TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.453 | Formula: C24H20N6O4
H donors: 4 H acceptors: 4 LogP: 2.02 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OCC2=C1C(c1ccc(cc1)C1C3=C(COC3=O)Nc3c1c(C)n[nH]3)c1c(N2)[nH]nc1C
InChi: 1S/C24H20N6O4/c1-9-15-17(19-13(7-33-23(19)31)25-21(15)29-27-9)11-3-5-12(6-4-11)18-16-10(2)28-30-22(16)26-14-8-34-24(32)20(14)18/h3-6,17-18H,7-8H2,1-2H3,(H2,25,27,29)(H2,26,28,30)
InChiKey: HDIVUDAGTYNBQQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0026	0.0026
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0078	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Brugia malayi	hypothetical protein	0.0023	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0017	0.0019	0.0009
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0078	0.018
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.012	0.012
Onchocerca volvulus		0.0019	0.0059	0.0158
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0059	0.0049
Echinococcus multilocularis	neurogenic locus notch protein	0.0017	0.0026	0.0013
Brugia malayi	Animal haem peroxidase family protein	0.0053	0.0659	0.0659
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0043	0.0474	0.0465
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0043	0.0474	0.0474
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	Cadherin domain containing protein	0.0017	0.0026	0.0026
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0043	0.0474	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0023	0.012	0.0111
Echinococcus multilocularis	neural cadherin	0.0017	0.0026	0.0013
Schistosoma mansoni	retinoic acid receptor RXR	0.0144	0.2255	0.7731
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0078	0.0102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.012	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.1014	0.1713
Loa Loa (eye worm)	DR-78	0.002	0.0078	0.0069
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0043	0.0474	0.0784
Onchocerca volvulus		0.0019	0.0059	0.0158
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0043	0.0474	0.0784
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0043	0.0474	0.0784
Schistosoma mansoni	peroxidasin	0.0053	0.0659	0.2197
Loa Loa (eye worm)	notch protein	0.0017	0.0026	0.0017
Onchocerca volvulus		0.0019	0.0059	0.0158
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0639	0.1067
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0026	0.0171	0.0823
Onchocerca volvulus	Protein ultraspiracle homolog	0.0043	0.0474	0.2175
Echinococcus granulosus	tumor protein p63	0.0348	0.5827	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0023	0.012	0.0175
Echinococcus multilocularis	neurogenic locus protein delta	0.0017	0.0026	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0043	0.0474	0.0474
Echinococcus granulosus	jun protein	0.0085	0.1218	0.2065
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0171	0.2566
Echinococcus multilocularis	transfer RNA-Lys	0.0046	0.0537	0.0892
Entamoeba histolytica	hypothetical protein	0.0074	0.1014	0.8854
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Onchocerca volvulus		0.0019	0.0059	0.0158
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0078	0.0102
Brugia malayi	nuclear hormone receptor	0.002	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0.0026	0.0084
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0068	0.0935
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0043	0.0474	0.0784
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0078	0.018
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0639	0.3206
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0135	0.2096	0.3577
Schistosoma mansoni	hypothetical protein	0.0074	0.1014	0.3426
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0285	0.4382
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0078	0.018
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1177	0.1169
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0639	0.1067
Loa Loa (eye worm)	animal heme peroxidase	0.0053	0.0659	0.0651
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.002	0.0078	0.0251
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0128	0.1973	0.3364
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0639	0.3206
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0043	0.0474	0.0784
Echinococcus multilocularis	jun protein	0.0085	0.1218	0.2065
Toxoplasma gondii	microneme protein MIC17B	0.0019	0.0059	0.0066
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0122	0.1858	0.3167
Onchocerca volvulus	Bile acid receptor homolog	0.0043	0.0474	0.2175
Schistosoma mansoni	zinc finger protein	0.002	0.0078	0.018
Schistosoma mansoni	heat shock protein	0.0032	0.0285	0.0898
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0128	0.1973	0.1965
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0078	0.0078
Mycobacterium tuberculosis	Possible chitinase	0.0067	0.0904	1
Brugia malayi	tailless protein	0.002	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0043	0.0474	0.0784
Echinococcus multilocularis	neurogenic locus protein delta	0.0017	0.0026	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Echinococcus multilocularis	notch	0.0017	0.0026	0.0013
Brugia malayi	hypothetical protein	0.002	0.0078	0.0078
Brugia malayi	Animal haem peroxidase family protein	0.0053	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0043	0.0474	0.1555
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0639	0.3206
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0043	0.0474	0.0474
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0171	0.0262
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0023	0.0124	0.5
Echinococcus granulosus	mitogen activated protein kinase 11	0.0128	0.1973	0.3364
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0017	0.0026	0.0026
Onchocerca volvulus		0.002	0.0078	0.0251
Echinococcus granulosus	aryl hydrocarbon receptor	0.0135	0.2096	0.3577
