Detailed information for compound 413132

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1036.64 | Formula: C53H78ClNO17
  • H donors: 8 H acceptors: 8 LogP: 3.66 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: C[C@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2(C(C1)[C@@H]1CC=C3[C@]([C@H]1CC2)(C)CC[C@@H](C3)O[C@@H]1O[C@H](CNC(=O)COc2ccc(cc2)Cl)[C@H]([C@@H]([C@H]1O[C@H]1O[C@H](C)[C@H]([C@@H]([C@@H]1O)O)O)O)O[C@H]1O[C@H](C)[C@H]([C@@H]([C@@H]1O)O)O)C
  • InChi: 1S/C53H78ClNO17/c1-24-13-18-53(65-22-24)25(2)38-35(72-53)20-34-32-12-7-28-19-31(14-16-51(28,5)33(32)15-17-52(34,38)6)68-50-47(71-49-44(62)42(60)40(58)27(4)67-49)45(63)46(70-48-43(61)41(59)39(57)26(3)66-48)36(69-50)21-55-37(56)23-64-30-10-8-29(54)9-11-30/h7-11,24-27,31-36,38-50,57-63H,12-23H2,1-6H3,(H,55,56)/t24-,25-,26+,27+,31-,32+,33-,34?,35-,36+,38-,39+,40+,41-,42-,43-,44-,45-,46+,47+,48+,49+,50+,51-,52-,53+/m0/s1
  • InChiKey: NBNDZRUBEJJCJK-MHIAJPTJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Endoplasmin precursor 0.0031 0.01 0.0116
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0011 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0053 0.0053
Brugia malayi heat shock protein 90 0.0031 0.01 0.0116
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0052 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.015
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0011 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0011 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0053 0.0062
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Brugia malayi hypothetical protein 0.0017 0.0009 0.0011
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1429 0.8607 1
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0011 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0585 0.068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0053 0.0062
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0061 0.176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0117 0.375
Onchocerca volvulus 0.0048 0.0203 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0053 0.0062
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0117 0.0622 0.0723
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0053 0.0062
Echinococcus multilocularis heat shock protein 0.0031 0.01 0.01
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Toxoplasma gondii microneme protein, putative 0.0019 0.0026 0.0089
Schistosoma mansoni transient receptor potential channel 0.0017 0.0011 0.0013
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0022 0.0577
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0017 0.0011 0.0013
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0017 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0011 0.0013
Echinococcus multilocularis endoplasmin 0.0025 0.0061 0.0061
Brugia malayi Endochitinase 0.0083 0.0412 0.0479
Brugia malayi voltage-dependent calcium channel 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus multilocularis shaker cognate 0.0017 0.0011 0.0011
Echinococcus granulosus heat shock protein 90 0.0025 0.0061 0.0071
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.1153 0.1339
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0011 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Brugia malayi cation channel family protein 0.0017 0.0011 0.0013
Echinococcus multilocularis transient receptor potential gamma protein 0.0017 0.0011 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0203 1
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0011 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0053 0.0053
Echinococcus granulosus two pore calcium channel protein 1 0.0017 0.0011 0.0013
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.1659 0.1928
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0182 0.1018 0.1182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0697 0.081
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0053 0.0053
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0011 0.0013
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0011 0.0013
Schistosoma mansoni vesicular acetylcholine transporter 0.1429 0.8607 1
Brugia malayi Transient-receptor-potential like protein 0.0017 0.0011 0.0013
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Toxoplasma gondii PAN domain-containing protein 0.0301 0.1739 1
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0011 0.0011
Toxoplasma gondii hypothetical protein 0.0019 0.0026 0.0089
Echinococcus granulosus calcium activated potassium channel 0.0199 0.112 0.1301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Onchocerca volvulus 0.0019 0.0026 0.003
Plasmodium falciparum heat shock protein 90 0.0031 0.01 0.1447
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0117 0.0622 0.0723
Loa Loa (eye worm) endoplasmin 0.0031 0.01 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0203 0.617
Echinococcus granulosus tumor protein p63 0.0717 0.4273 0.4965
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0203 0.557
Echinococcus multilocularis expressed conserved protein 0.0189 0.1059 0.1059
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0053 0.0062
Echinococcus multilocularis heat shock protein 90 0.0025 0.0061 0.0061
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0017 0.0011 0.0052
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) calcium channel 0.0017 0.0011 0.0013
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0052 0.0225 1
Mycobacterium ulcerans putative regulatory protein 0.0047 0.0195 0.581
Echinococcus granulosus tar DNA binding protein 0.0129 0.0697 0.081
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0011 0.0013
Schistosoma mansoni aryl hydrocarbon receptor 0.0185 0.1032 0.1199
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0117 0.0622 0.0622
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0017 0.0011 0.0013
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0011 0.0013
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0129 0.1917
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0011 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0011 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.01 0.4208
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.1659 0.1659
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0083 0.0415 0.0482
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Onchocerca volvulus 0.0048 0.0198 0.0231
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0017 0.0011 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0434 0.0504
