Detailed information for compound 407584

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1603.26 | Formula: C82H104ClN17O15
  • H donors: 16 H acceptors: 16 LogP: 4.35 Rotable bonds: 53
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)N)C)CCCCNC(C)C)CC(C)C)Cc1ccc(cc1)NC(=O)C)Cc1ccc(cc1)NC(=O)[C@@H]1CNC(=O)N1)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc2c(c1)cccc2)NC(=O)C)Cc1ccc(cc1)Cl)Cc1cccnc1
  • InChi: 1S/C82H104ClN17O15/c1-46(2)36-62(72(105)92-61(17-10-11-34-86-47(3)4)81(114)100-35-13-18-70(100)80(113)88-48(5)71(84)104)93-74(107)65(39-52-22-29-59(30-23-52)89-49(6)102)95-76(109)66(40-53-24-31-60(32-25-53)91-78(111)68-44-87-82(115)99-68)97-79(112)69(45-101)98-77(110)67(42-55-14-12-33-85-43-55)96-75(108)64(38-51-20-27-58(83)28-21-51)94-73(106)63(90-50(7)103)41-54-19-26-56-15-8-9-16-57(56)37-54/h8-9,12,14-16,19-33,37,43,46-48,61-70,86,101H,10-11,13,17-18,34-36,38-42,44-45H2,1-7H3,(H2,84,104)(H,88,113)(H,89,102)(H,90,103)(H,91,111)(H,92,105)(H,93,107)(H,94,106)(H,95,109)(H,96,108)(H,97,112)(H,98,110)(H2,87,99,115)/t48-,61+,62+,63-,64-,65-,66+,67-,68+,69+,70+/m1/s1
  • InChiKey: MKPGJCFULHSGDD-YAYFWMKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Toxoplasma gondii cathepsin CPL 0.0058 0.0372 0.0648
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0589 0.4203 0.4186
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0013 0.0045 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1392 0.9999 1
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0803 0.5749 0.5749
Plasmodium vivax unspecified product 0.0036 0.021 0.0288
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Trypanosoma cruzi cysteine proteinase, putative 0.0036 0.021 0.0316
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis SH2 domain containing protein 7 0.0589 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus granulosus SH2 motif 0.0589 0.4203 0.4203
Onchocerca volvulus 0.0589 0.4203 0.4203
Echinococcus multilocularis SHC transforming protein 3 0.0589 0.4203 0.4203
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0589 0.4203 0.4203
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Loa Loa (eye worm) TK/CSK protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) SH2 domain-containing protein 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni tyrosine kinase 0.1392 0.9999 0.9999
Brugia malayi cathepsin L-like cysteine proteinase 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0803 0.5749 0.5749
Echinococcus multilocularis heat shock protein 70 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Echinococcus granulosus retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Abl 0.1392 0.9999 0.9999
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.021 0.0366
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Echinococcus granulosus natriuretic peptide receptor 1 0.0803 0.5749 0.5749
Schistosoma mansoni tensin-related 0.0589 0.4203 0.4203
Entamoeba histolytica tyrosin kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0803 0.5749 0.5749
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0372 0.0372
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Giardia lamblia Kinase 0.0803 0.5749 0.9999
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis raf serine:threonine protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0013 0.0045 0.0077
Echinococcus multilocularis protein Wnt 2 0.0014 0.0051 0.0051
Echinococcus multilocularis N chimaerin 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Loa Loa (eye worm) Wnt2 protein 0.0014 0.0051 0.0051
Brugia malayi Tyrosine-protein kinase abl-1 0.1392 0.9999 1
Echinococcus granulosus hypothetical protein 0.0589 0.4203 0.4203
Echinococcus granulosus retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Loa Loa (eye worm) RGC/RGC protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus kinase suppressor of Ras 1 0.0803 0.5749 0.5749
Loa Loa (eye worm) RGC/RGC protein kinase 0.0803 0.5749 0.5749
Brugia malayi fibroinase precursor 0.0013 0.0045 0.0045
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0013 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Schistosoma mansoni wnt related 0.0014 0.0051 0.0051
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0372 0.0648
Echinococcus granulosus tyrosine protein kinase pr2 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.1392 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0013 0.0045 0.0077
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Loa Loa (eye worm) SRC-1 0.1392 0.9999 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0803 0.5749 0.5749
Echinococcus granulosus tyrosine protein kinase Srms 0.1392 0.9999 0.9999
Schistosoma mansoni serine/threonine protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0803 0.5749 0.5749
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosin kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis tyrosine protein kinase HCK 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Onchocerca volvulus 0.1392 0.9999 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni ephrin receptor 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus granulosus tyrosine protein kinase csk 0.0803 0.5749 0.5749
