TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.403 | Formula: C21H21FN2O
H donors: 0 H acceptors: 1 LogP: 3.92 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)c1oc(c(c1)c1ccncc1)c1ccc(cc1)F
InChi: 1S/C21H21FN2O/c1-24-12-8-16(9-13-24)20-14-19(15-6-10-23-11-7-15)21(25-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16H,8-9,12-13H2,1H3
InChiKey: SEUSQHGEXNTGPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Eimeria tenella	cGMP-dependent protein kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	expressed protein	0.0032	0.0307	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0344	0.0344
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0344	0.05
Brugia malayi	Carboxylesterase family protein	0.0025	0.0217	0.0317
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.129	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.006	0.0658	0.0625
Brugia malayi	Temporarily assigned gene name protein 44	0.0027	0.0235	0.0364
Brugia malayi	tumor suppressor.	0.0315	0.3904	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.129	1
Mycobacterium ulcerans	hypothetical protein	0.0059	0.0653	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0344	1
Onchocerca volvulus		0.0056	0.0605	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0344	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0344	0.2548
Brugia malayi	hypothetical protein	0.0025	0.0217	0.0317
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0032	0.0307	0.0555
Loa Loa (eye worm)	carboxylesterase	0.0025	0.0217	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Brugia malayi	Carboxylesterase family protein	0.0025	0.0217	0.0317
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0605	0.1336
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.129	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.129	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0025	0.0217	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0344	0.05
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Schistosoma mansoni	hypothetical protein	0.0011	0.0035	0.0035
Leishmania major	hypothetical protein, conserved	0.0024	0.0206	0.1599
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0344	0.2548
Echinococcus multilocularis	microtubule associated protein 2	0.067	0.8431	0.8426
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0344	0.05
Trypanosoma brucei	hypothetical protein	0.011	0.129	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.006	0.0658	0.0625
Echinococcus granulosus	carboxylesterase 5A	0.0149	0.1798	0.1769
Echinococcus granulosus	protein quaking	0.0027	0.0234	0.02
Schistosoma mansoni	cpg binding protein	0.0059	0.0645	0.0645
Echinococcus granulosus	microtubule associated protein 2	0.067	0.8431	0.8426
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.011	0.129	1
Echinococcus multilocularis	expressed conserved protein	0.006	0.0658	0.0625
Brugia malayi	Egg laying defective protein 4	0.006	0.0658	0.1474
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0072	0.0037
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0206	0.1523
Echinococcus multilocularis	carboxylesterase 5A	0.0149	0.1798	0.1769
Brugia malayi	beta-lactamase	0.0035	0.0344	0.0651
Mycobacterium ulcerans	lipase LipD	0.0035	0.0344	0.2921
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0025	0.0217	0.0183
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0112	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0658	0.0658
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0344	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0235	0.0316
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0149	0.1798	0.1798
Brugia malayi	beta-lactamase family protein	0.0035	0.0344	0.0651
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0298	0.2182
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0344	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0344	0.0651
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0298	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0072	0.0072
Schistosoma mansoni	gliotactin	0.0025	0.0217	0.0217
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0344	0.05
Echinococcus granulosus	cpg binding protein	0.0059	0.0645	0.0613
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0344	0.05
Trichomonas vaginalis	spcc417.12 protein, putative	0.0025	0.0217	0.5579
Loa Loa (eye worm)	carboxylesterase	0.0025	0.0217	0.0269
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0466	0.0925
Trichomonas vaginalis	rotamase, putative	0.0032	0.0298	0.8386
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.129	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.006	0.0658	0.0625
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.2763	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1798	0.4442
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0298	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Schistosoma mansoni	hypothetical protein	0.0793	1	1
Loa Loa (eye worm)	AGC/PKG protein kinase	0.006	0.0658	0.1432
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0344	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0072	0.0037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0466	0.0432
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0344	0.2921
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0466	0.0432
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.129	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0344	0.2921
Onchocerca volvulus		0.0035	0.0344	0.3281
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.129	1
Schistosoma mansoni	hypothetical protein	0.033	0.4098	0.4098
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0344	0.2548
Echinococcus granulosus	acetylcholinesterase	0.0149	0.1798	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0344	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0025	0.0217	0.0183
Brugia malayi	hypothetical protein	0.0024	0.0206	0.0289
Echinococcus granulosus	para nitrobenzyl esterase	0.0025	0.0217	0.0183
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.006	0.0658	0.5225
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0344	0.031
Schistosoma mansoni	hypothetical protein	0.0027	0.0234	0.0234
Trypanosoma brucei	calpain, putative	0.011	0.129	1
Echinococcus granulosus	BC026374 protein S09 family	0.0025	0.0217	0.0183
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0344	0.05
