TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475.798 | Formula: C23H21Cl3N4O
H donors: 1 H acceptors: 2 LogP: 6.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)n1nc(c2c1c1cc(Cl)c(cc1C2)C)C(=O)NN1CCCCC1
InChi: 1S/C23H21Cl3N4O/c1-13-9-14-10-17-21(23(31)28-29-7-3-2-4-8-29)27-30(22(17)16(14)12-18(13)25)20-6-5-15(24)11-19(20)26/h5-6,9,11-12H,2-4,7-8,10H2,1H3,(H,28,31)
InChiKey: KYLWGEHXPLSXCG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References
Mus musculus	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0112	0.2322	0.248
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.055	0.1645
Schistosoma mansoni	sugar transporter	0.0015	0.0144	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Schistosoma mansoni	neurotransmitter gated ion channel	0.0052	0.0967	0.1035
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0174	0.3701	0.3609
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0039	0.0674	0.2063
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.2203	0.7196
Giardia lamblia	Kinase, CMGC CK2	0.0144	0.3038	1
Schistosoma mansoni	sugar transporter	0.0015	0.0144	0.0095
Brugia malayi	Cation transporter family protein	0.0112	0.2322	0.3841
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0144	0.016
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0645	0.0508
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0526	1
Entamoeba histolytica	protein kinase, putative	0.0034	0.0562	0.1686
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0372	0.0315
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.2322	0.3841
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0039	0.0674	0.1834
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0052	0.0967	0.1094
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Plasmodium vivax	hexose transporter	0.0107	0.2203	0.209
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus granulosus	cpg binding protein	0.003	0.0476	0.0537
Loa Loa (eye worm)	sugar transporter	0.0107	0.2203	0.2353
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0144	0.028
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Trypanosoma cruzi	casein kinase II, putative	0.0144	0.3038	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Echinococcus granulosus	solute carrier family 22	0.0015	0.0144	0.016
Entamoeba histolytica	protein kinase, putative	0.0034	0.0562	0.1686
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.006	0.1162	0.1922
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Schistosoma mansoni	protein kinase	0.0144	0.3038	0.34
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Echinococcus multilocularis	dnaJ subfamily B	0.0402	0.882	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.006	0.0066
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0144	0.016
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1003	0.1135
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0858	0.097
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Brugia malayi	Sugar transporter family protein	0.0015	0.0144	0.0238
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0563	0.0425
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.055	0.1404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0342	0.0321
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0112	0.2322	0.2582
Onchocerca volvulus		0.0112	0.2322	1
Brugia malayi	hypothetical protein	0.0015	0.0144	0.0238
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Plasmodium vivax	unspecified product	0.0144	0.3038	0.2937
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1006	0.1335
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0112	0.2322	0.2582
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0039	0.0674	0.0731
Echinococcus granulosus	casein kinase ii subunit alpha	0.0144	0.3038	0.3443
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0858	0.097
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0112	0.2322	0.248
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.055	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0526	0.0559
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0144	0.028
Trypanosoma brucei	glucose transporter 2A	0.0033	0.055	0.0559
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0967	0.1599
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0112	0.2322	0.2631
Plasmodium falciparum	casein kinase II beta chain	0.0039	0.0674	0.0538
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0112	0.2322	0.2631
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0112	0.2322	0.248
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0645	0.1731
Brugia malayi	hypothetical protein	0.0052	0.0967	0.1599
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0276	0.0724
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0061	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0112	0.2322	0.3841
Onchocerca volvulus		0.0112	0.2322	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0112	0.2322	0.248
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0645	0.0776
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0372	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0372	0.079
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0144	0.3038	0.3443
Brugia malayi	hypothetical protein	0.0052	0.0967	0.1599
Onchocerca volvulus		0.0047	0.0858	0.3278
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0112	0.2322	0.2631
Echinococcus granulosus	solute carrier family 22	0.0015	0.0144	0.016
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0372	0.0232
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0052	0.0967	0.1094
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Toxoplasma gondii	protein kinase, putative	0.0303	0.66	1
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0495	0.0559
Trypanosoma brucei	RNA helicase, putative	0.0339	0.7409	1
Schistosoma mansoni	nAChR subunit	0.0052	0.0967	0.1035
Loa Loa (eye worm)	casein kinase II	0.0011	0.006	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.055	0.1645
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0052	0.0967	0.1094
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0526	0.1563
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0342	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0563	0.0425
Loa Loa (eye worm)	ACC-1 protein	0.0112	0.2322	0.248
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0342	0.0385
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0858	0.097
Schistosoma mansoni	cpg binding protein	0.003	0.0476	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Onchocerca volvulus		0.0112	0.2322	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0562	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0562	0.0599
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.006	0.1162	0.1257
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0645	0.0508