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0372 0.0372
Onchocerca volvulus 0.1392 0.9999 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0036 0.021 0.0316
Echinococcus granulosus expressed conserved protein 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine kinase 0.1392 0.9999 0.9999
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Brugia malayi Protein kinase domain containing protein 0.1392 0.9999 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0803 0.5749 0.5749
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0589 0.4203 0.4203
Trichomonas vaginalis protein tyrosine kinase, putative 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Onchocerca volvulus 0.0803 0.5749 0.5749
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0803 0.5749 0.5749
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0372 0.0599
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0058 0.0372 0.0372
Onchocerca volvulus 0.0058 0.0372 0.0372
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Giardia lamblia Protein 21.1 0.0803 0.5749 0.9999
Echinococcus granulosus Protein Wnt-11b 0.0014 0.0051 0.0051
Echinococcus granulosus epidermal growth factor receptor 0.0803 0.5749 0.5749
Leishmania major cysteine peptidase A (CPA) 0.0058 0.0372 0.0575
Echinococcus multilocularis SH2 motif 0.0589 0.4203 0.4203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1392 0.9999 0.9999
Brugia malayi wnt family protein 0.0014 0.0051 0.0051
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0013 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni tyrosine kinase 0.1392 0.9999 0.9999
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0803 0.5749 1
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) STAT protein 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0803 0.5749 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0207
Plasmodium vivax unspecified product 0.0023 0.0118 0.0127
Trypanosoma cruzi protein kinase, putative 0.0803 0.5749 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0372 0.0599
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Brugia malayi Cathepsin L-like precursor 0.0035 0.0207 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0045 0.0077
Echinococcus granulosus tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Plasmodium vivax tyrosine kinase-like protein, putative 0.081 0.5797 1
Echinococcus granulosus NCK adaptor protein 0.0589 0.4203 0.4203
Echinococcus granulosus Protein Wnt-5 0.0014 0.0051 0.0051
Schistosoma mansoni tensin 0.0589 0.4203 0.4203
Echinococcus granulosus tensin 0.0589 0.4203 0.4203
Leishmania major hypothetical protein, conserved 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Echinococcus granulosus cathepsin l1 0.0035 0.0207 0.0207
Brugia malayi integrin-linked kinase 0.0803 0.5749 0.5749
Trypanosoma brucei Pseudokinase, putative 0.0803 0.5749 1
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0045 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Brugia malayi hypothetical protein 0.0589 0.4203 0.4203
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0803 0.5749 0.5749
Schistosoma mansoni serine/threonine protein kinase 0.0803 0.5749 0.5749
Brugia malayi Guanylyl cyclase protein 23 0.0803 0.5749 0.5749
Echinococcus granulosus cathepsin L cysteine protease 0.0036 0.021 0.021
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Brugia malayi C-terminal src kinase protein 1 0.0803 0.5749 0.5749
Echinococcus granulosus suppressor of cytokine signaling 6 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/INSR protein kinase 0.0803 0.5749 0.5749
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0207 0.0207
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Brugia malayi Furin-like cysteine rich region family protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Echinococcus granulosus poly adp ribose polymerase 2 0.0011 0.0029 0.0029
Loa Loa (eye worm) cysteine protease 0.0058 0.0372 0.0372
Echinococcus granulosus retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Echinococcus granulosus tyrosine protein kinase ABL1 0.1392 0.9999 0.9999
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0013 0.0045 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0207 0.0359
Echinococcus granulosus poly ADP ribose polymerase 1 0.0011 0.0029 0.0029
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0045 0.0045
Brugia malayi SRC-1 0.1392 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Schistosoma mansoni serine/threonine protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus tyrosine protein kinase Blk 0.1392 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Echinococcus granulosus receptor type guanylyl cyclase 0.0803 0.5749 0.5749
Plasmodium falciparum protein kinase, putative 0.0803 0.5749 0.9917
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0803 0.5749 0.5749
Brugia malayi Immunoglobulin I-set domain containing protein 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.1392 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0029
