Detailed information for compound 450822

Basic information

Technical information
  • TDR Targets ID: 450822
  • Name: N-(4-fluorophenyl)-7-methyl-2-pyridin-2-ylimi dazo[1,2-a]pyridin-3-amine
  • MW: 318.348 | Formula: C19H15FN4
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Nc1c(nc2n1ccc(c2)C)c1ccccn1
  • InChi: 1S/C19H15FN4/c1-13-9-11-24-17(12-13)23-18(16-4-2-3-10-21-16)19(24)22-15-7-5-14(20)6-8-15/h2-12,22H,1H3
  • InChiKey: LVQKVQKIAUNNEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-7-methyl-2-(2-pyridyl)imidazo[1,2-a]pyridin-3-amine
  • N-(4-fluorophenyl)-7-methyl-2-(2-pyridyl)-3-imidazo[1,2-a]pyridinamine
  • N-(4-fluorophenyl)-7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-amine
  • (4-fluorophenyl)-[7-methyl-2-(2-pyridyl)imidazo[1,2-a]pyridin-3-yl]amine
  • N-(4-fluorophenyl)-7-methyl-2-pyridin-2-ylimidazo[3,2-a]pyridin-3-amine
  • N-(4-fluorophenyl)-7-methyl-2-(2-pyridyl)imidazo[3,2-a]pyridin-3-amine
  • N-(4-fluorophenyl)-7-methyl-2-(2-pyridyl)-3-imidazo[3,2-a]pyridinamine
  • (4-fluorophenyl)-[7-methyl-2-(2-pyridyl)imidazo[3,2-a]pyridin-3-yl]amine
  • N-(4-fluorophenyl)-7-methyl-2-pyridin-2-yl-imidazo[3,2-a]pyridin-3-amine
  • C273-0218
  • NCGC00106780-01
  • STK228354

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neurogenic locus notch protein 0.0058 0.018 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0624
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.056
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0003 0.5
Brugia malayi Trypsin family protein 0.0331 0.3638 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.1594 0.1594
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0062 0.023 0.023
Echinococcus granulosus protein jagged 1 0.0058 0.018 0.018
Echinococcus multilocularis laminin 0.012 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.012 0.0975 0.2676
Loa Loa (eye worm) hypothetical protein 0.0046 0.0037 0.0093
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0363 0.0363
Echinococcus granulosus slit 2 protein 0.0058 0.018 0.018
Echinococcus multilocularis fibrillin 1 0.012 0.0975 0.0975
Echinococcus multilocularis neural cadherin 0.0058 0.018 0.018
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.018 0.0494
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni cell polarity protein 0.0058 0.018 0.018
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1941 0.1941
Brugia malayi Calcium binding EGF domain containing protein 0.012 0.0975 0.2681
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Echinococcus multilocularis neurogenic locus notch protein 4 0.0058 0.018 0.018
Onchocerca volvulus 0.0066 0.0283 0.0299
Loa Loa (eye worm) hypothetical protein 0.012 0.0975 0.2676
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1941 0.5332
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.012 0.0975 0.2676
Brugia malayi Bromodomain containing protein 0.0046 0.0035 0.0098
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.012 0.0975 0.0975
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0003 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0062 0.023 0.023
Echinococcus granulosus transmembrane protease serine 3 0.0062 0.023 0.023
Schistosoma mansoni alpha glucosidase 0.0044 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0331 0.3638 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Echinococcus granulosus neurogenic locus notch protein 4 0.0058 0.018 0.018
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0062 0.023 0.0631
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Echinococcus granulosus glycoprotein Antigen 5 0.0062 0.023 0.023
Echinococcus granulosus delta-like protein 1 0.0058 0.018 0.018
Brugia malayi Muscle positioning protein 4 0.0058 0.018 0.0494
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0331 0.3638 0.3638
Onchocerca volvulus 0.0269 0.2858 0.7745
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) trypsin family protein 0.0062 0.023 0.0624
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0058 0.018 0.018
Onchocerca volvulus 0.0062 0.023 0.0144
Schistosoma mansoni notch 0.0058 0.018 0.018
Echinococcus multilocularis transmembrane protease serine 3 0.0062 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0066 0.0283 0.0283
