TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.35 | Formula: C14H13N5O2S
H donors: 4 H acceptors: 3 LogP: 2.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(sc2c1c(C)n[nH]2)C(=O)N)Nc1ccccc1
InChi: 1S/C14H13N5O2S/c1-7-9-10(11(12(15)20)22-13(9)19-18-7)17-14(21)16-8-5-3-2-4-6-8/h2-6H,1H3,(H2,15,20)(H,18,19)(H2,16,17,21)
InChiKey: GSCAIAFNYPEEIT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, beta polypeptide	Starlite/ChEMBL	References
Homo sapiens	casein kinase 2, alpha 1 polypeptide		References
Homo sapiens	p21 protein (Cdc42/Rac)-activated kinase 4	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References
Homo sapiens	casein kinase 2, alpha prime polypeptide		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	casein kinase II beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	YOR039Wp-like protein, related	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	casein kinase ii regulatory subunit protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium knowlesi	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania major	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania donovani	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	CMGC kinase, CK2 family	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium parvum	putative casein kinase II regulatory subunit; besthit Pf 23508244	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania major	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania donovani	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	casein kinase ii beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania mexicana	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Theileria parva	casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	hypothetical protein	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania mexicana	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	Protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	ko:K03097 casein kinase 2, alpha polypeptide, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, CMGC CK2	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Loa Loa (eye worm)	CMGC/CK2 protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	unspecified product	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	Get druggable targets OG5_131977	All targets in OG5_131977
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania braziliensis	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Babesia bovis	protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	serine/threonine-protein kinase PAK 7	Get druggable targets OG5_131977	All targets in OG5_131977
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	ck2 beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	Casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium parvum	casein kinase II, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	casein kinase II beta 4 subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II, alpha chain (CK II)	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania braziliensis	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma congolense	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha 1 polypeptide	391 aa	316 aa	51.3 %
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha prime polypeptide	350 aa	319 aa	50.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Echinococcus granulosus	casein kinase ii subunit beta	0.0044	0.1437	0.1581
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Schistosoma mansoni	hypothetical protein	0.0019	0.0214	0.0299
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.0703	0.0982
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0021	0.0299	0.0329
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.1437	0.2008
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0019	0.0214	0.0235
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0214	0.0214
Echinococcus multilocularis	rac serine:threonine kinase	0.0029	0.0703	0.0773
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0299	0.0329
Entamoeba histolytica	hypothetical protein	0.0019	0.0214	0.0299
Entamoeba histolytica	protein kinase, putative	0.0042	0.1311	0.1832
Entamoeba histolytica	p21-activated kinase	0.0023	0.0418	0.0584
Entamoeba histolytica	protein kinase, putative	0.0039	0.1192	0.1665
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Entamoeba histolytica	protein kinase, putative	0.0023	0.0418	0.0584
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.1437	0.5
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.1437	0.1298
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0499	0.0549
Brugia malayi	Casein kinase II, alpha chain	0.0163	0.7158	0.7158
Toxoplasma gondii	ck2 beta subunit	0.0044	0.1437	0.0411
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0214	0.0214
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0499	0.0549
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0499	0.0549
Plasmodium vivax	unspecified product	0.0163	0.7158	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0044	0.1437	0.0411
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0042	0.1311	0.1311
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0021	0.0299	0.0329
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.1437	0.2008
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0299	0.0418
Giardia lamblia	Casein kinase II beta chain	0.0044	0.1437	0.1659
Loa Loa (eye worm)	Csnk2b protein	0.0044	0.1437	0.1437
Brugia malayi	WH1 domain containing protein	0.0019	0.0214	0.0214
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0019	0.0214	0.0299
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0163	0.7158	0.7158
Schistosoma mansoni	hypothetical protein	0.0019	0.0214	0.0299
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0222	1	1
Entamoeba histolytica	protein kinase 2, putative	0.0027	0.0584	0.0816
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0029	0.0703	0.0181
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0203	0.9093	1
