TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.521 | Formula: C21H26N4O4S
H donors: 1 H acceptors: 4 LogP: 0.82 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCCN1CCN(CC1)CC(=O)N1c2ccccc2N(S(=O)(=O)c2c1cccc2)C
InChi: 1S/C21H26N4O4S/c1-22-17-6-2-3-7-18(17)25(19-8-4-5-9-20(19)30(22,28)29)21(27)16-24-12-10-23(11-13-24)14-15-26/h2-9,26H,10-16H2,1H3
InChiKey: AOWXEELBADFMHQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.011	0.0625	0.0625
Schistosoma mansoni	biogenic amine (5HT) receptor	0.011	0.0625	0.1406
Onchocerca volvulus		0.0111	0.0632	0.3857
Toxoplasma gondii	ABC1 family protein	0.0035	0.0035	0.0045
Echinococcus granulosus	cathepsin L	0.0034	0.0028	0.0061
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Schistosoma mansoni	neuropeptide f receptor 76f	0.011	0.0625	0.1406
Brugia malayi	cathepsin L precursor	0.0034	0.0028	0.0028
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0035	0.0075
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	dro:myosuppressin receptor	0.011	0.0625	0.1403
Onchocerca volvulus		0.011	0.0625	0.3811
Echinococcus multilocularis	neuropeptide receptor	0.011	0.0625	0.1403
Schistosoma mansoni	opsin-like receptor	0.011	0.0625	0.1406
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0035	0.5
Loa Loa (eye worm)	cathepsin B	0.0207	0.1394	0.1394
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	tachykinin peptides receptor 99D	0.011	0.0625	0.1403
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.011	0.0625	0.3811
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus multilocularis	cathepsin L	0.0034	0.0028	0.0061
Schistosoma mansoni	neuropeptide receptor	0.011	0.0625	0.1406
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0273	0.0615
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0625	0.1403
Schistosoma mansoni	opsin-like receptor	0.011	0.0625	0.1406
Schistosoma mansoni	amine GPCR	0.011	0.0625	0.1406
Onchocerca volvulus	Cathepsin F homolog	0.0111	0.0632	0.3857
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0632	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0034	0.0028	0.0064
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.011	0.0625	0.1403
Onchocerca volvulus		0.011	0.0625	0.3811
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0035	0.0078
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.008	0.0387	0.0387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.0273	0.1564
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Brugia malayi	Pre-SET motif family protein	0.0204	0.137	0.137
Onchocerca volvulus		0.011	0.0625	0.3811
Brugia malayi	neuropeptide F receptor	0.011	0.0625	0.0625
Brugia malayi	Cathepsin L-like precursor	0.008	0.0387	0.0387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.0632	0.3857
Schistosoma mansoni	adenoreceptor	0.011	0.0625	0.1406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0592	0.4444	1
Echinococcus granulosus	sex peptide receptor	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0632	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0111	0.0632	1
Schistosoma mansoni	biogenic amine receptor	0.011	0.0625	0.1406
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0592	0.4444	1
Echinococcus multilocularis	fmrfamide receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	melatonin receptor type 1A	0.011	0.0625	0.0625
Brugia malayi	follicle stimulating hormone receptor	0.011	0.0625	0.0625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Echinococcus granulosus	g protein coupled receptor	0.011	0.0625	0.1403
Schistosoma mansoni	hypothetical protein	0.0031	0.0002	0.0003
Echinococcus granulosus	cathepsin L cysteine protease	0.0065	0.0273	0.0611
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0592	0.4444	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.011	0.0625	0.1403
Schistosoma mansoni	opsin-like receptor	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	AKH receptor	0.011	0.0625	0.0625
Schistosoma mansoni	neuropeptide F-like receptor	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Onchocerca volvulus	Neuropeptide F receptor homolog	0.011	0.0625	0.3811
Echinococcus granulosus	neuropeptides capa receptor	0.011	0.0625	0.1403
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0028	0.0064
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0273	0.4054
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0682	0.0682
Echinococcus granulosus	tumor protein p63	0.0331	0.2377	0.5347
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Echinococcus multilocularis	g-protein coupled receptor	0.011	0.0625	0.1403
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Schistosoma mansoni	myosin xvIII	0.011	0.0625	0.1406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.011	0.0625	0.1406
Schistosoma mansoni	hypothetical protein	0.011	0.0625	0.1406
Schistosoma mansoni	neuropeptide receptor	0.011	0.0625	0.1406
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.011	0.0625	0.1406
Echinococcus granulosus	g protein coupled receptor	0.011	0.0625	0.1403
Echinococcus multilocularis	neuropeptide s receptor	0.011	0.0625	0.1403
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Entamoeba histolytica	cysteine proteinase, putative	0.008	0.0387	0.5946
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.0632	0.1419
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0111	0.0632	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0111	0.0632	0.1422
