TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 549.103 | Formula: C31H37ClN4O3
H donors: 2 H acceptors: 3 LogP: 7.07 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(nc1)NC(=O)c1ccccc1NC(=O)c1ccc(cc1OC1CCN(CC1)C(C)C)C(C)(C)C
InChi: 1S/C31H37ClN4O3/c1-20(2)36-16-14-23(15-17-36)39-27-18-21(31(3,4)5)10-12-25(27)30(38)34-26-9-7-6-8-24(26)29(37)35-28-13-11-22(32)19-33-28/h6-13,18-20,23H,14-17H2,1-5H3,(H,34,38)(H,33,35,37)
InChiKey: GFCCHQMIWNOCGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	penicillin-binding protein, putative	0.0025	0.0463	0.8082
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.009	0.009
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0025	0.0481	0.0564
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0031	0.0638	0.1525
Echinococcus multilocularis	survival motor neuron protein 1	0.0161	0.4182	0.4182
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0025	0.0481	0.0092
Trichomonas vaginalis	ran, putative	0.0026	0.0499	0.872
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0499	0.0585
Toxoplasma gondii	hypothetical protein	0.0052	0.1204	0.1431
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0321	0.8529	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0037	0.0037
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0751	0.0751
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0463	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0028	0.0028
Toxoplasma gondii	hypothetical protein	0.002	0.035	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Echinococcus granulosus	inositol monophosphatase 1	0.0025	0.048	0.048
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0025	0.0463	0.1054
Echinococcus granulosus	transmembrane protease serine 3	0.0031	0.0638	0.0638
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.057	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0032	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0463	0.1054
Schistosoma mansoni	lamin	0.0018	0.0296	0.0296
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1599	0.19
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0499	0.0593
Entamoeba histolytica	Ran family GTPase	0.0026	0.0499	0.2045
Loa Loa (eye worm)	PAN domain-containing protein	0.002	0.035	0.035
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.057	0.0669
Echinococcus granulosus	lamin	0.0018	0.0296	0.0296
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0499	0.1193
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0039	0.0859	0.0859
Brugia malayi	hypothetical protein	0.0031	0.0638	0.1525
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0922	0.2097
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0751	0.0881
Schistosoma mansoni	hypothetical protein	0.005	0.1168	0.1168
Onchocerca volvulus		0.0035	0.0747	0.5179
Loa Loa (eye worm)	PAN domain-containing protein	0.002	0.035	0.035
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.0481	0.8406
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Echinococcus granulosus	glycoprotein Antigen 5	0.0031	0.0638	0.0638
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0025	0.0481	0.0481
Echinococcus multilocularis	musashi	0.0018	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Schistosoma mansoni	aldehyde dehydrogenase	0.0041	0.0922	0.0922
Loa Loa (eye worm)	PAN domain-containing protein	0.002	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0751	0.0751
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0025	0.0463	0.0463
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0499	0.0585
Onchocerca volvulus		0.002	0.035	0.0625
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0644	0.0644
Onchocerca volvulus		0.002	0.035	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0161	0.4182	0.4182
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0041	0.0922	0.2097
Echinococcus granulosus	tissue type plasminogen activator	0.005	0.1168	0.1168
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0751	0.0881
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0751	0.0893
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0751	0.0751
Onchocerca volvulus		0.0031	0.0638	0.3924
Brugia malayi	Protein kinase domain containing protein	0.005	0.1168	0.2793
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Echinococcus granulosus	geminin	0.0115	0.2938	0.2938
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0031	0.0638	0.0638
Plasmodium falciparum	importin beta, putative	0.0035	0.0751	0.3771
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0023	0.0409	0.8823
Echinococcus granulosus	enteropeptidase	0.0031	0.0638	0.0638
Schistosoma mansoni	intermediate filament proteins	0.0018	0.0296	0.0296
Brugia malayi	intermediate filament protein	0.0018	0.0296	0.0707
Echinococcus granulosus	Mastin	0.0031	0.0638	0.0638
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0499	0.0499
Brugia malayi	Importin beta-1 subunit	0.0035	0.0751	0.1797
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0463	1
Leishmania major	importin beta-1 subunit, putative	0.0028	0.057	0.0669
Echinococcus granulosus	beta LACTamase domain containing family member	0.0025	0.0463	0.0463
Toxoplasma gondii	PAN domain-containing protein	0.002	0.035	0.0416
