Detailed information for compound 337106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.353 | Formula: C22H26Cl2NO2-
  • H donors: 0 H acceptors: 0 LogP: 5.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1CC2N(C1C[C@H](C2)OC(c1ccc(cc1)Cl)c1ccccc1)C.[Cl-]
  • InChi: 1S/C22H26ClNO2.ClH/c1-24-18-12-19(14-20(24)21(13-18)25-2)26-22(15-6-4-3-5-7-15)16-8-10-17(23)11-9-16;/h3-11,18-22H,12-14H2,1-2H3;1H/p-1/t18?,19-,20?,21-,22?;/m0./s1
  • InChiKey: UCNVSBQROAIZQM-PTBTZKMRSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.0213 0.0067 0.1613
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0003 0.0003
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0 0.0009
Echinococcus multilocularis serotonin transporter 0.0109 0.0031 0.0755
Schistosoma mansoni neuropeptide f receptor 76f 0.0213 0.0067 0.1613
Schistosoma mansoni neuropeptide receptor 0.0213 0.0067 0.1613
Chlamydia trachomatis DNA ligase 0.002 0 0.0001
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0028 0.0003 0.0075
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0007 0.0172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0 0.0005
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0016 0.0382
Brugia malayi nuclear hormone receptor 0.0021 0.0001 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0003 0.007
Schistosoma mansoni topbp1 0.002 0 0.0009
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0213 0.0067 0.1613
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0031 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Onchocerca volvulus 0.0154 0.0047 0.1125
Loa Loa (eye worm) G-protein coupled receptor 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.0236 0.0075 0.1808
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.001 0.001
Brugia malayi hypothetical protein 0.0032 0.0005 0.0115
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0007 0.0172
Echinococcus granulosus neuropeptide FF receptor 2 0.0213 0.0067 0.1613
Plasmodium vivax replication factor C subunit 1, putative 0.002 0 0.0009
Echinococcus granulosus geminin 0.0342 0.0111 0.2687
Schistosoma mansoni intermediate filament proteins 0.0027 0.0003 0.0074
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0001 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0011 0.0263
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0016 0.0382
Trypanosoma brucei trypanothione reductase 0.0048 0.001 0.0238
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.002 0 0.0009
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0003 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0016 0.0382
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0016 0.0382
Schistosoma mansoni opsin-like receptor 0.0213 0.0067 0.1613
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0001 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0017 0.0423
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Brugia malayi neuropeptide F receptor 0.0213 0.0067 0.1613
Echinococcus granulosus dro:myosuppressin receptor 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0058 0.0013 0.0324
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Schistosoma mansoni hypothetical protein 0.0342 0.0111 0.2687
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0003 0.0074
Schistosoma mansoni hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0001 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0029 0.069
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Brugia malayi neuropeptide F receptor 0.0213 0.0067 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0009 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Brugia malayi Melatonin receptor type 1A 0.0213 0.0067 0.1613
Entamoeba histolytica hypothetical protein 0.002 0 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0213 0.0067 0.1613
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 2.9136 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0213 0.0067 0.1613
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0213 0.0067 0.1613
Entamoeba histolytica hypothetical protein 0.0038 0.0007 0.0156
Brugia malayi hypothetical protein 0.005 0.0011 0.0263
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0213 0.0067 0.1613
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.1223 0.0414 1
Onchocerca volvulus 0.0021 0.0001 0.0017
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0007 0.0172
Loa Loa (eye worm) RNA binding protein 0.0065 0.0016 0.0382
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0074
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0 0.0004
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.0096 0.2316
Brugia malayi hypothetical protein 0.0154 0.0047 0.1125
Brugia malayi ecdysteroid receptor 0.0021 0.0001 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0007 0.0161
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0031 0.0755
Brugia malayi GnHR receptor homolog 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Onchocerca volvulus 0.1223 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0001 0.0017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0213 0.0067 0.1613
Schistosoma mansoni DNA ligase IV 0.002 0 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0001 0.0017
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 1.1075 0.3797 1
Brugia malayi hypothetical protein 0.0038 0.0007 0.0161
Onchocerca volvulus 0.0213 0.0067 0.1613
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0001 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0213 0.0067 0.1613
Brugia malayi G-protein coupled receptor 0.0213 0.0067 0.1613
Brugia malayi steroid hormone receptor 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis nibrin 0.002 0 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0016 0.0382
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0003 0.0075
Echinococcus granulosus intermediate filament protein 0.0027 0.0003 0.0074
Echinococcus granulosus peptide allatostatin:somatostatin 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0017
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0007 0.0007
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.1223 0.0414 0.0413
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0213 0.0067 0.1613
