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Onchocerca volvulus 0.0078 0.0536 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0252 0.0252
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.0059 0.0556
Trypanosoma cruzi major cysteine proteinase, putative 0.0036 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0342 0.0922
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Giardia lamblia Cathepsin B precursor 0.0306 0.3133 1
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0252 0.4706
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0036 0.0059 0.0059
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0036 0.0059 0.0556
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0536 0.0536
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0036 0.0059 0.0556
Echinococcus multilocularis cathepsin L 0.0053 0.0252 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0908 1 1
Echinococcus granulosus cathepsin L 0.0036 0.0059 0.0059
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0252 0.2386
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0536 0.0536
Loa Loa (eye worm) blistered cuticle protein 3 0.0072 0.047 0.047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0908 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0252 0.0252
Brugia malayi Blistered cuticle protein 3 0.0072 0.047 0.047
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0342 0.0922
Echinococcus granulosus cysteine protease 0.0053 0.0252 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0908 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.0059 0.0556
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0036 0.0059 0.0556
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Onchocerca volvulus 0.0078 0.0536 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0061 0.0342 0.0342
Loa Loa (eye worm) polyprenyl synthetase 0.0124 0.1057 0.1057
Plasmodium falciparum serine repeat antigen 6 0.0036 0.0059 0.0556
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0036 0.0059 0.1097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0536 1
Schistosoma mansoni cathepsin S (C01 family) 0.0036 0.0059 0.0059
Plasmodium vivax vivapain-1 0.0053 0.0252 0.2386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Onchocerca volvulus 0.0078 0.0536 1
Leishmania major farnesyl pyrophosphate synthase 0.0124 0.1057 0.3372
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0306 0.3133 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0252 0.0629
Toxoplasma gondii preprocathepsin c precursor, putative 0.0036 0.0059 0.0188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0059 0.0059
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0034 0.0031 0.01
Entamoeba histolytica cysteine protease, putative 0.0078 0.0536 1
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0536 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0036 0.0059 0.0059
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0252 0.4706
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0124 0.1057 1
Loa Loa (eye worm) ctsf protein 0.0078 0.0536 0.0536
Plasmodium falciparum serine repeat antigen 1 0.0036 0.0059 0.0556
Echinococcus granulosus cathepsin l1 0.0078 0.0536 0.0536
Echinococcus multilocularis cathepsin L 0.0036 0.0059 0.0059
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Loa Loa (eye worm) hypothetical protein 0.0078 0.0536 0.0536
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0536 0.0536
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0536 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0036 0.0059 0.0059
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.0059 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Schistosoma mansoni cathepsin B (C01 family) 0.0036 0.0059 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0059 0.0059
Leishmania major ferric reductase, putative 0.0034 0.0031 0.01
Plasmodium vivax vivapain-3 0.0053 0.0252 0.2386
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0124 0.1057 0.3246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Schistosoma mansoni cathepsin C 0.0036 0.0059 0.0059
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0124 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Onchocerca volvulus 0.0078 0.0536 1
Plasmodium vivax unspecified product 0.0036 0.0059 0.0556
Brugia malayi Cathepsin L-like precursor 0.0061 0.0342 0.0342
Brugia malayi Cathepsin L-like precursor 0.0061 0.0342 0.0342
Plasmodium falciparum serine repeat antigen 2 0.0036 0.0059 0.0556
Giardia lamblia Cathepsin B precursor 0.0306 0.3133 1
Toxoplasma gondii cathepsin CPL 0.0078 0.0536 0.1709
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0342 0.0342
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0536 0.1709
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0059 0.0059
Brugia malayi cathepsin L-like precursor 0.0061 0.0342 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0061 0.0342 0.0342
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0036 0.0059 0.1097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Echinococcus granulosus cathepsin b 0.0908 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Echinococcus multilocularis cathepsin b 0.0908 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0252 0.4706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0342 0.0342
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0124 0.1057 0.3372
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0059 0.0059
Onchocerca volvulus 0.0078 0.0536 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0306 0.3133 0.3133
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0031 0 0.5
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0124 0.1057 0.1057
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0536 0.0536
Onchocerca volvulus 0.0078 0.0536 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Onchocerca volvulus 0.0061 0.0342 0.5946
Loa Loa (eye worm) cathepsin B 0.0306 0.3133 0.3133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0536 0.0536
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.0059 0.0059
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0252 0.0252
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0031 0.0031
Plasmodium falciparum serine repeat antigen 4 0.0036 0.0059 0.0556
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Echinococcus granulosus cathepsin L 0.0053 0.0252 0.0252
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0536 0.5069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0252 0.0805
Plasmodium falciparum serine repeat antigen 9 0.0036 0.0059 0.0556
Plasmodium falciparum serine repeat antigen 8 0.0036 0.0059 0.0556
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0036 0.0059 0.0556
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0031 0.0031
Trypanosoma cruzi major cysteine proteinase, putative 0.0036 0.0059 0.0059
Echinococcus multilocularis cysteine protease 0.0078 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Plasmodium falciparum serine repeat antigen 5 0.0036 0.0059 0.0556
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0536 0.0536
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0342 0.6391
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0536 0.1709
Echinococcus multilocularis cathepsin b 0.0908 1 1
Brugia malayi fibroinase precursor 0.0036 0.0059 0.0059
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0124 0.1057 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0036 0.0059 0.0556
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0252 0.0252
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0124 0.1057 0.3246
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0536 0.1551
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0036 0.0059 0.0556
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0252 0.0252
Plasmodium falciparum serine repeat antigen 3 0.0036 0.0059 0.0556
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0536 0.5069
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0059 0.0059
Plasmodium vivax vivapain-2 0.0078 0.0536 0.5069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.3133 0.3133
Plasmodium falciparum serine repeat antigen 7 0.0036 0.0059 0.0556
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0252 0.0629
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0536 0.5069
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0124 0.1057 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.0059 0.0059
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0036 0.0059 0.0556
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0124 0.1057 0.3246
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0252 0.0252
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0252 0.4706
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0124 0.1057 0.1057
Treponema pallidum octaprenyl-diphosphate synthase 0.0031 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0252 0.0805
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0536 0.0536
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0536 0.1551
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0252 0.0252
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0031 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0536 0.1551
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0536 0.0536
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0536 0.0536
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0124 0.1057 0.1057
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0031 0 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0536 0.0536
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0536 0.0536
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0124 0.1057 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0252 0.4706
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0536 0.0536
Toxoplasma gondii cathepsin B 0.0306 0.3133 1
Brugia malayi Cathepsin L-like precursor 0.0078 0.0536 0.0536
Echinococcus granulosus cathepsin b 0.0908 1 1
Echinococcus granulosus cathepsin l1 0.0061 0.0342 0.0342
Entamoeba histolytica cysteine protease, putative 0.0036 0.0059 0.1097
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0908 1 1
Toxoplasma gondii cathepsin CPC1 0.0036 0.0059 0.0188
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0061 0.0342 0.0342
Brugia malayi Polyprenyl synthetase family protein 0.0124 0.1057 0.1057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0059 0.0059
Trypanosoma brucei cysteine peptidase C (CPC) 0.0306 0.3133 1
Leishmania major cathepsin L-like protease 0.0078 0.0536 0.1709
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0059 0.0059

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 120.9 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
LD50 (functional) = 260 uM Lethal dose required to inhibit the growth of human KB (nasopharyngeal carcinoma) cell line ChEMBL. 15857119
TI (functional) = 2.15 Therapeutic index (TI) value as ratio of lethal dose (LD50) to the inhibitory concentration (IC50) ChEMBL. 15857119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.