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0563	0.0425
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0112	0.2322	0.2631
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0114	0.2365	0.2679
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0563	0.0425
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0144	0.028
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0858	0.091
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Loa Loa (eye worm)	Csnk2b protein	0.0039	0.0674	0.0718
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0858	0.091
Leishmania major	glucose transporter, lmgt2	0.0033	0.055	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.055	0.1645
Brugia malayi	Sugar transporter family protein	0.0015	0.0144	0.0238
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0114	0.2365	1
Schistosoma mansoni	hypothetical protein	0.0339	0.7409	0.839
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Schistosoma mansoni	cpg binding protein	0.0028	0.044	0.0433
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0112	0.2322	0.2631
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0112	0.2322	0.2631
Entamoeba histolytica	casein kinase, putative	0.0144	0.3038	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus multilocularis	glycine receptor subunit beta	0.0112	0.2322	0.2631
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0562	0.0599
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3038	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.055	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0144	0.3038	0.3246
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0563	0.0425
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0562	0.0576
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0144	0.0095
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0112	0.2322	0.3841
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.055	0.1645
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Loa Loa (eye worm)	MBCTL1	0.0053	0.1003	0.107
Brugia malayi	Casein kinase II, alpha chain	0.0144	0.3038	0.5026
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Onchocerca volvulus		0.0052	0.0967	0.3779
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.055	0.1645
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0144	0.016
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0114	0.2365	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0112	0.2322	0.2631
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0114	0.2365	0.7673
Loa Loa (eye worm)	hypothetical protein	0.0426	0.9355	1
Echinococcus granulosus	tumor protein p63	0.0332	0.7252	0.8222
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0261	0.0528
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	major facilitator superfamily protein	0.0015	0.0144	0.0238
Onchocerca volvulus		0.0052	0.0967	0.3779
Loa Loa (eye worm)	sugar transporter	0.0015	0.0144	0.0151
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.2322	0.2582
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0897	0.0955
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.2203	0.319
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0144	0.016
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0052	0.0967	0.1031
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1003	0.1135
Loa Loa (eye worm)	LGC-31 protein	0.0112	0.2322	0.248
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0144	0.016
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0144	0.0238
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0342	0.0945
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.006	0.0066
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0144	0.028
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0645	0.1731
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0526	0.0593
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0563	0.0649
Brugia malayi	hypothetical protein	0.0015	0.0144	0.0238
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0563	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Brugia malayi	mbt repeat family protein	0.0047	0.0858	0.1419
Schistosoma mansoni	glucose transport protein	0.0107	0.2203	0.2446
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0563	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0052	0.0967	0.1031
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0144	0.0238
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0039	0.0674	0.2437
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0144	0.036
Brugia malayi	hypothetical protein	0.0052	0.0967	0.1599
Schistosoma mansoni	sugar transporter	0.0015	0.0144	0.0095
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.3949	0.4476
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.2322	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Echinococcus multilocularis	General substrate transporter	0.0092	0.1866	0.2114
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0562	0.093
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0342	0.0321
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1003	0.1135
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0144	0.3038	0.2937
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0858	0.097
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Onchocerca volvulus		0.0049	0.0897	0.3456
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0112	0.2322	0.2631
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0562	0.0599
Brugia malayi	Cation transporter family protein	0.0112	0.2322	0.3841
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0562	0.1686
Leishmania major	casein kinase II, putative	0.0144	0.3038	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.2322	0.3841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0039	0.0674	0.1834
Plasmodium vivax	casein kinase II beta chain, putative	0.0039	0.0674	0.0538
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0102	0.0106
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0112	0.2322	0.248
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.2322	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.006	0.1162	0.1257
Schistosoma mansoni	neurotransmitter gated ion channel	0.006	0.1162	0.1257
Toxoplasma gondii	CMGC kinase, CK2 family	0.0144	0.3038	0.4484
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0526	0.1563
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0112	0.2322	0.3841
Schistosoma mansoni	hypothetical protein	0.0402	0.882	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0052	0.0967	0.1599
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0114	0.2365	0.2631
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0144	0.036
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.044	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Schistosoma mansoni	casein kinase II beta subunit	0.0039	0.0674	0.0701