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0019	0.0214	0.0214
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0203	0.9093	1
Giardia lamblia	Kinase, CMGC CK2	0.0163	0.7158	1
Schistosoma mansoni	protein kinase	0.0021	0.0299	0.0418
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0019	0.0214	0.0235
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Echinococcus multilocularis	nervana 2	0.0025	0.0499	0.0549
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Schistosoma mansoni	protein kinase	0.0021	0.0299	0.0418
Leishmania major	casein kinase II, putative	0.0163	0.7158	1
Schistosoma mansoni	casein kinase II beta subunit	0.0044	0.1437	0.2008
Echinococcus granulosus	nervana 2	0.0025	0.0499	0.0549
Entamoeba histolytica	hypothetical protein	0.0019	0.0214	0.0299
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0027	0.0584	0.0642
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0214	0.0299
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0044	0.1437	0.0215
Entamoeba histolytica	protein kinase, putative	0.0021	0.0299	0.0418
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.0703	0.0982
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0027	0.0584	0.0642
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Brugia malayi	Csnk2b protein	0.0044	0.1437	0.1437
Schistosoma mansoni	protein kinase	0.0019	0.0214	0.0299
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Echinococcus granulosus	nervana 2	0.0025	0.0499	0.0549
Trypanosoma brucei	Casein kinase II	0.0163	0.7158	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.0703	0.0982
Brugia malayi	Protein kinase domain	0.0021	0.0299	0.0299
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Echinococcus multilocularis	PAK box P21 Rho binding	0.0019	0.0214	0.0235
Schistosoma mansoni	protein kinase	0.0163	0.7158	1
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0299	0.0329
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0019	0.0214	0.0235
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0039	0.1192	0.1192
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0299	0.0329
Echinococcus granulosus	serine/threonine protein kinase	0.0029	0.0703	0.0773
Trypanosoma cruzi	casein kinase II, putative	0.0163	0.7158	1
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0299	0.0418
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0214	0.0299
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0499	0.0549
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0163	0.7158	0.7872
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.1437	0.1298
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0299	0.0418
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0214	0.0214
Entamoeba histolytica	casein kinase, putative	0.0163	0.7158	1
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0163	0.7158	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Echinococcus multilocularis	nervana 2	0.0025	0.0499	0.0549
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.1437	0.5
Echinococcus multilocularis	casein kinase ii subunit beta	0.0044	0.1437	0.1581
Giardia lamblia	Kinase, AGC PKA	0.0027	0.0584	0.0415
Echinococcus granulosus	serine threonine protein kinase nrc	0.0027	0.0584	0.0642
Echinococcus multilocularis	PAK box P21 Rho binding	0.0021	0.0299	0.0329
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Schistosoma mansoni	hypothetical protein	0.0019	0.0214	0.0299
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.1311	0.1832
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.1437	0.1298
Echinococcus granulosus	PAK box P21 Rho binding	0.0019	0.0214	0.0235
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0163	0.7158	1
Schistosoma mansoni	tyrosine kinase	0.0019	0.0214	0.0299
Toxoplasma gondii	CMGC kinase, CK2 family	0.0163	0.7158	1
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0299	0.0329
Entamoeba histolytica	protein kinase domain containing protein	0.0163	0.7158	1
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.1437	0.1298
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0299	0.0418
Echinococcus granulosus	casein kinase ii subunit alpha	0.0163	0.7158	0.7872
Entamoeba histolytica	protein kinase, putative	0.0042	0.1311	0.1832
Schistosoma mansoni	protein kinase	0.0021	0.0299	0.0418
Entamoeba histolytica	protein kinase, putative	0.0021	0.0299	0.0418
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1311	0.1311
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0119	0.0167
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.1437	0.1298
Brugia malayi	p70 ribosomal S6 kinase beta	0.0039	0.1192	0.1192
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.0703	0.0982
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.1437	0.2008
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.1437	0.2008
Entamoeba histolytica	protein kinase, putative	0.0023	0.0418	0.0584
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.1437	0.1298
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0299	0.0418
Trypanosoma cruzi	Protein kinase B	0.0029	0.0703	0.0181
Trichomonas vaginalis	CMGC family protein kinase	0.0163	0.7158	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9 uM	Inhibitory activity against Akt1	ChEMBL.	16216502
IC50 (binding)	= 9 uM	Inhibitory activity against Akt1	ChEMBL.	16216502
IC50 (binding)	= 11 uM	Inhibitory activity against CK2	ChEMBL.	16216502
IC50 (binding)	= 11 uM	Inhibitory activity against CK2	ChEMBL.	16216502
IC50 (binding)	= 13 uM	Inhibitory activity against Pak4	ChEMBL.	16216502
IC50 (binding)	= 13 uM	Inhibitory activity against Pak4	ChEMBL.	16216502
IC50 (binding)	= 20 uM	Inhibitory activity against KDR	ChEMBL.	16216502
IC50 (binding)	> 20 uM	Inhibitory activity against Plk1	ChEMBL.	16216502
IC50 (binding)	= 20 uM	Inhibitory activity against KDR	ChEMBL.	16216502
IC50 (binding)	> 20 uM	Inhibitory activity against Plk1	ChEMBL.	16216502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL199996

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 348364