TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.484 | Formula: C19H24N4O3S
H donors: 3 H acceptors: 3 LogP: 4.98 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc(cc1)Nc1snc(c1C(=N)NCC1CCCCC1)O
InChi: 1S/C19H24N4O3S/c1-26-19(25)13-7-9-14(10-8-13)22-18-15(17(24)23-27-18)16(20)21-11-12-5-3-2-4-6-12/h7-10,12,22H,2-6,11H2,1H3,(H2,20,21)(H,23,24)
InChiKey: DYTOKIJZRBPJGY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	Get druggable targets OG5_127304	All targets in OG5_127304
Echinococcus granulosus	dual specificity mitogen activated protein	Get druggable targets OG5_127304	All targets in OG5_127304
Schistosoma japonicum	Dual specificity mitogen-activated protein kinase kinase 2, putative	Get druggable targets OG5_127304	All targets in OG5_127304
Cryptosporidium hominis	protein kinase NPK2 (EC 2.7.1.-)	Get druggable targets OG5_127304	All targets in OG5_127304
Trichomonas vaginalis	STE family protein kinase	Get druggable targets OG5_127304	All targets in OG5_127304
Leishmania mexicana	protein kinase, putative,mitogen activated protein kinase, putative	Get druggable targets OG5_127304	All targets in OG5_127304
Leishmania donovani	mitogen-activated protein kinase kinase 5	Get druggable targets OG5_127304	All targets in OG5_127304
Trypanosoma brucei gambiense	protein kinase, putative,MAP kinase kinase, putative	Get druggable targets OG5_127304	All targets in OG5_127304
Leishmania infantum	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	Get druggable targets OG5_127304	All targets in OG5_127304
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	Get druggable targets OG5_127304	All targets in OG5_127304
Trichomonas vaginalis	STE family protein kinase	Get druggable targets OG5_127304	All targets in OG5_127304
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	Get druggable targets OG5_127304	All targets in OG5_127304
Candida albicans	member of the HOG1 MAPK cascade	Get druggable targets OG5_127304	All targets in OG5_127304
Trypanosoma congolense	mitogen-activated protein kinase kinase 5	Get druggable targets OG5_127304	All targets in OG5_127304
Candida albicans	likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W)	Get druggable targets OG5_127304	All targets in OG5_127304
Cryptosporidium parvum	protein kinase NPK2	Get druggable targets OG5_127304	All targets in OG5_127304
Echinococcus multilocularis	dual specificity mitogen activated protein	Get druggable targets OG5_127304	All targets in OG5_127304
Candida albicans	likely MAP kinase kinase that can functionally substitute for S. cerevisiae STE7 (YDL159W)	Get druggable targets OG5_127304	All targets in OG5_127304
Trichomonas vaginalis	STE family protein kinase	Get druggable targets OG5_127304	All targets in OG5_127304
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	Get druggable targets OG5_127304	All targets in OG5_127304
Leishmania braziliensis	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	Get druggable targets OG5_127304	All targets in OG5_127304
Giardia lamblia	Kinase, STE STE20	Get druggable targets OG5_127304	All targets in OG5_127304
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	Get druggable targets OG5_127304	All targets in OG5_127304
Schistosoma japonicum	Dual specificity mitogen-activated protein kinase kinase 1, putative	Get druggable targets OG5_127304	All targets in OG5_127304
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127304	All targets in OG5_127304

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0009	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0619	0.0619
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0443	0.0443
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0024	0.1004	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0443	0.0443
Schistosoma mansoni	alpha glucosidase	0.0024	0.1004	0.1004
Schistosoma mansoni	tyrosine kinase	0.008	0.4525	0.4525
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0443	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0015	0.0443	0.0443
Onchocerca volvulus	Fxna peptidase homolog	0.0018	0.0619	0.0184
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.009	0.5134	1
Schistosoma mansoni	coup transcription factor	0.0015	0.0443	0.0443
Brugia malayi	SRC-1	0.0009	0.0095	0.0095
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0018	0.0619	0.5
Loa Loa (eye worm)	SRC-1	0.0009	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0112	0.6511	0.6511
Brugia malayi	ecdysteroid receptor	0.0015	0.0443	0.0443
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0443	0.0443
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0024	0.1004	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0443	0.0443
Leishmania major	alpha glucosidase II subunit, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0443	0.0443
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0009	0.0095	0.0095
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0024	0.1004	0.1004
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0024	0.1004	0.0852
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0024	0.1004	0.1004
Brugia malayi	FXNA	0.0018	0.0619	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0015	0.0443	0.0443
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0024	0.1004	0.1004
