Detailed information for compound 433758

Basic information

Technical information
  • TDR Targets ID: 433758
  • Name: 5H-benzo[c][1]benzazepine-6,11-dione
  • MW: 223.227 | Formula: C14H9NO2
  • H donors: 1 H acceptors: 2 LogP: 2.27 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1c2ccccc2[nH]c(=O)c2c1cccc2
  • InChi: 1S/C14H9NO2/c16-13-9-5-1-2-6-10(9)14(17)15-12-8-4-3-7-11(12)13/h1-8H,(H,15,17)
  • InChiKey: USJALFVAJSYMSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5H-benzo[c][1]benzazepine-6,11-quinone
  • 1143-50-6
  • Oprea1_353454
  • 5H-Dibenzo[b,e]azepine-6,11-dione
  • 6,11(5H)-Morphanthridinedione
  • AIDS-127133
  • 5H-Dibenz(b,e)azepine-6,11-dione
  • EINECS 214-539-6
  • NSC 144965
  • AIDS127133
  • NSC144965

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Plasmodium vivax peptide deformylase, putative 0.0392 0.8283 1
Onchocerca volvulus 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0133 0.2531 0.2531
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1289 0.1289
Brugia malayi hypothetical protein 0.0031 0.0275 0.0275
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.015 0.2911 1
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Schistosoma mansoni peroxidasin 0.047 1 1
Echinococcus granulosus geminin 0.0196 0.3929 0.3929
Onchocerca volvulus Peroxidasin homolog 0.047 1 1
Echinococcus multilocularis protein jagged 1 0.0152 0.2957 0.2957
Onchocerca volvulus Peroxidasin homolog 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0507 0.0507
Plasmodium vivax ataxin-2 like protein, putative 0.0031 0.0275 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.04 0.04
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Brugia malayi Blistered cuticle protein 3 0.047 1 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0119 0.2238 0.2238
Loa Loa (eye worm) animal heme peroxidase 0.047 1 1
Schistosoma mansoni slit 0.0152 0.2957 0.2957
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0828 0.0828
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0119 0.2238 0.2238
Echinococcus multilocularis neurogenic locus notch protein 4 0.0152 0.2957 0.2957
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0119 0.2238 0.2238
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1289 0.1289
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Echinococcus multilocularis slit 2 protein 0.0152 0.2957 0.2957
Onchocerca volvulus Putative cubilin 0.0152 0.2957 0.2664
Brugia malayi hypothetical protein 0.002 0.0034 0.0034
Echinococcus multilocularis protein jagged 1 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni peroxidasin 0.047 1 1
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0392 0.8283 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1289 0.1289
Echinococcus granulosus protein jagged 2 0.0152 0.2957 0.2957
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Echinococcus granulosus fibropellin Ia 0.0152 0.2957 0.2957
Loa Loa (eye worm) blistered cuticle protein 3 0.047 1 1
Echinococcus granulosus neural cadherin 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0152 0.2957 0.2957
Echinococcus multilocularis geminin 0.0196 0.3929 0.3929
Echinococcus multilocularis neurogenic locus notch protein 0.0152 0.2957 0.2957
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0018
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0133 0.2531 0.2531
Loa Loa (eye worm) animal heme peroxidase 0.047 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0828 0.0828
Brugia malayi Calcium binding EGF domain containing protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Echinococcus granulosus neurogenic locus protein delta 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.2531 0.2531
Onchocerca volvulus 0.0152 0.2957 0.2664
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.0275 0.0944
Chlamydia trachomatis peptide deformylase 0.0392 0.8283 0.5
Onchocerca volvulus 0.047 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0828 0.0828
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Echinococcus granulosus protein jagged 2 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0036 0.04 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0018
Echinococcus multilocularis neural cadherin 0.0152 0.2957 0.2957
Echinococcus multilocularis fibropellin Ia 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0828 0.0828
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.52 0.52
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.04 0.04
Plasmodium falciparum peptide deformylase 0.0392 0.8283 1
Leishmania major polypeptide deformylase-like protein, putative 0.015 0.2911 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1289 0.1289
Giardia lamblia High cysteine protein 0.0152 0.2957 0.5
Brugia malayi Animal haem peroxidase family protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) notch protein 0.0152 0.2957 0.2957
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0828 0.0828
Treponema pallidum polypeptide deformylase (def) 0.0392 0.8283 0.5
Onchocerca volvulus 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Onchocerca volvulus 0.0152 0.2957 0.2664
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Trypanosoma brucei Polypeptide deformylase 1 0.015 0.2911 1
Echinococcus granulosus GPCR family 2 0.0019 0.0018 0.0018
Echinococcus granulosus tar DNA binding protein 0.0076 0.1289 0.1289
Trypanosoma brucei Peptide deformylase 2 0.015 0.2911 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0152 0.2957 0.2957
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Brugia malayi notch-like transmembrane receptor 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0929 0.0929
Brugia malayi Pre-SET motif family protein 0.0253 0.52 0.52
Echinococcus granulosus protein jagged 1 0.0152 0.2957 0.2957
Toxoplasma gondii EGF family domain-containing protein 0.0152 0.2957 0.357
Brugia malayi Animal haem peroxidase family protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.04 0.04
Brugia malayi Peroxidasin 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0275 0.0275
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.015 0.2911 1
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1289 0.1289
Brugia malayi Muscle positioning protein 4 0.0152 0.2957 0.2957
Schistosoma mansoni septate junction protein 0.0152 0.2957 0.2957
