Detailed information for compound 338390

Basic information

Technical information
  • TDR Targets ID: 338390
  • Name: 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-1,3-thi azol-3-ium-3-yl]decyl]-4-methyl-1,3-thiazol-3 -ium-5-yl]ethanol diiodide
  • MW: 680.488 | Formula: C22H38I2N2O2S2
  • H donors: 2 H acceptors: 2 LogP: 7.15 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCc1sc[n+](c1C)CCCCCCCCCC[n+]1csc(c1C)CCO.[I-].[I-]
  • InChi: 1S/C22H38N2O2S2.2HI/c1-19-21(11-15-25)27-17-23(19)13-9-7-5-3-4-6-8-10-14-24-18-28-22(12-16-26)20(24)2;;/h17-18,25-26H,3-16H2,1-2H3;2*1H/q+2;;/p-2
  • InChiKey: PNTCRJCREMUMDK-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]decyl]-4-methyl-thiazol-3-ium-5-yl]ethanol diiodide
  • 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-3-thiazol-3-iumyl]decyl]-4-methyl-5-thiazol-3-iumyl]ethanol diiodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0043 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Plasmodium vivax vivapain-2 0.0069 0.0075 0.0084
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0069 0.0075 0.0084
Echinococcus multilocularis Zinc finger, PHD finger 0.0063 0.0047 0.0043
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0069 0.0075 0.0098
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.2348
Loa Loa (eye worm) cathepsin B 0.0056 0.0019 0.0019
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0775 0.3125 0.3121
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0043 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0063 0.0047 0.0043
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0063 0.0047 0.0081
Echinococcus multilocularis cysteine protease 0.0069 0.0075 0.0084
Brugia malayi aspartic protease BmAsp-1, identical 0.0201 0.0644 0.0902
Brugia malayi SH2 domain containing protein 0.1191 0.4921 0.6945
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0417 0.1576 0.4574
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0069 0.0075 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.1217 0.7652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) cysteine protease 0.0069 0.0075 0.0098
Echinococcus granulosus cathepsin b 0.0146 0.0406 0.0552
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0146 0.0406 0.0401
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0207 0.06
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni cathepsin D (A01 family) 0.2367 1 1
Entamoeba histolytica hypothetical protein 0.0333 0.1217 0.7652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0019 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Echinococcus granulosus cathepsin l1 0.0069 0.0075 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0849 0.3446 0.4853
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.2348
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.016 0.0468 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0468 0.0653
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0063 0.0047 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0207
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0898 0.3657 0.5159
Toxoplasma gondii aspartyl protease ASP1 0.0849 0.3446 1
Toxoplasma gondii aspartyl protease ASP3 0.0201 0.0644 0.1824
Plasmodium falciparum plasmepsin X 0.0201 0.0644 0.1757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.016 0.0468 0.2751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0138 0.0374 0.1086
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.016 0.0468 0.0639
Loa Loa (eye worm) hypothetical protein 0.0849 0.3446 0.4861
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0417 0.1576 0.4574
Leishmania major phosphatidylinositol 3-kinase, putative 0.0062 0.0043 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0075 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0417 0.1576 0.2219
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus multilocularis cysteine protease 0.0069 0.0075 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0082 0.0131 0.2489
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.016 0.0468 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 0.0207
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0075 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Plasmodium falciparum plasmepsin I 0.0849 0.3446 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0163 0.0222
Loa Loa (eye worm) aspartyl protease 6 0.0201 0.0644 0.0902
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0529
Plasmodium falciparum plasmepsin VII 0.0201 0.0644 0.1757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Toxoplasma gondii cathepsin CPL 0.0069 0.0075 0.0164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Plasmodium vivax aspartyl proteinase, putative 0.0201 0.0644 0.1757
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0417 0.1576 0.4574
Brugia malayi hypothetical protein 0.0201 0.0644 0.0902
Trypanosoma cruzi target of rapamycin kinase 3 0.013 0.0337 0.2044
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Plasmodium vivax plasmepsin IV, putative 0.0849 0.3446 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0043 0.0052
Giardia lamblia GTOR 0.016 0.0468 0.6929
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0359 0.1325 0.1865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Plasmodium falciparum plasmepsin II 0.0849 0.3446 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0957 0.1331
Schistosoma mansoni hypothetical protein 0.0286 0.1011 0.1006
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Loa Loa (eye worm) hypothetical protein 0.0201 0.0644 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0043 0.0037
Echinococcus multilocularis cathepsin b 0.0146 0.0406 0.0552
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0146 0.0406 0.04
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.016 0.0468 0.288
Loa Loa (eye worm) hypothetical protein 0.0069 0.0075 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1691 0.7083 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0303 0.1087 0.1515
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0043 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Leishmania major phosphatidylinositol 3-kinase, putative 0.0063 0.0047 0.0617
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0043 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0849 0.3446 0.3442
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0207
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0062 0.0043 0.0037
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0075 0.0098
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0073 0.0094 0.1669
Loa Loa (eye worm) hypothetical protein 0.1191 0.4921 0.6945
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Plasmodium falciparum plasmepsin VIII, putative 0.0201 0.0644 0.1757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Toxoplasma gondii aspartyl protease 0.0201 0.0644 0.1824
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0417 0.1576 1
Loa Loa (eye worm) hypothetical protein 0.0664 0.2647 0.3732
Loa Loa (eye worm) hypothetical protein 0.0898 0.3657 0.5159
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.016 0.0468 0.0639
Plasmodium falciparum plasmepsin IX 0.0201 0.0644 0.1757
Plasmodium falciparum plasmepsin V 0.0201 0.0644 0.1757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0146 0.0406 0.1178
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0201 0.0644 0.1824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.019 0.0598 0.3601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Loa Loa (eye worm) fibroinase 0.0069 0.0075 0.0098
Plasmodium falciparum plasmepsin III 0.0201 0.0644 0.1757
Brugia malayi RNA binding protein 0.0062 0.0043 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Brugia malayi hypothetical protein 0.0201 0.0644 0.0902
Brugia malayi sulfakinin receptor protein 0.0664 0.2647 0.3732
Loa Loa (eye worm) ctsf protein 0.0069 0.0075 0.0098
