Detailed information for compound 42637

Basic information

Technical information
  • TDR Targets ID: 42637
  • Name: trilithium (2S)-2-[[ethyl(oxido)phosphinothio yl]amino]pentanedioate
  • MW: 273.028 | Formula: C7H11Li3NO5PS
  • H donors: 1 H acceptors: 5 LogP: 1.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)[C@@H](NP(=S)(CC)[O-])CCC(=O)[O-].[Li+].[Li+].[Li+]
  • InChi: 1S/C7H14NO5PS.3Li/c1-2-14(13,15)8-5(7(11)12)3-4-6(9)10;;;/h5H,2-4H2,1H3,(H,9,10)(H,11,12)(H2,8,13,15);;;/q;3*+1/p-3/t5-,14?;;;/m0.../s1
  • InChiKey: WVPOAQAWZPUCLI-OMIINEQVSA-K  


Substructure search Similarity search

Network

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Synonyms

  • trilithium (2S)-2-[[ethyl(oxidanidyl)phosphinothioyl]amino]pentanedioate
  • trilithium (2S)-2-[[ethyl(oxido)thiophosphoryl]amino]glutarate
  • trilithium (2S)-2-[(ethyl-oxidophosphinothioyl)amino]pentanedioate
  • trilithium (2S)-2-[(ethyl-oxido-phosphinothioyl)amino]pentanedioate
  • trilithium (2S)-2-[(ethyl-oxido-thiophosphoryl)amino]glutarate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) peptidase family M13 containing protein 0.0967 0.1872 0.1872
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.1917 0.3829 1
Loa Loa (eye worm) hypothetical protein 0.0522 0.0955 0.0955
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.1503 0.2975 0.46
Trypanosoma brucei squalene synthase, putative 0.0796 0.1518 0.393
Echinococcus granulosus Squalene phytoene synthase 0.0248 0.039 0.0582
Loa Loa (eye worm) hypothetical protein 0.0082 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Leishmania major lanosterol synthase, putative 0.1395 0.2753 0.9245
Onchocerca volvulus 0.0251 0.0395 0.1966
Echinococcus granulosus expressed protein 0.0784 0.1494 0.2293
Schistosoma mansoni neprilysin-2 (M13 family) 0.0471 0.0848 0.1344
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.1006 0.1952 0.1952
Trypanosoma cruzi hypothetical protein, conserved 0.0522 0.0955 0.2449
Giardia lamblia Rab geranylgeranyltransferase 0.0522 0.0955 0.2196
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2088 0.4182 1
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0082 0.0047 0.0063
Brugia malayi B-box zinc finger family protein 0.0082 0.0047 0.0033
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0522 0.0955 0.1476
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0522 0.0955 0.2449
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.1503 0.2975 0.6813
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0243 0.038 0.0603
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0023 0.0023
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.4912 1 1
Schistosoma mansoni peroxidasin 0.0066 0.0014 0.0023
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.3121 0.6311 0.6306
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0023 0.0035
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.1503 0.2975 0.2975
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.3121 0.6311 0.9756
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.3121 0.6311 0.6311
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.1503 0.2975 0.6813
Schistosoma mansoni neprilysin 0.0243 0.038 0.0603
Trypanosoma brucei C-8 sterol isomerase, putative 0.0188 0.0265 0.0637
Loa Loa (eye worm) blistered cuticle protein 3 0.0066 0.0014 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.1006 0.1952 0.507
Schistosoma mansoni peptidylglycine monooxygenase 0.1658 0.3295 0.5221
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0522 0.0955 0.0942
Plasmodium vivax farnesyltransferase beta subunit, putative 0.1503 0.2975 0.6261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0023 0.0013
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.2088 0.4182 0.6458
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Trypanosoma cruzi hypothetical protein, conserved 0.0522 0.0955 0.2449
Loa Loa (eye worm) hypothetical protein 0.1211 0.2374 0.2374
Brugia malayi B-box type zinc-finger protein ncl-1 0.0082 0.0047 0.0033
Echinococcus multilocularis brain tumor protein 0.0082 0.0047 0.0073
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0471 0.0848 0.1344
Loa Loa (eye worm) zinc metallopeptidase 4 0.0227 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0967 0.1872 0.1872
Trypanosoma brucei lanosterol synthase 0.1917 0.3829 1
Toxoplasma gondii peptidase family M13 protein 0.1211 0.2374 0.7022
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0841 0.1612 0.16
Trypanosoma cruzi lanosterol synthase, putative 0.1917 0.3829 1
Loa Loa (eye worm) hypothetical protein 0.0967 0.1872 0.1872
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0082 0.0047 0.0074
Loa Loa (eye worm) hypothetical protein 0.0082 0.0047 0.0047
Schistosoma mansoni dopamine-beta-monooxygenase 0.1658 0.3295 0.5221
Toxoplasma gondii hypothetical protein 0.1082 0.2109 0.571
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.1082 0.2109 0.4524
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.1211 0.2374 0.2363
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1658 0.3295 0.3285
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1503 0.2975 0.6813
Onchocerca volvulus 0.0469 0.0845 0.4285
Loa Loa (eye worm) hypothetical protein 0.1211 0.2374 0.2374
Brugia malayi peptidase family M13 containing protein 0.0227 0.0347 0.0333
Loa Loa (eye worm) hypothetical protein 0.0248 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.2088 0.4182 0.4182
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0471 0.0848 0.1344