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0106	0.124	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0344	1
Plasmodium falciparum	cGMP-dependent protein kinase	0.006	0.0658	1
Brugia malayi	Carboxylesterase family protein	0.0149	0.1798	0.4469
Schistosoma mansoni	hypothetical protein	0.033	0.4098	0.4098
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0658	0.0658
Trichomonas vaginalis	esterase, putative	0.0035	0.0344	1
Brugia malayi	Carboxylesterase family protein	0.0025	0.0217	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0344	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0115	0.008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0466	0.0432
Toxoplasma gondii	ABC1 family protein	0.0035	0.0344	0.2654
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0206	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0241
Brugia malayi	hypothetical protein	0.0027	0.0235	0.0364
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.129	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0344	0.05
Trichomonas vaginalis	rotamase, putative	0.0032	0.0307	0.8723
Trypanosoma brucei	calpain-like protein, putative	0.011	0.129	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0217	0.0217
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0344	0.05
Echinococcus granulosus	acetylcholinesterase	0.0149	0.1798	0.1769
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0217	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269
Echinococcus granulosus	neuroligin	0.0025	0.0217	0.0183
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0344	0.0605
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0206	0.1462
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0344	0.5
Brugia malayi	Carboxylesterase family protein	0.0025	0.0217	0.0317
Echinococcus multilocularis	acetylcholinesterase	0.0149	0.1798	0.1769
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.011	0.129	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.129	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0466	0.0432
Schistosoma mansoni	hypothetical protein	0.0027	0.0234	0.0234
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0466	0.0466
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0466	0.097
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0118	0.14	0.14
Schistosoma mansoni	acetylcholinesterase	0.0025	0.0217	0.0217
Onchocerca volvulus		0.0035	0.0344	0.3281
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0605	0.1293
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0072	0.0037
Echinococcus granulosus	hypothetical protein	0.0027	0.0234	0.02
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0025	0.0217	0.0217
Schistosoma mansoni	cpg binding protein	0.0056	0.0605	0.0605
Loa Loa (eye worm)	carboxylesterase	0.0149	0.1798	0.4442
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0025	0.0217	0.5579
Echinococcus multilocularis	cpg binding protein	0.0059	0.0645	0.0613
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0298	0.2182
Leishmania major	hypothetical protein, conserved	0.0035	0.0344	0.2667
Brugia malayi	Carboxylesterase family protein	0.0149	0.1798	0.4469
Echinococcus multilocularis	acetylcholinesterase	0.0149	0.1798	0.1769
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0344	0.0344
Brugia malayi	beta-lactamase family protein	0.0035	0.0344	0.0651
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.001	0.0021	0.016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1798	0.4442
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0344	0.05
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0.0021	0.5
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0025	0.0217	0.0183
Echinococcus multilocularis	protein quaking	0.0027	0.0234	0.02
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0344	0.0605
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0206	0.1462
Schistosoma mansoni	BC026374 protein (S09 family)	0.0025	0.0217	0.0217
Echinococcus multilocularis	geminin	0.033	0.4098	0.4077
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.011	0.129	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.129	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.129	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0298	0.2182
Echinococcus multilocularis	dnaJ subfamily B	0.0793	1	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0025	0.0217	0.0217
Echinococcus granulosus	cGMP dependent protein kinase	0.006	0.0658	0.0625
Echinococcus granulosus	expressed protein	0.0032	0.0307	0.0273
Schistosoma mansoni	rotamase	0.0032	0.0307	0.0307
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0115	0.008
Loa Loa (eye worm)	tumor suppressor	0.0315	0.3904	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0072	0.0037
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0344	0.05
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0298	0.2307
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0344	1
Echinococcus granulosus	geminin	0.033	0.4098	0.4077
Echinococcus granulosus	cGMP dependent protein kinase 1	0.006	0.0658	0.0625
Schistosoma mansoni	microtubule-associated protein tau	0.067	0.8431	0.8431
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0344	0.031
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.129	1
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0032	0.0307	0.0508
Loa Loa (eye worm)	acetylcholinesterase 1	0.0149	0.1798	0.4442
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0344	0.2921
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0307	0.8723
Onchocerca volvulus		0.0035	0.0344	0.3281
Echinococcus multilocularis	neuroligin	0.0025	0.0217	0.0183
Schistosoma mansoni	cpg binding protein	0.0059	0.0645	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0217	0.0269

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	< 50 %	Anticoccidial activity (percent reduction in oocyst production) against Eimeria tenella in white leghorn chickens at 100 ppm	ChEMBL.	15922595
Activity (functional)	= 79 %	Anticoccidial activity (percent reduction in oocyst production) against Eimeria acervulina in white leghorn chickens at 100 ppm; Range= 50-79 %	ChEMBL.	15922595
IC50 (binding)	= 2.1 nM	In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	15922595
IC50 (binding)	= 2.1 nM	In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	15922595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL435110

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 336325