Detailed information for compound 428251

Basic information

Technical information
  • TDR Targets ID: 428251
  • Name: N-(2-diethylaminoethyl)-2-iodobenzamide
  • MW: 346.207 | Formula: C13H19IN2O
  • H donors: 1 H acceptors: 1 LogP: 2.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1ccccc1I)CC
  • InChi: 1S/C13H19IN2O/c1-3-16(4-2)10-9-15-13(17)11-7-5-6-8-12(11)14/h5-8H,3-4,9-10H2,1-2H3,(H,15,17)
  • InChiKey: WNSWOZIBBVUJBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-iodo-benzamide
  • N-(2-(diethylamino)ethyl)-2-iodobenzamide
  • N-(2-(diethylamino)ethyl)-4-iodobenzamide
  • AO-365/41690498
  • STK191932

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0592 0.2236 0.3573
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Schistosoma mansoni tyrosine kinase 0.0042 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0404 0.1475 0.2357
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0126
Echinococcus granulosus NDR protein kinase 0.0161 0.0493 0.0601
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0042 0.0014 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.1083 0.4217 0.4217
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0168 0.0524 0.0524
Echinococcus granulosus roundabout 2 0.0056 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0092 0.0216 0.0345
Loa Loa (eye worm) hypothetical protein 0.1589 0.6258 1
Schistosoma mansoni nephrin 0.0095 0.0227 0.0227
Echinococcus multilocularis death associated protein kinase 1 0.1749 0.6905 0.8557
Schistosoma mansoni rhogef and pleckstrin domain protein 0.004 0.0005 0.0005
Echinococcus granulosus neuroglian 0.0073 0.0139 0.0162
Brugia malayi Protein kinase domain containing protein 0.0151 0.0453 0.0453
Echinococcus granulosus serine:threonine protein kinase N2 0.0161 0.0493 0.0601
Schistosoma mansoni ephrin receptor 0.0048 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0005 0.0007
Echinococcus granulosus intersectin 2 0.0052 0.0054 0.0057
Loa Loa (eye worm) TKL/MLK/MLK protein kinase 0.0039 0.0002 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.2149 0.2149
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0056 0.0068 0.0109
Onchocerca volvulus 0.0404 0.1475 0.4216
Schistosoma mansoni tyrosine kinase 0.0073 0.0137 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.31 0.3836
Entamoeba histolytica protein kinase , putative 0.0179 0.0567 0.4761
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0056 0.0068 0.0068
Echinococcus granulosus Diacylglycerol kinase theta 0.0143 0.042 0.0511
Entamoeba histolytica protein kinase, putative 0.0169 0.0528 0.4389
Loa Loa (eye worm) TK protein kinase 0.0057 0.0074 0.0119
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0769 0.2949 0.2949
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.029 0.1016 0.1016
Schistosoma mansoni hypothetical protein 0.062 0.2349 0.2349
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0493 0.0493
Echinococcus granulosus myotubularin protein 13 0.0152 0.0456 0.0555
Echinococcus granulosus protein kinase c eta type 0.0143 0.042 0.0511
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0613 0.2319 0.3706
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Schistosoma mansoni tyrosine kinase 0.0061 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0261 0.0899 0.1437
Loa Loa (eye worm) hypothetical protein 0.0058 0.008 0.0128
Echinococcus granulosus tyrosine protein kinase HCK 0.0057 0.0074 0.0082
Leishmania major hypothetical protein, conserved 0.0617 0.2333 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0304 0.1073 0.132
Schistosoma mansoni serine/threonine kinase 0.0161 0.0493 0.0493
Echinococcus multilocularis serine:threonine protein kinase N2 0.0161 0.0493 0.0601
Brugia malayi serine/threonine protein kinase 6 0.0179 0.0567 0.0567
Brugia malayi Ras association domain family 1 isoform A 0.0143 0.042 0.042
Loa Loa (eye worm) SRC-1 0.0073 0.0137 0.0219
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0907 0.3506 1
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0493 0.0493
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0065 0.0106 0.0121
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0275 0.0956 0.1528
Echinococcus multilocularis tyrosine protein kinase Abl 0.0042 0.0014 0.0007
Echinococcus multilocularis Diacylglycerol kinase theta 0.0143 0.042 0.0511
Entamoeba histolytica diacylglycerol kinase, putative 0.0143 0.042 0.3344
Loa Loa (eye worm) hypothetical protein 0.0092 0.0216 0.0345