Echinococcus multilocularis tripartite motif containing protein 3 0.0082 0.0047 0.0073
Schistosoma mansoni gabp alpha 0.0076 0.0035 0.0055
Brugia malayi Ets-domain containing protein 0.0076 0.0035 0.0021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Echinococcus granulosus endothelin converting enzyme 1 0.1211 0.2374 0.3656
Onchocerca volvulus 0.1006 0.1952 1
Trypanosoma cruzi phytoene synthase, putative 0.0248 0.039 0.0965
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.1006 0.1952 0.3003
Brugia malayi Pre-SET motif family protein 0.022 0.0333 0.0319
Schistosoma mansoni ets-related 0.023 0.0352 0.0558
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.0014 0.0014
Plasmodium vivax prenyltransferase alpha subunit, putative 0.2088 0.4182 1
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0035 0.0054
Leishmania major squalene synthase, putative 0.0796 0.1518 0.5066
Leishmania major C-8 sterol isomerase-like protein 0.0188 0.0265 0.0821
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0469 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Trypanosoma cruzi protein farnesyltransferase, putative 0.1503 0.2975 0.7758
Brugia malayi Ets-domain containing protein 0.0076 0.0035 0.0021
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0082 0.0047 0.0063
Schistosoma mansoni hypothetical protein 0.0082 0.0047 0.0074
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0023 0.0036
Echinococcus granulosus brain tumor protein 0.0082 0.0047 0.0051
Mycobacterium leprae probable zinc metalloprotease 0.1211 0.2374 0.5
Echinococcus multilocularis microtubule associated protein 2 0.073 0.1384 0.2139
Schistosoma mansoni peptidylglycine monooxygenase 0.0082 0.0047 0.0074
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0035 0.0032
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Loa Loa (eye worm) peptidase family M13 containing protein 0.0967 0.1872 0.1872
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.2088 0.4182 0.6627
Leishmania major hypothetical protein, conserved 0.0248 0.039 0.1243
Schistosoma mansoni protein farnesyltransferase subunit beta 0.1503 0.2975 0.4715
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0522 0.0955 0.2449
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.1006 0.1952 0.507
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0248 0.039 0.1938
Toxoplasma gondii hypothetical protein 0.1006 0.1952 0.4937
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.14 0.2763 0.4378
Giardia lamblia Rab geranylgeranyltransferase 0.2088 0.4182 1
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.2088 0.4182 1
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.14 0.2763 0.6588
Trypanosoma cruzi hypothetical protein, conserved 0.1006 0.1952 0.507
Leishmania major farnesyltransferase beta subunit 0.1503 0.2975 1
Loa Loa (eye worm) B-box zinc finger family protein 0.0082 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0188 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Loa Loa (eye worm) hypothetical protein 0.0469 0.0845 0.0845
Trypanosoma brucei protein farnesyltransferase beta subunit 0.1503 0.2975 0.7758
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0227 0.0347 0.055
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.1006 0.1952 0.507
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.3121 0.6311 0.9757
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.1006 0.1952 0.507
Plasmodium falciparum protein farnesyltransferase subunit beta 0.1503 0.2975 0.6261
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.1006 0.1952 0.507
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.1006 0.1952 0.3091
Schistosoma mansoni microtubule-associated protein tau 0.073 0.1384 0.2192
Loa Loa (eye worm) hypothetical protein 0.0082 0.0047 0.0047
Onchocerca volvulus 0.074 0.1404 0.717
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.14 0.2763 0.4272
Schistosoma mansoni endothelin-converting enzyme-related 0.0227 0.0347 0.055
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.1006 0.1952 0.3094
Echinococcus multilocularis peroxidasin 0.0066 0.0014 0.0022
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0188 0.0265 0.0637
Echinococcus multilocularis Squalene phytoene synthase 0.0248 0.039 0.0603
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0333 0.0333
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.2088 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Echinococcus granulosus protein farnesyltransferase subunit beta 0.1503 0.2975 0.4588
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.14 0.2763 0.2763
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.2088 0.4182 1
Leishmania major geranylgeranyltransferase, putative 0.0522 0.0955 0.3157
Brugia malayi Peptidase family M13 containing protein 0.1211 0.2374 0.2363
Echinococcus granulosus protein prenyltransferase alpha subunit 0.1006 0.1952 0.3003
Giardia lamblia Rab geranylgeranyltransferase 0.1006 0.1952 0.4608
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.1503 0.2975 1
Trypanosoma cruzi hypothetical protein, conserved 0.1006 0.1952 0.507
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.1006 0.1952 0.1941
Schistosoma mansoni brat protein 0.0082 0.0047 0.0074
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0082 0.0047 0.0033
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Echinococcus multilocularis expressed protein 0.0784 0.1494 0.231
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.14 0.2763 0.4378