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0803 0.5749 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Plasmodium falciparum tyrosine kinase-like protein 0.0803 0.5749 0.9917
Echinococcus granulosus tankyrase 0.0075 0.0494 0.0494
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Plasmodium falciparum tyrosine kinase-like protein 0.081 0.5797 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0803 0.5749 0.5749
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0118 0.0154
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Echinococcus multilocularis tyrosine protein kinase csk 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Loa Loa (eye worm) protein kinase domain-containing protein 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Onchocerca volvulus Tyrosine kinase homolog 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Blk 0.1392 0.9999 0.9999
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0058 0.0372 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0372 0.0344
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0011 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.1392 0.9999 0.9999
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0589 0.4203 0.4203
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Brugia malayi SH2 domain containing protein 0.1392 0.9999 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0372 0.0372
Schistosoma mansoni tyrosine protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/FAK protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus tyrosine protein kinase csk 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.021 0.0181
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.1392 0.9999 0.9999
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0589 0.4203 0.4203
Echinococcus multilocularis wnt family member wnt11 2 0.0014 0.0051 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica protein kinase, putative 0.0589 0.4203 0.4186
Onchocerca volvulus 0.0803 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus granulosus protein tyrosine kinase 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0803 0.5749 0.5737
Schistosoma mansoni suppressor of cytokine signaling 0.0589 0.4203 0.4203
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0013 0.0045 0.0077
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0803 0.5749 0.5749
Echinococcus multilocularis WNT 0.0014 0.0051 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/ROR protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Brugia malayi wnt family protein 0.0014 0.0051 0.0051
Schistosoma mansoni serine/threonine RGC 0.0803 0.5749 0.5749
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0589 0.4203 0.4203
Brugia malayi SH2 domain containing protein 0.1392 0.9999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) TK/DDR protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0372 0.0344
Echinococcus granulosus raf serine:threonine protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0011 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0589 0.4203 0.4203
Schistosoma mansoni protein tyrosine kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1392 0.9999 0.9999
Echinococcus multilocularis cysteine protease 0.0058 0.0372 0.0372
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0589 0.4203 0.4203
Echinococcus granulosus c src tyrosine kinase 0.1392 0.9999 0.9999
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Trypanosoma brucei protein kinase, putative 0.0803 0.5749 1
Entamoeba histolytica cysteine surface protein, putative 0.0803 0.5749 0.5737
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0372 0.0599
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0803 0.5749 0.5749
Echinococcus granulosus Protein Wnt-111 0.0014 0.0051 0.0051
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0803 0.5749 0.5749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0045 0.0045
Echinococcus granulosus cysteine protease 0.0036 0.021 0.021
Plasmodium vivax tyrosine kinase-like protein, putative 0.0803 0.5749 0.9917
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0589 0.4203 0.4203
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0045 0.0045
Plasmodium vivax vivapain-2 0.0058 0.0372 0.057
Onchocerca volvulus Tankyrase homolog 0.0067 0.0439 0.0439
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0803 0.5749 0.5749
Schistosoma mansoni wnt related 0.0014 0.0051 0.0051
Echinococcus granulosus cathepsin l1 0.0058 0.0372 0.0372
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus multilocularis receptor type guanylyl cyclase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0029 0.0029
Schistosoma mansoni suppressor of cytokine signaling 0.0589 0.4203 0.4203
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Brugia malayi STAT protein, DNA binding domain containing protein 0.0589 0.4203 0.4203
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0372 0.0599
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1392 0.9999 0.9999
