Detailed information for compound 338390

Basic information

Technical information
  • TDR Targets ID: 338390
  • Name: 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-1,3-thi azol-3-ium-3-yl]decyl]-4-methyl-1,3-thiazol-3 -ium-5-yl]ethanol diiodide
  • MW: 680.488 | Formula: C22H38I2N2O2S2
  • H donors: 2 H acceptors: 2 LogP: 7.15 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCc1sc[n+](c1C)CCCCCCCCCC[n+]1csc(c1C)CCO.[I-].[I-]
  • InChi: 1S/C22H38N2O2S2.2HI/c1-19-21(11-15-25)27-17-23(19)13-9-7-5-3-4-6-8-10-14-24-18-28-22(12-16-26)20(24)2;;/h17-18,25-26H,3-16H2,1-2H3;2*1H/q+2;;/p-2
  • InChiKey: PNTCRJCREMUMDK-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]decyl]-4-methyl-thiazol-3-ium-5-yl]ethanol diiodide
  • 2-[3-[10-[5-(2-hydroxyethyl)-4-methyl-3-thiazol-3-iumyl]decyl]-4-methyl-5-thiazol-3-iumyl]ethanol diiodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0442 0.1688 0.2377
Plasmodium falciparum plasmepsin IX 0.0201 0.0644 0.1757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) cysteine protease 0.0069 0.0075 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0063 0.0047 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0138 0.0374 0.1086
Plasmodium vivax plasmepsin IV, putative 0.0849 0.3446 1
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0289 0.1026 0.2976
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Toxoplasma gondii aspartyl protease ASP1 0.0849 0.3446 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) hypothetical protein 0.1191 0.4921 0.6945
Loa Loa (eye worm) hypothetical protein 0.0201 0.0644 0.0902
Schistosoma mansoni hypothetical protein 0.0286 0.1011 0.1006
Loa Loa (eye worm) cathepsin B 0.0056 0.0019 0.0019
Plasmodium vivax vivapain-2 0.0069 0.0075 0.0084
Brugia malayi sulfakinin receptor protein 0.0664 0.2647 0.3732
Plasmodium vivax vivapain-2 0.0069 0.0075 0.0084
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0063 0.0047 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.016 0.0468 0.0639
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0043 0.0052
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0063 0.0047 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0417 0.1576 0.2219
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.016 0.0468 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Plasmodium falciparum plasmepsin VIII, putative 0.0201 0.0644 0.1757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0152
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.016 0.0468 0.2751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0075 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus multilocularis expressed conserved protein 0.0286 0.1011 0.1407
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0775 0.3125 0.44
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trypanosoma brucei target of rapamycin kinase 3, putative 0.013 0.0337 0.7096
Plasmodium vivax plasmepsin V, putative 0.0201 0.0644 0.1757
Brugia malayi hypothetical protein 0.0201 0.0644 0.0902
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0075 0.0069
Echinococcus multilocularis cathepsin b 0.0146 0.0406 0.0552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Brugia malayi aspartic protease BmAsp-2, identical 0.0201 0.0644 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Plasmodium falciparum plasmepsin X 0.0201 0.0644 0.1757
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Echinococcus multilocularis cysteine protease 0.0069 0.0075 0.0084
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0016 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0124 0.0313 0.1885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0529
Leishmania major cysteine peptidase A (CPA) 0.0069 0.0075 0.1252
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0395 0.1483 0.939
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1691 0.7083 0.7081
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0456 0.1746 0.2458
Brugia malayi aspartic protease BmAsp-1, identical 0.0201 0.0644 0.0902
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1691 0.7083 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0849 0.3446 0.4853
Echinococcus granulosus tachykinin peptides receptor 99D 0.0636 0.2524 0.3549
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0417 0.1576 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0207 0.06
Brugia malayi hypothetical protein 0.0664 0.2647 0.3732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0178
Brugia malayi SH2 domain containing protein 0.1191 0.4921 0.6945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1691 0.7083 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0201 0.0644 0.0902
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0063 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.1691 0.7083 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0849 0.3446 0.4853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0146 0.0406 0.04
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0898 0.3657 0.5159
Giardia lamblia GTOR 0.016 0.0468 0.6929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus granulosus cathepsin L cysteine proteinase 0.0069 0.0075 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0207
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0146 0.0406 0.1178
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0146 0.0406 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Echinococcus multilocularis cysteine protease 0.0069 0.0075 0.0084
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0062 0.0043 0.0038
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0063 0.0047 0.0041
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0062 0.0043 0.0037
Echinococcus multilocularis Zinc finger, PHD finger 0.0063 0.0047 0.0043
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0075 0.0186
Schistosoma mansoni memapsin-2 (A01 family) 0.0201 0.0644 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0207 0.06
Plasmodium falciparum plasmepsin III 0.0201 0.0644 0.1757
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0775 0.3125 0.3121
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0359 0.1325 0.1865
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0063 0.0047 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0207
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0849 0.3446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Loa Loa (eye worm) fibroinase 0.0069 0.0075 0.0098
Toxoplasma gondii aspartyl protease 0.0201 0.0644 0.1824
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0417 0.1576 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Brugia malayi Pepsin A precursor 0.0201 0.0644 0.0902
Plasmodium falciparum plasmepsin I 0.0849 0.3446 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0417 0.1576 0.4574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trypanosoma cruzi target of rapamycin kinase 3 0.013 0.0337 0.2044
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0617
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0957 0.1331
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0075 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Leishmania major phosphatidylinositol 3-kinase, putative 0.0062 0.0043 0.0529
Toxoplasma gondii cathepsin CPL 0.0069 0.0075 0.0164
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1691 0.7083 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0644 0.0902
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0201 0.0644 0.1824
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0957 0.1331
Echinococcus granulosus cathepsin b 0.0146 0.0406 0.0552
Entamoeba histolytica cysteine protease, putative 0.0069 0.0075 0.0186
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0075 0.0069
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0636 0.2524 0.3549
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0075 0.0186
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.016 0.0468 0.288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0043 0.0052
Loa Loa (eye worm) phosphatidylinositol 3 0.0692 0.2766 0.39
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 0.0207
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0016 0.001