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3198 0.6468 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1006 0.1952 0.4112
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0522 0.0955 0.1478
Trypanosoma cruzi lanosterol synthase, putative 0.1917 0.3829 1
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0522 0.0955 0.2241
Echinococcus granulosus microtubule associated protein 2 0.073 0.1384 0.2122
Trypanosoma cruzi squalene synthase, putative 0.0796 0.1518 0.393
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0522 0.0955 0.1513
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0981 0.1899 0.2927
Loa Loa (eye worm) fli-1 protein 0.023 0.0352 0.0352
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0227 0.0347 0.055
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.1006 0.1952 0.4639
Loa Loa (eye worm) hypothetical protein 0.1211 0.2374 0.2374
Loa Loa (eye worm) hypothetical protein 0.0967 0.1872 0.1872
Loa Loa (eye worm) B-box zinc finger family protein 0.0082 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Schistosoma mansoni hypothetical protein 0.0082 0.0047 0.0074
Schistosoma mansoni hypothetical protein 0.0082 0.0047 0.0074
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Trypanosoma cruzi squalene synthase, putative 0.0796 0.1518 0.393
Loa Loa (eye worm) hypothetical protein 0.0967 0.1872 0.1872
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.2088 0.4182 0.6466
Echinococcus multilocularis brain tumor protein 0.0082 0.0047 0.0073
Brugia malayi B-box type zinc-finger protein ncl-1 0.0082 0.0047 0.0033
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.14 0.2763 0.4259
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.14 0.2763 0.6253
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.2088 0.4182 0.4174
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0471 0.0848 0.1344
Schistosoma mansoni peroxidasin 0.0066 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Trypanosoma cruzi protein farnesyltransferase, putative 0.1503 0.2975 0.7758
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1503 0.2975 0.6813
Loa Loa (eye worm) hypothetical protein 0.0065 0.0012 0.0012
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.1503 0.2975 0.6813
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0035 0.0035
Giardia lamblia Prenyltransferase 0.1503 0.2975 0.7082
Echinococcus granulosus tripartite motif containing protein 3 0.0082 0.0047 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.3198 0.6468 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1211 0.2374 0.3761
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0471 0.0848 0.1344
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.2088 0.4182 0.4182
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.0014 0.0014
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.1006 0.1952 0.3091
Brugia malayi Fli-1 protein 0.023 0.0352 0.0338
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.1503 0.2975 0.7099
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.1006 0.1952 0.507
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Schistosoma mansoni peptidyl-glycine monooxygenase 0.3121 0.6311 1
Loa Loa (eye worm) hypothetical protein 0.074 0.1404 0.1404
Loa Loa (eye worm) RING finger protein nhl-1 0.0082 0.0047 0.0047
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0188 0.0265 0.0251
Entamoeba histolytica hypothetical protein 0.0082 0.0047 0.0058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0014 0.0014
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.1006 0.1952 0.3018
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0522 0.0955 0.1478
Schistosoma mansoni hypothetical protein 0.0243 0.038 0.0603
Loa Loa (eye worm) NCL-1 protein 0.0082 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Leishmania major protein farnesyltransferase alpha subunit, putative 0.1006 0.1952 0.6535
Brugia malayi B-box zinc finger family protein 0.0082 0.0047 0.0033
Loa Loa (eye worm) hypothetical protein 0.1658 0.3295 0.3295
Mycobacterium ulcerans zinc metalloprotease 0.1211 0.2374 1
Schistosoma mansoni hypothetical protein 0.0248 0.039 0.0618
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0227 0.0347 0.055
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0227 0.0347 0.055
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0248 0.039 0.0907
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.1006 0.1952 0.507
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.1006 0.1952 0.3018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0817 0.1561 0.1549
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0227 0.0347 0.055
Loa Loa (eye worm) hypothetical protein 0.0522 0.0955 0.0955
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0023 0.0009
Echinococcus multilocularis endothelin converting enzyme 1 0.1211 0.2374 0.367
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.1211 0.2374 0.6152
Loa Loa (eye worm) hypothetical protein 0.0984 0.1906 0.1906
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.1503 0.2975 0.2965
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2088 0.4182 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.14 0.2763 0.2753
Brugia malayi hypothetical protein 0.0469 0.0845 0.0832
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1503 0.2975 0.6813

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.24 uM Inhibitory activity against zinc-dependent Glutamate Carboxypeptidase G ChEMBL. 10360747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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