Brugia malayi cathepsin L-like precursor 0.0035 0.0207 0.0207
Onchocerca volvulus 0.0058 0.0372 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Schistosoma mansoni wnt-5 0.0014 0.0051 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Onchocerca volvulus 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0803 0.5749 0.5749
Trichomonas vaginalis AGC family protein kinase 0.0803 0.5749 1
Brugia malayi cathepsin L precursor 0.0013 0.0045 0.0045
Echinococcus multilocularis 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni cathepsin S (C01 family) 0.0013 0.0045 0.0045
Trypanosoma cruzi cysteine protease, putative 0.0036 0.021 0.0316
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Echinococcus granulosus protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Onchocerca volvulus 0.0803 0.5749 0.5749
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1392 0.9999 0.9999
Brugia malayi Variant SH3 domain containing protein 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0362 0.0362
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.021 0.0181
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1392 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/EPH protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Brugia malayi wnt family protein 0.0014 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Loa Loa (eye worm) CWN-2 protein 0.0014 0.0051 0.0051
Echinococcus multilocularis NCK adaptor protein 0.0589 0.4203 0.4203
Echinococcus multilocularis tyrosine kinase 0.1392 0.9999 0.9999
Schistosoma mansoni SH2A 0.0589 0.4203 0.4203
Brugia malayi Protein kinase domain containing protein 0.1392 0.9999 1
Schistosoma mansoni growth factor receptor-bound protein 0.0589 0.4203 0.4203
Onchocerca volvulus 0.0803 0.5749 0.5749
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.1392 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Onchocerca volvulus 0.0058 0.0372 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni GTPase activating protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Onchocerca volvulus 0.1392 0.9999 1
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis CAMK family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trypanosoma cruzi protein kinase, putative 0.0803 0.5749 1
Schistosoma mansoni tensin 0.0589 0.4203 0.4203
Toxoplasma gondii cathepsin B 0.0013 0.0045 0.0077
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0803 0.5749 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.021 0.021
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Echinococcus multilocularis kinase suppressor of Ras 1 0.0803 0.5749 0.5749
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0013 0.0045 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0013 0.0045 0.0077
Echinococcus granulosus cathepsin L 0.0036 0.021 0.021
Onchocerca volvulus 0.1392 0.9999 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0589 0.4203 0.4203
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Schistosoma mansoni cathepsin s 0.0023 0.0118 0.0118
Brugia malayi hypothetical protein 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0058 0.0372 0.0372
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase Src42A 0.1392 0.9999 0.9999
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0045 0.0077
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0803 0.5749 0.5749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Echinococcus granulosus SH2 motif 0.0589 0.4203 0.4203
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0045 0.0045
Brugia malayi Wnt-2 protein precursor 0.0014 0.0051 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0118
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0118 0.0118
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0372 0.0372
Entamoeba histolytica hypothetical protein 0.0013 0.0045 0.0015
Echinococcus multilocularis tyrosine protein kinase csk 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Echinococcus granulosus fibroblast growth factor receptor 4 0.0803 0.5749 0.5749
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1392 0.9999 0.9999
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0803 0.5749 0.5749
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0058 0.0372 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Brugia malayi WGR domain containing protein 0.0011 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0372 0.0372
Onchocerca volvulus 0.1392 0.9999 1
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0589 0.4203 0.4203
Brugia malayi Protein kinase domain containing protein 0.1392 0.9999 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0803 0.5749 0.5749
Echinococcus granulosus SH2 domain containing adapter protein F 0.0589 0.4203 0.4203
Schistosoma mansoni growth factor receptor-bound protein 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0589 0.4203 0.4203
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Brugia malayi Sex muscle abnormal protein 5 0.0589 0.4203 0.4203
Echinococcus multilocularis epidermal growth factor receptor 0.0803 0.5749 0.5749
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1392 0.9999 0.9999