Giardia lamblia	Sugar-proton symporter	0.0015	0.0144	0.028
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0039	0.0674	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Leishmania major	glucose transporter, lmgt1	0.0033	0.055	0.1404
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0112	0.2322	0.2631
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0112	0.2322	0.3841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0144	0.036
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.055	0.1645
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Entamoeba histolytica	hypothetical protein	0.006	0.1162	0.3699
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0495	0.0559
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0106	0.2193	0.2342
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0052	0.0967	0.1599
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0526	0.1563
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0526	0.0593
Brugia malayi	casein kinase II, putaitve	0.0011	0.006	0.01
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0526	0.0559
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0342	0.0201
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0112	0.2322	0.3841
Entamoeba histolytica	hypothetical protein	0.0024	0.0342	0.0945
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0967	0.1599
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Echinococcus granulosus	General substrate transporter	0.0092	0.1866	0.2114
Plasmodium falciparum	protein kinase 7	0.0303	0.66	0.655
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0112	0.2322	0.2631
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Echinococcus granulosus	dnaJ subfamily B	0.0402	0.882	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1003	0.166
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0112	0.2322	0.248
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.055	0.0559
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0144	0.028
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0144	0.0151
Brugia malayi	Sugar transporter family protein	0.0107	0.2203	0.3645
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0372	0.0395
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Loa Loa (eye worm)	ACC-1 protein	0.0112	0.2322	0.248
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0645	0.069
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.006	0.1162	0.1922
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Schistosoma mansoni	nAChR subunit	0.0052	0.0967	0.1035
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0144	0.5
Giardia lamblia	Hexose transporter	0.0015	0.0144	0.028
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0526	0.087
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0039	0.0674	0.2063
Echinococcus granulosus	nAChR subunit	0.006	0.1162	0.1315
Onchocerca volvulus		0.006	0.1162	0.4674
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0342	0.0945
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Brugia malayi	hypothetical protein	0.0052	0.0967	0.1599
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1003	0.1076
Schistosoma mansoni	hypothetical protein	0.0107	0.2203	0.2446
Schistosoma mansoni	cpg binding protein	0.003	0.0476	0.0474
Loa Loa (eye worm)	GABA receptor subunit	0.006	0.1162	0.1239
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0114	0.2365	0.2679
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1149	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0112	0.2322	0.2582
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0052	0.0967	0.1094
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0455	1	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0144	0.016
Echinococcus multilocularis	nAChR subunit	0.006	0.1162	0.1315
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0342	0.0684
Schistosoma mansoni	hypothetical protein	0.0285	0.6196	0.7005
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0213	0.0239
Echinococcus granulosus	casein kinase ii subunit beta	0.0039	0.0674	0.0762
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0858	0.3278
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.055	0.1404
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0858	0.0914
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.055	0.1645
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0144	0.016
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0144	0.028
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2203	0.2496
Schistosoma mansoni	protein kinase	0.0034	0.0562	0.0573
Schistosoma mansoni	acetylcholine receptor-related	0.0052	0.0967	0.1035
Leishmania major	glucose transporter, lmgt3	0.0033	0.055	0.1404
Loa Loa (eye worm)	acetylcholine receptor protein	0.0052	0.0967	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0897	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0562	0.0573
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.3949	0.4476
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.006	0.1162	0.1922
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.055	0.0559
Toxoplasma gondii	ck2 beta subunit	0.0039	0.0674	0.0822
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0144	0.3038	0.2937
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0039	0.0674	0.0822
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0174	0.3701	0.551
Onchocerca volvulus	Putative nachr subunit	0.0112	0.2322	1
Onchocerca volvulus		0.0112	0.2322	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0476	0.0537
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.055	0.0559
Brugia malayi	CXXC zinc finger family protein	0.0028	0.044	0.0727
Loa Loa (eye worm)	hypothetical protein	0.006	0.1162	0.1239
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0342	0.1219
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0039	0.0674	0.1834
Echinococcus granulosus	glycine receptor subunit beta	0.0112	0.2322	0.2631
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0039	0.0674	0.2437
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0112	0.2322	0.2631
Brugia malayi	excitatory GABA receptor EXP-1A	0.0112	0.2322	0.3841
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Trypanosoma brucei	glucose transporter 1E	0.0033	0.055	0.0559
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0052	0.0967	0.1599
Plasmodium falciparum	casein kinase II beta chain	0.0039	0.0674	0.0538
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.006	0.1162	0.1922
Schistosoma mansoni	glucose transporter	0.0015	0.0144	0.0095
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0342	0.0201
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0526	0.087
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0342	0.3046
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0391	0.0415
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0858	0.091