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0632	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0625	0.1403
Echinococcus multilocularis	serotonin receptor	0.011	0.0625	0.1403
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.0632	0.1419
Schistosoma mansoni	cathepsin B (C01 family)	0.0034	0.0028	0.0064
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0207	0.1394	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	G protein-coupled receptor	0.011	0.0625	0.0625
Brugia malayi	cathepsin F-like cysteine proteinase	0.0034	0.0028	0.0028
Giardia lamblia	Cathepsin B precursor	0.0207	0.1394	1
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0273	0.4054
Onchocerca volvulus		0.011	0.0625	0.3811
Loa Loa (eye worm)	TYRA-2 protein	0.011	0.0625	0.0625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.1293	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.011	0.0625	0.0625
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0034	0.0028	0.0064
Brugia malayi	sulfakinin receptor protein	0.1293	1	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	G-protein coupled receptor	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	Dopamine receptor protein 1	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Onchocerca volvulus		0.011	0.0625	0.3811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0387	0.2293
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0028	0.0028
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.0632	0.1419
Plasmodium vivax	vivapain-2	0.0111	0.0632	1
Schistosoma mansoni	hypothetical protein	0.011	0.0625	0.1406
Onchocerca volvulus		0.0111	0.0632	0.3857
Onchocerca volvulus		0.011	0.0625	0.3811
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0632	0.1422
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0592	0.4444	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0273	0.1754
Echinococcus multilocularis	sex peptide receptor	0.011	0.0625	0.1403
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0207	0.1394	0.3137
Brugia malayi	neuropeptide F receptor	0.011	0.0625	0.0625
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0625	0.1406
Schistosoma mansoni	hypothetical protein	0.0031	0.0002	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.008	0.0387	0.0387
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0111	0.0632	0.1419
Brugia malayi	GnHR receptor homolog	0.011	0.0625	0.0625
Echinococcus granulosus	serotonin receptor	0.011	0.0625	0.1403
Echinococcus granulosus	g-protein coupled receptor	0.011	0.0625	0.1403
Plasmodium vivax	vivapain-3	0.0065	0.0273	0.4322
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0002	0.0002
Onchocerca volvulus		0.011	0.0625	0.3811
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	G protein coupled receptor 139	0.011	0.0625	0.1403
Echinococcus granulosus	alpha 1A adrenergic receptor	0.011	0.0625	0.1403
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0625	0.1403
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.0273	0.0273
Echinococcus multilocularis	dro:myosuppressin receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Trypanosoma cruzi	major cysteine proteinase, putative	0.0034	0.0028	0.0064
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0035	0.004
Brugia malayi	ORL1-like opioid receptor	0.011	0.0625	0.0625
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.004
Trichomonas vaginalis	esterase, putative	0.0035	0.0035	0.004
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Onchocerca volvulus		0.0111	0.0632	0.3857
Onchocerca volvulus		0.0035	0.0035	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.011	0.0625	0.1406
Loa Loa (eye worm)	ctsf protein	0.0111	0.0632	0.0632
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	biogenic amine receptor	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	amine GPCR	0.011	0.0625	0.1406
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0035	0.0078
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Echinococcus granulosus	cysteine protease	0.0065	0.0273	0.0611
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.0632	0.0632
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0034	0.0028	0.0028
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0034	0.0028	0.0451
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0028	0.0064
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	neuropeptide F-like receptor	0.011	0.0625	0.1406
Echinococcus granulosus	neuropeptide receptor A26	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.154	1
Brugia malayi	putative neuropeptide receptor	0.011	0.0625	0.0625
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0625	0.1403
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.011	0.0625	0.1403
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.011	0.0625	0.1403
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.004
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Brugia malayi	Serotonin receptor	0.011	0.0625	0.0625
Echinococcus granulosus	7TM GPCR rhodopsin	0.011	0.0625	0.1403
Onchocerca volvulus		0.011	0.0625	0.3811
Onchocerca volvulus		0.011	0.0625	0.3811
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0035	0.5
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0034	0.0028	0.0028
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	neuropeptide FF receptor 2	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0287	0.0287
Schistosoma mansoni	neuropeptide receptor	0.011	0.0625	0.1406
