TDR Targets

Basic information

Technical information

TDR Targets ID: 42637
Name: trilithium (2S)-2-[[ethyl(oxido)phosphinothio yl]amino]pentanedioate
MW: 273.028 | Formula: C7H11Li3NO5PS
H donors: 1 H acceptors: 5 LogP: 1.45 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: [O-]C(=O)[C@@H](NP(=S)(CC)[O-])CCC(=O)[O-].[Li+].[Li+].[Li+]
InChi: 1S/C7H14NO5PS.3Li/c1-2-14(13,15)8-5(7(11)12)3-4-6(9)10;;;/h5H,2-4H2,1H3,(H,9,10)(H,11,12)(H2,8,13,15);;;/q;3*+1/p-3/t5-,14?;;;/m0.../s1
InChiKey: WVPOAQAWZPUCLI-OMIINEQVSA-K

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

trilithium (2S)-2-[[ethyl(oxidanidyl)phosphinothioyl]amino]pentanedioate
trilithium (2S)-2-[[ethyl(oxido)thiophosphoryl]amino]glutarate
trilithium (2S)-2-[(ethyl-oxidophosphinothioyl)amino]pentanedioate
trilithium (2S)-2-[(ethyl-oxido-phosphinothioyl)amino]pentanedioate
trilithium (2S)-2-[(ethyl-oxido-thiophosphoryl)amino]glutarate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tripartite motif containing protein 3	0.0082	0.0047	0.0051
Leishmania major	C-8 sterol isomerase-like protein	0.0188	0.0265	0.0821
Echinococcus multilocularis	brain tumor protein	0.0082	0.0047	0.0073
Echinococcus multilocularis	Squalene phytoene synthase	0.0248	0.039	0.0603
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.14	0.2763	0.2753
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.1006	0.1952	0.1941
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0082	0.0047	0.0074
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0841	0.1612	0.16
Brugia malayi	hypothetical protein	0.0469	0.0845	0.0832
Brugia malayi	Hypothetical RING finger protein F54G8.4 in chromosome III	0.0082	0.0047	0.0033
Brugia malayi	B-box type zinc-finger protein ncl-1	0.0082	0.0047	0.0033
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.1211	0.2374	0.3761
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0265	0.0265
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.1006	0.1952	0.4639
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0047	0.0047
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.1006	0.1952	0.507
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.2088	0.4182	1
Toxoplasma gondii	hypothetical protein	0.1006	0.1952	0.4937
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.2088	0.4182	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.1006	0.1952	0.6535
Schistosoma mansoni	dopamine-beta-monooxygenase	0.1658	0.3295	0.5221
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0522	0.0955	0.1478
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0817	0.1561	0.1549
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.1503	0.2975	0.2965
Echinococcus multilocularis	GA binding protein alpha chain	0.0076	0.0035	0.0054
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0227	0.0347	0.055
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1503	0.2975	0.6813
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.1006	0.1952	0.3091
Schistosoma mansoni	hypothetical protein	0.0082	0.0047	0.0074
Schistosoma mansoni	peroxidasin	0.0066	0.0014	0.0023
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.2088	0.4182	0.4182
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0522	0.0955	0.1513
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0188	0.0265	0.0251
Trypanosoma brucei	squalene synthase, putative	0.0796	0.1518	0.393
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.1006	0.1952	0.507
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.1006	0.1952	0.3094
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.14	0.2763	0.2763
Brugia malayi	Ets-domain containing protein	0.0076	0.0035	0.0021
Loa Loa (eye worm)	fli-1 protein	0.023	0.0352	0.0352
Leishmania major	hypothetical protein, conserved	0.0248	0.039	0.1243
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.1006	0.1952	0.507
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.1658	0.3295	0.3285
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0248	0.039	0.1938
Leishmania major	geranylgeranyltransferase, putative	0.0522	0.0955	0.3157
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.1503	0.2975	0.4715
Loa Loa (eye worm)	hypothetical protein	0.0469	0.0845	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0967	0.1872	0.1872
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.2088	0.4182	1
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0522	0.0955	0.2449
Loa Loa (eye worm)	hypothetical protein	0.0967	0.1872	0.1872
Schistosoma mansoni	microtubule-associated protein tau	0.073	0.1384	0.2192
Schistosoma mansoni	hypothetical protein	0.0248	0.039	0.0618
Trypanosoma cruzi	squalene synthase, putative	0.0796	0.1518	0.393
Schistosoma mansoni	hypothetical protein	0.0082	0.0047	0.0074
Brugia malayi	B-box zinc finger family protein	0.0082	0.0047	0.0033
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.1006	0.1952	0.507
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0967	0.1872	0.1872
Brugia malayi	Fli-1 protein	0.023	0.0352	0.0338
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.1006	0.1952	0.3091
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0248	0.039	0.0907
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0471	0.0848	0.1344
Trypanosoma cruzi	hypothetical protein, conserved	0.1006	0.1952	0.507
Brugia malayi	B-box zinc finger family protein	0.0082	0.0047	0.0033
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1503	0.2975	0.7758