Loa Loa (eye worm) TK/ACK protein kinase 0.0803 0.5749 0.5749
Plasmodium falciparum protein kinase, putative 0.081 0.5797 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0589 0.4203 0.4203
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0803 0.5749 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0589 0.4203 0.4203
Echinococcus granulosus cathepsin b 0.0013 0.0045 0.0045
Echinococcus multilocularis SH2 motif 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0118 0.0118
Echinococcus multilocularis integrin linked protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TK family protein kinase 0.0803 0.5749 1
Schistosoma mansoni signal transduction protein lnk-related 0.0589 0.4203 0.4203
Echinococcus granulosus activated cdc42 kinase 1 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1392 0.9999 0.9999
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0207 0.0178
Entamoeba histolytica SH2 domain containing protein 0.0589 0.4203 0.4186
Giardia lamblia Kinase, NEK 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1392 0.9999 0.9999
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0803 0.5749 0.5749
Schistosoma mansoni adapter molecule crk 0.0589 0.4203 0.4203
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0589 0.4203 0.4203
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0589 0.4203 0.4203
Brugia malayi cathepsin B-like cysteine proteinase 0.0013 0.0045 0.0045
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0803 0.5749 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Echinococcus multilocularis signal transduction protein lnk realted 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Entamoeba histolytica ankyrin repeat protein 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0045 0.0045
Echinococcus granulosus cathepsin L cysteine proteinase 0.0058 0.0372 0.0372
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Brugia malayi hypothetical protein 0.1392 0.9999 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Echinococcus granulosus insulin receptor 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0077
Echinococcus multilocularis protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0589 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0118
Entamoeba histolytica cysteine proteinase 2 0.0036 0.021 0.0181
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0803 0.5749 1
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis cathepsin b 0.0013 0.0045 0.0045
Echinococcus granulosus Protein Wnt-04 0.0014 0.0051 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Echinococcus granulosus N chimaerin 0.0589 0.4203 0.4203
Echinococcus multilocularis cathepsin L 0.0013 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0013 0.0045 0.0045
Echinococcus multilocularis activated cdc42 kinase 1 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0051
Echinococcus multilocularis natriuretic peptide receptor 1 0.0803 0.5749 0.5749
Trypanosoma cruzi major cysteine proteinase, putative 0.0013 0.0045 0.0026
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus granulosus protein Wnt 2 0.0014 0.0051 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus granulosus cathepsin L 0.0013 0.0045 0.0045
Echinococcus multilocularis epidermal growth factor receptor 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Echinococcus granulosus ephrin type A receptor 4 A 0.0803 0.5749 0.5749
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0589 0.4203 0.4203
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0372 0.0372
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0023 0.0118 0.0118
Loa Loa (eye worm) tnks protein 0.0069 0.0447 0.0447
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus epidermal growth factor receptor 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0589 0.4203 0.4203
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1392 0.9999 0.9999
Echinococcus multilocularis tensin 0.0589 0.4203 0.4203
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0372 0.0599
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.021 0.0181
Trypanosoma cruzi major cysteine proteinase, putative 0.0013 0.0045 0.0026
Brugia malayi Cathepsin L-like precursor 0.0023 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0013 0.0045 0.0077
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus tyrosine protein kinase Fyn 0.1392 0.9999 0.9999
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0013 0.0045 0.0045
Brugia malayi wnt family protein 0.0014 0.0051 0.0051
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0589 0.4203 0.4203
Brugia malayi Variant SH3 domain containing protein 0.0589 0.4203 0.4203
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0013 0.0045 0.0015
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0372 0.0372
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Schistosoma mansoni cathepsin B (C01 family) 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Echinococcus multilocularis tyrosine protein kinase shark 0.1393 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.1393 1 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni wnt related 0.0014 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Echinococcus multilocularis transfer RNA-Thr 0.0803 0.5749 0.5749
