Detailed information for compound 343164

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.317 | Formula: C17H14N4O4
  • H donors: 2 H acceptors: 6 LogP: 2.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)ncc(c2O)C(=O)NCc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C17H14N4O4/c1-10-2-7-13-15(22)14(9-18-16(13)20-10)17(23)19-8-11-3-5-12(6-4-11)21(24)25/h2-7,9H,8H2,1H3,(H,19,23)(H,18,20,22)
  • InChiKey: HHAVWYHRLUEVRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 306 aa 26.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 304 aa 25.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 318 aa 22.3 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0253 0.0253
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0413 0.0413
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.3201 1
Leishmania major hypothetical protein, conserved 0.0036 0.0413 0.2968
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0079 0.1023 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0077
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0079 0.1023 0.1023
Brugia malayi CXXC zinc finger family protein 0.0029 0.0316 0.0713
Schistosoma mansoni hypothetical protein 0.0036 0.0413 0.0413
Brugia malayi beta-lactamase 0.0036 0.0413 0.0937
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0413 0.0937
Schistosoma mansoni serine/threonine protein kinase 0.031 0.4319 0.4319
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0155 0.3059
Schistosoma mansoni hypothetical protein 0.0011 0.0058 0.0058
Loa Loa (eye worm) beta-lactamase 0.0036 0.0413 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0316 0.0713
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0155 0.1001
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0041 0.0488 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0155 0.1155
Trichomonas vaginalis esterase, putative 0.0036 0.0413 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0155 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0253 0.603
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.031 0.4319 0.4319
Entamoeba histolytica hypothetical protein 0.0025 0.0253 0.568
Schistosoma mansoni cpg binding protein 0.0031 0.034 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0059 0.1237
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0267 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0079 0.1023 0.1023
Entamoeba histolytica hypothetical protein 0.0036 0.0413 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0155 0.1001
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0413 0.0413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0768 0.5821
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0253 0.2145
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0155 0.1001
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0079 0.1023 0.2189
Schistosoma mansoni cpg binding protein 0.0029 0.0316 0.0316
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0155 0.1155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0267 0.0598
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0413 0.0413
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0074 0.0956 0.8903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Brugia malayi Serine/threonine-protein kinase Pim-3 0.031 0.4319 1
Leishmania major hypothetical protein, conserved 0.0025 0.0258 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0768 0.5821
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0155 0.1001
Loa Loa (eye worm) GMP reductase 0.0033 0.0364 0.0824
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.031 0.4319 0.4319
Schistosoma mansoni hypothetical protein 0.0174 0.2382 0.2382
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0413 0.378
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0042 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0042 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0413 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0768 0.7355
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0768 0.0768
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Schistosoma mansoni cpg binding protein 0.0031 0.034 0.034
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0155 0.0155
Leishmania major guanosine monophosphate reductase 0.0079 0.1023 1
Schistosoma mansoni hypothetical protein 0.0008 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0036 0.0413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0079 0.1023 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Brugia malayi beta-lactamase family protein 0.0036 0.0413 0.0937
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0155 0.0155
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0413 0.0413
Brugia malayi GMP reductase 0.0033 0.0364 0.0824
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0079 0.1023 0.1023
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0155 0.0155
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0155 0.1001
Toxoplasma gondii ABC1 family protein 0.0036 0.0413 0.3672
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Echinococcus granulosus cpg binding protein 0.0031 0.034 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0203 0.1635
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0253 0.2008
Onchocerca volvulus 0.0036 0.0413 0.0242
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0413 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0155 0.0155
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0155 0.1155
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0692 0.6568
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Leishmania major inosine-5-monophosphate dehydrogenase 0.0079 0.1023 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0155 0.0155
Brugia malayi hypothetical protein 0.0016 0.0129 0.028
Echinococcus multilocularis cpg binding protein 0.0031 0.034 0.034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0768 0.7061
Giardia lamblia Kinesin-5 0.0026 0.0267 1
Echinococcus granulosus kinesin family 1 0.02 0.2753 0.2753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0258 0.2063