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0285	0.1405
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0059	0.0066
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0059	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Onchocerca volvulus		0.002	0.0078	0.0251
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0043	0.0474	0.0474
Echinococcus granulosus	mitogen activated protein kinase 14	0.0128	0.1973	0.3364
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Loa Loa (eye worm)	blistered cuticle protein 3	0.0053	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0068	0.0935
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0171	1
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0171	0.0262
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0017	0.0026	0.0084
Brugia malayi	notch-like transmembrane receptor	0.0017	0.0026	0.0026
Plasmodium vivax	hypothetical protein, conserved	0.0125	0.1921	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Toxoplasma gondii	microneme protein MIC4	0.0019	0.0059	0.0066
Schistosoma mansoni	RAR-like nuclear receptor	0.0043	0.0474	0.1555
Brugia malayi	Endochitinase	0.0089	0.1275	0.1275
Onchocerca volvulus	Dual oxidase homolog	0.0053	0.0659	0.3073
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0128	0.1973	1
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0125	0.1921	0.3276
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0078	0.0102
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0078	0.0078
Echinococcus multilocularis	protein jagged 1	0.0017	0.0026	0.0013
Onchocerca volvulus		0.0043	0.0474	0.2175
Brugia malayi	nuclear receptor NHR-88	0.0043	0.0474	0.0474
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0032	0.0285	0.4228
Treponema pallidum	heat shock protein 90	0.0026	0.0171	0.5
Echinococcus granulosus	neurogenic locus notch protein 4	0.0017	0.0026	0.0013
Schistosoma mansoni	endoplasmin	0.0032	0.0285	0.0898
Brugia malayi	Blistered cuticle protein 3	0.0053	0.0659	0.0659
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0017	0.0026	0.000000073068
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0639	1
Onchocerca volvulus		0.0019	0.0059	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0043	0.0474	0.0474
Schistosoma mansoni	peroxidasin	0.0053	0.0659	0.2197
Loa Loa (eye worm)	animal heme peroxidase	0.0053	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1811	0.1803
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0059	0.0066
Onchocerca volvulus		0.0053	0.0659	0.3073
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0078	0.0102
Brugia malayi	hypothetical protein	0.002	0.0078	0.0078
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	endochitinase	0.0089	0.1275	0.1275
Schistosoma mansoni	coup transcription factor	0.0043	0.0474	0.1555
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0639	0.2125
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Brugia malayi	hypothetical protein	0.0053	0.0659	0.0659
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0043	0.0474	0.1555
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0085	0.1218	0.2065
Entamoeba histolytica	hypothetical protein	0.0074	0.1014	0.8854
Loa Loa (eye worm)	chitinase I	0.0079	0.1108	0.11
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Brugia malayi	PAS domain containing protein	0.0063	0.0822	0.0822
Echinococcus multilocularis	heat shock protein 90	0.0032	0.0285	0.0459
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0043	0.0474	0.0465
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.0639	1
Brugia malayi	nuclear hormone receptor	0.0043	0.0474	0.0474
Echinococcus granulosus	endoplasmin	0.0026	0.0171	0.0262
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Toxoplasma gondii	heat shock protein HSP90	0.0032	0.0285	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.1014	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0078	0.0102
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0171	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0043	0.0474	0.0474
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0023	0.012	0.0327
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Onchocerca volvulus		0.0019	0.0059	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Brugia malayi	hypothetical protein	0.0067	0.0897	0.0897
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Echinococcus granulosus	protein jagged 2	0.0017	0.0026	0.0013
Toxoplasma gondii	PAN domain-containing protein	0.0297	0.4925	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0078	0.0102
Echinococcus multilocularis	ecdysone induced protein 78C	0.0043	0.0474	0.0784
Leishmania major	chitinase	0.0079	0.1108	0.5597
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Schistosoma mansoni	jun-related protein	0.0069	0.0938	0.3163
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Toxoplasma gondii	heat shock protein 90, putative	0.0032	0.0285	0.0529
Onchocerca volvulus	Peroxidase homolog	0.0053	0.0659	0.3073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.012	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Leishmania major	protein kinase, putative	0.0017	0.0026	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1801	0.1793
Brugia malayi	hypothetical protein	0.0074	0.1014	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0023	0.012	0.0111
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0059	0.0049
Brugia malayi	nuclear receptor RXR	0.002	0.0078	0.0078
Brugia malayi	nuclear receptor RXR	0.0023	0.012	0.012
Brugia malayi	Muscle positioning protein 4	0.0017	0.0026	0.0026
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	MAP kinase sur-1	0.0052	0.0639	0.0639
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0017	0.0026	0.0084
Toxoplasma gondii	hypothetical protein	0.0019	0.0059	0.0066
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0049