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0005 0.0113
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis lamin dm0 0.0027 0.0003 0.0074
Loa Loa (eye worm) inositol-1 0.004 0.0007 0.0177
Schistosoma mansoni amine GPCR 0.0213 0.0067 0.1613
Toxoplasma gondii ATPase, AAA family protein 0.002 0 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0009 0.0221
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis sex peptide receptor 0.0213 0.0067 0.1613
Leishmania major trypanothione reductase 0.0048 0.001 0.0238
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0031 0.0755
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0003 0.007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0005 0.0113
Echinococcus granulosus replication factor c subunit 1 0.002 0 0.0009
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0 0.0004
Brugia malayi ORL1-like opioid receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis fmrfamide receptor 0.0213 0.0067 0.1613
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0213 0.0067 0.1613
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0001 0.0017
Onchocerca volvulus 0.0213 0.0067 0.1613
Echinococcus multilocularis G-protein coupled receptor, putative 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.1223 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0 0.0009
Echinococcus granulosus fmrfamide receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0007 0.0177
Schistosoma mansoni lamin 0.0027 0.0003 0.0074
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0011 0.0263
Onchocerca volvulus 0.0109 0.0031 0.0755
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0032 0.0005 0.0113
Echinococcus multilocularis g-protein coupled receptor 0.0213 0.0067 0.1613
Plasmodium falciparum thioredoxin reductase 0.0048 0.001 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0001 0.0017
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0044 0.0043
Brugia malayi TAR-binding protein 0.0065 0.0016 0.0382
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0009 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0001 0.0017
Echinococcus multilocularis neuropeptide FF receptor 2 0.0213 0.0067 0.1613
Schistosoma mansoni growth hormone secretagogue receptor 0.0213 0.0067 0.1613
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.1223 0.0414 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0016 0.0391
Echinococcus multilocularis neuropeptide Y receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus nibrin 0.002 0 0.0009
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0213 0.0067 0.1613
Plasmodium vivax glutathione reductase, putative 0.0048 0.001 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0001 0.0017
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0113
Brugia malayi Pax transcription activation domain interacting protein 0.002 0 0.0009
Schistosoma mansoni lamin 0.0027 0.0003 0.0074
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0031 0.0755
Schistosoma mansoni ap endonuclease 0.0019 0 0.0005
Echinococcus granulosus tumor protein p63 0.0393 0.0129 0.3112
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0007 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0001 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Brugia malayi Serotonin receptor 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.001 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0035 0.0856
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0016 0.0386
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0016 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0017
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0003 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0003 0.007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0005 0.0113
Brugia malayi AKH receptor 0.0213 0.0067 0.1613
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0003 0.0003
Echinococcus granulosus g-protein coupled receptor 0.0213 0.0067 0.1613
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0001 0.0017
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0016 0.0391
Echinococcus granulosus g protein coupled receptor 0.0213 0.0067 0.1613
Brugia malayi intermediate filament protein 0.0027 0.0003 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0009 0.0221
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0109 0.0031 0.0755
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0001 0.0017
Echinococcus granulosus serotonin transporter 0.0109 0.0031 0.0755
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0075 0.1808
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0001 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Echinococcus granulosus neuropeptide receptor A26 0.0213 0.0067 0.1613
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor 0.0213 0.0067 0.1613
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Echinococcus granulosus sex peptide receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0058 0.0013 0.0324
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 1.1075 0.3797 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Brugia malayi glutathione reductase 0.0048 0.001 0.0243
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni biogenic amine (5HT) receptor 0.0213 0.0067 0.1613
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0003 0.0074
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0109 0.0031 0.0755
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.001 0.0243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0017
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi Tachykinin-like peptides receptor 99D 0.0213 0.0067 0.1613
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0003 0.007
Brugia malayi putative neuropeptide receptor 0.0213 0.0067 0.1613
Brugia malayi sulfakinin receptor protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0001 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0009 0.0221
Schistosoma mansoni alpha-1 adrenergic receptor 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus tm gpcr rhodopsin 0.0213 0.0067 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Schistosoma mansoni biogenic amine receptor 0.0213 0.0067 0.1613
