Detailed information for compound 343247

Basic information

Technical information
  • TDR Targets ID: 343247
  • Name: S-[6-[[5-[5-(ethylamino)-4-methoxyoxan-2-yl]o xy-4-hydroxy-6-methoxy-2-methyloxan-3-yl]amin o]oxy-4-hydroxy-2-methyloxan-3-yl] 4-(3,5-dih ydroxy-4-methoxy-6-methyloxan-2-yl)oxy-5-iodo -2,3-dimethoxy-6-methylbenzenecarbothioate
  • MW: 976.864 | Formula: C38H61IN2O17S
  • H donors: 6 H acceptors: 5 LogP: 1.3 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCNC1COC(CC1OC)OC1C(OC)OC(C(C1O)NOC1CC(O)C(C(O1)C)SC(=O)c1c(C)c(I)c(c(c1OC)OC)OC1OC(C)C(C(C1O)OC)O)C
  • InChi: 1S/C38H61IN2O17S/c1-11-40-19-14-52-22(13-21(19)47-6)56-33-28(44)26(16(3)54-38(33)51-10)41-58-23-12-20(42)35(18(5)53-23)59-36(46)24-15(2)25(39)31(34(50-9)30(24)48-7)57-37-29(45)32(49-8)27(43)17(4)55-37/h16-23,26-29,32-33,35,37-38,40-45H,11-14H2,1-10H3
  • InChiKey: LLRIDSCDUGRTJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • S-[6-[[5-[5-(ethylamino)-4-methoxy-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methoxy-2-methyl-tetrahydropyran-3-yl]amino]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-benzenecarbothioate
  • 4-[(3,5-dihydroxy-4-methoxy-6-methyl-2-tetrahydropyranyl)oxy]-5-iodo-2,3-dimethoxy-6-methylbenzenecarbothioic acid S-[6-[[5-[[5-(ethylamino)-4-methoxy-2-tetrahydropyranyl]oxy]-4-hydroxy-6-methoxy-2-methyl-3-tetrahydropyranyl]amino]oxy-4-hydroxy-2-methyl-3-tetrahydropyranyl] ester
  • S-[6-[[5-[5-(ethylamino)-4-methoxy-oxan-2-yl]oxy-4-hydroxy-6-methoxy-2-methyl-oxan-3-yl]amino]oxy-4-hydroxy-2-methyl-oxan-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyl-oxan-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-benzenecarbothioate
  • 4-(3,5-dihydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-thiobenzoic acid S-[6-[[5-[5-(ethylamino)-4-methoxy-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methoxy-2-methyl-tetrahydropyran-3-yl]amino]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] ester
  • S-[6-[[5-(5-ethylamino-4-methoxyoxan-2-yl)oxy-4-hydroxy-6-methoxy-2-methyloxan-3-yl]amino]oxy-4-hydroxy-2-methyloxan-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methylbenzenecarbothioate
  • S-[6-[[5-(5-ethylamino-4-methoxy-tetrahydropyran-2-yl)oxy-4-hydroxy-6-methoxy-2-methyl-tetrahydropyran-3-yl]amino]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-benzenecarbothioate
  • 4-[(3,5-dihydroxy-4-methoxy-6-methyl-2-tetrahydropyranyl)oxy]-5-iodo-2,3-dimethoxy-6-methylbenzenecarbothioic acid S-[[6-[[5-[(5-ethylamino-4-methoxy-2-tetrahydropyranyl)oxy]-4-hydroxy-6-methoxy-2-methyl-3-tetrahydropyranyl]amino]oxy-4-hydroxy-2-methyl-3-tetrahydropyranyl]] ester
  • 4-(3,5-dihydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-thiobenzoic acid S-[6-[[5-(5-ethylamino-4-methoxy-tetrahydropyran-2-yl)oxy-4-hydroxy-6-methoxy-2-methyl-tetrahydropyran-3-yl]amino]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] ester
  • S-[6-[[5-(5-ethylamino-4-methoxy-oxan-2-yl)oxy-4-hydroxy-6-methoxy-2-methyl-oxan-3-yl]amino]oxy-4-hydroxy-2-methyl-oxan-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyl-oxan-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methyl-benzenecarbothioate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0073 0.0248 0.0012
Brugia malayi Spectrin alpha chain 0.0071 0.0236 0.0369
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0073 0.0248 0.0012
Loa Loa (eye worm) animal heme peroxidase 0.0505 0.312 0.312
Schistosoma mansoni hypothetical protein 0.0073 0.0248 0.0234
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Schistosoma mansoni signal transduction protein lnk-related 0.0073 0.0248 0.0234
Brugia malayi Animal haem peroxidase family protein 0.0505 0.312 0.545
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0073 0.0248 0.0012
Brugia malayi tRNA modification GTPase TrmE family protein 0.0073 0.0248 0.039
Echinococcus granulosus tensin 0.0073 0.0248 0.0012
Onchocerca volvulus 0.0073 0.0248 0.0796
Onchocerca volvulus 0.0071 0.0236 0.0757
Brugia malayi Variant SH3 domain containing protein 0.0073 0.0248 0.039
Echinococcus granulosus growth factor receptor bound protein 2 0.0144 0.0721 0.0496
Onchocerca volvulus Peroxidase homolog 0.0505 0.312 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0565 0.3523 0.3366
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Brugia malayi Variant SH3 domain containing protein 0.0144 0.0721 0.1223
Brugia malayi Variant SH3 domain containing protein 0.0073 0.0248 0.039
Onchocerca volvulus 0.0071 0.0236 0.0757
