TDR Targets

Basic information

Technical information

TDR Targets ID: 454678
Name: 2-[(E)-2-(2-fluorophenyl)ethenyl]-5-(2-fluoro phenyl)sulfonylpyridine
MW: 357.374 | Formula: C19H13F2NO2S
H donors: 0 H acceptors: 3 LogP: 4.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccccc1/C=C/c1ccc(cn1)S(=O)(=O)c1ccccc1F
InChi: 1S/C19H13F2NO2S/c20-17-6-2-1-5-14(17)9-10-15-11-12-16(13-22-15)25(23,24)19-8-4-3-7-18(19)21/h1-13H/b10-9+
InChiKey: AMJJFRAHQZYBJE-MDZDMXLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(2-fluorophenyl)sulfonyl-2-[(E)-2-(2-fluorophenyl)vinyl]pyridine
2-[(E)-2-(2-fluorophenyl)ethenyl]-5-(2-fluorophenyl)sulfonyl-pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0273	0.4105
Echinococcus multilocularis	geminin	0.0177	0.304	0.5541
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0142	0.2415	0.439
Onchocerca volvulus		0.001	0.0058	0.0043
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0547	0.1238
Trichomonas vaginalis	esterase, putative	0.0038	0.0547	0.8774
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0547	1
Echinococcus granulosus	g protein coupled receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Echinococcus granulosus	dro:myosuppressin receptor	0.001	0.0058	0.0048
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Onchocerca volvulus		0.0038	0.0547	0.0944
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.2226	0.4042
Trypanosoma cruzi	trypanothione reductase, putative	0.0023	0.0283	0.1913
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1108	1
Loa Loa (eye worm)	G-protein coupled receptor	0.001	0.0058	0.0045
Loa Loa (eye worm)	melatonin receptor type 1A	0.001	0.0058	0.0045
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0017	0.0174	0.0143
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0023	0.0283	0.0599
Echinococcus granulosus	neuropeptides capa receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Brugia malayi	hypothetical protein	0.0009	0.0035	0.0003
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0671	0.1108
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0063	0.0031
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0039	0.0071
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.001	0.0058	0.0048
Echinococcus granulosus	protein cereblon	0.0312	0.5461	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0023	0.0283	0.0251
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0023	0.0283	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Schistosoma mansoni	amine GPCR	0.001	0.0058	0.0106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.1108	0.1981
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0105	0.0135
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0588	0.1025
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	Dopamine receptor	0.001	0.0058	0.0026
Echinococcus multilocularis	g-protein coupled receptor	0.001	0.0058	0.0048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Schistosoma mansoni	opsin-like receptor	0.001	0.0058	0.0106
Schistosoma mansoni	amine GPCR	0.001	0.0058	0.0106
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0039	0.0012
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	Serotonin receptor	0.001	0.0058	0.0026
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0032	0.0059
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.001	0.0058	0.0106
Echinococcus granulosus	biogenic amine 5HT receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0619	1
Schistosoma mansoni	adenoreceptor	0.001	0.0058	0.0106
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0671	0.0641
Schistosoma mansoni	amine GPCR	0.001	0.0058	0.0106
Echinococcus multilocularis	neuropeptide receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0063	0.0031
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0063	0.0057
Brugia malayi	Animal haem peroxidase family protein	0.0242	0.4212	0.4193
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0063	0.0116
Brugia malayi	Peroxidasin	0.0242	0.4212	0.4193
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0063	0.0057
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.2226	0.4042
Brugia malayi	Animal haem peroxidase family protein	0.0242	0.4212	0.4193
Schistosoma mansoni	hypothetical protein	0.0312	0.5461	1
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0105	0.0135
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0063	0.0057
Echinococcus granulosus	neuropeptide receptor	0.001	0.0058	0.0048
Echinococcus granulosus	alpha 1A adrenergic receptor	0.001	0.0058	0.0048
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.001	0.0058	0.0043
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0273	0.0418
Echinococcus multilocularis	neuropeptides capa receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0547	0.8774
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Plasmodium vivax	thioredoxin reductase, putative	0.0066	0.1052	1
Loa Loa (eye worm)	animal heme peroxidase	0.0242	0.4212	0.7244
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0063	0.0057
Brugia malayi	ORL1-like opioid receptor	0.001	0.0058	0.0026
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0547	0.0893
Onchocerca volvulus		0.001	0.0058	0.0043
