Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AStacin protease | 0.0629 | 0.5566 | 0.5566 |
Loa Loa (eye worm) | matrixin family protein | 0.021 | 0.0643 | 0.0643 |
Echinococcus multilocularis | laminin | 0.0324 | 0.1984 | 0.1984 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.2471 | 0.2471 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0324 | 0.1984 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0166 | 0.0122 | 0.0122 |
Echinococcus multilocularis | Tolloid protein 1 | 0.1006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.16 | 0.16 |
Onchocerca volvulus | Matrilysin homolog | 0.0282 | 0.1481 | 0.8757 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0321 | 0.1947 | 0.1947 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1006 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0324 | 0.1984 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0321 | 0.1947 | 0.1947 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0324 | 0.1984 | 0.1984 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 0.2987 | 0.2987 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0416 | 0.3063 | 0.3063 |
Loa Loa (eye worm) | hypothetical protein | 0.0965 | 0.9519 | 0.9519 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0366 | 0.2471 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0366 | 0.2471 | 0.2471 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0366 | 0.2471 | 0.5 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0366 | 0.2471 | 0.2471 |
Loa Loa (eye worm) | matrixin family protein | 0.0301 | 0.1704 | 0.1704 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0292 | 0.16 | 0.16 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1984 | 0.1984 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0416 | 0.3063 | 0.3063 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0321 | 0.1947 | 0.1947 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0321 | 0.1947 | 0.9031 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0366 | 0.2471 | 0.2471 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.16 | 0.16 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0366 | 0.2471 | 0.2471 |
Onchocerca volvulus | Arrow homolog | 0.0292 | 0.16 | 1 |
Echinococcus granulosus | laminin | 0.0324 | 0.1984 | 0.1984 |
Schistosoma mansoni | egf-like domain protein | 0.0292 | 0.16 | 0.16 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0366 | 0.2471 | 0.2471 |
Brugia malayi | Matrixin family protein | 0.0301 | 0.1704 | 0.2709 |
Echinococcus multilocularis | fibrillin 1 | 0.0324 | 0.1984 | 0.1984 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at 5-HT1A receptor in Swiss Albino mouse assessed as decrease in 8-OH-DPAT induced body temperature | ChEMBL. | 17321139 | |
Activity (functional) | = 4.6 | Anxiolytic-like activity in Swiss Albino mouse at 5 mg/kg by four plate test | ChEMBL. | 17321139 |
Activity (functional) | = 5.1 | Anxiolytic-like activity in Swiss Albino mouse at 10 mg/kg by four plate test | ChEMBL. | 17321139 |
Activity (functional) | = 5.6 | Anxiolytic-like activity in Swiss Albino mouse at 20 mg/kg by four plate test | ChEMBL. | 17321139 |
Activity (functional) | 0 | Antagonist activity at 5-HT1A receptor in Swiss Albino mouse assessed as decrease in 8-OH-DPAT induced body temperature | ChEMBL. | 17321139 |
Activity (functional) | = 4.6 | Anxiolytic-like activity in Swiss Albino mouse at 5 mg/kg by four plate test | ChEMBL. | 17321139 |
Activity (functional) | = 5.1 | Anxiolytic-like activity in Swiss Albino mouse at 10 mg/kg by four plate test | ChEMBL. | 17321139 |
Activity (functional) | = 5.6 | Anxiolytic-like activity in Swiss Albino mouse at 20 mg/kg by four plate test | ChEMBL. | 17321139 |
Ki (binding) | = 25 nM | Displacement of [3H]ketanserin from serotonin 5HT2A receptor in rat brain cortex | ChEMBL. | 17321139 |
Ki (binding) | = 25 nM | Displacement of [3H]ketanserin from serotonin 5HT2A receptor in rat brain cortex | ChEMBL. | 17321139 |
Ki (binding) | = 47 nM | Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus | ChEMBL. | 17321139 |
Ki (binding) | = 47 nM | Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus | ChEMBL. | 17321139 |
Ki (binding) | = 21190 nM | Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatal membrane | ChEMBL. | 17321139 |
Ki (binding) | = 21190 nM | Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatal membrane | ChEMBL. | 17321139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.