TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.438 | Formula: C19H19N3O2S
H donors: 3 H acceptors: 3 LogP: 2.68 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)c1ccc(s1)c1ccc(cn1)CNCCc1ccccc1
InChi: 1S/C19H19N3O2S/c23-19(22-24)18-9-8-17(25-18)16-7-6-15(13-21-16)12-20-11-10-14-4-2-1-3-5-14/h1-9,13,20,24H,10-12H2,(H,22,23)
InChiKey: VEZBAVITAWDRDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histone deacetylase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K06067 histone deacetylase 1/2, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K01463 Hdac3 [EC:3.5.1.-], putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	RPD3/HD1 histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC2	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei gambiense	histone deacetylase 1,histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC3	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma congolense	histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Giardia lamblia	Histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Entamoeba histolytica	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 3 (HD3)	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium berghei	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Theileria parva	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium knowlesi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 1 (HD1)	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	Histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium vivax	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Babesia bovis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium falciparum	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	histone deacetylase HDA2/Rpd3p	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0063	0.014	0.014
Schistosoma mansoni	nephrin	0.0063	0.014	0.6939
Echinococcus granulosus	anosmin 1	0.0034	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0063	0.014	0.394
Brugia malayi	histone deacetylase 3 (HD3)	0.0077	0.0202	0.5908
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0034	0.0016	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0034	0.0016	0.0016
Echinococcus granulosus	anosmin 1	0.0034	0.0016	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Toxoplasma gondii	histone deacetylase HDAC2	0.0077	0.0202	0.5
Echinococcus multilocularis	histone deacetylase 3	0.0077	0.0202	0.0202
Onchocerca volvulus		0.0065	0.015	0.4246
Schistosoma mansoni	cell adhesion molecule	0.0034	0.0016	0.0812
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0063	0.014	0.014
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.014	0.394
Echinococcus multilocularis	roundabout 2	0.0063	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0035	0.002	0.0104
Brugia malayi	histone deacetylase 1 (HD1)	0.0077	0.0202	0.5908
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.015	0.7415
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0016	0.0812
Onchocerca volvulus		0.0063	0.014	0.394
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Echinococcus granulosus	serine:threonine protein kinase	0.2325	1	1
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Plasmodium falciparum	histone deacetylase 1	0.0077	0.0202	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Brugia malayi	hypothetical protein	0.0106	0.033	1
Schistosoma mansoni	myosin-binding protein-related	0.0063	0.014	0.6939
Echinococcus multilocularis	usherin	0.0034	0.0016	0.0016
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0034	0.0016	0.0016
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0034	0.0016	0.0016
Echinococcus granulosus	EG95	0.0034	0.0016	0.0016
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0034	0.0016	0.0016
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0034	0.0016	0.0016
Echinococcus multilocularis	anosmin 1	0.0034	0.0016	0.0016
Schistosoma mansoni	neuroglian	0.0063	0.014	0.6939
Echinococcus granulosus	neuroglian	0.0063	0.014	0.014
Echinococcus granulosus	roundabout 2	0.0063	0.014	0.014
Echinococcus granulosus	contactin	0.0063	0.014	0.014
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0034	0.0016	0.0016
Schistosoma mansoni	histone deacetylase	0.0077	0.0202	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0034	0.0016	0.0812
Loa Loa (eye worm)	CAMK protein kinase	0.0065	0.015	0.4246
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0034	0.0016	0.0016
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Schistosoma mansoni	factor for adipocyte differentiation	0.0034	0.0016	0.0812
Echinococcus multilocularis	titin	0.0034	0.0016	0.0016
Schistosoma mansoni	cell adhesion molecule	0.0063	0.014	0.6939
Schistosoma mansoni	cell adhesion molecule	0.0063	0.014	0.6939
Schistosoma mansoni	titin	0.0065	0.015	0.7415
Schistosoma mansoni	hemicentin	0.0063	0.014	0.6939
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0202	0.5
Schistosoma mansoni	ephrin receptor	0.0034	0.0016	0.0812
Schistosoma mansoni	cell adhesion molecule	0.0063	0.014	0.6939
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Echinococcus multilocularis	anosmin 1	0.0034	0.0016	0.0016
Echinococcus multilocularis	transfer RNA-Phe	0.0063	0.014	0.014
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0063	0.014	0.014
Echinococcus multilocularis	neuroglian	0.0063	0.014	0.014
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0034	0.0016	0.0016
Giardia lamblia	Histone deacetylase	0.0077	0.0202	0.5
Echinococcus granulosus	roundabout 2	0.0063	0.014	0.014
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.014	0.394
Entamoeba histolytica	histone deacetylase, putative	0.0077	0.0202	0.5
Echinococcus granulosus	G1Y162 protein	0.0034	0.0016	0.0016
Echinococcus multilocularis	serine:threonine protein kinase	0.2325	1	1
Schistosoma mansoni	nephrin	0.0063	0.014	0.6939