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0023	0.0283	0.4837
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Onchocerca volvulus	Chorion peroxidase homolog	0.0242	0.4212	0.7698
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Schistosoma mansoni	biogenic amine receptor	0.001	0.0058	0.0106
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0273	0.0242
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0547	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Schistosoma mansoni	biogenic amine receptor	0.001	0.0058	0.0106
Trichomonas vaginalis	mucin-desulfating sulfatase, putative	0.0009	0.0035	0.0045
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0063	0.0052
Echinococcus granulosus	neuropeptides capa receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0063	0.0057
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0547	0.8774
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Onchocerca volvulus		0.0038	0.0547	0.0944
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0063	0.0116
Brugia malayi	ecdysteroid receptor	0.0011	0.0063	0.0031
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0141	0.1005
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Brugia malayi	G-protein coupled receptor	0.001	0.0058	0.0026
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0017	0.0174	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0566	0.0926
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Schistosoma mansoni	neuropeptide receptor	0.001	0.0058	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0023	0.0283	0.0599
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0283	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0058	0.0048
Echinococcus multilocularis	allatostatin A receptor	0.001	0.0058	0.0048
Onchocerca volvulus		0.001	0.0058	0.0043
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.001	0.0058	0.0045
Loa Loa (eye worm)	animal heme peroxidase	0.0242	0.4212	0.7244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0058	0.0106
Echinococcus granulosus	allatostatin A receptor	0.001	0.0058	0.0048
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	neuropeptide s receptor	0.001	0.0058	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0063	0.0031
Echinococcus granulosus	neuropeptide Y receptor	0.001	0.0058	0.0048
Brugia malayi	GnHR receptor homolog	0.001	0.0058	0.0026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0547	0.0517
Brugia malayi	Dopamine receptor protein 1	0.001	0.0058	0.0026
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.1108	0.1079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0063	0.0054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0619	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0063	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0063	0.0054
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0063	0.0052
Echinococcus multilocularis	neuropeptides capa receptor	0.001	0.0058	0.0048
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.001	0.0058	0.0026
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0023	0.0283	0.1913
Brugia malayi	Melatonin receptor type 1A	0.001	0.0058	0.0026
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0058	0.0048
Onchocerca volvulus	Dual oxidase homolog	0.0242	0.4212	0.7698
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0023	0.0283	0.0599
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus multilocularis	serotonin receptor	0.001	0.0058	0.0048
Onchocerca volvulus	Neuropeptide F receptor homolog	0.001	0.0058	0.0043
Echinococcus granulosus	7tm_1 domain containing protein	0.001	0.0058	0.0048
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0063	0.0116
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.1913
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0058	0.0106
Toxoplasma gondii	NADPH-glutathione reductase	0.0023	0.0283	0.2404
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0189	0.0346
Echinococcus multilocularis	neuropeptide FF receptor 2	0.001	0.0058	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0063	0.0031
Echinococcus granulosus	g protein coupled receptor	0.001	0.0058	0.0048
Schistosoma mansoni	neuropeptide f receptor 76f	0.001	0.0058	0.0106
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0063	0.0057
Brugia malayi	neuropeptide F receptor	0.001	0.0058	0.0026
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.001	0.0058	0.0048
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.001	0.0058	0.0106
Plasmodium falciparum	thioredoxin reductase	0.0066	0.1052	1
Echinococcus granulosus	geminin	0.0177	0.304	0.5541
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Schistosoma mansoni	amine GPCR	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0063	0.0057
Brugia malayi	putative neuropeptide receptor NPR1	0.001	0.0058	0.0026
Brugia malayi	beta-lactamase family protein	0.0038	0.0547	0.0517
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0547	0.1238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0063	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0039	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0547	0.4438
Schistosoma mansoni	biogenic amine receptor	0.001	0.0058	0.0106