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.009	0.009
Mycobacterium ulcerans	lipase LipD	0.0025	0.0463	0.1054
Onchocerca volvulus		0.0031	0.0638	0.3924
Onchocerca volvulus		0.0025	0.0463	0.1921
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.057	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0025	0.0463	0.1054
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0025	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Loa Loa (eye worm)	PAN domain-containing protein	0.002	0.035	0.035
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0481	0.8406
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0025	0.0481	0.0481
Loa Loa (eye worm)	MH2 domain-containing protein	0.0081	0.201	0.201
Onchocerca volvulus		0.002	0.035	0.0625
Toxoplasma gondii	1,3(4)-beta-glucanase	0.002	0.035	0.0416
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0036	0.0788	0.0788
Loa Loa (eye worm)	transcription factor SMAD2	0.0081	0.201	0.201
Onchocerca volvulus		0.002	0.035	0.0625
Brugia malayi	beta-lactamase family protein	0.0025	0.0463	0.1108
Brugia malayi	Trypsin family protein	0.0031	0.0638	0.1525
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0644	0.0644
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0039	0.0859	0.1955
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0747	0.0747
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0157	0.4062	0.9241
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.057	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0025	0.0481	0.0564
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0025	0.0481	0.0481
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0025	0.048	0.0563
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0009	0.0037	0.0037
Echinococcus granulosus	cpg binding protein	0.0037	0.0802	0.0802
Mycobacterium ulcerans	beta-lactamase	0.0025	0.0463	0.1054
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0025	0.0463	0.1054
Toxoplasma gondii	PAN domain-containing protein	0.002	0.035	0.0416
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0552	0.1319
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0025	0.048	0.0563
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Onchocerca volvulus		0.0033	0.069	0.4521
Toxoplasma gondii	aldehyde dehydrogenase	0.0041	0.0922	0.1095
Toxoplasma gondii	PAN domain-containing protein	0.002	0.035	0.0416
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0041	0.0922	0.1081
Mycobacterium leprae	Probable lipase LipE	0.0025	0.0463	1
Echinococcus multilocularis	lamin dm0	0.0018	0.0296	0.0296
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.1023	0.12
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0031	0.0644	0.154
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.1292	0.1515
Toxoplasma gondii	kringle domain-containing protein	0.005	0.1168	0.1388
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Onchocerca volvulus		0.002	0.035	0.0625
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0041	0.0922	0.0922
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Brugia malayi	cytoplasmic intermediate filament protein	0.001	0.0063	0.0151
Onchocerca volvulus		0.0031	0.0638	0.3924
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Brugia malayi	Trypsin-like protease protein 5	0.0031	0.0638	0.1525
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0169	0.4396	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0025	0.048	0.1093
Leishmania major	mitochondrial DNA polymerase beta	0.0321	0.8529	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0321	0.8529	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0025	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Echinococcus multilocularis	lamin	0.0018	0.0296	0.0296
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0025	0.0481	0.1151
Entamoeba histolytica	hypothetical protein	0.0028	0.057	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0025	0.0463	0.1108
Toxoplasma gondii	hypothetical protein	0.002	0.035	0.0416
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.1168	0.137
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.3929	0.4606
Onchocerca volvulus		0.0031	0.0638	0.3924
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0025	0.0463	0.0463
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0039	0.0859	0.1955
Leishmania major	hypothetical protein, conserved	0.0025	0.0463	0.0543
Brugia malayi	MH2 domain containing protein	0.0081	0.201	0.4806
Brugia malayi	Trypsin family protein	0.0031	0.0638	0.1525
Leishmania major	GTP-binding protein, putative	0.0026	0.0499	0.0585
Schistosoma mansoni	cpg binding protein	0.0037	0.0802	0.0802
Onchocerca volvulus		0.0025	0.0463	0.1921
Echinococcus multilocularis	Mastin	0.0031	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Schistosoma mansoni	hypothetical protein	0.0115	0.2938	0.2938
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0031	0.0638	0.0638
Toxoplasma gondii	microneme protein MIC17C	0.002	0.035	0.0416
Brugia malayi	Kringle domain containing protein	0.005	0.1168	0.2793
Onchocerca volvulus		0.002	0.035	0.0625
Schistosoma mansoni	aldehyde dehydrogenase	0.0041	0.0922	0.0922
Trichomonas vaginalis	inositol monophosphatase, putative	0.0025	0.048	0.8391