Onchocerca volvulus 0.0331 0.3638 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Brugia malayi Trypsin family protein 0.0062 0.023 0.0631
Loa Loa (eye worm) Notch2 0.0058 0.018 0.0487
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0003 1
Brugia malayi Bromodomain containing protein 0.0091 0.0597 0.164
Loa Loa (eye worm) bone morphogenetic protein 1b 0.012 0.0975 0.2676
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Onchocerca volvulus 0.0062 0.023 0.0144
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni septate junction protein 0.0058 0.018 0.018
Schistosoma mansoni notch 0.0058 0.018 0.018
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0062 0.023 0.023
Brugia malayi Cadherin domain containing protein 0.0058 0.018 0.0494
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0003 0.0003
Schistosoma mansoni egf-like domain protein 0.012 0.0975 0.0975
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Brugia malayi Trypsin family protein 0.0062 0.023 0.0631
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.018 0.0494
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0331 0.3638 0.3638
Echinococcus granulosus protein jagged 2 0.0058 0.018 0.018
Brugia malayi notch-like transmembrane receptor 0.0058 0.018 0.0494
Schistosoma mansoni laminin gamma-3 chain 0.0058 0.018 0.018
Leishmania major hypothetical protein, conserved 0.0066 0.0283 1
Echinococcus granulosus fibropellin Ia 0.0058 0.018 0.018
Toxoplasma gondii EGF family domain-containing protein 0.0058 0.018 0.0251
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0624
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0062 0.023 0.023
Echinococcus multilocularis protein jagged 2 0.0058 0.018 0.018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Brugia malayi Cadherin domain containing protein 0.0058 0.018 0.0494
Schistosoma mansoni slit 0.0058 0.018 0.018
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus multilocularis protein jagged 1 0.0058 0.018 0.018
Loa Loa (eye worm) notch protein 0.0058 0.018 0.0487
Loa Loa (eye worm) TK/ROR protein kinase 0.0066 0.0283 0.0771
Loa Loa (eye worm) hypothetical protein 0.0331 0.3638 1
Onchocerca volvulus 0.0062 0.023 0.0144
Toxoplasma gondii PAN domain-containing protein 0.0601 0.7059 1
Echinococcus multilocularis neurogenic locus protein delta 0.0058 0.018 0.018
Echinococcus granulosus Mastin 0.0062 0.023 0.023
Echinococcus multilocularis neurogenic locus protein delta 0.0058 0.018 0.018
Brugia malayi Fibulin-1 precursor 0.012 0.0975 0.2681
Loa Loa (eye worm) hypothetical protein 0.0052 0.0102 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0003 0.5
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Echinococcus granulosus notch 0.0058 0.018 0.018
Echinococcus multilocularis enteropeptidase 0.0062 0.023 0.023
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.012 0.0975 0.2676
Brugia malayi Trypsin family protein 0.0062 0.023 0.0631
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0003 0.5
Toxoplasma gondii kringle domain-containing protein 0.0066 0.0283 0.0397
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Echinococcus granulosus neurogenic locus protein delta 0.0058 0.018 0.018
Brugia malayi hypothetical protein 0.0062 0.023 0.0631
Echinococcus multilocularis neurogenic locus notch protein 0.0058 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0624
Echinococcus granulosus Tolloid protein 1 0.012 0.0975 0.0975
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.012 0.0975 0.2676
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Brugia malayi GCC2 and GCC3 family protein 0.0058 0.018 0.0494
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.018 0.0494
Echinococcus multilocularis tumor protein p63 0.0408 0.4616 0.4616
Echinococcus granulosus protein jagged 2 0.0058 0.018 0.018
Brugia malayi Kringle domain containing protein 0.0066 0.0283 0.0778
Mycobacterium ulcerans hypothetical protein 0.0062 0.023 0.5
Echinococcus granulosus protein jagged 1 0.0058 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0085 0.0531 0.1454
Toxoplasma gondii calcium binding egf domain-containing protein 0.012 0.0975 0.1379
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Echinococcus multilocularis notch 0.0058 0.018 0.018
Brugia malayi Trypsin-like protease protein 5 0.0062 0.023 0.0631