Schistosoma mansoni	myosin xvIII	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0063	0.0031
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Toxoplasma gondii	thioredoxin reductase	0.0066	0.1052	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Schistosoma mansoni	hypothetical protein	0.0177	0.304	0.5568
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0058	0.0106
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.001	0.0058	0.0048
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.001	0.0058	0.0106
Echinococcus multilocularis	neuropeptide receptor	0.001	0.0058	0.0048
Schistosoma mansoni	neuropeptide receptor	0.001	0.0058	0.0106
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0058	0.0106
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0547	0.1002
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0225	0.1832
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0588	0.1025
Echinococcus multilocularis	orexin receptor type 2	0.001	0.0058	0.0048
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0058	0.0106
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0547	1
Schistosoma mansoni	hypothetical protein	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.0461
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0039	0.0071
Brugia malayi	larval opioid receptor	0.001	0.0058	0.0026
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0023	0.0283	0.1526
Onchocerca volvulus	Peroxidase homolog	0.0242	0.4212	0.7698
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Schistosoma mansoni	opsin-like receptor	0.001	0.0058	0.0106
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0023	0.0283	0.2404
Brugia malayi	AKH receptor	0.001	0.0058	0.0026
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0273	0.4105
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0547	0.1002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0063	0.0116
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0058	0.0106
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0032	0.0059
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.1913
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Trichomonas vaginalis	Phosphoglycerol transferase I, putative	0.0009	0.0035	0.0045
Schistosoma mansoni	hypothetical protein	0.001	0.0058	0.0106
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0105	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0063	0.0031
Onchocerca volvulus		0.001	0.0058	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0063	0.0116
Schistosoma mansoni	peroxidasin	0.0242	0.4212	0.7713
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.0127
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Brugia malayi	beta-lactamase family protein	0.0038	0.0547	0.0517
Schistosoma mansoni	growth hormone secretagogue receptor	0.001	0.0058	0.0106
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0105	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Loa Loa (eye worm)	TYRA-2 protein	0.001	0.0058	0.0045
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.0517
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0058	0.0048
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.001	0.0058	0.0106
Echinococcus multilocularis	fmrfamide receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	peroxidasin	0.0242	0.4212	0.7699
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0032	0.0059
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0039	0.0007
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0058	0.0106
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.025	0.4356	0.7494
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Echinococcus multilocularis	serotonin receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Echinococcus multilocularis	neuropeptide s receptor	0.001	0.0058	0.0048
Onchocerca volvulus		0.001	0.0058	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0063	0.0031
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	peptide allatostatin:somatostatin	0.001	0.0058	0.0048
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.001	0.0058	0.0106
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0039	0.0013
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0063	0.0031
Plasmodium falciparum	thioredoxin reductase	0.0023	0.0283	0.2404
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0547	0.1238
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Echinococcus multilocularis	neuropeptide receptor A26	0.001	0.0058	0.0048
Onchocerca volvulus	Peroxidasin homolog	0.0242	0.4212	0.7698
Schistosoma mansoni	hypothetical protein	0.0177	0.304	0.5568
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0023	0.0283	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0063	0.0116
Schistosoma mansoni	hypothetical protein	0.001	0.0058	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0063	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0063	0.0031
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0069	0.1108	0.1899
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0063	0.0057
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.0461
Brugia malayi	putative neuropeptide receptor	0.001	0.0058	0.0026
Loa Loa (eye worm)	thioredoxin reductase	0.0066	0.1052	0.1768
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0063	0.0054