Schistosoma mansoni	tyrosine kinase	0.0082	0.4645	0.4645
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0015	0.0443	0.0443
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0443	0.0443
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0024	0.1004	0.0587
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0009	0.0095	0.0095
Echinococcus granulosus	lysosomal alpha glucosidase	0.0167	1	1
Onchocerca volvulus	Fxna peptidase homolog	0.0018	0.0619	0.0184
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0018	0.0619	0.0619
Schistosoma mansoni	tyrosine kinase	0.0009	0.0095	0.0095
Brugia malayi	Peptidase family M28 containing protein	0.0112	0.6511	0.6511
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0443	0.0443
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0443	0.0443
Brugia malayi	nicalin	0.0018	0.0619	0.0619
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0018	0.0619	0.0619
Trypanosoma brucei	glucosidase, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0443	0.0443
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0049	0.2589	0.2589
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0009	0.0095	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	protein kinase	0.009	0.5134	0.5134
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0443	0.0443
Brugia malayi	steroid hormone receptor	0.0015	0.0443	0.0443
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.1004	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0619	0.0619
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0443	0.0443
Onchocerca volvulus	Fxna peptidase homolog	0.0018	0.0619	0.0184
Schistosoma mansoni	tyrosine kinase	0.008	0.4525	0.4525
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0443	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Brugia malayi	photoreceptor-specific nuclear receptor	0.0015	0.0443	0.0443
Brugia malayi	leucyl aminopeptidase	0.0018	0.0619	0.0619
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0443	0.0443
Brugia malayi	Furin-like cysteine rich region family protein	0.0151	0.9015	0.9015
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0009	0.0095	0.0095
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0009	0.0095	0.0095
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0443	0.0443
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0018	0.0619	0.0619
Echinococcus granulosus	insulin receptor	0.0049	0.2589	0.2589
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0443	0.0443
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0112	0.6511	0.6349
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0009	0.0095	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0443	0.0443
Leishmania major	glycosyl hydrolase-like protein	0.0024	0.1004	0.0852
Echinococcus multilocularis	epidermal growth factor receptor	0.0151	0.9015	0.9015
Loa Loa (eye worm)	leucyl aminopeptidase	0.0018	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0619	0.0619
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0443	0.0443
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0018	0.0619	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.009	0.5134	0.5134
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0018	0.0619	0.0619
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0112	0.6511	0.6511
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0443	0.0443
Echinococcus multilocularis	epidermal growth factor receptor	0.0082	0.4645	0.4645
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.1004	0.0852
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0015	0.0443	0.0443
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0009	0.0095	0.0095
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0009	0.0095	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Schistosoma mansoni	tyrosine kinase	0.0009	0.0095	0.0095
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0009	0.0095	0.0095
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0443	0.0443
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0443	0.0443
Echinococcus multilocularis	insulin receptor	0.0049	0.2589	0.2589
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0018	0.0619	0.0619
Echinococcus granulosus	dual specificity mitogen activated protein	0.009	0.5134	0.5134
Schistosoma mansoni	tyrosine kinase	0.0082	0.4645	0.4645
Schistosoma mansoni	alpha-glucosidase	0.0167	1	1
Mycobacterium tuberculosis	Conserved protein	0.0018	0.0619	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0082	0.4645	0.4645
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0443	0.0443
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0024	0.1004	0.0852
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0443	0.0443
Echinococcus granulosus	neutral alpha glucosidase AB	0.0024	0.1004	0.1004
Onchocerca volvulus		0.0018	0.0619	0.0184
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0009	0.0095	0.0095
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0018	0.0619	0.0619
Brugia malayi	Protein kinase domain containing protein	0.0049	0.2589	0.2589
Schistosoma mansoni	alpha-glucosidase	0.0167	1	1
Schistosoma mansoni	tyrosine kinase	0.008	0.4525	0.4525
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0112	0.6511	0.6511