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Schistosoma mansoni sorbin 0.0071 0.0236 0.0221
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0073 0.0248 0.0248
Echinococcus multilocularis SHC transforming protein 3 0.0073 0.0248 0.0012
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0071 0.0236 0.0221
Onchocerca volvulus 0.0093 0.0384 0.1232
Schistosoma mansoni SH2A 0.0073 0.0248 0.0234
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0474 0.2915 0.2743
Echinococcus granulosus tyrosine protein kinase Src42A 0.0565 0.3523 0.3366
Schistosoma mansoni hypothetical protein 0.0073 0.0248 0.0234
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0073 0.0248 0.0012
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Echinococcus granulosus NCK adaptor protein 0.0144 0.0721 0.0496
Echinococcus multilocularis N chimaerin 0.0073 0.0248 0.0012
Echinococcus multilocularis tyrosine protein kinase Srms 0.0494 0.3051 0.2882
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0058 0.0148 0.0148
Echinococcus multilocularis tyrosine protein kinase Blk 0.0494 0.3051 0.2882
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0073 0.0248 0.0012
Brugia malayi RhoGAP domain containing protein 0.0073 0.0248 0.039
Schistosoma mansoni cell polarity protein 0.0071 0.0236 0.0221
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Echinococcus granulosus chromobox protein 1 0.0081 0.0301 0.0067
Schistosoma mansoni vav2 0.0073 0.0248 0.0234
Schistosoma mansoni suppressor of cytokine signaling 0.0073 0.0248 0.0234
Echinococcus granulosus tyrosine protein kinase Srms 0.0093 0.0384 0.0152
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0073 0.0248 0.0012
Echinococcus multilocularis signal transduction protein lnk realted 0.0073 0.0248 0.0012
Onchocerca volvulus 0.0073 0.0248 0.0796
Echinococcus granulosus expressed conserved protein 0.0073 0.0248 0.0012
Onchocerca volvulus 0.0505 0.312 1
Schistosoma mansoni tyrosine kinase 0.0565 0.3523 0.3685
Echinococcus granulosus chromobox protein 1 0.0081 0.0301 0.0067
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0073 0.0248 0.0012
Echinococcus granulosus SH2 domain containing protein 7 0.0073 0.0248 0.0012
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0073 0.0248 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Schistosoma mansoni dreadlocks/dock 0.0071 0.0236 0.0221
Echinococcus multilocularis chromobox protein 1 0.0081 0.0301 0.0067
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0256 1
Brugia malayi chromobox protein homolog 3 0.0045 0.0065 0.0068
Schistosoma mansoni peroxidasin 0.0505 0.312 0.326
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0073 0.0248 0.0052
Brugia malayi SH2 domain containing protein 0.0093 0.0384 0.063
Schistosoma mansoni formin binding protein and related proteins 0.0071 0.0236 0.0221
Trichomonas vaginalis p67phox protein, putative 0.0071 0.0236 0.7244
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0073 0.0248 0.0234
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0093 0.0384 0.0636
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0256 1
Brugia malayi Animal haem peroxidase family protein 0.0505 0.312 0.545
Schistosoma mansoni hypothetical protein 0.0071 0.0236 0.0221
Schistosoma mansoni peroxidasin 0.0505 0.312 0.326
Onchocerca volvulus 0.0093 0.0384 0.1232
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Schistosoma mansoni eps8-related protein 0.0071 0.0236 0.0221
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0164 0.0857 0.0636
Loa Loa (eye worm) hypothetical protein 0.0093 0.0384 0.0384
Echinococcus multilocularis tyrosine protein kinase HCK 0.0421 0.2566 0.2386
Echinococcus granulosus c src tyrosine kinase 0.0164 0.0857 0.0636
Brugia malayi protein-tyrosine kinase 0.0071 0.0236 0.0369
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369
Echinococcus granulosus suppressor of cytokine signaling 6 0.0073 0.0248 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Echinococcus multilocularis chromobox protein 1 0.0081 0.0301 0.0067
Echinococcus multilocularis SH2 motif 0.0073 0.0248 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Echinococcus granulosus tyrosine kinase 0.0494 0.3051 0.2882
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Entamoeba histolytica protein kinase, putative 0.0073 0.0248 0.0052
Echinococcus granulosus tyrosine protein kinase Blk 0.0494 0.3051 0.2882
Onchocerca volvulus 0.0093 0.0384 0.1232
Entamoeba histolytica protein kinase, putative 0.0421 0.2566 1
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369
Onchocerca volvulus Putative cortactin 0.0071 0.0236 0.0757