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.1082	0.2109	0.4524
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.14	0.2763	0.4259
Echinococcus granulosus	brain tumor protein	0.0082	0.0047	0.0051
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.1503	0.2975	0.6813
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Giardia lamblia	Prenyltransferase	0.1503	0.2975	0.7082
Loa Loa (eye worm)	hypothetical protein	0.0248	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.007	0.0023	0.0009
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.1006	0.1952	0.4112
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0471	0.0848	0.1344
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0967	0.1872	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0188	0.0265	0.0637
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.14	0.2763	0.4272
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0469	0.0845	0.0845
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.2088	0.4182	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0047	0.0047
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Schistosoma mansoni	gabp alpha	0.0076	0.0035	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.3121	0.6311	0.9757
Entamoeba histolytica	hypothetical protein	0.0082	0.0047	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0967	0.1872	0.1872
Loa Loa (eye worm)	hypothetical protein	0.1658	0.3295	0.3295
Loa Loa (eye worm)	NCL-1 protein	0.0082	0.0047	0.0047
Brugia malayi	peptidase family M13 containing protein	0.0227	0.0347	0.0333
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.14	0.2763	0.4378
Leishmania major	squalene synthase, putative	0.0796	0.1518	0.5066
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0522	0.0955	0.2449
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.2088	0.4182	0.4174
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0227	0.0347	0.0347
Toxoplasma gondii	hypothetical protein	0.1082	0.2109	0.571
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.14	0.2763	0.6588
Onchocerca volvulus		0.0251	0.0395	0.1966
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.007	0.0023	0.0023
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.1006	0.1952	0.1952
Trypanosoma brucei	flagellum-adhesion glycoprotein, putative	0.0082	0.0047	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0967	0.1872	0.1872
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0471	0.0848	0.1344
Brugia malayi	Peptidase family M13 containing protein	0.1211	0.2374	0.2363
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0471	0.0848	0.1344
Trypanosoma cruzi	hypothetical protein, conserved	0.0522	0.0955	0.2449
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.0333	0.0333
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.1503	0.2975	1
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.1006	0.1952	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Giardia lamblia	Rab geranylgeranyltransferase	0.1006	0.1952	0.4608
Schistosoma mansoni	peptidylglycine monooxygenase	0.0082	0.0047	0.0074
Schistosoma mansoni	hypothetical protein	0.0082	0.0047	0.0074
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.1503	0.2975	0.6261
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.1503	0.2975	0.7758
Trypanosoma cruzi	squalene synthase, putative	0.0796	0.1518	0.393
Brugia malayi	Pre-SET motif family protein	0.022	0.0333	0.0319
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.1006	0.1952	0.507
Echinococcus granulosus	expressed protein	0.0784	0.1494	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.1503	0.2975	0.46
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0981	0.1899	0.2927
Echinococcus granulosus	microtubule associated protein 2	0.073	0.1384	0.2122
Schistosoma mansoni	brat protein	0.0082	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0522	0.0955	0.2449
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0014	0.0014
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.1211	0.2374	0.2363
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.1006	0.1952	0.3003
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Echinococcus multilocularis	microtubule associated protein 2	0.073	0.1384	0.2139
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Mycobacterium ulcerans	zinc metalloprotease	0.1211	0.2374	1
Loa Loa (eye worm)	hypothetical protein	0.1211	0.2374	0.2374
Brugia malayi	Ets-domain containing protein	0.0076	0.0035	0.0021
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.14	0.2763	0.6253
Giardia lamblia	Rab geranylgeranyltransferase	0.0522	0.0955	0.2196
Echinococcus granulosus	endothelin converting enzyme 1	0.1211	0.2374	0.3656
Schistosoma mansoni	neprilysin	0.0243	0.038	0.0603
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0188	0.0265	0.0637
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0471	0.0848	0.1344
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0522	0.0955	0.1476
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0522	0.0955	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.3121	0.6311	0.9756
Schistosoma mansoni	peroxidasin	0.0066	0.0014	0.0023
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.1503	0.2975	0.6261
Toxoplasma gondii	peptidase family M13 protein	0.1211	0.2374	0.7022
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.007	0.0023	0.0036
Trypanosoma cruzi	lanosterol synthase, putative	0.1917	0.3829	1
