Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0087 | 0.0047 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.016 | 0.1148 | 0.2864 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.0615 | 0.206 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0087 | 0.0047 |
Onchocerca volvulus | 0.0037 | 0.0087 | 0.033 | |
Onchocerca volvulus | 0.0198 | 0.1481 | 0.7881 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.0118 | 0.079 | 0.2644 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0032 | 0.008 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.0615 | 0.206 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0195 | 0.1046 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0085 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0081 | 0.0463 | 0.1155 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0173 | 0.0433 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0173 | 0.0928 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1184 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0032 | 0.008 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0087 | 0.0044 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0087 | 0.0464 |
Schistosoma mansoni | carbonic anhydrase | 0.0491 | 0.4007 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.0615 | 0.3294 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0032 | 0.0172 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0167 | 0.1206 | 0.4038 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0469 | 0.3815 | 0.4776 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0087 | 0.0044 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0026 | 0.0065 |
Brugia malayi | hypothetical protein | 0.0243 | 0.1869 | 1 |
Echinococcus granulosus | expressed protein | 0.0373 | 0.2987 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0087 | 0.0291 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0195 | 0.0488 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0441 | 0.1101 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.1617 | 0.8652 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0087 | 0.0044 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0085 | 0.0213 |
Plasmodium falciparum | inorganic anion exchanger, inorganic anion antiporter | 0.0032 | 0.004 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0087 | 0.0001 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0032 | 0.0107 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0087 | 0.0001 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0087 | 0.0047 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0032 | 0.008 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0026 | 0.0087 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.008 | 0.0201 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0491 | 0.4007 | 0.3983 |
Chlamydia trachomatis | sulfate transporter | 0.0032 | 0.004 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.079 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0229 | 0.1747 | 0.4285 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0211 | 0.1129 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0366 | 0.2932 | 0.9815 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0087 | 0.0464 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0118 | 0.079 | 0.4227 |
Onchocerca volvulus | 0.0031 | 0.0032 | 0.0034 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0087 | 0.0047 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0026 | 0.2985 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0026 | 0.0139 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.079 | 0.1971 |
Leishmania major | carbonic anhydrase-like protein | 0.0118 | 0.079 | 0.1796 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0769 | 0.4114 |
Onchocerca volvulus | 0.0037 | 0.0087 | 0.033 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0026 | 0.0139 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0087 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0034 | 0.0059 | 0.0199 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0173 | 0.0433 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0087 | 0.0291 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0251 | 0.1939 | 0.2394 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0087 | 0.0003 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0032 | 0.0107 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0945 | 0.7932 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0087 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0404 | 0.2162 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.008 | 0.043 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0491 | 0.4007 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0491 | 0.4007 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0173 | 0.058 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0046 | 0.0164 | 0.0409 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0118 | 0.079 | 0.4227 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0769 | 0.4114 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0127 | 0.0426 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0087 | 0.0464 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0173 | 0.0928 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1184 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0085 | 0.0457 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0087 | 0.0047 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0087 | 0.0464 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0087 | 0.0044 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0026 | 0.0139 |
Plasmodium vivax | sulfate transporter, putative | 0.0032 | 0.004 | 0.2287 |
Toxoplasma gondii | inorganic anion transporter, sulfate permease (SulP) family protein | 0.0032 | 0.004 | 0.459 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0026 | 0.0065 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1869 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0085 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0229 | 0.1747 | 0.2151 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0173 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0085 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0167 | 0.1206 | 0.4038 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0087 | 0.0044 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.008 | 0.0201 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0087 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0087 | 0.0464 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0243 | 0.1869 | 0.6255 |
Schistosoma mansoni | serine-rich repeat protein | 0.0086 | 0.051 | 0.1273 |
Brugia malayi | Cache domain containing protein | 0.0074 | 0.0404 | 0.2162 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0087 | 0.0001 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.008 | 0.0269 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0087 | 0.0088 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0118 | 0.079 | 0.4227 |
Onchocerca volvulus | 0.0244 | 0.1872 | 1 | |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.005 | 0.0197 | 0.0659 |
Echinococcus granulosus | carbonic anhydrase II | 0.0118 | 0.079 | 0.2644 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.004 | 0.0116 | 0.0622 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0087 | 0.0088 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0085 | 0.0608 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.008 | 0.043 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0087 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.051 | 0.1273 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.005 | 0.0197 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.079 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0032 | 0.0107 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0085 | 0.0046 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0087 | 0.0001 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.008 | 0.0269 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0026 | 0.0139 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0366 | 0.2932 | 0.9815 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0087 | 0.0626 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0085 | 0.0608 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0087 | 0.0464 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0087 | 0.0001 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0034 | 0.0059 | 0.0148 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0087 | 0.0626 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0087 | 0.0044 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0302 | 0.1615 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.1872 | 0.1802 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0034 | 0.0059 | 0.0199 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0491 | 0.4007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0087 | 0.0464 |
Onchocerca volvulus | 0.0037 | 0.0087 | 0.033 | |
Echinococcus multilocularis | expressed protein | 0.0373 | 0.2987 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0087 | 0.0217 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0037 | 0.0083 | 0.0446 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0127 | 0.0426 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0173 | 0.058 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0118 | 0.079 | 0.4227 |
Loa Loa (eye worm) | glutamate receptor | 0.004 | 0.0116 | 0.0622 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.079 | 0.1971 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0087 | 0.0044 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0026 | 0.0087 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.1811 | 0.2233 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0032 | 0.008 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0085 | 0.0213 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0087 | 1 |
Echinococcus granulosus | peregrin | 0.003 | 0.0026 | 0.0087 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0087 | 0.0217 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0769 | 0.4114 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0032 | 0.0172 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0085 | 0.9847 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0026 | 0.0087 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0085 | 0.0286 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.1617 | 0.8652 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0032 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0197 | 0.1054 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0022 | 0.0075 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0173 | 0.058 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0026 | 0.2985 |
Onchocerca volvulus | 0.005 | 0.0195 | 0.0918 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0087 | 0.0626 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0118 | 0.079 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0243 | 0.1869 | 0.6255 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0173 | 0.0433 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0085 | 0.0286 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0087 | 0.0001 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0032 | 0.3699 |
Onchocerca volvulus | Putative sulfate transporter | 0.0198 | 0.1481 | 0.7881 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0026 | 0.6504 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0195 | 0.0488 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | < 57 % | In vivo triglyceride lowering activity dosed at 0.10 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 78 % | In vivo Triglyceride lowering activity at dose as 0.01 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 89 % | In vivo sterol lowering activity dosed at 0.10 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 89 % | In vivo Sterol lowering activity at dose as 0.01 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 92 % | In vivo triglyceride lowering activity, dosed at 0.03 % of the diet | ChEMBL. | 6604816 |
Diet (functional) | = 100 % | In vivo Sterol lowering activity at dose as 0.03 % of the diet | ChEMBL. | 6604816 |
Inhibition (binding) | < 72 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Inhibition (binding) | < 72 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.