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0342	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0278	0.6045	0.6461
Trypanosoma cruzi	hexose transporter	0.0033	0.055	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Onchocerca volvulus		0.006	0.1162	0.4674
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	Csnk2b protein	0.0039	0.0674	0.1116
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0052	0.0967	0.1035
Trypanosoma brucei	Casein kinase II	0.0144	0.3038	0.3984
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0526	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Trypanosoma brucei	glucose transporter, putative	0.0033	0.055	0.0559
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0144	0.0151
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0563	0.0425
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0174	0.3701	0.3609
Echinococcus multilocularis	tumor protein p63	0.0332	0.7252	0.8222
Trichomonas vaginalis	CMGC family protein kinase	0.0144	0.3038	1
Schistosoma mansoni	protein kinase	0.0034	0.0562	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0052	0.0967	0.1094
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0562	0.0635
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0278	0.6045	1
Schistosoma mansoni	nAChR subunit	0.0112	0.2322	0.2582
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0563	0.0425
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0342	0.1219
Schistosoma mansoni	glucose transport protein	0.0107	0.2203	0.2446
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0645	0.1731
Echinococcus multilocularis	nAChR subunit	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus granulosus	nAChR subunit	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0227	0.4885	0.5221
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0372	0.0232
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0112	0.2322	0.2631
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Onchocerca volvulus		0.0028	0.044	0.1358
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0342	0.0385
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0372	0.0354
Brugia malayi	mbt repeat family protein	0.0047	0.0858	0.1419
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0112	0.2322	0.2631
Onchocerca volvulus		0.0112	0.2322	1
Brugia malayi	hypothetical protein	0.0015	0.0144	0.0238
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0342	0.0272
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.2322	0.2631
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0372	0.079
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0144	0.016
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0563	0.0425
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0342	0.0684
Brugia malayi	major facilitator superfamily protein	0.0015	0.0144	0.0238
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.2322	0.3841
Leishmania major	protein kinase, putative	0.0034	0.0562	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0342	0.0363
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0114	0.2365	0.3912
Brugia malayi	hypothetical protein	0.0025	0.0372	0.0616
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0144	0.0238
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0144	0.028
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0261	0.0528
Mycobacterium ulcerans	sugar transporter	0.0015	0.0144	0.036
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0563	0.0649
Brugia malayi	Cation transporter family protein	0.0112	0.2322	0.3841
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.2203	0.2496
Plasmodium falciparum	hexose transporter	0.0107	0.2203	0.209
Schistosoma mansoni	neurotransmitter gated ion channel	0.0052	0.0967	0.1035
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Brugia malayi	hypothetical protein	0.0016	0.0172	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1003	0.107
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Brugia malayi	hypothetical protein	0.0052	0.0967	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus multilocularis	glycine receptor subunit beta	0.0112	0.2322	0.2631
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0144	0.028
Leishmania major	hypothetical protein, conserved	0.0025	0.0372	0.079
Plasmodium vivax	casein kinase II beta chain, putative	0.0039	0.0674	0.0538
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0144	0.016
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Echinococcus granulosus	glycine receptor subunit beta	0.0112	0.2322	0.2631
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0526	0.0531
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0645	0.1731
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Echinococcus granulosus	solute carrier family 22	0.0015	0.0144	0.016
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0967	0.1031
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0039	0.0674	0.2063
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Giardia lamblia	Casein kinase II beta chain	0.0039	0.0674	0.2063
Brugia malayi	Cam kinase protein 1	0.0034	0.0562	0.093
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0052	0.0967	0.1599
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0342	0.0307
Schistosoma mansoni	sugar transporter	0.0015	0.0144	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0144	0.0151
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0112	0.2322	0.3841
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0858	0.0914
Echinococcus multilocularis	casein kinase ii subunit beta	0.0039	0.0674	0.0762
Onchocerca volvulus		0.0052	0.0967	0.3779
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.2322	0.3841
Schistosoma mansoni	glucose transport protein	0.0107	0.2203	0.2446
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0144	0.028
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0114	0.2365	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2322	0.248
Schistosoma mansoni	protein kinase	0.0034	0.0562	0.0573
Onchocerca volvulus		0.0112	0.2322	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1003	0.1135

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 200 nM	Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptor	ChEMBL.	17149879
Ki (binding)	= 200 nM	Displacement of [3H]CP-55940 from CD1 mouse spleen CB2 receptor	ChEMBL.	17149879
Ki (binding)	= 916 nM	Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptor	ChEMBL.	17149879
Ki (binding)	= 916 nM	Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptor	ChEMBL.	17149879
Ratio Ki (binding)	= 4.6	Selectivity for CD1 mouse CB2 receptor over CB1 receptor	ChEMBL.	17149879
Ratio Ki (binding)	= 4.6	Selectivity for CD1 mouse CB2 receptor over CB1 receptor	ChEMBL.	17149879

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL386644

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 409925