Schistosoma mansoni adapter molecule crk 0.0144 0.0721 0.0732
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0565 0.3523 0.3366
Loa Loa (eye worm) blistered cuticle protein 3 0.0505 0.312 0.312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0093 0.0384 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0565 0.3523 0.3366
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Schistosoma mansoni apoptosis stimulating of P53 0.0071 0.0236 0.0221
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Schistosoma mansoni shc transforming protein 0.0073 0.0248 0.0234
Echinococcus granulosus tyrosine protein kinase Src42A 0.0474 0.2915 0.2743
Brugia malayi Protein kinase domain containing protein 0.0093 0.0384 0.063
Echinococcus multilocularis peroxidasin 0.0505 0.312 0.2954
Echinococcus granulosus tyrosine protein kinase shark 0.0093 0.0384 0.0152
Leishmania major cathepsin L-like protease 0.0074 0.0256 1
Loa Loa (eye worm) STAT protein 0.0073 0.0248 0.0248
Echinococcus granulosus peroxidasin 0.0505 0.312 0.2954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0065 0.0209
Schistosoma mansoni C-fyn 0.0071 0.0236 0.0221
Loa Loa (eye worm) SH2 domain-containing protein 0.0073 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0372 0.0364
Brugia malayi Src substrate cortactin 0.0071 0.0236 0.0369
Brugia malayi Sex muscle abnormal protein 5 0.0144 0.0721 0.1223
Loa Loa (eye worm) hypothetical protein 0.0045 0.0065 0.0065
Brugia malayi Heterochromatin protein 1 0.0081 0.0301 0.0484
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0071 0.0236 0.0757
Echinococcus multilocularis tyrosine protein kinase shark 0.0093 0.0384 0.0152
Echinococcus granulosus tyrosine protein kinase Lyn 0.0565 0.3523 0.3366
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0148 0.0214
Echinococcus multilocularis c src tyrosine kinase 0.0164 0.0857 0.0636
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0148 0.0148
Brugia malayi Peripheral plasma membrane protein CASK 0.0071 0.0236 0.0369
Brugia malayi Tyrosine-protein kinase abl-1 0.0893 0.5703 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0565 0.3523 0.3366
Schistosoma mansoni sorting nexin 0.0071 0.0236 0.0221
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0236 0.8124
Echinococcus granulosus SH2 motif 0.0073 0.0248 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Loa Loa (eye worm) TK/ABL protein kinase 0.1539 1 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0071 0.0236 0.0221
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0088 0.0969
Schistosoma mansoni tyrosine kinase 0.0093 0.0384 0.0377
Loa Loa (eye worm) hypothetical protein 0.0573 0.3576 0.3576
Echinococcus granulosus tyrosine protein kinase HCK 0.0421 0.2566 0.2386
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0565 0.3523 0.3366
Onchocerca volvulus 0.0073 0.0248 0.0796
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0073 0.0248 0.0012
Onchocerca volvulus 0.0093 0.0384 0.1232
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Echinococcus granulosus SH2 motif 0.0073 0.0248 0.0012
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Onchocerca volvulus 0.0071 0.0236 0.0757
Brugia malayi Protein kinase domain containing protein 0.0093 0.0384 0.063
Echinococcus granulosus SH2 domain containing adapter protein F 0.0073 0.0248 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0565 0.3523 0.3366
Brugia malayi SH3 domain containing protein 0.0071 0.0236 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0073 0.0248 0.0248
Schistosoma mansoni tensin 0.0073 0.0248 0.0234
Loa Loa (eye worm) thyroid receptor interactor 0.0071 0.0236 0.0236
Onchocerca volvulus Peroxidase homolog 0.0505 0.312 1
Onchocerca volvulus 0.0071 0.0236 0.0757
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Entamoeba histolytica SH2 domain containing protein 0.0073 0.0248 0.0052
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0213 0.5946
Schistosoma mansoni Dab2-interacting protein-like 0.0071 0.0236 0.0221
Leishmania major cathepsin L-like protease 0.0074 0.0256 1
Brugia malayi hypothetical protein 0.0073 0.0248 0.039
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0494 0.3051 0.2882
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Loa Loa (eye worm) TK protein kinase 0.0421 0.2566 0.2566
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0073 0.0248 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Onchocerca volvulus 0.0093 0.0384 0.1232
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0144 0.0721 0.0721