Brugia malayi p70 ribosomal S6 kinase beta 0.0161 0.0493 0.0493
Schistosoma mansoni tyrosine kinase 0.0066 0.0109 0.0109
Entamoeba histolytica protein kinase, putative 0.0179 0.0567 0.4761
Echinococcus multilocularis serine:threonine protein kinase 38 0.0161 0.0493 0.0601
Loa Loa (eye worm) AGC/PKN protein kinase 0.0161 0.0493 0.0787
Schistosoma mansoni diacylglycerol kinase theta 0.0143 0.042 0.042
Brugia malayi Protein kinase domain containing protein 0.0161 0.0493 0.0493
Brugia malayi protein kinase C II. 0.0613 0.2319 0.2319
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Echinococcus multilocularis NCK adaptor protein 0.0047 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0459 0.1697 0.2711
Brugia malayi C1-like domain containing protein 0.0412 0.1508 0.1508
Brugia malayi Protein kinase c protein 2 0.0418 0.1532 0.1532
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0161 0.0493 0.0601
Echinococcus multilocularis tyrosine protein kinase Srms 0.0065 0.0106 0.0121
Echinococcus granulosus titin 0.0045 0.0024 0.002
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0143 0.042 0.0671
Brugia malayi Protein kinase domain containing protein 0.0169 0.0528 0.0528
Echinococcus multilocularis roundabout 2 0.0056 0.0068 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0077 0.0156 0.0249
Echinococcus granulosus protein kinase c iota type 0.048 0.1783 0.2203
Loa Loa (eye worm) AUR protein kinase 0.0179 0.0567 0.0905
Leishmania major protein kinase, putative 0.0179 0.0567 0.2428
Schistosoma mansoni nephrin 0.0056 0.0068 0.0068
Echinococcus multilocularis myotubularin protein 13 0.0152 0.0456 0.0555
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0567 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0161 0.0493 0.3055
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0073 0.0137 0.016
Loa Loa (eye worm) hypothetical protein 0.0413 0.1511 0.2414
Echinococcus granulosus roundabout 2 0.0056 0.0068 0.0075
Echinococcus granulosus tyrosine protein kinase Src64B 0.0073 0.0137 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0024 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Echinococcus multilocularis RNA directed DNA polymerase 0.0254 0.0869 0.1068
Trypanosoma brucei aurora B kinase 0.0179 0.0567 0.0129
Onchocerca volvulus 0.0168 0.0524 0.1498
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0064 0.0101 0.0161
Onchocerca volvulus 0.0413 0.1511 0.4318
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0968 0.3751 0.5994
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0592 0.2236 0.3573
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0058 0.0079 0.0088
Loa Loa (eye worm) hypothetical protein 0.0753 0.2885 0.461
Echinococcus multilocularis stromal cell derived factor 2 0.0168 0.0524 0.064
Loa Loa (eye worm) AUR protein kinase 0.0179 0.0567 0.0905
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Echinococcus granulosus tyrosine protein kinase Lyn 0.0081 0.017 0.02
Schistosoma mansoni cell adhesion molecule 0.0056 0.0068 0.0068
Echinococcus multilocularis aurora kinase A 0.0179 0.0567 0.0693
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0254 0.0869 0.1068
Echinococcus granulosus Protein kinase C brain isozyme 0.0571 0.2149 0.2656
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.004 0.0039
Entamoeba histolytica MIR domain protein 0.0168 0.0524 0.435
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0528 0.0528
Echinococcus granulosus tyrosine protein kinase Src42A 0.0069 0.0124 0.0143
Brugia malayi protein unc-22 0.0045 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0453 0.0453
Schistosoma mansoni titin 0.0045 0.0024 0.0024
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0073 0.0137 0.016
Brugia malayi protein-tyrosine kinase 0.0065 0.0106 0.0106
Schistosoma mansoni vav2 0.0159 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Plasmodium falciparum serine/threonine protein kinase, putative 0.0179 0.0567 0.5
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0156 0.0475 0.0578
Trypanosoma cruzi aurora B kinase, putative 0.0179 0.0567 0.1616
Brugia malayi Variant SH3 domain containing protein 0.004 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0137 0.016
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0151 0.0452 0.0452
Echinococcus multilocularis roundabout 2 0.0056 0.0068 0.0075
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0161 0.0493 0.0601