Echinococcus granulosus peroxidasin 0.047 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0828 0.0828
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0392 0.8283 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1289 0.1289
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Echinococcus granulosus notch 0.0152 0.2957 0.2957
Echinococcus granulosus neurogenic locus notch protein 0.0152 0.2957 0.2957
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0392 0.8283 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0031 0.0275 0.0332
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1289 0.1289
Echinococcus multilocularis neurogenic locus protein delta 0.0152 0.2957 0.2957
Brugia malayi Animal haem peroxidase family protein 0.047 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi Cadherin domain containing protein 0.0152 0.2957 0.2957
Leishmania major hypothetical protein, conserved 0.0031 0.0275 0.0944
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0196 0.3929 0.3929
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0175 0.346 0.346
Brugia malayi TAR-binding protein 0.0076 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.015 0.2911 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0018 0.0018
Onchocerca volvulus 0.0152 0.2957 0.2664
Echinococcus granulosus slit 2 protein 0.0152 0.2957 0.2957
Echinococcus granulosus protein jagged 1 0.0152 0.2957 0.2957
Onchocerca volvulus Dual oxidase homolog 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.0828 0.0828
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1289 0.1289
Brugia malayi hypothetical protein 0.0175 0.346 0.346
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0018
Onchocerca volvulus Neurogenic locus notch homolog 0.0152 0.2957 0.2664
Echinococcus granulosus delta-like protein 1 0.0152 0.2957 0.2957
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0018 0.0018
Echinococcus granulosus neurogenic locus notch protein 0.0152 0.2957 0.2957
Trypanosoma brucei PAB1-binding protein , putative 0.0031 0.0275 0.0944
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0119 0.2238 0.2238
Echinococcus multilocularis neurogenic locus protein delta 0.0152 0.2957 0.2957
Plasmodium vivax SET domain protein, putative 0.0036 0.04 0.0483
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Onchocerca volvulus Peroxidase homolog 0.047 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0018
Loa Loa (eye worm) RNA binding protein 0.0076 0.1289 0.1289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0018 0.0018
Mycobacterium ulcerans peptide deformylase 0.0392 0.8283 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.015 0.2911 1
Brugia malayi GCC2 and GCC3 family protein 0.0152 0.2957 0.2957
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Echinococcus multilocularis notch 0.0152 0.2957 0.2957
Toxoplasma gondii hypothetical protein 0.0392 0.8283 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.04 0.04
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.0275 0.0332
Echinococcus multilocularis protein jagged 2 0.0152 0.2957 0.2957
Onchocerca volvulus Peroxidase homolog 0.047 1 1
Echinococcus multilocularis peroxidasin 0.047 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.037 0.037
Schistosoma mansoni notch 0.0152 0.2957 0.2957
Brugia malayi Delta serrate ligand family protein 0.0152 0.2957 0.2957
Trichomonas vaginalis set domain proteins, putative 0.0288 0.5974 0.5
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0152 0.2957 0.2664
Schistosoma mansoni hypothetical protein 0.0196 0.3929 0.3929
Loa Loa (eye worm) animal heme peroxidase 0.047 1 1
Onchocerca volvulus 0.0152 0.2957 0.2664
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi Animal haem peroxidase family protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Echinococcus multilocularis fat cadherin tumor suppressor 0.0152 0.2957 0.2957
Echinococcus granulosus neurogenic locus notch protein 4 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Onchocerca volvulus Chorion peroxidase homolog 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi Cadherin domain containing protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0041 0.0507 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.04 0.04
Loa Loa (eye worm) animal heme peroxidase 0.047 1 1
Brugia malayi RNA binding protein 0.0076 0.1289 0.1289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.04 0.04
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Brugia malayi EGF-like domain containing protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Brugia malayi Animal haem peroxidase family protein 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Onchocerca volvulus 0.0152 0.2957 0.2664
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.04 0.0483
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.0275 0.0944
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0119 0.2238 0.2238
Schistosoma mansoni hypothetical protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.006 0.0929 0.0929
Schistosoma mansoni cell polarity protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Echinococcus multilocularis neurogenic locus notch protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Loa Loa (eye worm) Notch2 0.0152 0.2957 0.2957
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0929 0.0929
Onchocerca volvulus 0.0175 0.346 0.3187
Brugia malayi Pre-SET motif family protein 0.0036 0.04 0.04
Echinococcus multilocularis GPCR, family 2 0.0019 0.0018 0.0018
Onchocerca volvulus 0.0288 0.5974 0.5806
Schistosoma mansoni laminin gamma-3 chain 0.0152 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0152 0.2957 0.2957
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.0828 0.0828
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0507 0.0507
Brugia malayi Calcium binding EGF domain containing protein 0.0152 0.2957 0.2957
Onchocerca volvulus Slit protein homolog 0.0152 0.2957 0.2664
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.0275 0.0332

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 50 uM Inhibition of human recombinant Chk1 ChEMBL. 17658776
IC50 (binding) > 50 uM Inhibition of human recombinant Chk1 ChEMBL. 17658776
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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