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1691 0.7083 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0617
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0178
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0178
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0206 0.0666 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0303 0.1087 0.1515
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0617
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0456 0.1746 0.2458
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0063 0.0047 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0163 0.0222
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0849 0.3446 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Plasmodium falciparum plasmepsin VI 0.0849 0.3446 1
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0468 0.0653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Brugia malayi Pepsin A precursor 0.0201 0.0644 0.0902
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.016 0.0468 0.0462
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0152
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0849 0.3446 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.0957 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Echinococcus granulosus tar DNA binding protein 0.0062 0.0043 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0417 0.1576 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0243 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) hypothetical protein 0.1691 0.7083 1
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1691 0.7083 1
Schistosoma mansoni dopamine-beta-monooxygenase 0.0898 0.3657 0.3653
Loa Loa (eye worm) hypothetical protein 0.0143 0.0396 0.0551
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0063 0.0047 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.8626
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0957 0.1331
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0636 0.2524 0.3549
Echinococcus granulosus expressed conserved protein 0.0286 0.1011 0.1407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0063 0.0047 0.0041
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0289 0.1026 0.2976
Trypanosoma brucei target of rapamycin kinase 3, putative 0.013 0.0337 0.7096
Loa Loa (eye worm) phosphatidylinositol 3 0.0692 0.2766 0.39
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0019 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0075 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0395 0.1483 0.939
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Brugia malayi aspartic protease BmAsp-2, identical 0.0201 0.0644 0.0902
Toxoplasma gondii target of rapamycin (TOR), putative 0.0122 0.0304 0.0831
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.0313 0.0434
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0075 0.0069
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0063 0.0047 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Onchocerca volvulus 0.0201 0.0644 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0105 0.0229 0.3242
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0849 0.3446 0.4853
Entamoeba histolytica cysteine protease, putative 0.0069 0.0075 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Schistosoma mansoni memapsin-2 (A01 family) 0.0201 0.0644 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Brugia malayi Eukaryotic aspartyl protease family protein 0.0201 0.0644 0.0902
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0063 0.0047 0.0136
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0062 0.0043 0.0038
Plasmodium falciparum plasmepsin IV 0.0849 0.3446 1
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0075 0.036
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0063 0.0047 0.0058
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0775 0.3125 0.44
Loa Loa (eye worm) hypothetical protein 0.0201 0.0644 0.0902
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0062 0.0043 0.0529
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0075 0.0069
Leishmania major cysteine peptidase A (CPA) 0.0069 0.0075 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 0.0207
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.0075 0.0098
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.016 0.0468 0.2751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Plasmodium vivax vivapain-2 0.0069 0.0075 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0406 0.0565
Loa Loa (eye worm) RNA binding protein 0.0062 0.0043 0.0052
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0146 0.0406 0.2487
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0075 0.0186
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0152
Echinococcus granulosus cathepsin b 0.0146 0.0406 0.0552
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0442 0.1688 0.2377
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.016 0.0468 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0849 0.3446 0.4861
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0146 0.0406 0.2484
Schistosoma mansoni peptidylglycine monooxygenase 0.0898 0.3657 0.3653
Echinococcus granulosus tachykinin peptides receptor 99D 0.0636 0.2524 0.3549
Echinococcus multilocularis expressed conserved protein 0.0286 0.1011 0.1407
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0146 0.0406 0.1178
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0063 0.0047 0.0041
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0063 0.0047 0.0136
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Onchocerca volvulus 0.0201 0.0644 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0529
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0289 0.1026 0.2976
Brugia malayi cathepsin B-like cysteine proteinase 0.0146 0.0406 0.0566
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Echinococcus granulosus cathepsin L cysteine proteinase 0.0069 0.0075 0.0084
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Brugia malayi TAR-binding protein 0.0062 0.0043 0.0052
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0062 0.0043 0.0038
Plasmodium vivax plasmepsin V, putative 0.0201 0.0644 0.1757
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0417 0.1576 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0069 0.0075 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0201 0.0644 0.0902
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.016 0.0468 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0124 0.0313 0.1885
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0957 0.1344
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0016 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0775 0.3125 0.44
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0257 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0207 0.06
Echinococcus multilocularis cathepsin b 0.0146 0.0406 0.0552
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0016 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.016 0.0468 0.288
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0075 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0146 0.0406 0.1178
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0063 0.0047 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1691 0.7083 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Echinococcus granulosus cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Brugia malayi hypothetical protein 0.0664 0.2647 0.3732
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Plasmodium vivax aspartyl proteinase, putative 0.0849 0.3446 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.013 0.0337 0.7096
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 34 nM In vitro inhibitory concentration of the compound against Plasmodium falciparum ChEMBL. 15887971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.