Trichomonas vaginalis	glutathione reductase, putative	0.0023	0.0283	0.4267
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0063	0.0057
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0063	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.001	0.0058	0.0026
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.1108	0.1981
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.001	0.0058	0.0026
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0032	0.0059
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0547	0.8774
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0063	0.0116
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0547	0.8774
Onchocerca volvulus		0.0242	0.4212	0.7698
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0063	0.0054
Loa Loa (eye worm)	blistered cuticle protein 3	0.0242	0.4212	0.7244
Brugia malayi	Blistered cuticle protein 3	0.0242	0.4212	0.4193
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.001	0.0058	0.0048
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Leishmania major	hypothetical protein, conserved	0.0038	0.0547	0.4505
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0547	0.0893
Onchocerca volvulus		0.001	0.0058	0.0043
Echinococcus multilocularis	neuropeptide Y receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	somatostatin receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	G protein coupled receptor 139	0.001	0.0058	0.0048
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0063	0.0116
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0063	0.0057
Entamoeba histolytica	hypothetical protein, conserved	0.0312	0.5461	1
Onchocerca volvulus	Peroxidasin homolog	0.0242	0.4212	0.7698
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.001	0.0058	0.0048
Echinococcus granulosus	G protein coupled receptor 139	0.001	0.0058	0.0048
Schistosoma mansoni	neuropeptide receptor	0.001	0.0058	0.0106
Leishmania major	trypanothione reductase	0.0066	0.1052	0.9457
Echinococcus granulosus	g-protein coupled receptor	0.001	0.0058	0.0048
Schistosoma mansoni	peroxidasin	0.0242	0.4212	0.7713
Brugia malayi	steroid hormone receptor	0.0011	0.0063	0.0031
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0023	0.0283	0.5
Onchocerca volvulus		0.001	0.0058	0.0043
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0063	0.0031
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.001	0.0058	0.0045
Echinococcus granulosus	7TM GPCR rhodopsin	0.001	0.0058	0.0048
Schistosoma mansoni	opsin-like receptor	0.001	0.0058	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0547	0.4505
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0671	0.1178
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0547	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0745	0.1364
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.001	0.0058	0.0048
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0063	0.0057
Echinococcus granulosus	hypothetical protein	0.001	0.0058	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.001	0.0058	0.0106
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.001	0.0058	0.0106
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1108	1
Echinococcus granulosus	serotonin receptor	0.001	0.0058	0.0048
Brugia malayi	Sulfatase family protein	0.0009	0.0035	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	somatostatin receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0058	0.0048
Onchocerca volvulus		0.001	0.0058	0.0043
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0063	0.0031
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0105	0.0193
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.001	0.0058	0.0106
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0039	0.00000000073963
Onchocerca volvulus		0.001	0.0058	0.0043
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0063	0.0057
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.001	0.0058	0.0048
Onchocerca volvulus		0.001	0.0058	0.0043
Mycobacterium ulcerans	lipase LipD	0.0038	0.0547	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.001	0.0058	0.0026
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0039	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0063	0.0031
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0063	0.0054
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0273	0.0444
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Onchocerca volvulus	Protein cereblon homolog	0.0312	0.5461	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0005
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0063	0.0057
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.001	0.0058	0.0045
Giardia lamblia	Sgs1 DNA helicase, putative	0.0009	0.0039	0.017
Loa Loa (eye worm)	hypothetical protein	0.0331	0.5802	1
Schistosoma mansoni	hypothetical protein	0.001	0.0058	0.0106
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0283	0.0599
Schistosoma mansoni	histamine h1 receptor	0.001	0.0058	0.0106
Brugia malayi	Dopamine receptor protein 2	0.001	0.0058	0.0026
Plasmodium falciparum	glutathione reductase	0.0066	0.1052	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0547	0.0949
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0063	0.0057