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Onchocerca volvulus		0.002	0.035	0.0625
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0375	1	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0025	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.005	0.1168	0.1168
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0032	0.0032
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0039	0.0859	0.1955
Toxoplasma gondii	microneme protein MIC17A	0.002	0.035	0.0416
Onchocerca volvulus		0.002	0.035	0.0625
Echinococcus multilocularis	enteropeptidase	0.0031	0.0638	0.0638
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0025	0.048	0.0563
Schistosoma mansoni	lamin	0.0018	0.0296	0.0296
Echinococcus multilocularis	ubiquitin specific protease 41	0.0025	0.0481	0.0481
Mycobacterium tuberculosis	Probable lipase LipD	0.0025	0.0463	0.1054
Toxoplasma gondii	microneme protein MIC4	0.002	0.035	0.0416
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0025	0.0481	0.0564
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0039	0.0859	0.0859
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0033	0.069	0.165
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Schistosoma mansoni	hypothetical protein	0.0031	0.0638	0.0638
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0031	0.0644	0.0644
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0039	0.0859	0.1008
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0463	0.1054
Mycobacterium ulcerans	hypothetical protein	0.0169	0.4396	1
Plasmodium falciparum	cysteine repeat modular protein 1	0.005	0.1168	1
Echinococcus multilocularis	tissue type plasminogen activator	0.005	0.1168	0.1168
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.001	0.0063	0.0063
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.009	0.009
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0321	0.8529	1
Echinococcus granulosus	intermediate filament protein	0.0018	0.0296	0.0296
Trichomonas vaginalis	esterase, putative	0.0025	0.0463	0.8082
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Brugia malayi	beta-lactamase family protein	0.0025	0.0463	0.1108
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0463	0.1054
Onchocerca volvulus		0.002	0.035	0.0625
Schistosoma mansoni	ran	0.0026	0.0499	0.0499
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0025	0.048	0.0571
Brugia malayi	hypothetical protein	0.0161	0.4182	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Toxoplasma gondii	PAN domain-containing protein	0.002	0.035	0.0416
Schistosoma mansoni	cpg binding protein	0.0037	0.0802	0.0802
Schistosoma mansoni	importin beta-1	0.0035	0.0751	0.0751
Loa Loa (eye worm)	inositol-1	0.0025	0.048	0.048
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0025	0.0481	0.0564
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0041	0.0922	0.0922
Echinococcus multilocularis	snurportin 1	0.0375	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0031	0.0644	0.0644
Onchocerca volvulus		0.0031	0.0638	0.3924
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Echinococcus granulosus	lamin dm0	0.0018	0.0296	0.0296
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0499	0.0585
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0039	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.3929	0.4606
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0031	0.0638	0.0638
Toxoplasma gondii	PAN/Apple domain-containing protein	0.002	0.035	0.0416
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0922	0.2097
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0922	0.2097
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0463	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0296	0.0296
Echinococcus granulosus	survival motor neuron protein 1	0.0161	0.4182	0.4182
Brugia malayi	Trypsin family protein	0.0031	0.0638	0.1525
Schistosoma mansoni	inositol monophosphatase	0.0025	0.048	0.048
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.1023	0.12
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Schistosoma mansoni	cpg binding protein	0.0035	0.0747	0.0747
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0025	0.048	0.8391
Echinococcus multilocularis	cpg binding protein	0.0037	0.0802	0.0802
Brugia malayi	Trypsin family protein	0.0031	0.0638	0.1525
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.005	0.1168	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0499	0.0499
Echinococcus multilocularis	geminin	0.0115	0.2938	0.2938
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0039	0.0859	0.2055
Echinococcus granulosus	ubiquitin specific protease 41	0.0025	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0481	0.0481
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0025	0.0463	0.0463
Schistosoma mansoni	inositol monophosphatase	0.0025	0.048	0.048
Toxoplasma gondii	ABC1 family protein	0.0025	0.0463	0.055
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0009	0.0037	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0644	0.0644
Echinococcus multilocularis	glycoprotein Antigen 5	0.0031	0.0638	0.0638
Brugia malayi	PAN domain containing protein	0.002	0.035	0.0837
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0499	0.0506
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0499	0.0499