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0063	0.014	0.014
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0035	0.002	0.0104
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0063	0.014	0.014
Brugia malayi	Histone deacetylase 1	0.0077	0.0202	0.5908
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0034	0.0016	0.0016
Echinococcus granulosus	usherin	0.0034	0.0016	0.0016
Echinococcus multilocularis	roundabout 2	0.0063	0.014	0.014
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0065	0.015	0.4246
Schistosoma mansoni	hypothetical protein	0.0034	0.0016	0.0812
Trypanosoma brucei	histone deacetylase 1	0.0077	0.0202	1
Schistosoma mansoni	histone deacetylase	0.0077	0.0202	1
Schistosoma mansoni	titin	0.0034	0.0016	0.0812
Echinococcus multilocularis	Fibronectin, type III	0.0034	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0063	0.014	0.6939
Echinococcus granulosus	Netrin receptor DCC	0.0034	0.0016	0.0016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0035	0.002	0.0104
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.015	0.4246
Echinococcus granulosus	histone deacetylase 1	0.0077	0.0202	0.0202
Schistosoma mansoni	factor for adipocyte differentiation	0.0034	0.0016	0.0812
Echinococcus multilocularis	roundabout 2	0.0063	0.014	0.014
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Echinococcus granulosus	nephrin	0.0063	0.014	0.014
Schistosoma mansoni	cell adhesion molecule	0.0063	0.014	0.6939
Toxoplasma gondii	histone deacetylase HDAC3	0.0077	0.0202	0.5
Loa Loa (eye worm)	histone deacetylase 1	0.0077	0.0202	0.5908
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Loa Loa (eye worm)	hypothetical protein	0.0063	0.014	0.394
Loa Loa (eye worm)	projectin	0.0063	0.014	0.394
Trypanosoma cruzi	histone deacetylase 1, putative	0.0077	0.0202	1
Schistosoma mansoni	tripartite motif protein trim9	0.0034	0.0016	0.0812
Echinococcus granulosus	titin	0.0065	0.015	0.015
Trypanosoma cruzi	histone deacetylase 1, putative	0.0077	0.0202	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.014	0.394
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.014	0.394
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Schistosoma mansoni	factor for adipocyte differentiation	0.0034	0.0016	0.0812
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0063	0.014	0.014
Loa Loa (eye worm)	histone deacetylase 3	0.0077	0.0202	0.5908
Echinococcus granulosus	cell adhesion molecule	0.0034	0.0016	0.0016
Schistosoma mansoni	titin	0.0063	0.014	0.6939
Echinococcus multilocularis	anosmin 1	0.0034	0.0016	0.0016
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0202	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0065	0.015	0.4246
Plasmodium vivax	histone deacetylase 1, putative	0.0077	0.0202	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0063	0.014	0.6939
Echinococcus granulosus	titin	0.0065	0.015	0.015
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0034	0.0016	0.0812
Echinococcus granulosus	histone deacetylase 3	0.0077	0.0202	0.0202
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0034	0.0016	0.0016
Onchocerca volvulus		0.0063	0.014	0.394
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0202	0.5908
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0035	0.002	0.0104
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0063	0.014	0.394
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0202	0.5
Echinococcus multilocularis	cell adhesion molecule	0.0034	0.0016	0.0016
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0034	0.0016	0.0016
Leishmania major	histone deacetylase, putative	0.0077	0.0202	1
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0034	0.0016	0.0016
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0016	0.0812
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0202	0.5
Echinococcus multilocularis	Netrin receptor DCC	0.0034	0.0016	0.0016
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0034	0.0016	0.0812
Leishmania major	histone deacetylase, putative	0.0077	0.0202	1
Echinococcus granulosus	Fibronectin type III	0.0034	0.0016	0.0016
Echinococcus granulosus	roundabout 2	0.0063	0.014	0.014
Schistosoma mansoni	hypothetical protein	0.0034	0.0016	0.0812
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0034	0.0016	0.0016
Echinococcus multilocularis	Netrin receptor DCC	0.0034	0.0016	0.0016
Brugia malayi	protein unc-22	0.0065	0.015	0.4246
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	0.2325	1	1
Echinococcus granulosus	Netrin receptor DCC	0.0034	0.0016	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.014	0.394
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0034	0.0016	0.0016
Echinococcus granulosus	anosmin 1	0.0034	0.0016	0.0016
Echinococcus multilocularis	histone deacetylase 1	0.0077	0.0202	0.0202
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0034	0.0016	0.0016
Echinococcus multilocularis	titin	0.0065	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0106	0.033	1
Onchocerca volvulus		0.0106	0.033	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.012 uM	Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)	ChEMBL.	17107790
IC50 (functional)	= 0.012 uM	Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)	ChEMBL.	17107790
IC50 (functional)	= 0.07 uM	Inhibition of MCF7 cell proliferation (mean of two experiments)	ChEMBL.	17107790
IC50 (functional)	= 0.07 uM	Inhibition of MCF7 cell proliferation (mean of two experiments)	ChEMBL.	17107790
IC50 (functional)	= 0.2 uM	Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)	ChEMBL.	17107790
IC50 (functional)	= 0.2 uM	Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)	ChEMBL.	17107790

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17107790

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL217531

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 376017