Brugia malayi GnHR receptor homolog 0.0558 0.3981 0.3982
Brugia malayi bone morphogenetic protein type 1 receptor 0.0803 0.5749 0.5749
Leishmania major protein kinase, putative 0.0803 0.5749 1
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0045 0.0077
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Onchocerca volvulus 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0803 0.5749 0.5737
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0803 0.5749 1
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.1392 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Brugia malayi Tyrosine-protein kinase PR2 0.0803 0.5749 0.5749
Echinococcus granulosus activin receptor type 0.0803 0.5749 0.5749
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0013 0.0045 0.0045
Echinococcus multilocularis wingless type MMTV integration site family 0.0014 0.0051 0.0051
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Echinococcus multilocularis activin receptor type 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0058 0.0372 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/RYK protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Giardia lamblia Kinase, NEK 0.0803 0.5749 0.9999
Loa Loa (eye worm) fibroinase 0.0058 0.0372 0.0372
Echinococcus granulosus tyrosine protein kinase Src42A 0.0589 0.4203 0.4203
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.021 0.021
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis FL cytokine receptor 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus granulosus Sterile alpha motif SAM 0.0007 0.0000000051917 0.0000000051917
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0029 0.0051
Onchocerca volvulus 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Echinococcus multilocularis protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Echinococcus granulosus tyrosine protein kinase 0.0803 0.5749 0.5749
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0803 0.5749 1
Loa Loa (eye worm) cathepsin B 0.0013 0.0045 0.0045
Trypanosoma cruzi cysteine proteinase, putative 0.0036 0.021 0.0316
Leishmania major protein kinase, putative 0.0803 0.5749 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0207 0.0207
Echinococcus multilocularis tensin 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Entamoeba histolytica serine/threonine kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis cysteine protease 0.0058 0.0372 0.0372
Schistosoma mansoni nck2/grb4 0.0589 0.4203 0.4203
Brugia malayi Protein kinase domain containing protein 0.1392 0.9999 1
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1392 0.9999 0.9999
Echinococcus granulosus protein Wnt 1 0.0014 0.0051 0.0051
Loa Loa (eye worm) TK protein kinase 0.1392 0.9999 1
Echinococcus multilocularis tyrosine protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0036 0.021 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Schistosoma mansoni cathepsin C 0.0013 0.0045 0.0045
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0011 0.0029 0.0029
Schistosoma mansoni tensin 0.0589 0.4203 0.4203
Onchocerca volvulus 0.0013 0.0045 0.0045
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0013 0.0045 0.0015
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0011 0.0029 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0372 0.0372
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.021 0.0316
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0589 0.4203 0.4203
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0036 0.021 0.0316
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0803 0.5749 0.5749
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0803 0.5749 0.5749
Echinococcus granulosus SHC transforming protein 3 0.0589 0.4203 0.4203
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.021 0.021
Onchocerca volvulus 0.1392 0.9999 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Toxoplasma gondii STE kinase 0.0803 0.5749 1
Onchocerca volvulus 0.0058 0.0372 0.0372
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Echinococcus multilocularis tyrosine kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni serine/threonine protein kinase 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.021 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0058 0.0372 0.057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0007 0.0000000051917 0.0000000051921
Echinococcus granulosus tyrosine protein kinase HCK 0.0803 0.5749 0.5749
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/ABL protein kinase 0.1392 0.9999 1
Brugia malayi Receptor family ligand binding region containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0372 0.0599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis cathepsin L 0.0036 0.021 0.021
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Echinococcus granulosus SH2 domain containing protein 7 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0045 0.0077