Onchocerca volvulus Neuropeptide F receptor homolog 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0001 0.0017
Schistosoma mansoni coup transcription factor 0.0021 0.0001 0.0017
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0213 0.0067 0.1613
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0011 0.0258
Schistosoma mansoni hypothetical protein 0.007 0.0017 0.0423
Schistosoma mansoni hypothetical protein 0.0213 0.0067 0.1613
Leishmania major hypothetical protein, conserved 0.005 0.0011 0.0258
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0213 0.0067 0.1613
Schistosoma mansoni inositol monophosphatase 0.004 0.0007 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0003 0.007
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.1223 0.0414 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0044 0.0043
Echinococcus multilocularis serotonin receptor 0.0213 0.0067 0.1613
Schistosoma mansoni neuropeptide F-like receptor 0.0213 0.0067 0.1613
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0029 0.069
Echinococcus granulosus neuropeptide receptor 0.0213 0.0067 0.1613
Echinococcus granulosus neuropeptides capa receptor 0.0213 0.0067 0.1613
Echinococcus granulosus allatostatin A receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis tumor protein p63 0.0393 0.0129 0.3112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0213 0.0067 0.1613
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.1223 0.0414 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0011 0.0263
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0016 0.0382
Schistosoma mansoni myosin xvIII 0.0213 0.0067 0.1613
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0001 0.0017
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.1223 0.0414 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0001 0.0017
Echinococcus multilocularis dro:myosuppressin receptor 0.0213 0.0067 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0009 0.0221
Echinococcus granulosus lamin 0.0027 0.0003 0.0074
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0031 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0213 0.0067 0.1613
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0001 0.0017
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0213 0.0067 0.1613
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.001 0.0246
Loa Loa (eye worm) hypothetical protein 0.0109 0.0031 0.0755
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0213 0.0067 0.1613
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0013 0.0324
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni biogenic amine receptor 0.0213 0.0067 0.1613
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0003 0.0003
Echinococcus granulosus serotonin receptor 0.0213 0.0067 0.1613
Trichomonas vaginalis conserved hypothetical protein 0.002 0 0.0004
Echinococcus granulosus somatostatin receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0213 0.0067 0.1613
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0001 0.0017
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0001 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0003 0.0075
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0001 0.0017
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0001 0.0017
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0 0.0004
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0 0.0004
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0031 0.0755
Schistosoma mansoni opsin-like receptor 0.0213 0.0067 0.1613
Echinococcus granulosus tar DNA binding protein 0.0065 0.0016 0.0382
Schistosoma mansoni survival motor neuron protein 0.0048 0.001 0.0246
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0113
Loa Loa (eye worm) glutathione reductase 0.0048 0.001 0.0243
Toxoplasma gondii exonuclease III APE 0.0019 0 0.0005
Brugia malayi G protein-coupled receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0154 0.0047 0.1125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0001 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0035 0.0035
Echinococcus granulosus microtubule associated protein 2 0.0803 0.027 0.6516
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trichomonas vaginalis conserved hypothetical protein 0.002 0 0.0004
Echinococcus granulosus lamin dm0 0.0027 0.0003 0.0074
Schistosoma mansoni hypothetical protein 0.0038 0.0007 0.0161
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0035 0.0856
Loa Loa (eye worm) neuropeptide F receptor 0.0213 0.0067 0.1613
Brugia malayi follicle stimulating hormone receptor 0.0213 0.0067 0.1613
Schistosoma mansoni topbp1 0.002 0 0.0009
Echinococcus granulosus hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0213 0.0067 0.1613
Echinococcus granulosus orexin receptor type 2 0.0213 0.0067 0.1613
Echinococcus granulosus 7tm_1 domain containing protein 0.0213 0.0067 0.1613
Echinococcus multilocularis neuropeptide receptor 0.0213 0.0067 0.1613
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0031 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0029 0.069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.0005
Schistosoma mansoni amine GPCR 0.0213 0.0067 0.1613
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0213 0.0067 0.1613
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0001 0.0017
Echinococcus granulosus g protein coupled receptor 0.0213 0.0067 0.1613
Schistosoma mansoni adenoreceptor 0.0213 0.0067 0.1613
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Brugia malayi MH2 domain containing protein 0.0122 0.0035 0.0856
Brugia malayi G-protein coupled receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0001 0.0017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0005 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0213 0.0067 0.1613
Brugia malayi Dopamine receptor protein 1 0.0213 0.0067 0.1613
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0003 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0213 0.0067 0.1613
Brugia malayi putative neuropeptide receptor NPR1 0.0213 0.0067 0.1613
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0001 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.002 0 0.0004
Brugia malayi larval opioid receptor 0.0213 0.0067 0.1613