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Echinococcus granulosus tumor protein p63 0.0408 0.4616 0.4616
Echinococcus multilocularis tissue type plasminogen activator 0.0066 0.0283 0.0283
Brugia malayi Delta serrate ligand family protein 0.0058 0.018 0.0494
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1941 0.5335
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Echinococcus multilocularis protein jagged 1 0.0058 0.018 0.018
Echinococcus multilocularis fibropellin Ia 0.0058 0.018 0.018
Echinococcus multilocularis neurogenic locus notch protein 0.0058 0.018 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0975 0.2676
Schistosoma mansoni notch 0.0058 0.018 0.018
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0058 0.018 0.0494
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0003 0.0003
Echinococcus granulosus laminin 0.012 0.0975 0.0975
Echinococcus granulosus neural cadherin 0.0058 0.018 0.018
Schistosoma mansoni notch 0.0058 0.018 0.018
Schistosoma mansoni bromodomain containing protein 0.0076 0.0417 0.0417
Trypanosoma brucei glucosidase, putative 0.0044 0.0003 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.012 0.0975 0.2676
Schistosoma mansoni hypothetical protein 0.0062 0.023 0.023
Echinococcus multilocularis fat cadherin tumor suppressor 0.0058 0.018 0.018
Onchocerca volvulus 0.006 0.0206 0.0076
Schistosoma mansoni alpha-glucosidase 0.0169 0.1594 0.1594
Echinococcus multilocularis glycoprotein Antigen 5 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.023 0.023
Onchocerca volvulus Arrow homolog 0.012 0.0975 0.2301
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0073 0.0193
Echinococcus granulosus enteropeptidase 0.0062 0.023 0.023
Schistosoma mansoni notch 0.0058 0.018 0.018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Onchocerca volvulus 0.0114 0.0891 0.2055
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.012 0.0975 0.2681
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0003 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.018 0.018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1941 0.1941
Toxoplasma gondii PAN domain-containing protein 0.0601 0.7059 1
Onchocerca volvulus 0.0062 0.023 0.0144
Echinococcus granulosus neurogenic locus notch protein 0.0058 0.018 0.018
Toxoplasma gondii calcium binding egf domain-containing protein 0.012 0.0975 0.1379
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0624
Brugia malayi Protein kinase domain containing protein 0.0066 0.0283 0.0778
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Onchocerca volvulus 0.0062 0.023 0.0144
Brugia malayi EGF-like domain containing protein 0.0058 0.018 0.0494
Echinococcus granulosus tissue type plasminogen activator 0.0066 0.0283 0.0283
Giardia lamblia High cysteine protein 0.0058 0.018 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0283 0.0771
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0003 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Schistosoma mansoni notch 0.0058 0.018 0.018
Echinococcus multilocularis Mastin 0.0062 0.023 0.023
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0003 0.0007
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0003 0.5
Plasmodium falciparum cysteine repeat modular protein 1 0.0066 0.0283 0.5
Echinococcus multilocularis Tolloid protein 1 0.012 0.0975 0.0975
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0062 0.023 0.023
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0066 0.0283 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0487
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0624
Echinococcus multilocularis slit 2 protein 0.0058 0.018 0.018
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1941 0.1941

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 162.24 % Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM ChEMBL. 17948976
Activity (functional) = 162.24 % Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM ChEMBL. 17948976
Inhibition (functional) = 0 % Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM ChEMBL. 17948976
Inhibition (functional) = 0 % Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM ChEMBL. 17948976
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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