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.016 0.0468 0.288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0063 0.0047 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0163 0.0222
Plasmodium vivax aspartyl proteinase, putative 0.0201 0.0644 0.1757
Echinococcus granulosus expressed conserved protein 0.0286 0.1011 0.1407
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0468 0.0653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0775 0.3125 0.44
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0163 0.0222
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0043 0.0052
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.016 0.0468 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0303 0.1087 0.1515
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.0313 0.0434
Echinococcus granulosus cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.016 0.0468 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.016 0.0468 0.0462
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0063 0.0047 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Entamoeba histolytica hypothetical protein 0.0333 0.1217 0.7652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.013 0.0337 0.7096
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0146 0.0406 0.0401
Loa Loa (eye worm) hypothetical protein 0.0898 0.3657 0.5159
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0075 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0257 0.0746
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0146 0.0406 0.2487
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Toxoplasma gondii target of rapamycin (TOR), putative 0.0122 0.0304 0.0831
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0062 0.0043 0.0152
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0146 0.0406 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0417 0.1576 0.4574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0468 0.0653
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0063 0.0047 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0417 0.1576 0.4574
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.0075 0.0098
Plasmodium vivax aspartyl proteinase, putative 0.0849 0.3446 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0406 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0043 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.019 0.0598 0.3601
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0849 0.3446 0.3442
Plasmodium falciparum plasmepsin IV 0.0849 0.3446 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.016 0.0468 0.2751
Loa Loa (eye worm) RNA binding protein 0.0062 0.0043 0.0052
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.016 0.0468 0.0639
Loa Loa (eye worm) hypothetical protein 0.0664 0.2647 0.3732
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0206 0.0666 1
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 0.0157
Plasmodium falciparum cysteine proteinase falcipain 3 0.0069 0.0075 0.0084
Schistosoma mansoni peptidylglycine monooxygenase 0.0898 0.3657 0.3653
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0062 0.0043 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0468 0.1357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0082 0.0131 0.2489
Loa Loa (eye worm) ctsf protein 0.0069 0.0075 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0043 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0957 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0075 0.0084
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.016 0.0468 1
Loa Loa (eye worm) aspartyl protease 6 0.0201 0.0644 0.0902
Plasmodium falciparum plasmepsin V 0.0201 0.0644 0.1757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Loa Loa (eye worm) hypothetical protein 0.0273 0.0957 0.1344
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 0.0207
Toxoplasma gondii aspartyl protease ASP3 0.0201 0.0644 0.1824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0304 0.0882
Echinococcus granulosus cathepsin b 0.0146 0.0406 0.0552
Brugia malayi TAR-binding protein 0.0062 0.0043 0.0052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0075 0.0084
Echinococcus granulosus tar DNA binding protein 0.0062 0.0043 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0173 0.0502
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0075 0.0098
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0617
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0063 0.0047 0.0043
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0043 0.0037
Brugia malayi cathepsin B-like cysteine proteinase 0.0146 0.0406 0.0566
Plasmodium falciparum plasmepsin VII 0.0201 0.0644 0.1757
Leishmania major phosphatidylinositol 3-kinase, putative 0.0063 0.0047 0.0617
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0289 0.1026 0.2976
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0069 0.0075 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0174 0.0504
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0849 0.3446 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0069 0.0075 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0303 0.1087 0.1515
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.2348
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0063 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0849 0.3446 0.4861
Plasmodium falciparum plasmepsin II 0.0849 0.3446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0337 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0075 0.1252
Schistosoma mansoni dopamine-beta-monooxygenase 0.0898 0.3657 0.3653
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0849 0.3446 0.4861
Onchocerca volvulus 0.0201 0.0644 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.1217 0.7652
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0063 0.0047 0.0178
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0063 0.0047 0.0043
Plasmodium falciparum plasmepsin VI 0.0849 0.3446 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0019 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0075 0.0218
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0105 0.0229 0.3242
Schistosoma mansoni cathepsin D (A01 family) 0.2367 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0243 0.0706
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0062 0.0043 0.0038
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0073 0.0094 0.1669
Brugia malayi RNA binding protein 0.0062 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.0143 0.0396 0.0551
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0146 0.0406 0.2484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0075 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0019 0.0056
Brugia malayi Eukaryotic aspartyl protease family protein 0.0201 0.0644 0.0902
Loa Loa (eye worm) hypothetical protein 0.0069 0.0075 0.0098
Echinococcus granulosus cathepsin l1 0.0069 0.0075 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.2348
Onchocerca volvulus 0.0201 0.0644 1
Brugia malayi hypothetical protein 0.0201 0.0644 0.0902
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Brugia malayi Cathepsin L-like precursor 0.0069 0.0075 0.0098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.021 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Echinococcus multilocularis cathepsin b 0.0146 0.0406 0.0552
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0401
Plasmodium vivax aspartyl protease, putative 0.0201 0.0644 0.1757
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0146 0.0406 0.8626
Leishmania major cathepsin L-like protease 0.0069 0.0075 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0043 0.0124
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0201 0.0644 0.0639
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0069 0.0075 0.0084
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0043 0.0052
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0417 0.1576 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 34 nM In vitro inhibitory concentration of the compound against Plasmodium falciparum ChEMBL. 15887971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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