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0258 0.2198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Entamoeba histolytica hypothetical protein 0.0036 0.0413 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0079 0.1023 0.2353
Brugia malayi hypothetical protein 0.0025 0.0258 0.0577
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0033 0.0364 0.0824
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0413 0.0413
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0155 0.3059
Plasmodium falciparum kinesin-5 0.0026 0.0267 0.0129
Toxoplasma gondii IMP dehydrogenas 0.0079 0.1023 1
Entamoeba histolytica kinesin, putative 0.0026 0.0267 0.6064
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0413 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0058 0.0058
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0156 0.116
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0413 0.3672
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0074 0.0956 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0768 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Schistosoma mansoni hypothetical protein 0.0171 0.2331 0.2331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trypanosoma cruzi GMP reductase 0.0079 0.1023 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0768 0.0768
Onchocerca volvulus 0.0036 0.0413 0.0242
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0155 0.034
Echinococcus multilocularis geminin 0.0171 0.2331 0.2331
Trypanosoma brucei GMP reductase 0.0079 0.1023 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0074 0.0956 1
Trypanosoma cruzi GMP reductase 0.0079 0.1023 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0413 0.0937
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0156 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0708 1 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0038 0.0431 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0155 0.034
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0155 0.1001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0155 0.1155
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.031 0.4319 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0253 0.0253
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0258 0.2063
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0041 0.0488 0.1223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0413 0.0413
Onchocerca volvulus 0.0036 0.0413 0.0242
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0258 0.2198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0059 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0413 0.378
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0079 0.1023 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0768 0.0768
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0155 0.0155
Plasmodium vivax kinesin-5 0.0026 0.0267 0.0129
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0253 0.2008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0116
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0768 0.5821
Entamoeba histolytica hypothetical protein 0.0036 0.0413 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0253 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0413 0.2222
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0155 0.034
Schistosoma mansoni hypothetical protein 0.0171 0.2331 0.2331
Echinococcus granulosus geminin 0.0171 0.2331 0.2331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Loa Loa (eye worm) CAMK/PIM protein kinase 0.031 0.4319 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.0079 0.1023 0.2353
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0449
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0042 0.0042
Onchocerca volvulus Putative GMP reductase 0.0033 0.0364 0.012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Brugia malayi beta-lactamase family protein 0.0036 0.0413 0.0937
Schistosoma mansoni hypothetical protein 0.0419 0.5885 0.5885
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0079 0.1023 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0768 0.0768
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0788 0.0788
Echinococcus granulosus dnaJ subfamily B 0.0419 0.5885 0.5885
Brugia malayi hypothetical protein 0.0036 0.0413 0.0937
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0079 0.1023 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0079 0.1023 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0079 0.1023 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0413 0.0413
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0038 0.0431 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0155 0.1155
Schistosoma mansoni kinesin eg-5 0.0026 0.0267 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0042 0.0823
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0042 0.0042
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.5885 0.5885
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Brugia malayi Protein kinase domain containing protein 0.031 0.4319 1
Schistosoma mansoni microtubule-associated protein tau 0.0708 1 1
Echinococcus multilocularis kinesin family 1 0.02 0.2753 0.2753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0155 0.3627
Loa Loa (eye worm) CAMK/PIM protein kinase 0.031 0.4319 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0033 0.0364 0.0824
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0267 0.2156
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0253 0.0253

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 99 nM Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane ChEMBL. 16099648
Ki (binding) = 99 nM Inhibition of [3H]-CGS-21,680 binding to adenosine A2a receptor of bovine striatal membrane ChEMBL. 16099648
Ki (binding) = 1634 nM Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane ChEMBL. 16099648
Ki (binding) = 1634 nM Inhibition of [3H]-CHA binding to adenosine A1 receptor of bovine brain cortical membrane ChEMBL. 16099648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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