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0009 0.0221
Plasmodium falciparum glutathione reductase 0.0048 0.001 0.0243
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0342 0.0111 0.2687
Schistosoma mansoni microtubule-associated protein tau 0.0803 0.027 0.6516
Onchocerca volvulus 0.0213 0.0067 0.1613
Mycobacterium ulcerans hypothetical protein 0.0028 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.002 0 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0011 0.0263
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0075
Onchocerca volvulus 0.0027 0.0003 0.0074
Onchocerca volvulus 0.0213 0.0067 0.1613
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Echinococcus multilocularis microtubule associated protein 2 0.0803 0.027 0.6516
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0001 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0001 0.0017
Echinococcus multilocularis musashi 0.0027 0.0003 0.0074
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus G protein coupled receptor 139 0.0213 0.0067 0.1613
Echinococcus multilocularis replication factor c subunit 1 0.002 0 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0213 0.0067 0.1613
Echinococcus granulosus alpha 1A adrenergic receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0007 0.0172
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0048 0.001 0.0246
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.0113
Brugia malayi DKFZp564C0469 protein 0.002 0 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0213 0.0067 0.1613
Giardia lamblia Replication factor C, subunit 1 0.002 0 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0016 0.0391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0017
Loa Loa (eye worm) neuropeptide F receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0001 0.0017
Brugia malayi hypothetical protein 0.0213 0.0067 0.1613
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0001 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0016 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0213 0.0067 0.1613
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0213 0.0067 0.1613
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Echinococcus multilocularis somatostatin receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis g protein coupled receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) TYRA-2 protein 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0001 0.0017
Brugia malayi Dopamine receptor protein 2 0.0213 0.0067 0.1613
Echinococcus multilocularis orexin receptor type 2 0.0213 0.0067 0.1613
Echinococcus multilocularis serotonin receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis neuropeptides capa receptor 0.0213 0.0067 0.1613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0016 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0001 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus 7TM GPCR rhodopsin 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0007 0.0161
Brugia malayi Serotonin receptor 0.0213 0.0067 0.1613
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0213 0.0067 0.1613
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0075 0.1808
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.0213 0.0067 0.1613
Brugia malayi G protein-coupled receptor F59B2.13 0.0213 0.0067 0.1613
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0003 0.007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0213 0.0067 0.1613
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0011 0.0258
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 2.9136 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Echinococcus multilocularis neuropeptide receptor A26 0.0213 0.0067 0.1613
Echinococcus multilocularis G protein coupled receptor 139 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0213 0.0067 0.1613
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0007 0.0172
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0031 0.0755
Entamoeba histolytica hypothetical protein 0.0038 0.0007 0.0156
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.0031 0.0082
Onchocerca volvulus 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0213 0.0067 0.1613
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0003 0.0003
Schistosoma mansoni neuropeptide receptor 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Loa Loa (eye worm) melatonin receptor type 1A 0.0213 0.0067 0.1613
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0001 0.0017
Onchocerca volvulus 0.0213 0.0067 0.1613
Brugia malayi topoisomerase 0.002 0 0.0009
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0 0.0004
Brugia malayi Dopamine receptor 0.0213 0.0067 0.1613
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0213 0.0067 0.1613
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 2.9136 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0213 0.0067 0.1613
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0001 0.0017
Schistosoma mansoni hypothetical protein 0.0048 0.001 0.0246
Onchocerca volvulus 0.002 0 0.0009
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus neuropeptide s receptor 0.0213 0.0067 0.1613
Echinococcus granulosus GPCR family 2 0.0032 0.0005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0213 0.0067 0.1613
Echinococcus granulosus biogenic amine 5HT receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0003 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0213 0.0067 0.1613
Echinococcus granulosus neuropeptides capa receptor 0.0213 0.0067 0.1613
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0007 0.0177
Toxoplasma gondii thioredoxin reductase 0.0048 0.001 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0001 0.0017
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0 0.0004
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0031 0.0755
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0003 0.0003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Brugia malayi RNA binding protein 0.0065 0.0016 0.0382
Echinococcus multilocularis allatostatin A receptor 0.0213 0.0067 0.1613
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.001 0.0243
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0213 0.0067 0.1613