Loa Loa (eye worm) SH2 domain-containing protein 0.0073 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Schistosoma mansoni growth factor receptor-bound protein 0.0144 0.0721 0.0732
Brugia malayi Myosin tail family protein 0.0071 0.0236 0.0369
Brugia malayi Animal haem peroxidase family protein 0.0505 0.312 0.545
Schistosoma mansoni nck2/grb4 0.0144 0.0721 0.0732
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0494 0.3051 0.2882
Loa Loa (eye worm) hypothetical protein 0.004 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Echinococcus multilocularis growth factor receptor bound protein 2 0.0144 0.0721 0.0496
Onchocerca volvulus Peroxidasin homolog 0.0505 0.312 1
Echinococcus multilocularis tensin 0.0073 0.0248 0.0012
Echinococcus granulosus tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Brugia malayi protein-tyrosine kinase 0.0494 0.3051 0.5328
Echinococcus multilocularis tyrosine protein kinase Abl 0.0717 0.4533 0.4401
Onchocerca volvulus 0.0073 0.0248 0.0796
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0093 0.0384 0.0152
Brugia malayi Animal haem peroxidase family protein 0.0505 0.312 0.545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Schistosoma mansoni tyrosine kinase 0.1466 0.9515 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Brugia malayi Protein kinase domain containing protein 0.0093 0.0384 0.063
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Schistosoma mansoni chromobox protein 0.0081 0.0301 0.0289
Onchocerca volvulus 0.0071 0.0236 0.0757
Schistosoma mansoni run and tbc1 domain containing 0.0071 0.0236 0.0221
Loa Loa (eye worm) animal heme peroxidase 0.0505 0.312 0.312
Brugia malayi Variant SH3 domain containing protein 0.0144 0.0721 0.1223
Onchocerca volvulus Peroxidasin homolog 0.0505 0.312 1
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0256 1
Schistosoma mansoni tyrosine kinase 0.0093 0.0384 0.0377
Echinococcus granulosus SHC transforming protein 3 0.0073 0.0248 0.0012
Brugia malayi Protein kinase domain containing protein 0.0093 0.0384 0.063
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Loa Loa (eye worm) animal heme peroxidase 0.0505 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0073 0.0248 0.0012
Onchocerca volvulus Chorion peroxidase homolog 0.0505 0.312 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0073 0.0248 0.0796
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0088 0.0969
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0073 0.0248 0.0796
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Brugia malayi Protein kinase domain containing protein 0.0093 0.0384 0.063
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0071 0.0236 0.0236
Echinococcus multilocularis NCK adaptor protein 0.0144 0.0721 0.0496
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0073 0.0248 0.0012
Onchocerca volvulus 0.0073 0.0248 0.0796
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Echinococcus granulosus N chimaerin 0.0073 0.0248 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0088 0.0282
Loa Loa (eye worm) TK protein kinase 0.0494 0.3051 0.3051
Echinococcus multilocularis SH2 motif 0.0073 0.0248 0.0012
Brugia malayi SRC-1 0.0565 0.3523 0.616
Echinococcus granulosus tyrosine protein kinase Src64B 0.0565 0.3523 0.3366
Echinococcus multilocularis 0.0073 0.0248 0.0012
Schistosoma mansoni growth factor receptor-bound protein 0.0144 0.0721 0.0732
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0073 0.0248 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Schistosoma mansoni tyrosine kinase 0.0164 0.0857 0.0875
Schistosoma mansoni dynamin-associated protein 0.0071 0.0236 0.0221
Onchocerca volvulus 0.0073 0.0248 0.0796
Loa Loa (eye worm) SH2 domain-containing protein 0.0073 0.0248 0.0248
Schistosoma mansoni tensin 0.0073 0.0248 0.0234
Echinococcus multilocularis tyrosine kinase 0.0093 0.0384 0.0152
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0073 0.0248 0.0234
Echinococcus granulosus tyrosine kinase 0.0093 0.0384 0.0152
Brugia malayi SH2 domain containing protein 0.0073 0.0248 0.039
Loa Loa (eye worm) SRC-1 0.0565 0.3523 0.3523
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0073 0.0248 0.0248
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0301 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0148 0.0214
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Loa Loa (eye worm) animal heme peroxidase 0.0505 0.312 0.312
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0236 0.8124
Brugia malayi Blistered cuticle protein 3 0.0505 0.312 0.545