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0063	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Loa Loa (eye worm)	animal heme peroxidase	0.0242	0.4212	0.7244
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Onchocerca volvulus		0.001	0.0058	0.0043
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0063	0.0031
Loa Loa (eye worm)	neuropeptide F receptor	0.001	0.0058	0.0045
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0547	0.8774
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.001	0.0058	0.0048
Brugia malayi	neuropeptide F receptor	0.001	0.0058	0.0026
Loa Loa (eye worm)	animal heme peroxidase	0.0242	0.4212	0.7244
Brugia malayi	follicle stimulating hormone receptor	0.025	0.4356	0.4338
Plasmodium vivax	glutathione reductase, putative	0.0066	0.1052	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0671	0.1178
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	thioredoxin glutathione reductase	0.0066	0.1052	0.1879
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0039	0.0013
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0547	0.0893
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0023	0.0283	0.1913
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	nuclear hormone receptor	0.0011	0.0063	0.0031
Onchocerca volvulus	Peroxidase homolog	0.0242	0.4212	0.7698
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0063	0.0031
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0547	0.1238
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0547	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.001	0.0058	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0063	0.0031
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0283	0.1913
Schistosoma mansoni	neuropeptide receptor	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0547	0.4505
Brugia malayi	Animal haem peroxidase family protein	0.0242	0.4212	0.4193
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.1108	0.1864
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Plasmodium falciparum	glutathione reductase	0.0023	0.0283	0.2404
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0087	0.0942
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.1108	0.2028
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0023	0.0283	0.2404
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0023	0.0283	0.4837
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0063	0.0031
Onchocerca volvulus		0.0011	0.0063	0.0052
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0547	0.1238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0547	0.1238
Echinococcus multilocularis	dro:myosuppressin receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Toxoplasma gondii	ABC1 family protein	0.0038	0.0547	0.5014
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0039	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0023	0.0283	0.1913
Brugia malayi	Thioredoxin reductase	0.0066	0.1052	0.1024
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0066	0.1052	0.2459
Loa Loa (eye worm)	G-protein coupled receptor	0.001	0.0058	0.0045
Echinococcus multilocularis	G-protein coupled receptor, putative	0.001	0.0058	0.0048
Brugia malayi	Animal haem peroxidase family protein	0.0242	0.4212	0.4193
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0063	0.0116
Trypanosoma cruzi	trypanothione reductase, putative	0.0066	0.1052	0.9457
Onchocerca volvulus		0.0242	0.4212	0.7698
Onchocerca volvulus		0.001	0.0058	0.0043
Trypanosoma brucei	trypanothione reductase	0.0066	0.1052	0.9457
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0273	0.0444
Echinococcus multilocularis	neuropeptide Y receptor	0.001	0.0058	0.0048
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0547	0.4505
Brugia malayi	glutathione reductase	0.0066	0.1052	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Brugia malayi	G protein-coupled receptor F59B2.13	0.001	0.0058	0.0026
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0023	0.0283	0.1526
Treponema pallidum	NADH oxidase	0.0023	0.0283	0.5
Loa Loa (eye worm)	glutathione reductase	0.0066	0.1052	0.1768
Onchocerca volvulus		0.001	0.0058	0.0043
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0547	0.1238
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0063	0.0054
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0032	0.0059
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.001	0.0058	0.0026
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0023	0.0283	0.1913
Echinococcus granulosus	neuropeptide receptor	0.001	0.0058	0.0048
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0547	0.0949
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.2415	0.4423
Brugia malayi	hypothetical protein	0.0127	0.2149	0.2123
Echinococcus granulosus	g protein coupled receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0058	0.0048
Trichomonas vaginalis	mercuric reductase, putative	0.0023	0.0283	0.4267
Onchocerca volvulus		0.001	0.0058	0.0043
Echinococcus granulosus	fmrfamide receptor	0.001	0.0058	0.0048
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0023	0.0283	0.1913
Echinococcus granulosus	neuropeptide Y receptor	0.001	0.0058	0.0048
