Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Alpha-1a adrenergic receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Bos taurus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0366 | 1 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0159 | 0 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0366 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0159 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000001 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000000001 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000000008 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000000008 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000004 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000004 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00001 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00001 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00002 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00002 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00003 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00003 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0001 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0001 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
Ki (binding) | = -9.3 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Ki (binding) | = -8 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Log Ki (binding) | = 8 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Log Ki (binding) | = 9.3 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.