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0151 0.0452 0.055
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.008 0.0167 0.0267
Echinococcus granulosus contactin 0.0056 0.0068 0.0075
Schistosoma mansoni rac gtpase activating protein 0.0143 0.042 0.042
Loa Loa (eye worm) TK protein kinase 0.0042 0.0012 0.0019
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0968 0.3751 0.3751
Loa Loa (eye worm) hypothetical protein 0.0056 0.0068 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0161 0.0493 0.3055
Echinococcus multilocularis protein kinase c epsilon type 0.0613 0.2319 0.2868
Onchocerca volvulus 0.0156 0.0475 0.1356
Schistosoma mansoni protein kinase C 0.0156 0.0475 0.0475
Brugia malayi hypothetical protein 0.008 0.0167 0.0167
Echinococcus multilocularis protein kinase c eta type 0.0143 0.042 0.0511
Brugia malayi Tyrosine-protein kinase abl-1 0.0042 0.0014 0.0014
Echinococcus granulosus N chimaerin 0.0151 0.0452 0.055
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0106 0.0121
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Echinococcus granulosus raf serine:threonine protein kinase 0.0169 0.0528 0.0645
Echinococcus granulosus ryanodine receptor 44f 0.1589 0.6258 0.7755
Loa Loa (eye worm) TK/ROR protein kinase 0.0042 0.0012 0.0019
Echinococcus granulosus aurora kinase A 0.0179 0.0567 0.0693
Giardia lamblia Aurora kinase 0.0179 0.0567 0.5
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Echinococcus granulosus growth factor receptor bound protein 2 0.0047 0.0032 0.0029
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0161 0.0493 0.0787
Schistosoma mansoni tyrosine kinase 0.0042 0.0014 0.0014
Brugia malayi MIR domain containing protein 0.0168 0.0524 0.0524
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0156 0.0475 0.0578
Schistosoma mansoni unc-13 (munc13) 0.0156 0.0475 0.0475
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0161 0.0493 0.0787
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0056 0.0068 0.0075
Echinococcus granulosus protein kinase c epsilon type 0.0613 0.2319 0.2868
Loa Loa (eye worm) hypothetical protein 0.0156 0.0475 0.0758
Loa Loa (eye worm) CAMK protein kinase 0.0045 0.0024 0.0039
Brugia malayi Hr1 repeat family protein 0.0161 0.0493 0.0493
Schistosoma mansoni protein kinase C mu 0.0412 0.1508 0.1508
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0179 0.0567 0.0693
Brugia malayi protein kinase C3,putative 0.0328 0.1167 0.1167
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0073 0.0137 0.016
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Echinococcus granulosus defective proboscis extension response 0.0058 0.0079 0.0088
Entamoeba histolytica protein kinase, putative 0.0161 0.0493 0.4045
Loa Loa (eye worm) hypothetical protein 0.0735 0.2813 0.4494
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0069 0.0124 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0167 0.0267
Echinococcus granulosus tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Loa Loa (eye worm) AGC/NDR protein kinase 0.0161 0.0493 0.0787
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0161 0.0493 0.0601
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0073 0.0137 0.016
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Schistosoma mansoni ryanodine receptor related 0.2515 1 1
Brugia malayi diacylglycerol kinase 0.0143 0.042 0.042
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0161 0.0493 0.0601
Echinococcus multilocularis expressed protein 0.0436 0.1605 0.1981
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0161 0.0493 0.0601
Loa Loa (eye worm) MIR domain-containing protein 0.0168 0.0524 0.0838
Loa Loa (eye worm) raf kinase 0.0143 0.042 0.0671
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0151 0.0452 0.055
Loa Loa (eye worm) hypothetical protein 0.0254 0.0869 0.1389
Echinococcus granulosus expressed protein 0.0436 0.1605 0.1981
Brugia malayi diacylglycerol kinase 0.0143 0.042 0.042
Entamoeba histolytica protein kinase, putative 0.0179 0.0567 0.4761
Entamoeba histolytica hypothetical protein 0.0143 0.042 0.3344
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0042 0.0012 0.0004
Echinococcus multilocularis protein kinase c iota type 0.048 0.1783 0.2203
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.1106 0.4312 0.534
Echinococcus granulosus tyrosine kinase 0.0065 0.0106 0.0121
Echinococcus multilocularis tyrosine protein kinase Blk 0.0065 0.0106 0.0121