Schistosoma mansoni	amine GPCR	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Echinococcus multilocularis	fmrfamide receptor	0.001	0.0058	0.0048
Schistosoma mansoni	alpha-1 adrenergic receptor	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.0054
Brugia malayi	G protein-coupled receptor	0.001	0.0058	0.0026
Echinococcus granulosus	tachykinin peptides receptor 99D	0.001	0.0058	0.0048
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0063	0.0116
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0066	0.1052	0.1879
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.001	0.0058	0.0026
Brugia malayi	hypothetical protein	0.0312	0.5461	0.5446
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.001	0.0058	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Onchocerca volvulus		0.0038	0.0547	0.0944
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Schistosoma mansoni	hypothetical protein	0.0131	0.2226	0.4077
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Onchocerca volvulus		0.001	0.0058	0.0043
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0547	0.1238
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	hypothetical protein	0.0242	0.4212	0.4193
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Brugia malayi	beta-lactamase	0.0038	0.0547	0.0517
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0069	0.1108	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0023	0.0283	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.001	0.0058	0.0048
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.001	0.0058	0.0048
Echinococcus granulosus	biogenic amine 5HT receptor	0.001	0.0058	0.0048
Brugia malayi	sulfakinin receptor protein	0.001	0.0058	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0547	1
Loa Loa (eye worm)	hypothetical protein	0.0312	0.5461	0.9409
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	protein cereblon	0.0312	0.5461	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0063	0.0057
Brugia malayi	G-protein coupled receptor	0.001	0.0058	0.0026
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0242	0.4212	0.7244
Brugia malayi	RE15519p	0.001	0.0058	0.0026
Echinococcus granulosus	sex peptide receptor	0.001	0.0058	0.0048
Echinococcus multilocularis	sex peptide receptor	0.001	0.0058	0.0048
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0547	0.1238
Onchocerca volvulus		0.001	0.0058	0.0043
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.2415	0.4423
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0058	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0035	0.0045
Onchocerca volvulus		0.0242	0.4212	0.7698
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0063	0.0057
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.001	0.0058	0.0048
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.4172	1
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0032	0.0059
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Brugia malayi	hypothetical protein	0.001	0.0058	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0192	0.0278
Echinococcus granulosus	neuropeptide receptor A26	0.001	0.0058	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0058	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0063	0.0031
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0547	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0745	0.1364
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.001	0.0058	0.0048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0105	0.0135
Onchocerca volvulus		0.001	0.0058	0.0043
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0023	0.0283	0.4837
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0039	0.0007
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0105	0.0135
Echinococcus granulosus	orexin receptor type 2	0.001	0.0058	0.0048
Brugia malayi	Animal haem peroxidase family protein	0.0242	0.4212	0.4193
Echinococcus granulosus	peroxidasin	0.0242	0.4212	0.7699
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1108	1
Loa Loa (eye worm)	neuropeptide F receptor	0.001	0.0058	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0058	0.0045
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0023	0.0283	0.2404
Echinococcus granulosus	neuropeptide FF receptor 2	0.001	0.0058	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2.6 nM	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	= 2.6 nM	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	> 2000 nM	Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	> 2000 nM	Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	> 4000 nM	Displacement of [3H]mesurgeline from human 5HT2C receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	> 4000 nM	Displacement of [3H]mesurgeline from human 5HT2C receptor expressed in CHO cells	ChEMBL.	17314044
Ki (binding)	> 9000 nM	Displacement of [3H]dofetilide from hERG expressed in HEK cells	ChEMBL.	17314044
Ki (binding)	> 9000 nM	Displacement of [3H]dofetilide from hERG expressed in HEK cells	ChEMBL.	17314044
Ratio Ki (binding)	> 1500	Selectivity for human 5HT2A receptor over human 5HT2C receptor	ChEMBL.	17314044

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL240665
PubChem: 21099473

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 454678