Entamoeba histolytica hypothetical protein 0.0038 0.0007 0.0156
Loa Loa (eye worm) hypothetical protein 0.0102 0.0029 0.069
Brugia malayi Inositol-1 0.004 0.0007 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0001 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0 0.0005
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.1223 0.0414 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0213 0.0067 0.1613
Schistosoma mansoni hypothetical protein 0.0023 0.0001 0.0033
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0031 0.0031
Brugia malayi nuclear receptor NHR-88 0.0021 0.0001 0.0017
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.1223 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0213 0.0067 0.1613
Echinococcus granulosus tm gpcr rhodopsin 0.0213 0.0067 0.1613
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0016 0.0391
Echinococcus multilocularis neuropeptide Y receptor 0.0213 0.0067 0.1613
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0007 0.0161
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0075
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.1223 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Brugia malayi hypothetical protein 0.002 0 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.0011 0.0263
Onchocerca volvulus 0.0027 0.0003 0.0074
Onchocerca volvulus 0.0213 0.0067 0.1613
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0213 0.0067 0.1613
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0035 0.0035
Onchocerca volvulus 0.0213 0.0067 0.1613
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0213 0.0067 0.1613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0001 0.0017
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.1223 0.0414 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0001 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0001 0.0033
Schistosoma mansoni amine GPCR 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0075
Brugia malayi Thioredoxin reductase 0.0048 0.001 0.0243
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0 0.0005
Schistosoma mansoni amine GPCR 0.0213 0.0067 0.1613
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0001 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.002 0 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0016 0.0382
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0213 0.0067 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0001 0.0017
Echinococcus granulosus g protein coupled receptor 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0001 0.0017
Echinococcus granulosus neuropeptide Y receptor 0.0213 0.0067 0.1613
Schistosoma mansoni histamine h1 receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0236 0.0075 0.1808
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0001 0.0017
Echinococcus granulosus neuropeptide Y receptor 0.0213 0.0067 0.1613
Brugia malayi RE15519p 0.0213 0.0067 0.1613
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.001 0.0243
Onchocerca volvulus 0.0213 0.0067 0.1613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0213 0.0067 0.1613
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Schistosoma mansoni neuropeptide receptor 0.0213 0.0067 0.1613
Entamoeba histolytica hypothetical protein 0.0038 0.0007 0.0156
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0213 0.0067 0.1613
Echinococcus multilocularis g protein coupled receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis lamin 0.0027 0.0003 0.0074
Echinococcus multilocularis geminin 0.0342 0.0111 0.2687
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.0096 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.002 0 0.0004
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0006 0.0006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0044 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0009 0.0221
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0213 0.0067 0.1613
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0016 0.0391
Loa Loa (eye worm) hypothetical protein 0.007 0.0017 0.0423
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0001 0.0017
Onchocerca volvulus 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0009 0.0221
Schistosoma mansoni ap endonuclease 0.0019 0 0.0005
Echinococcus multilocularis neuropeptide s receptor 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.0213 0.0067 0.1613
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.1223 0.0414 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0017
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0007 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0005 0.0113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0007 0.0172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.001 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Trypanosoma cruzi hypothetical protein, conserved 0.002 0 0.0004
Schistosoma mansoni inositol monophosphatase 0.004 0.0007 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0016 0.0382
Mycobacterium tuberculosis Probable reductase 0.0109 0.0031 0.0031
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0007 0.0172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.0096 0.2316
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0001 0.0017
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0213 0.0067 0.1613
Schistosoma mansoni amine GPCR 0.0213 0.0067 0.1613
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0011 0.0258
Schistosoma mansoni neuropeptide receptor 0.0213 0.0067 0.1613
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0213 0.0067 0.1613
Echinococcus granulosus rhodopsin orphan GPCR 0.0213 0.0067 0.1613
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0009

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 32 nM Displacement of [3H]-WIN- 35,428 from Dopamine transporter of rat caudate putamen ChEMBL. 15857139
IC50 (functional) = 179 nM Inhibition of [3H]-dopamine uptake into rat striatal synaptosomes ChEMBL. 15857139
IC50 (binding) > 100000 nM Displacement of [3H]-paroxetine from Serotonin transporter of rat caudate putamen ChEMBL. 15857139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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