Echinococcus granulosus	neuropeptide s receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.011	0.0625	0.0625
Brugia malayi	Melatonin receptor type 1A	0.011	0.0625	0.0625
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.011	0.0625	0.1403
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.0632	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Echinococcus granulosus	orexin receptor type 2	0.011	0.0625	0.1403
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.011	0.0625	0.0625
Echinococcus granulosus	cathepsin L	0.0065	0.0273	0.0611
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Brugia malayi	beta-lactamase family protein	0.0035	0.0035	0.0035
Schistosoma mansoni	cathepsin S (C01 family)	0.0034	0.0028	0.0064
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0035	0.0078
Echinococcus multilocularis	orexin receptor type 2	0.011	0.0625	0.1403
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.0632	0.1419
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0002	0.0002
Schistosoma mansoni	amine GPCR	0.011	0.0625	0.1406
Schistosoma mansoni	alpha-1 adrenergic receptor	0.011	0.0625	0.1406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Echinococcus granulosus	neuropeptide Y receptor	0.011	0.0625	0.1403
Onchocerca volvulus		0.0035	0.0035	0.004
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0034	0.0028	0.0064
Schistosoma mansoni	neuropeptide receptor	0.011	0.0625	0.1406
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Brugia malayi	fibroinase precursor	0.0034	0.0028	0.0028
Onchocerca volvulus		0.011	0.0625	0.3811
Echinococcus granulosus	allatostatin A receptor	0.011	0.0625	0.1403
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0139	0.0313
Echinococcus granulosus	g protein coupled receptor	0.011	0.0625	0.1403
Echinococcus multilocularis	fmrfamide receptor	0.011	0.0625	0.1403
Schistosoma mansoni	hypothetical protein	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0273	0.4054
Echinococcus granulosus	cathepsin b	0.0592	0.4444	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0065	0.0273	0.1564
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0632	0.1422
Brugia malayi	Cathepsin L-like precursor	0.008	0.0387	0.0387
Schistosoma mansoni	amine GPCR	0.011	0.0625	0.1406
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Giardia lamblia	Cathepsin B precursor	0.0207	0.1394	1
Toxoplasma gondii	cathepsin CPL	0.0111	0.0632	0.4419
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.011	0.0625	0.1403
Brugia malayi	Papain family cysteine protease containing protein	0.0034	0.0028	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Echinococcus granulosus	cathepsin l1	0.0111	0.0632	0.1419
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0028	0.0064
Onchocerca volvulus		0.0232	0.1593	1
Echinococcus multilocularis	cathepsin L	0.0065	0.0273	0.0611
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0034	0.0028	0.0028
Echinococcus granulosus	cathepsin b	0.0592	0.4444	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0065	0.0273	0.0615
Schistosoma mansoni	amine GPCR	0.011	0.0625	0.1406
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0111	0.0632	0.0632
Onchocerca volvulus		0.0111	0.0632	0.3857
Schistosoma mansoni	cathepsin C	0.0034	0.0028	0.0064
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.011	0.0625	0.1403
Plasmodium vivax	unspecified product	0.0065	0.0273	0.4322
Plasmodium vivax	vivapain-2	0.0111	0.0632	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0625	0.1406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0111	0.0632	0.1419
Echinococcus multilocularis	cysteine protease	0.0111	0.0632	0.1419
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0034	0.0028	0.0451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.0632	0.3857
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Brugia malayi	cathepsin B-like cysteine proteinase	0.0592	0.4444	0.4444
Loa Loa (eye worm)	neuropeptide F receptor	0.011	0.0625	0.0625
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.011	0.0625	0.1406
Brugia malayi	Dopamine receptor protein 2	0.011	0.0625	0.0625
Onchocerca volvulus		0.011	0.0625	0.3811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0028	0.0064
Onchocerca volvulus		0.011	0.0625	0.3811
Brugia malayi	Cathepsin L-like cysteine proteinase	0.008	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0273	0.0615
Echinococcus multilocularis	neuropeptide Y receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.1593	1
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.0632	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Brugia malayi	G-protein coupled receptor	0.011	0.0625	0.0625
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Echinococcus multilocularis	G protein coupled receptor 139	0.011	0.0625	0.1403
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0035	0.0078
Onchocerca volvulus		0.0048	0.0139	0.0707
Onchocerca volvulus		0.0111	0.0632	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Brugia malayi	Serotonin receptor	0.011	0.0625	0.0625
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0034	0.0028	0.0451
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1394	0.3137
Onchocerca volvulus		0.011	0.0625	0.3811
Onchocerca volvulus		0.011	0.0625	0.3811
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0034	0.0028	0.0451
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0625	0.1403
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0034	0.0028	0.0451