Echinococcus multilocularis sodium channel protein 0.0017 0.0011 0.0011
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0053 0.0062
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0053 0.0062
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0378 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0053 0.0062
Toxoplasma gondii ion channel protein 0.0052 0.0225 0.1241
Brugia malayi hypothetical protein 0.0017 0.0011 0.0013
Brugia malayi CHE-14 protein 0.0086 0.0434 0.0504
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0017 0.0011 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0017 0.0011 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0053 0.0062
Echinococcus multilocularis transfer RNA-Gly 0.0017 0.0011 0.0011
Schistosoma mansoni transient receptor potential channel 4 0.0017 0.0011 0.0013
Schistosoma mansoni calcium-activated potassium channel 0.0182 0.1018 0.1182
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0089
Entamoeba histolytica hypothetical protein 0.0111 0.0585 0.4695
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus multilocularis two pore calcium channel protein 2 0.0017 0.0011 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0012 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.01 0.4208
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus granulosus potassium large conductance calcium activated 0.0199 0.112 0.1301
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0697 0.081
Echinococcus granulosus hypothetical protein 0.0017 0.0011 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0011 0.0013
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0292 1
Echinococcus granulosus ryanodine receptor 44f 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0203 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0012 0.0012
Toxoplasma gondii PAN domain-containing protein 0.0301 0.1739 1
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0026 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0203 0.6844
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0053 0.0062
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0017 0.0011 0.0013
Echinococcus granulosus two pore calcium channel protein 2 0.0017 0.0011 0.0013
Schistosoma mansoni calcium-activated potassium channel 0.0199 0.112 0.1301
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0697 0.081
Toxoplasma gondii ion channel protein 0.0052 0.0225 0.1241
Brugia malayi olfactory channel protein osm-9 0.0017 0.0012 0.0014
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0053 0.0062
Echinococcus multilocularis calcium activated potassium channel 0.0199 0.112 0.112
Schistosoma mansoni transient receptor potential channel 0.0017 0.0012 0.0014
Echinococcus granulosus single minded 2 0.0047 0.0195 0.0227
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0011 0.0013
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0017 0.0011 0.0013
Echinococcus granulosus p2X purinoceptor 4 0.0206 0.1163 0.1351
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0011 0.0011
Echinococcus granulosus aryl hydrocarbon receptor 0.0137 0.0745 0.0866
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0052 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0547 0.0636
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0017 0.0011 0.0013
Echinococcus granulosus voltage gated hydrogen channel 1 0.0017 0.0011 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0129 0.2937
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0011 0.0013
Schistosoma mansoni heat shock protein 0.0031 0.01 0.0116
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Echinococcus multilocularis sodium leak channel non selective protein 0.0017 0.0011 0.0011
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0011 0.0011
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0011 0.0013
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0114 0.0605 0.0605
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0001
Toxoplasma gondii microneme protein MIC4 0.0019 0.0026 0.0089
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0434 1
Echinococcus granulosus heat shock protein 0.0031 0.01 0.0116
Echinococcus multilocularis p2X purinoceptor 4 0.0206 0.1163 0.1163
Schistosoma mansoni P2X receptor subunit 0.0206 0.1163 0.1351
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0203 0.557
Echinococcus granulosus sodium channel protein 0.0017 0.0011 0.0013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0203 0.1
Onchocerca volvulus 0.0019 0.0026 0.003
Schistosoma mansoni heat shock protein 0.0031 0.01 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0697 0.081
Echinococcus granulosus shaker cognate 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0019 0.0026 0.003
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0012 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0127 0.0681 0.0792
Schistosoma mansoni endoplasmin 0.0031 0.01 0.0116
Loa Loa (eye worm) hypothetical protein 0.0106 0.0553 0.0642
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0011 0.0013
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Loa Loa (eye worm) RNA binding protein 0.0129 0.0697 0.081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0053 0.0053
Onchocerca volvulus Putative endochitinase 0.0083 0.0412 0.0479
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0017 0.0011 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0053 0.0062
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0026 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0011 0.0011
Echinococcus multilocularis vesicular acetylcholine transporter 0.1429 0.8607 0.8607
Brugia malayi cation channel family protein 0.0017 0.0011 0.0013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0129 0.418
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0061 0.2404
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0061 0.1223
Schistosoma mansoni calcium-activated potassium channel 0.0052 0.0225 0.0262
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0089
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0014
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.01 0.4159
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0292 1
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0019 0.0026 0.003
Toxoplasma gondii hypothetical protein 0.0117 0.0622 0.3537
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0011 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0053 0.0062
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0434 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0011 0.0013