Trichomonas vaginalis	D-aminoacylase, putative	0.0025	0.0463	0.8082
Trichomonas vaginalis	D-aminoacylase, putative	0.0025	0.0463	0.8082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0031	0.0644	0.0644
Onchocerca volvulus		0.0025	0.0463	0.1921
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0025	0.048	0.8391
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0025	0.048	0.5
Onchocerca volvulus		0.005	0.1168	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0086	0.0206
Loa Loa (eye worm)	PAN domain-containing protein	0.002	0.035	0.035
Mycobacterium tuberculosis	Probable lipase LipE	0.0025	0.0463	0.1054
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0638	0.1451
Brugia malayi	beta-lactamase	0.0025	0.0463	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0028	0.0028
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.1168	0.1168
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0031	0.0638	0.0638
Schistosoma mansoni	hypothetical protein	0.0115	0.2938	0.2938
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Schistosoma mansoni	survival motor neuron protein	0.0033	0.069	0.069
Toxoplasma gondii	PAN domain-containing protein	0.0317	0.8415	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0152	0.3929	0.4606
Onchocerca volvulus		0.0031	0.0638	0.3924
Schistosoma mansoni	ran	0.0026	0.0499	0.0499
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0025	0.0463	0.1054
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0499	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0747	0.1787
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Brugia malayi	RNA, U transporter 1	0.01	0.2514	0.6011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0638	0.0638
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0023	0.0409	0.093
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0025	0.0481	0.0481
Loa Loa (eye worm)	trypsin family protein	0.0031	0.0638	0.0638
Onchocerca volvulus		0.002	0.035	0.0625
Brugia malayi	Intermediate filament tail domain containing protein	0.0018	0.0296	0.0707
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0463	0.0543
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Trichomonas vaginalis	penicillin-binding protein, putative	0.0025	0.0463	0.8082
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.0481	0.8406
Loa Loa (eye worm)	beta-lactamase	0.0025	0.0463	0.0463
Schistosoma mansoni	cercarial elastase (S01 family)	0.0031	0.0638	0.0638
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0751	0.4086
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0031	0.0644	0.0644
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0025	0.048	0.0563
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0031	0.0644	0.0644
Mycobacterium ulcerans	esterase/lipase LipP	0.0025	0.0463	0.1054
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.1023	0.12
Schistosoma mansoni	hypothetical protein	0.0375	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0552	0.0552
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0463	0.0543
Echinococcus multilocularis	inositol monophosphatase 1	0.0025	0.048	0.048
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.1023	0.12
Toxoplasma gondii	subtilisin SUB12	0.002	0.035	0.0416
Toxoplasma gondii	microneme protein, putative	0.002	0.035	0.0416
Leishmania major	hypothetical protein, conserved	0.005	0.1168	0.137
Toxoplasma gondii	PAN domain-containing protein	0.0317	0.8415	1
Schistosoma mansoni	hypothetical protein	0.0033	0.069	0.069
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0032	0.0032
Mycobacterium tuberculosis	Probable hydrolase	0.0025	0.0463	0.1054
Loa Loa (eye worm)	hypothetical protein	0.002	0.035	0.035
Schistosoma mansoni	hypothetical protein	0.0031	0.0638	0.0638
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1815	0.1815
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.0296	0.0296
Mycobacterium tuberculosis	Probable esterase LipL	0.0025	0.0463	0.1054
Echinococcus multilocularis	transmembrane protease serine 3	0.0031	0.0638	0.0638
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0031	0.0638	0.0638
Toxoplasma gondii	microneme protein MIC17B	0.002	0.035	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0463	0.0463
Onchocerca volvulus		0.002	0.035	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0286	0.0286
Brugia malayi	Inositol-1	0.0025	0.048	0.1149
Trichomonas vaginalis	D-aminoacylase, putative	0.0025	0.0463	0.8082

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 1.2 uM	Anticoagulant potency in human citrated plasma assessed as concentration required to double activated partial thromboplastin time	ChEMBL.	17624775
Activity (functional)	= 1.8 uM	Anticoagulant potency in human citrated plasma assessed as concentration required to double prothrombin time	ChEMBL.	17624775
Kapp (binding)	= 25 10^6L/mol	Inhibition of human factor 2a	ChEMBL.	17624775
Kapp (binding)	= 25 10^6L/mol	Inhibition of human factor 2a	ChEMBL.	17624775
Kapp (binding)	= 3440 10^6L/mol	Inhibition of human factor 10a	ChEMBL.	17624775
Kapp (binding)	= 3440 10^6L/mol	Inhibition of human factor 10a	ChEMBL.	17624775

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL236032

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 445147