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus signal transduction protein lnk realted 0.0589 0.4203 0.4203
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Loa Loa (eye worm) TK/FER protein kinase 0.1392 0.9999 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0803 0.5749 0.5737
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Onchocerca volvulus 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0589 0.4203 0.4203
Brugia malayi RhoGAP domain containing protein 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1392 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0051
Plasmodium vivax vivapain-2 0.0058 0.0372 0.057
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Toxoplasma gondii cathepsin CPC2 0.0013 0.0045 0.0077
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0207 0.0359
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.021 0.021
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis c src tyrosine kinase 0.1392 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Plasmodium falciparum protein kinase, putative 0.0803 0.5749 0.9917
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0013 0.0045 0.0077
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0589 0.4203 0.4203
Brugia malayi Variant SH3 domain containing protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0051
Onchocerca volvulus Cathepsin F homolog 0.0058 0.0372 0.0372
Brugia malayi Cathepsin L-like precursor 0.0035 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1392 0.9999 0.9999
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Entamoeba histolytica tyrosin kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Entamoeba histolytica ankyrin repeat protein 0.0803 0.5749 0.5737
Brugia malayi Wnt-4 protein precursor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0803 0.5749 0.5749
Echinococcus granulosus activated cdc42 kinase 1 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0013 0.0045 0.0015
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0029 0.0051
Schistosoma mansoni ephrin receptor 0.0803 0.5749 0.5749
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Echinococcus multilocularis insulin receptor 0.0803 0.5749 0.5749
Plasmodium falciparum cysteine proteinase falcipain 3 0.0058 0.0372 0.057
Brugia malayi Raf kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis WNT 0.0014 0.0051 0.0051
Trichomonas vaginalis STE family protein kinase 0.0803 0.5749 1
Brugia malayi hypothetical protein 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Onchocerca volvulus 0.0058 0.0372 0.0372
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0803 0.5749 0.5749
Echinococcus multilocularis tyrosine protein kinase csk 0.0803 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Onchocerca volvulus 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0803 0.5749 0.5749
Schistosoma mansoni tyrosine kinase 0.1392 0.9999 0.9999
Echinococcus granulosus integrin linked protein kinase 0.0803 0.5749 0.5749
Plasmodium vivax vivapain-1 0.0036 0.021 0.0288
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0803 0.5749 0.5737
Brugia malayi ephrin receptor 1 precursor 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Entamoeba histolytica tyrosine kinase, putative 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Schistosoma mansoni tankyrase 0.0075 0.0495 0.0495
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Entamoeba histolytica cysteine protease, putative 0.0058 0.0372 0.0344
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0803 0.5749 0.5749
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0372 0.0372
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0803 0.5749 0.5749
Trypanosoma brucei Flagellum attachment zone protein 20 0.0803 0.5749 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0045 0.0045
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Brugia malayi Variant SH3 domain containing protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK/Met protein kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Entamoeba histolytica hypothetical protein 0.0803 0.5749 0.5737
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0035 0.0207 0.031
Echinococcus granulosus cathepsin b 0.0013 0.0045 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Schistosoma mansoni vav2 0.0589 0.4203 0.4203
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.021 0.021
Brugia malayi Tnks protein 0.0074 0.0488 0.0488
Echinococcus multilocularis protein tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni shc transforming protein 0.0589 0.4203 0.4203
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0803 0.5749 0.5749
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0589 0.4203 0.4203
Echinococcus granulosus suppressor of cytokine signaling 7 0.0589 0.4203 0.4203
Schistosoma mansoni protein kinase 0.0803 0.5749 0.5749
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0118 0.0154
Echinococcus multilocularis protein Wnt 1 0.0014 0.0051 0.0051
Brugia malayi protein-tyrosine kinase 0.1392 0.9999 1