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0032 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0613 0.2319 0.2319
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0161 0.0493 0.0787
Schistosoma mansoni neuroglian 0.0056 0.0068 0.0068
Brugia malayi Protein kinase domain containing protein 0.0161 0.0493 0.0493
Brugia malayi RhoGEF domain containing protein 0.0143 0.042 0.042
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0002 0.0002
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0045 0.0024 0.0039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0137 0.016
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Echinococcus multilocularis Immunoglobulin 0.0058 0.0079 0.0088
Echinococcus multilocularis tyrosine protein kinase HCK 0.0057 0.0074 0.0082
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0179 0.0567 0.4761
Loa Loa (eye worm) RasGEF domain-containing protein 0.0143 0.042 0.0671
Trichomonas vaginalis AGC family protein kinase 0.0161 0.0493 0.3055
Schistosoma mansoni atypical protein kinase C 0.0493 0.1836 0.1836
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0269 0.0932 0.1489
Loa Loa (eye worm) hypothetical protein 0.0261 0.0899 0.1437
Brugia malayi SRC-1 0.0073 0.0137 0.0137
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0161 0.0493 0.0601
Brugia malayi serine/threonine kinase 12 0.0179 0.0567 0.0567
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0056 0.0068 0.0075
Schistosoma mansoni protein kinase C mu 0.0143 0.042 0.042
Echinococcus multilocularis neuroglian 0.0073 0.0139 0.0162
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0137 0.016
Echinococcus multilocularis c src tyrosine kinase 0.0042 0.0014 0.0007
Brugia malayi RhoGAP domain containing protein 0.0143 0.042 0.042
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0151 0.0453 0.0551
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0073 0.0137 0.016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0313 0.1108 1
Echinococcus granulosus microtubule associated protein 2 0.0806 0.31 0.3836
Brugia malayi Pleckstrin Homology Domain 0.0152 0.0456 0.0456
Schistosoma mansoni tyrosine kinase 0.0073 0.0137 0.0137
Schistosoma mansoni unc-13 (munc13) 0.0156 0.0475 0.0475
Echinococcus multilocularis N chimaerin 0.0151 0.0452 0.055
Brugia malayi Variant SH3 domain containing protein 0.0151 0.0452 0.0452
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0077 0.0156 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0453 0.0453
Trichomonas vaginalis mannosyltransferase 1, putative 0.0168 0.0524 0.6015
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0151 0.0452 0.0722
Echinococcus multilocularis titin 0.0045 0.0024 0.002
Schistosoma mansoni TPX2 protein 0.0151 0.0454 0.0454
Echinococcus multilocularis neuroglian 0.0056 0.0068 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.2149 0.2149
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0056 0.0068 0.0075
Schistosoma mansoni diacylglycerol kinase theta 0.0143 0.042 0.042
Schistosoma mansoni vesicular amine transporter 0.0074 0.0144 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0493 0.0493
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0571 0.2149 0.2656
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.31 0.31
Echinococcus multilocularis raf serine:threonine protein kinase 0.0169 0.0528 0.0645
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0042 0.0014 0.0007
Brugia malayi RhoGAP domain containing protein 0.0151 0.0452 0.0452
Brugia malayi serine/threonine-protein kinase 6 0.0179 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0567 1
Onchocerca volvulus Tyrosine kinase homolog 0.0905 0.3499 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1106 0.4312 0.534
Schistosoma mansoni protein kinase 0.0179 0.0567 0.0567
Loa Loa (eye worm) AUR protein kinase 0.0179 0.0567 0.0905
Echinococcus granulosus unc 13 munc13 0.0156 0.0475 0.0578
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0179 0.0567 0.5
Brugia malayi Fibronectin type III domain containing protein 0.008 0.0167 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0024 0.0024
Echinococcus multilocularis ryanodine receptor 44f 0.1589 0.6258 0.7755
Loa Loa (eye worm) hypothetical protein 0.008 0.0167 0.0267
Loa Loa (eye worm) ryanodine receptor 0.094 0.3638 0.5813
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0151 0.0453 0.0551
Echinococcus granulosus roundabout 2 0.0114 0.0304 0.0366
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0152 0.0456 0.0728
