Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0499 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0499 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0499 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0499 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0499 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0499 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0216 | 0.1816 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0216 | 0.1816 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0499 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0499 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0499 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0499 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0499 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0499 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0216 | 0.1816 | 0.1816 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0499 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0499 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0499 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0499 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.00000006 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00000006 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0000004 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0000004 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00002 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00002 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00008 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00008 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
IC50 (binding) | > 0.001 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
Ki (binding) | = -6.7 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Log Ki (binding) | = 6.7 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.