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0443	0.0443
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0151	0.9015	0.9015
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0018	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0443	0.0443
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0443	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0015	0.0443	0.0443
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0167	1	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0024	0.1004	0.0852
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0443	0.0443
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	1	1
Schistosoma mansoni	tyrosine kinase	0.0151	0.9015	0.9015
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0443	0.0443
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0443	0.0443
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0443	0.0443
Brugia malayi	Tyrosine-protein kinase abl-1	0.0009	0.0095	0.0095
Schistosoma mansoni	tyrosine kinase	0.0009	0.0095	0.0095
Schistosoma mansoni	tyrosine kinase	0.0009	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0619	0.0619
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0095	0.0095
Echinococcus multilocularis	dual specificity mitogen activated protein	0.009	0.5134	0.5134
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0015	0.0443	0.0443
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0443	0.0443
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0024	0.1004	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0443	0.0443
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0112	0.6511	0.6511
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.009	0.5134	1
Echinococcus granulosus	epidermal growth factor receptor	0.0151	0.9015	0.9015
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0009	0.0095	0.0095
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.0443	0.0443
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0443	0.0443
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0024	0.1004	0.0852
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0024	0.1004	0.5
Trichomonas vaginalis	STE family protein kinase	0.009	0.5134	1
Schistosoma mansoni	nicalin (M28 family)	0.0018	0.0619	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0015	0.0443	0.0443
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0443	0.0443
Schistosoma mansoni	tyrosine kinase	0.0049	0.2589	0.2589
Trichomonas vaginalis	STE family protein kinase	0.009	0.5134	1
Trichomonas vaginalis	STE family protein kinase	0.009	0.5134	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Schistosoma mansoni	tyrosine kinase	0.0049	0.2589	0.2589
Onchocerca volvulus		0.0167	1	1
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0443	0.0443
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0024	0.1004	0.0852
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0443	0.0443
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.009	0.5134	0.5134
Loa Loa (eye worm)	TK/INSR protein kinase	0.0049	0.2589	0.2589
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0443	0.0443
Echinococcus multilocularis		0.0047	0.2427	0.2427
Giardia lamblia	Kinase, STE STE20	0.009	0.5134	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0024	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1004	0.1004
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0024	0.1004	0.0852
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0024	0.1004	0.0852
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0443	0.0443
Brugia malayi	Steroid receptor seven-up type 2	0.0015	0.0443	0.0443
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0009	0.0095	0.0095
Brugia malayi	nuclear hormone receptor	0.0015	0.0443	0.0443
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0082	0.4645	0.4645
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0443	0.0443
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0018	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0443	0.0443
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0009	0.0095	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0443	0.0443
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0443	0.0443
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0024	0.1004	0.0852
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0024	0.1004	0.0852
Echinococcus granulosus	c src tyrosine kinase	0.0009	0.0095	0.0095
Echinococcus multilocularis	c src tyrosine kinase	0.0009	0.0095	0.0095
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0024	0.1004	0.0852
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0619	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0049	0.2589	0.2589
Trichomonas vaginalis	alpha-glucosidase, putative	0.0024	0.1004	0.0852
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.009	0.5134	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0443	0.0443
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0443	0.0443
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0443	0.0443

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.35 uM	Inhibition of MEK1	ChEMBL.	16725322
IC50 (binding)	= 0.35 uM	Inhibition of MEK1	ChEMBL.	16725322

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 368286