Schistosoma mansoni hypothetical protein 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0372 0.0648
Loa Loa (eye worm) wnt-4 protein 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0207
Entamoeba histolytica cysteine protease, putative 0.0036 0.021 0.0181
Schistosoma mansoni tyrosine kinase 0.1392 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1392 0.9999 0.9999
Entamoeba histolytica receptor protein kinase, putative 0.0803 0.5749 0.5737
Loa Loa (eye worm) SH2 domain-containing protein 0.0589 0.4203 0.4203
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0803 0.5749 0.5749
Entamoeba histolytica hypothetical protein, conserved 0.0803 0.5749 0.5737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0207
Schistosoma mansoni tensin-related 0.0589 0.4203 0.4203
Onchocerca volvulus 0.0035 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus multilocularis tankyrase 0.0075 0.0494 0.0494
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus granulosus tyrosine kinase 0.1392 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0589 0.4203 0.4203
Loa Loa (eye worm) SH2 domain-containing protein 0.0589 0.4203 0.4203
Toxoplasma gondii cathepsin CPC1 0.0013 0.0045 0.0077
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Entamoeba histolytica receptor protein kinase, putative 0.0803 0.5749 0.5737
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.021 0.0181
Onchocerca volvulus 0.0589 0.4203 0.4203
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0589 0.4203 0.4203
Entamoeba histolytica protein kinase domain containing protein 0.0803 0.5749 0.5737
Plasmodium falciparum cysteine proteinase falcipain 1 0.0036 0.021 0.0288
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0803 0.5749 0.5749
Brugia malayi Tensin 0.0589 0.4203 0.4203
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0803 0.5749 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0589 0.4203 0.4203
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Entamoeba histolytica protein kinase, putative 0.0803 0.5749 0.5737
Echinococcus multilocularis tyrosine protein kinase csk 0.0803 0.5749 0.5749
Loa Loa (eye worm) ctsf protein 0.0058 0.0372 0.0372
Leishmania major cathepsin L-like protease 0.0058 0.0372 0.0575
Echinococcus multilocularis growth factor receptor bound protein 2 0.0589 0.4203 0.4203
Schistosoma mansoni wnt related 0.0014 0.0051 0.0051
Trypanosoma brucei cysteine peptidase C (CPC) 0.0013 0.0045 0.0026
Loa Loa (eye worm) hypothetical protein 0.0803 0.5749 0.5749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0372 0.0648
Onchocerca volvulus 0.0058 0.0372 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0803 0.5749 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0589 0.4203 0.4203
Brugia malayi SH2 domain containing protein 0.0589 0.4203 0.4203
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0803 0.5749 1
Toxoplasma gondii protein kinase domain-containing protein 0.0803 0.5749 1
Echinococcus multilocularis cathepsin b 0.0013 0.0045 0.0045
Brugia malayi Cathepsin L-like precursor 0.0058 0.0372 0.0372
Entamoeba histolytica cysteine proteinase 1, putative 0.0036 0.021 0.0181
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Echinococcus multilocularis SH2 motif 0.0589 0.4203 0.4203
Loa Loa (eye worm) RGC/RGC protein kinase 0.0803 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0589 0.4203 0.4203
Loa Loa (eye worm) TK protein kinase 0.0803 0.5749 0.5749
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0803 0.5749 0.5749
Brugia malayi WGR domain containing protein 0.0011 0.0029 0.0029
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0589 0.4203 0.4203
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0589 0.4203 0.4203
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0372 0.0372
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Onchocerca volvulus 0.0589 0.4203 0.4203
Trichomonas vaginalis protein kinase atn1, putative 0.0803 0.5749 1
Entamoeba histolytica tyrosin kinase, putative 0.0803 0.5749 0.5737
Plasmodium vivax protein kinase, putative 0.0803 0.5749 0.9917
Plasmodium vivax vivapain-3 0.0036 0.021 0.0288
Toxoplasma gondii protein kinase 0.0803 0.5749 1
Schistosoma mansoni tyrosine kinase 0.0803 0.5749 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0077
Brugia malayi Protein kinase domain containing protein 0.0803 0.5749 0.5749
Trichomonas vaginalis TKL family protein kinase 0.0803 0.5749 1
Loa Loa (eye worm) TK/FER protein kinase 0.0803 0.5749 0.5749

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.1 nM Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK-293 cells ChEMBL. 11462984
IC50 (functional) = 10.8 nM Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK-293 cells ChEMBL. 11462984
Inhibition (functional) > 80 % Compound was tested for inhibition of Leutenizing hormone release at 48 hours (intermediate duration) in castrated male rat assay ChEMBL. 11462984
Kd (functional) = 9.2 Competitive antagonism of GnRH-induced response in the reporter gene assay ChEMBL. 11462984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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