Schistosoma mansoni cell adhesion molecule 0.0056 0.0068 0.0068
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0058 0.0079 0.0079
Onchocerca volvulus 0.0261 0.0899 0.2569
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0073 0.0137 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0068 0.0068
Echinococcus granulosus ryanodine receptor 44f 0.2037 0.8067 1
Echinococcus granulosus protein kinase C gamma type 0.0428 0.1572 0.1941
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0151 0.0452 0.0452
Echinococcus multilocularis Rac GTPase activating protein 1 0.0143 0.042 0.0511
Echinococcus granulosus RNA directed DNA polymerase 0.0254 0.0869 0.1068
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0567 1
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Entamoeba histolytica protein kinase, putative 0.0161 0.0493 0.4045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0008 0.0008
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0341 0.122 0.1949
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0068 0.0075
Echinococcus multilocularis unc 13 (munc13) 0.0156 0.0475 0.0578
Echinococcus granulosus titin 0.0045 0.0024 0.002
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0412 0.1508 0.1508
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0412 0.1508 0.2409
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0143 0.042 0.0671
Echinococcus granulosus tyrosine protein kinase Blk 0.0065 0.0106 0.0121
Onchocerca volvulus 0.0864 0.3331 0.9521
Entamoeba histolytica protein kinase, putative 0.0169 0.0528 0.4389
Loa Loa (eye worm) AGC/AKT protein kinase 0.0169 0.0528 0.0844
Echinococcus multilocularis serine:threonine protein kinase N2 0.0457 0.1689 0.2085
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0073 0.0137 0.016
Toxoplasma gondii aurora kinase 0.0179 0.0567 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0161 0.0493 0.0787
Echinococcus multilocularis intersectin 2 0.0052 0.0054 0.0057
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0907 0.3506 1
Echinococcus granulosus neuroglian 0.0056 0.0068 0.0075
Echinococcus granulosus twitchin 0.0081 0.0172 0.0202
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0126
Onchocerca volvulus 0.0592 0.2236 0.6391
Echinococcus multilocularis serine threonine protein kinase 0.0428 0.1572 0.1941
Loa Loa (eye worm) TK protein kinase 0.0065 0.0106 0.017
Loa Loa (eye worm) hypothetical protein 0.0397 0.1445 0.231
Echinococcus multilocularis Immunoglobulin 0.0058 0.0079 0.0088
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0058 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0143 0.042 0.042
Echinococcus multilocularis ryanodine receptor 44f 0.2037 0.8067 1
Loa Loa (eye worm) hypothetical protein 0.0592 0.2236 0.3573
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0042 0.0014 0.0014
Echinococcus granulosus Immunoglobulin 0.0058 0.0079 0.0088
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0179 0.0567 0.4761
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0179 0.0567 0.0693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0068 0.0068
Schistosoma mansoni cell adhesion molecule 0.0099 0.0244 0.0244
Onchocerca volvulus 0.0045 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.0143 0.042 0.0671
Echinococcus multilocularis roundabout 2 0.0114 0.0304 0.0366
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0179 0.0567 0.4761
Echinococcus granulosus Rac GTPase activating protein 1 0.0143 0.042 0.0511
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0042 0.0012 0.0004
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0306 0.1081 0.1081
Echinococcus granulosus stromal cell derived factor 2 0.0168 0.0524 0.064
Entamoeba histolytica protein kinase domain containing protein 0.0179 0.0567 0.4761
Trichomonas vaginalis AGC family protein kinase 0.0169 0.0528 0.6393
Toxoplasma gondii AGC kinase 0.0161 0.0493 0.4949
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.0479 0.1777 0.2839
Echinococcus granulosus c src tyrosine kinase 0.0042 0.0014 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0012 0.0012
Brugia malayi cation channel family protein 0.1075 0.4186 0.4186
Loa Loa (eye worm) ryanodine receptor 0.0594 0.2241 0.3581
Loa Loa (eye worm) hypothetical protein 0.0306 0.1081 0.1727
Entamoeba histolytica diacylglycerol kinase, putative 0.0143 0.042 0.3344

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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