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0011 0.0013
Brugia malayi ion channel NompC 0.0017 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0083 0.0415 0.0482
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0012 0.0014
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0017 0.0011 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Brugia malayi Death domain containing protein 0.0015 0.000000015116 0.000000017563
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Trichomonas vaginalis heat shock protein, putative 0.0031 0.01 0.2142
Echinococcus multilocularis ryanodine receptor 44f 0.0017 0.0011 0.0011
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0017 0.0011 0.0013
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0129 1
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.01 0.4159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0053 0.0062
Schistosoma mansoni single-minded 0.0064 0.0296 0.0344
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Echinococcus multilocularis protein patched 0.0086 0.0434 0.0434
Loa Loa (eye worm) voltage-gated calcium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0061 0.1223
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0645 0.0749
Brugia malayi endochitinase 0.0074 0.0358 0.0416
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0053 0.0062
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0011 0.0011
Onchocerca volvulus 0.0017 0.0011 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0019 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0117 0.0622 0.0723
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0117 0.0622 0.0723
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.015
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0358 0.0416
Brugia malayi Uncoordinated protein 44 0.0015 0.000000015116 0.000000017563
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.01 0.4208
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0011 0.0013
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0089
Leishmania major hypothetical protein, conserved 0.0052 0.0225 0.62
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.013 0.0701 0.0814
Leishmania major chitinase 0.0074 0.0358 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0011 0.0013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0083 0.0415 0.0482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0053 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0585 0.0585
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.000000015116 0.000000017563
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0378 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0053 0.0062
Brugia malayi aryl hydrocarbon receptor AHR-1 0.012 0.0641 0.0745
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0011 0.0011
Echinococcus multilocularis potassium large conductance calcium activated 0.0199 0.112 0.112
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0434 0.0434
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0203 0.617
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0017 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0117 0.375
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0011 0.0011
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0011 0.0013
Echinococcus granulosus sodium leak channel non selective protein 0.0017 0.0011 0.0013
Onchocerca volvulus 0.0019 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0012 0.0126
Schistosoma mansoni voltage-gated cation channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0011 0.0013
Schistosoma mansoni P2X receptor subunit 0.0068 0.0322 0.0374
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.01 0.4208
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) voltage-dependent calcium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.015
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0547 0.0636
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0126
Echinococcus multilocularis p2X purinoceptor 4 0.0206 0.1163 0.1163
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0203 0.617
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0017 0.0011 0.0013
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Schistosoma mansoni P2X receptor subunit 0.0068 0.0322 0.0374
Entamoeba histolytica hypothetical protein 0.0111 0.0585 0.4695
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0011 0.0013
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Echinococcus granulosus expressed conserved protein 0.0189 0.1059 0.1231
Schistosoma mansoni voltage-gated ion channel 0.0017 0.0011 0.0013
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0017 0.0011 0.0013
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0061 0.2404
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.1134 1
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0053 0.0062
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0203 0.617
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.012 0.0641 0.0745
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0053 0.0062
Onchocerca volvulus Putative endochitinase 0.0083 0.0412 0.0479
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0012 0.0014
Echinococcus multilocularis tumor protein p63 0.0717 0.4273 0.4273
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0053 0.0062
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0011 0.0013
Plasmodium falciparum endoplasmin, putative 0.0019 0.0026 0.0233
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0012 0.0014
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.013 0.0701 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0053 0.0062
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0017 0.0011 0.0013
Echinococcus granulosus TRP transient receptor potential channel 0.0017 0.0011 0.0013
Schistosoma mansoni vesicular amine transporter 0.0018 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0086 0.0434 0.0504
Echinococcus granulosus calcium activated potassium channel variant 0.0182 0.1018 0.1182
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0053 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0053 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0697 0.081
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0053 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0697 0.081
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0061 0.149
Schistosoma mansoni coup transcription factor 0.0024 0.0053 0.0062
