TDR Targets

Basic information

Technical information

TDR Targets ID: 433792
Name: 5-[3-[[1-(benzenesulfonyl)piperidin-4-yl]amin o]phenyl]-4-bromo-3-(carboxymethyloxy)thiophe ne-2-carboxylic acid
MW: 595.483 | Formula: C24H23BrN2O7S2
H donors: 3 H acceptors: 6 LogP: 4.76 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)COc1c(Br)c(sc1C(=O)O)c1cccc(c1)NC1CCN(CC1)S(=O)(=O)c1ccccc1
InChi: 1S/C24H23BrN2O7S2/c25-20-21(34-14-19(28)29)23(24(30)31)35-22(20)15-5-4-6-17(13-15)26-16-9-11-27(12-10-16)36(32,33)18-7-2-1-3-8-18/h1-8,13,16,26H,9-12,14H2,(H,28,29)(H,30,31)
InChiKey: RRZXWGWXNQLBPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[3-[[1-(benzenesulfonyl)-4-piperidyl]amino]phenyl]-4-bromo-3-(carboxymethyloxy)thiophene-2-carboxylic acid
5-[3-[[1-(benzenesulfonyl)-4-piperidinyl]amino]phenyl]-4-bromo-3-(carboxymethyloxy)-2-thiophenecarboxylic acid
4-bromo-3-(carboxymethyloxy)-5-[3-[[1-(phenylsulfonyl)piperidin-4-yl]amino]phenyl]thiophene-2-carboxylic acid
5-[3-[(1-besyl-4-piperidyl)amino]phenyl]-4-bromo-3-(carboxymethyloxy)-2-thenoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0372	0.0407	0.0407
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0164	0.0153	0.0153
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0164	0.0153	0.1537
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0018	0.0184
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0481	0.0541	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Onchocerca volvulus		0.0164	0.0153	1
Schistosoma mansoni	hypothetical protein	0.0164	0.0153	0.1537
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.0153	0.5953
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0033	0.0329
Trichomonas vaginalis	conserved hypothetical protein	0.0372	0.0407	0.409
Echinococcus granulosus	neuropeptide s receptor	0.05	0.0565	0.0565
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0423	0.0471	0.0471
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0153	0.1537
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0852	0.0996	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0852	0.0996	1
Giardia lamblia	GTOR	0.0852	0.0996	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0164	0.0153	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	0.042
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0164	0.0153	0.1537
Echinococcus multilocularis	neuropeptide s receptor	0.05	0.0565	0.0565
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0164	0.0153	0.0445
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0711	0.0823	0.8264
Leishmania major	hypothetical protein, conserved	0.3014	0.3644	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0164	0.0153	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0153	0.1537
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0547	0.0622	0.1808
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0711	0.0823	0.2391
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0164	0.0153	0.0445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0153	0.0153
Leishmania major	hypothetical protein, unknown function	0.0164	0.0153	0.042
Echinococcus multilocularis	serine protein kinase ATM	0.0711	0.0823	0.0823
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0852	0.0996	0.2894
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0164	0.0153	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0153	0.1537
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0423	0.0471	0.4725
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0153	0.1537
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0164	0.0153	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0164	0.0153	0.5
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0852	0.0996	0.0996
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0153	0.1537
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0164	0.0153	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0164	0.0153	0.1537
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0164	0.0153	0.0153
Loa Loa (eye worm)	phosphatidylinositol 3	0.0852	0.0996	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0852	0.0996	0.2894
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0153	0.1537
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0852	0.0996	0.2894
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0852	0.0996	1
Echinococcus granulosus	serine protein kinase ATM	0.0711	0.0823	0.0823
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.034	0.3415
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0033	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0153	0.1537
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0423	0.0471	0.4725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0536	0.0608	0.6106
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0153	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0372	0.0407	0.409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0153	0.1537
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0153	0.1537
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	0.1537
Echinococcus multilocularis		0.0164	0.0153	0.0153
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0164	0.0153	0.0445
Brugia malayi	FAT domain containing protein	0.0372	0.0407	0.409
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0164	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0547	0.0622	0.6248
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0711	0.0823	0.8264
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0852	0.0996	0.2734
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0852	0.0996	0.2734
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0018	0.0184
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0481	0.0541	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0481	0.0541	0.1571
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0153	0.1537
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0033	0.1274
Plasmodium vivax	hypothetical protein	0.0164	0.0153	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0852	0.0996	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0164	0.0153	0.1537
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0033	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Mycobacterium leprae	conserved hypothetical protein	0.0164	0.0153	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0852	0.0996	0.0996