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0073 0.0248 0.0234
Schistosoma mansoni chromobox protein 0.0081 0.0301 0.0289
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0071 0.0236 0.8124
Echinococcus multilocularis SH2 motif 0.0073 0.0248 0.0012
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0144 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Echinococcus granulosus tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0073 0.0248 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0717 0.4533 0.794
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0565 0.3523 0.3366
Echinococcus multilocularis SH2 domain containing protein 7 0.0073 0.0248 0.0012
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0071 0.0236 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Brugia malayi hypothetical protein 0.0093 0.0384 0.063
Schistosoma mansoni tyrosine kinase 0.0164 0.0857 0.0875
Onchocerca volvulus 0.0505 0.312 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0073 0.0248 0.039
Echinococcus multilocularis tensin 0.0073 0.0248 0.0012
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0144 0.0721 0.0732
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Schistosoma mansoni GTPase activating protein 0.0073 0.0248 0.0234
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0236 0.8124
Brugia malayi Animal haem peroxidase family protein 0.0505 0.312 0.545
Onchocerca volvulus 0.0505 0.312 1
Brugia malayi Fes/CIP4 homology domain containing protein 0.0071 0.0236 0.0369
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Loa Loa (eye worm) guanylate kinase 0.0071 0.0236 0.0236
Loa Loa (eye worm) protein-tyrosine kinase 0.0071 0.0236 0.0236
Schistosoma mansoni tensin-related 0.0073 0.0248 0.0234
Brugia malayi SH2 domain containing protein 0.0093 0.0384 0.063
Brugia malayi hypothetical protein 0.0505 0.312 0.545
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1539 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0144 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Loa Loa (eye worm) TK/FER protein kinase 0.0093 0.0384 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Echinococcus granulosus tyrosine protein kinase Fyn 0.0565 0.3523 0.3366
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0071 0.0236 0.0236
Schistosoma mansoni tensin 0.0073 0.0248 0.0234
Brugia malayi STAT protein, DNA binding domain containing protein 0.0073 0.0248 0.039
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0071 0.0236 0.7244
Schistosoma mansoni hypothetical protein 0.0071 0.0236 0.0221
Loa Loa (eye worm) p53BP2 0.0071 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0236 0.7244
Brugia malayi Peroxidasin 0.0505 0.312 0.545
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0073 0.0248 0.039
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Echinococcus granulosus suppressor of cytokine signaling 7 0.0073 0.0248 0.0012
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0073 0.0248 0.0248
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0164 0.0857 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Onchocerca volvulus Dual oxidase homolog 0.0505 0.312 1
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Leishmania major cathepsin L-like protease 0.0074 0.0256 1
Echinococcus granulosus hypothetical protein 0.0073 0.0248 0.0012
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0071 0.0236 0.0221
Loa Loa (eye worm) hypothetical protein 0.0071 0.0236 0.0236
Brugia malayi Guanylate kinase family protein 0.0071 0.0236 0.0369
Loa Loa (eye worm) hypothetical protein 0.0505 0.312 0.312
Echinococcus granulosus signal transduction protein lnk realted 0.0073 0.0248 0.0012
Schistosoma mansoni suppressor of cytokine signaling 0.0073 0.0248 0.0234
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0248
Schistosoma mansoni tyrosine kinase 0.0565 0.3523 0.3685
Onchocerca volvulus 0.0093 0.0384 0.1232
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0565 0.3523 0.3366
Brugia malayi Tensin 0.0073 0.0248 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0256 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0164 0.0857 0.0636
Schistosoma mansoni tensin-related 0.0073 0.0248 0.0234
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0236 0.0369

Activities

Activity type Activity value Assay description Source Reference
K obs (binding) = 4.1 uM Binding affinity towards DNA extracted from MOLT-4 cells ChEMBL. 16134928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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