Onchocerca volvulus		0.011	0.0625	0.3811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.011	0.0625	0.1406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0034	0.0028	0.0451
Echinococcus granulosus	peptide allatostatin:somatostatin	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0031	0.0002	0.0003
Echinococcus multilocularis	cathepsin b	0.0592	0.4444	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0035	0.0075
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0034	0.0028	0.0028
Brugia malayi	Dopamine receptor	0.011	0.0625	0.0625
Echinococcus granulosus	biogenic amine 5HT receptor	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Mycobacterium ulcerans	lipase LipD	0.0035	0.0035	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.011	0.0625	0.1406
Plasmodium vivax	serine-repeat antigen (SERA)	0.0034	0.0028	0.0451
Plasmodium vivax	unspecified product	0.0034	0.0028	0.0451
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0632	0.0632
Leishmania major	cysteine peptidase A (CPA)	0.0111	0.0632	0.4393
Onchocerca volvulus		0.008	0.0387	0.2293
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	neuropeptide F receptor	0.011	0.0625	0.0625
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0034	0.0028	0.0451
Brugia malayi	G protein-coupled receptor F59B2.13	0.011	0.0625	0.0625
Echinococcus multilocularis	neuropeptide Y receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.137	0.137
Brugia malayi	beta-lactamase family protein	0.0035	0.0035	0.0035
Echinococcus granulosus	biogenic amine 5HT receptor	0.011	0.0625	0.1403
Echinococcus multilocularis	allatostatin A receptor	0.011	0.0625	0.1403
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.011	0.0625	0.1406
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Loa Loa (eye worm)	G-protein coupled receptor	0.011	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0632	0.1422
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus granulosus	7tm_1 domain containing protein	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.011	0.0625	0.1403
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Loa Loa (eye worm)	fibroinase	0.0111	0.0632	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	cathepsin F (C01 family)	0.008	0.0387	0.0871
Schistosoma mansoni	hypothetical protein	0.0031	0.0002	0.0003
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0034	0.0028	0.0451
Trypanosoma cruzi	cysteine protease, putative	0.0065	0.0273	0.0615
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Echinococcus multilocularis	neuropeptides capa receptor	0.011	0.0625	0.1403
Brugia malayi	RE15519p	0.011	0.0625	0.0625
Echinococcus multilocularis	somatostatin receptor	0.011	0.0625	0.1403
Brugia malayi	beta-lactamase	0.0035	0.0035	0.0035
Brugia malayi	cathepsin L-like precursor	0.008	0.0387	0.0387
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0632	0.1422
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0034	0.0028	0.0028
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0035	0.004
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0533	0.0533
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0035	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.011	0.0625	0.1406
Entamoeba histolytica	cysteine proteinase, putative	0.0065	0.0273	0.4054
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.011	0.0625	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	cysteine protease	0.0111	0.0632	0.0632
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1394	0.8728
Echinococcus granulosus	somatostatin receptor	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0065	0.0273	0.4054
Onchocerca volvulus		0.011	0.0625	0.3811
Echinococcus granulosus	neuropeptide Y receptor	0.011	0.0625	0.1403
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.008	0.0387	0.0871
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0287	0.0287
Echinococcus granulosus	neuropeptide receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.011	0.0625	0.0625
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0533	0.0533
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.011	0.0625	0.1403
Entamoeba histolytica	cysteine proteinase 1, putative	0.0065	0.0273	0.4054
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Schistosoma mansoni	hypothetical protein	0.011	0.0625	0.1406
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Onchocerca volvulus		0.0035	0.0035	0.004
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.011	0.0625	0.1403
Echinococcus granulosus	cathepsin l1	0.008	0.0387	0.0868
Trypanosoma cruzi	major cysteine proteinase, putative	0.0034	0.0028	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0273	0.1754
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Onchocerca volvulus		0.0111	0.0632	0.3857
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0592	0.4444	0.4444
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0625	0.1403
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0111	0.0632	0.0632
Onchocerca volvulus		0.011	0.0625	0.3811
Brugia malayi	putative neuropeptide receptor NPR1	0.011	0.0625	0.0625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0533	0.0533
Schistosoma mansoni	growth hormone secretagogue receptor	0.011	0.0625	0.1406
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Brugia malayi	Papain family cysteine protease containing protein	0.0065	0.0273	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0065	0.0273	0.4054
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.011	0.0625	0.1403