Plasmodium vivax endoplasmin, putative 0.0031 0.01 0.1447
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.0012 0.0014
Schistosoma mansoni transient receptor potential channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0053 0.0062
Brugia malayi nuclear hormone receptor 0.0024 0.0053 0.0062
Brugia malayi endochitinase 0.0083 0.0412 0.0479
Echinococcus granulosus heat shock protein 90 0.0031 0.01 0.0116
Schistosoma mansoni two-pore calcium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0117 0.0622 0.0723
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0203 0.1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0203 0.0236
Echinococcus multilocularis p2X purinoceptor 4 0.0206 0.1163 0.1163
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Schistosoma mansoni hypothetical protein 0.0083 0.0415 0.0482
Brugia malayi PAS domain containing protein 0.0064 0.0296 0.0344
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.003
Onchocerca volvulus 0.0019 0.0026 0.003
Onchocerca volvulus 0.0019 0.0026 0.003
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0011 0.0013
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0011 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0017 0.0011 0.0013
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0011 0.0013
Schistosoma mansoni ryanodine receptor related 0.0017 0.0011 0.0013
Echinococcus granulosus p2X purinoceptor 4 0.0206 0.1163 0.1351
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0017 0.0011 0.0013
Schistosoma mansoni patched 1 0.0086 0.0434 0.0504
Entamoeba histolytica hypothetical protein 0.0111 0.0585 0.4695
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0203 0.557
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0061 0.5
Brugia malayi TAR-binding protein 0.0129 0.0697 0.081
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0012 0.0043
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.01 0.0516
Onchocerca volvulus 0.0105 0.0547 0.0636
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0053 0.0062
Brugia malayi vesicular acetylcholine transporter unc-17 0.1429 0.8607 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0012 0.0014
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0011 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.013 0.0701 0.0814
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0063 0.0292 0.0339
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0053 0.0053
Loa Loa (eye worm) ryanodine receptor 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Onchocerca volvulus Putative endochitinase 0.0074 0.0358 0.0416
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.015
Echinococcus granulosus transient receptor potential gamma protein 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Brugia malayi steroid hormone receptor 0.0024 0.0053 0.0062
Loa Loa (eye worm) ion channel NompC 0.0017 0.0011 0.0013
Loa Loa (eye worm) microfilarial chitinase 0.0072 0.0346 0.0402
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0061 0.2676
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0012 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0053 0.0062
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0011 0.0013
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0203 0.6844
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0011 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0011 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0053 0.0062
Leishmania major hypothetical protein, conserved 0.0017 0.0011 0.0052
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0012 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0014
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0011 0.0011
Onchocerca volvulus Putative endochitinase 0.0074 0.0358 0.0416
Echinococcus multilocularis two pore calcium channel protein 1 0.0017 0.0011 0.0011
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0017 0.0011 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0053 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0011 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0203 0.617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0117 0.375
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0622 1
Treponema pallidum heat shock protein 90 0.0025 0.0061 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0011 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0061 0.1223
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0697 0.081
Mycobacterium ulcerans hypothetical protein 0.0048 0.0203 0.617
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0062
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.003
Toxoplasma gondii heat shock protein HSP90 0.0031 0.01 0.0516
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0011 0.0043
Onchocerca volvulus 0.0019 0.0026 0.003
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0053 0.0053
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0005
Entamoeba histolytica chitinase, putative 0.0074 0.0358 0.2496
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Brugia malayi PAN domain containing protein 0.0019 0.0026 0.003
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0053 0.0062
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0011 0.0011
Echinococcus multilocularis calcium activated potassium channel variant 0.0182 0.1018 0.1018
Schistosoma mansoni hypothetical protein 0.0117 0.0622 0.0723
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0011 0.0013
Echinococcus multilocularis protein dispatched 1 0.0099 0.0508 0.0508
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0017 0.0011 0.0013
Toxoplasma gondii hypothetical protein 0.0019 0.0026 0.0089
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0015 0.000000015116 0.000000017563
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0011 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0011 0.0013
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0017 0.0011 0.0013
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Onchocerca volvulus 0.0019 0.0026 0.003
Echinococcus multilocularis transfer RNA-Lys 0.0047 0.0195 0.0195
Echinococcus granulosus vesicular acetylcholine transporter 0.1429 0.8607 1
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0026 0.0089
Onchocerca volvulus Putative endochitinase 0.0083 0.0412 0.0479
Loa Loa (eye worm) hypothetical protein 0.0201 0.1134 0.1317
Brugia malayi nuclear receptor NHR-88 0.0024 0.0053 0.0062
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0017 0.0011 0.0013