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0481	0.0541	0.5431
Schistosoma mansoni	hypothetical protein	0.0372	0.0407	0.409
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0852	0.0996	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0164	0.0153	0.0153
Entamoeba histolytica	protein kinase rad3, putative	0.0481	0.0541	0.4601
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0372	0.0407	0.0407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0153	0.0153
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0153	0.0153
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0164	0.0153	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0317	0.034	0.3415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0153	0.0445
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0481	0.0541	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0852	0.0996	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0033	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0394	0.0435	0.1195
Onchocerca volvulus		0.0164	0.0153	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0153	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0018	0.0184
Plasmodium vivax	hypothetical protein, conserved	0.0164	0.0153	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0164	0.0153	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0153	0.1537
Echinococcus multilocularis	neuropeptide receptor A26	0.05	0.0565	0.0565
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0852	0.0996	0.0996
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0153	0.1537
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0033	0.009
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0852	0.0996	0.2894
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0852	0.0996	0.0996
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0711	0.0823	0.8264
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0033	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.8202	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0164	0.0153	0.0153
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0018	0.0184
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0164	0.0153	0.1537
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	0.1537
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0481	0.0541	0.5431
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0852	0.0996	0.2734
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	0.0445
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0164	0.0153	0.0153
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0164	0.0153	0.1537
Trypanosoma cruzi	target of rapamycin kinase 3	0.0852	0.0996	0.2894
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.0481	0.0541	0.5431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Toxoplasma gondii	FATC domain-containing protein	0.0711	0.0823	0.8264
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0164	0.0153	0.0445
Loa Loa (eye worm)	phosphatidylinositol 3	0.0852	0.0996	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0536	0.0608	0.6106
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0033	0.0329
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0852	0.0996	0.2734
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0153	0.1537
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Leishmania major	phosphatidylinositol kinase, putative	0.0164	0.0153	0.042
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0033	0.0033
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0852	0.0996	0.2734
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0394	0.0435	0.1264
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0711	0.0823	0.8264
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0423	0.0471	0.0471
Entamoeba histolytica	hypothetical protein	0.0711	0.0823	0.7949
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0852	0.0996	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0164	0.0153	0.1537
Trypanosoma cruzi	hypothetical protein, conserved	0.285	0.3443	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0153	0.1537
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0852	0.0996	1
Trichomonas vaginalis	conserved hypothetical protein	0.0536	0.0608	0.6106
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0249	0.0257	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0153	0.042
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0153	0.1537
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0852	0.0996	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0153	0.1537
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0153	0.0445
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0153	0.1537
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0852	0.0996	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0153	0.0153
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0852	0.0996	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0164	0.0153	0.0153
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0481	0.0541	0.5431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0033	0.0329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Echinococcus granulosus	neuropeptide receptor A26	0.05	0.0565	0.0565
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0164	0.0153	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0423	0.0471	0.4725
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0852	0.0996	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0164	0.0153	0.1537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0852	0.0996	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0164	0.0153	0.1537
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0153	0.1537
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0164	0.0153	0.0445
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0164	0.0153	0.0445
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0536	0.0608	0.6106
Loa Loa (eye worm)	hypothetical protein	0.0536	0.0608	0.6106

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.055 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360
Ki (binding)	= 0.055 uM	Inhibition of human recombinant PTP1B	ChEMBL.	17705360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 17759046

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 433792