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.1503	0.2975	0.6813
Loa Loa (eye worm)	hypothetical protein	0.2088	0.4182	0.4182
Onchocerca volvulus		0.0469	0.0845	0.4285
Leishmania major	lanosterol synthase, putative	0.1395	0.2753	0.9245
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.4912	1	1
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.1503	0.2975	0.2975
Mycobacterium leprae	probable zinc metalloprotease	0.1211	0.2374	0.5
Trypanosoma cruzi	lanosterol synthase, putative	0.1917	0.3829	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0227	0.0347	0.055
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1503	0.2975	0.7758
Trypanosoma cruzi	phytoene synthase, putative	0.0248	0.039	0.0965
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.2088	0.4182	0.6458
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Echinococcus multilocularis	endothelin converting enzyme 1	0.1211	0.2374	0.367
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0227	0.0347	0.055
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.2088	0.4182	0.6466
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0012	0.0012
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0522	0.0955	0.0942
Loa Loa (eye worm)	RING finger protein nhl-1	0.0082	0.0047	0.0047
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.2088	0.4182	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Schistosoma mansoni	peptidylglycine monooxygenase	0.1658	0.3295	0.5221
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.1006	0.1952	0.3003
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1503	0.2975	0.6813
Loa Loa (eye worm)	hypothetical protein	0.0522	0.0955	0.0955
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.1006	0.1952	0.3018
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.2088	0.4182	0.6627
Loa Loa (eye worm)	hypothetical protein	0.074	0.1404	0.1404
Schistosoma mansoni	endothelin-converting enzyme-related	0.0227	0.0347	0.055
Loa Loa (eye worm)	hypothetical protein	0.0522	0.0955	0.0955
Loa Loa (eye worm)	blistered cuticle protein 3	0.0066	0.0014	0.0014
Trypanosoma brucei	flagellum-adhesion glycoprotein, putative	0.0082	0.0047	0.0063
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.007	0.0023	0.0035
Loa Loa (eye worm)	B-box zinc finger family protein	0.0082	0.0047	0.0047
Onchocerca volvulus		0.1006	0.1952	1
Loa Loa (eye worm)	B-box zinc finger family protein	0.0082	0.0047	0.0047
Echinococcus multilocularis	brain tumor protein	0.0082	0.0047	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.14	0.2763	0.4378
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.007	0.0023	0.0013
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Schistosoma mansoni	hypothetical protein	0.0243	0.038	0.0603
Brugia malayi	B-box type zinc-finger protein ncl-1	0.0082	0.0047	0.0033
Trypanosoma brucei	lanosterol synthase	0.1917	0.3829	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.2088	0.4182	1
Echinococcus multilocularis	peroxidasin	0.0066	0.0014	0.0022
Schistosoma mansoni	ets-related	0.023	0.0352	0.0558
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0522	0.0955	0.2241
Onchocerca volvulus		0.074	0.1404	0.717
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Giardia lamblia	Rab geranylgeranyltransferase	0.2088	0.4182	1
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0076	0.0035	0.0035
Echinococcus multilocularis	expressed protein	0.0784	0.1494	0.231
Echinococcus granulosus	Squalene phytoene synthase	0.0248	0.039	0.0582
Loa Loa (eye worm)	hypothetical protein	0.3121	0.6311	0.6311
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.3198	0.6468	1
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.1211	0.2374	0.6152
Echinococcus granulosus	GA binding protein alpha chain	0.0076	0.0035	0.0032
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.3121	0.6311	0.6306
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0227	0.0347	0.055
Echinococcus granulosus	tm gpcr rhodopsin	0.3198	0.6468	1
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.1503	0.2975	0.4588
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.1006	0.1952	0.507
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.1917	0.3829	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1503	0.2975	0.6813
Loa Loa (eye worm)	hypothetical protein	0.1211	0.2374	0.2374
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0243	0.038	0.0603
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0227	0.0347	0.055
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.1503	0.2975	0.7099
Trypanosoma cruzi	hypothetical protein, conserved	0.1006	0.1952	0.507
Echinococcus multilocularis	tripartite motif containing protein 3	0.0082	0.0047	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0984	0.1906	0.1906
Loa Loa (eye worm)	hypothetical protein	0.1211	0.2374	0.2374
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.1503	0.2975	0.6813
Leishmania major	farnesyltransferase beta subunit	0.1503	0.2975	1
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.3121	0.6311	1
Trypanosoma brucei	hypothetical protein, conserved	0.1006	0.1952	0.507

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.24 uM	Inhibitory activity against zinc-dependent Glutamate Carboxypeptidase G	ChEMBL.	10360747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10707383

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 42637