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0026 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0127 0.0681 0.0792
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0026 0.0089
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Schistosoma mansoni P2X receptor subunit 0.0206 0.1163 0.1351
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.01 0.4208
Plasmodium vivax potassium channel, putative 0.0052 0.0225 0.35
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0011 0.0013
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.01 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0017 0.0011 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0043
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0017 0.0011 0.0084
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.01 0.4159
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0053 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0117 0.375
Onchocerca volvulus 0.0137 0.0742 0.0862
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0236
Echinococcus multilocularis aryl hydrocarbon receptor 0.0137 0.0745 0.0745
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0225 0.0262
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0011 0.0011
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0011 0.0013
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0017 0.0011 0.0013
Plasmodium falciparum potassium channel 0.0052 0.0225 0.35
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0203 1
Leishmania major hypothetical protein, unknown function 0.0017 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.003
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0203 0.0236
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Echinococcus multilocularis heat shock protein 90 0.0031 0.01 0.01
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0292 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0697 0.081
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0017 0.0011 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0026 0.0398
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0011 0.0013
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0011 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0011 0.0011
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0585 0.068
Onchocerca volvulus 0.0024 0.0053 0.0062
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0203 0.0236
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0061 0.0071
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0011 0.0013
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0017 0.0011 0.0013
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0026 0.003
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0053 0.0062
Echinococcus granulosus endoplasmin 0.0025 0.0061 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0053 0.0062
Brugia malayi hypothetical protein 0.0111 0.0585 0.068
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0011 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0011 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0053 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0053 0.0062
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Brugia malayi ecdysteroid receptor 0.0024 0.0053 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0111 0.0585 0.068
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0026 0.0089
Onchocerca volvulus 0.0019 0.0026 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0203 0.617
Toxoplasma gondii subtilisin SUB12 0.0019 0.0026 0.0089
Loa Loa (eye worm) hypothetical protein 0.0137 0.0742 0.0862
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.1134 0.1317
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0017 0.0011 0.0013
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.1134 0.1317
Schistosoma mansoni endoplasmin 0.0031 0.01 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013
Loa Loa (eye worm) heat shock protein 90 0.0031 0.01 0.0116
Onchocerca volvulus 0.0117 0.0622 0.0723
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0078
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1429 0.8607 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0053 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0031 0.01 0.2609
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0697 0.0697
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0053 0.0062
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0011 0.0013
Brugia malayi RNA binding protein 0.0129 0.0697 0.081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0053 0.0062
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.000000015116 0.000000015116
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0011 0.0013
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0017 0.0011 0.0013
Brugia malayi bHLH-PAS transcription factor 0.0047 0.0195 0.0227
Entamoeba histolytica hypothetical protein 0.0111 0.0585 0.4695
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0011 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0053 0.0062
Plasmodium vivax heat shock protein 86, putative 0.0031 0.01 0.1447
Leishmania major calcium/potassium channel (CAKC), putative 0.0052 0.0225 0.62
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0011 0.0013
Echinococcus granulosus p2X purinoceptor 4 0.0206 0.1163 0.1351
Trypanosoma brucei heat shock protein, putative 0.0031 0.01 0.4159
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.000000015116 0.000000017563
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0053 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0203 0.617
Plasmodium falciparum conserved protein, unknown function 0.0117 0.0622 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0017 0.0011 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0011 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0434 0.0504
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0129 0.1917
Loa Loa (eye worm) chitinase I 0.0074 0.0358 0.0416
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0203 0.1
Schistosoma mansoni voltage-dependent calcium channel 0.0017 0.0011 0.0013
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0017 0.0011 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0011 0.0013

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) 0 Cytotoxicity against human A549 cells by MTT assay ChEMBL. 16905317
IC50 (ADMET) 0 Cytotoxicity against human BGC823 cells by MTT assay ChEMBL. 16905317
IC50 (ADMET) 0 Cytotoxicity against human HGC27 cells by MTT assay ChEMBL. 16905317

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.