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0035	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.011	0.0625	0.1406
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0625	0.1406
Echinococcus multilocularis	neuropeptide FF receptor 2	0.011	0.0625	0.1403
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0034	0.0028	0.0451
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0034	0.0028	0.0064
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0034	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Brugia malayi	cathepsin L-like cysteine proteinase	0.0034	0.0028	0.0028
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0533	0.0533
Brugia malayi	hypothetical protein	0.011	0.0625	0.0625
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0034	0.0028	0.0451
Echinococcus granulosus	neuropeptides capa receptor	0.011	0.0625	0.1403
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0592	0.4444	1
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.0632	0.3857
Schistosoma mansoni	hypothetical protein	0.0067	0.0287	0.0646
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.0632	0.1422
Echinococcus multilocularis	neuropeptide receptor A26	0.011	0.0625	0.1403
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.011	0.0625	0.0625
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0111	0.0632	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0035	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.004
Echinococcus granulosus	fmrfamide receptor	0.011	0.0625	0.1403
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.0028	0.0064
Schistosoma mansoni	histamine h1 receptor	0.011	0.0625	0.1406
Echinococcus granulosus	neuropeptide receptor	0.011	0.0625	0.1403
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Brugia malayi	MH2 domain containing protein	0.0117	0.0682	0.0682
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.0273	0.0615
Entamoeba histolytica	cysteine proteinase 2	0.0065	0.0273	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.011	0.0625	0.1406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Toxoplasma gondii	cathepsin B	0.0207	0.1394	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0273	0.0615
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0387	0.2293
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0682	0.0682
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Echinococcus multilocularis	serotonin receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.008	0.0387	0.0387
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0632	0.3857
Echinococcus multilocularis	neuropeptides capa receptor	0.011	0.0625	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.011	0.0625	0.0625
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.011	0.0625	0.0625
Leishmania major	cathepsin L-like protease	0.0111	0.0632	0.4393
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Onchocerca volvulus		0.0111	0.0632	0.3857
Trypanosoma cruzi	cysteine proteinase, putative	0.0065	0.0273	0.0615
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0035	0.0549
Brugia malayi	larval opioid receptor	0.011	0.0625	0.0625
Echinococcus multilocularis	cysteine protease	0.0111	0.0632	0.1419
Schistosoma mansoni	biogenic amine receptor	0.011	0.0625	0.1406
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.011	0.0625	0.0625
Plasmodium vivax	serine-repeat antigen (SERA)	0.0034	0.0028	0.0451
Echinococcus granulosus	hypothetical protein	0.011	0.0625	0.1403
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0065	0.0273	0.0615
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0632	0.4393
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0625	0.1403
Echinococcus multilocularis	tumor protein p63	0.0331	0.2377	0.5347
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0139	0.0139
Echinococcus multilocularis	G-protein coupled receptor, putative	0.011	0.0625	0.1403
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0207	0.1394	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0002	0.0002
Echinococcus multilocularis	cathepsin b	0.0592	0.4444	1
Brugia malayi	G-protein coupled receptor	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.011	0.0625	0.0625
Plasmodium vivax	vivapain-1	0.0065	0.0273	0.4322
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0035	0.0035
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.011	0.0625	0.0625
Giardia lamblia	Cathepsin B precursor	0.0207	0.1394	1
Echinococcus multilocularis	neuropeptide receptor	0.011	0.0625	0.1403
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0632	0.0632
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0625	0.1406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0632	0.3857

Activities

Activity type	Activity value	Assay description	Source	Reference
Rectal temperature (functional)	= 34.4 degrees C	Rectal temperature of mice treated with compound in apomorphine (16 mg/kg injected sc 30 min before temp. recording) after its oral administration at 400mg/kg, 0.5 hr before rectal temperature measurement	ChEMBL.	2016710
Rectal temperature (functional)	= 34.4 degrees C	Rectal temperature of mice treated with compound in apomorphine (16 mg/kg injected sc 30 min before temp. recording) after its oral administration at 400mg/kg, 0.5 hr before rectal temperature measurement	ChEMBL.	2016710

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 14868696

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 35925