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0078	0.018
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0023	0.012	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0904	0.0896
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0023	0.012	0.0111
Loa Loa (eye worm)	Notch2	0.0017	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Brugia malayi	Delta serrate ligand family protein	0.0017	0.0026	0.0026
Brugia malayi	nuclear receptor NHR-88	0.002	0.0078	0.0078
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0043	0.0474	0.0784
Onchocerca volvulus	Chorion peroxidase homolog	0.0053	0.0659	0.3073
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0639	0.2095
Entamoeba histolytica	chitinase, putative	0.0079	0.1108	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0026	0.0026
Trypanosoma brucei	protein kinase, putative	0.0052	0.0639	0.2095
Schistosoma mansoni	aryl hydrocarbon receptor	0.0182	0.2909	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0017	0.0026	0.0013
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0043	0.0474	0.1555
Echinococcus granulosus	single minded 2	0.0046	0.0537	0.0892
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0043	0.0474	0.0465
Loa Loa (eye worm)	heat shock protein 90	0.0032	0.0285	0.0276
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0019	0.0063	0.0127
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0128	0.1973	0.3364
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Schistosoma mansoni	nuclear hormone receptor	0.0043	0.0474	0.1555
Toxoplasma gondii	microneme protein MIC17C	0.0019	0.0059	0.0066
Schistosoma mansoni	thyroid hormone receptor	0.0043	0.0474	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0128	0.1973	0.3364
Brugia malayi	ecdysone receptor	0.002	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0904	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0026	0.0026
Echinococcus granulosus	protein jagged 1	0.0017	0.0026	0.0013
Onchocerca volvulus	Putative endochitinase	0.0089	0.1275	0.6061
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0125	0.1921	0.3276
Loa Loa (eye worm)	animal heme peroxidase	0.0053	0.0659	0.0651
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0125	0.1921	0.1921
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0639	0.3206
Brugia malayi	Animal haem peroxidase family protein	0.0053	0.0659	0.0659
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0078	0.0102
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0078	0.0078
Schistosoma mansoni	single-minded	0.0063	0.0822	0.2761
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0055	0.0233
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0285	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0639	0.3206
Trypanosoma cruzi	Heat shock protein 83, putative	0.0032	0.0285	0.1405
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0639	0.1067
Brugia malayi	hypothetical protein	0.0016	0.0009	0.0009
Brugia malayi	bZIP transcription factor family protein	0.0085	0.1218	0.1218
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0043	0.0474	0.0474
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0078	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Loa Loa (eye worm)	nuclear hormone receptor	0.002	0.0078	0.0069
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0043	0.0474	0.0465
Onchocerca volvulus	Putative endochitinase	0.0089	0.1275	0.6061
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0128	0.1973	0.3364
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0285	0.1405
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0043	0.0474	0.0474
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0078	0.0078
Loa Loa (eye worm)	microfilarial chitinase	0.0077	0.1071	0.1063
Brugia malayi	conserved hypotetical protein	0.002	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Schistosoma mansoni	notch	0.0017	0.0028	0.0008
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0043	0.0474	0.1555
Plasmodium falciparum	heat shock protein 90	0.0032	0.0285	0.1171
Onchocerca volvulus		0.0053	0.0659	0.3073
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0059	0.0049
Onchocerca volvulus		0.0019	0.0059	0.0158
Schistosoma mansoni	nuclear receptor	0.002	0.0078	0.018
Toxoplasma gondii	microneme protein, putative	0.0019	0.0059	0.0066
Echinococcus granulosus	peroxidasin	0.0053	0.0659	0.1103
Leishmania major	protein kinase, putative	0.0017	0.0026	0.0084
Schistosoma mansoni	hypothetical protein	0.0069	0.0938	0.3163
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0063	0.0053
Loa Loa (eye worm)	endoplasmin	0.0032	0.0285	0.0276
Brugia malayi	hypothetical protein	0.0023	0.012	0.012
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0024	0.0144	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Echinococcus granulosus	slit 2 protein	0.0017	0.0026	0.0013
Echinococcus granulosus	neurogenic locus notch protein	0.0017	0.0026	0.0013
Echinococcus granulosus	neurogenic locus protein delta	0.0017	0.0026	0.0013
Schistosoma mansoni	nuclear receptor	0.002	0.0078	0.018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0043	0.0474	0.0784
Echinococcus multilocularis	heat shock protein	0.0032	0.0285	0.0459
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.012	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0043	0.0474	0.0474
Echinococcus granulosus	protein jagged 1	0.0017	0.0026	0.0013
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0043	0.0474	0.0465
Onchocerca volvulus		0.0051	0.0617	0.2868
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0078	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1921	0.1914
Echinococcus granulosus	ecdysone induced protein 78C	0.0043	0.0474	0.0784
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0017	0.0026	0.0013
Echinococcus multilocularis	endoplasmin	0.0026	0.0171	0.0262
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0043	0.0474	0.0784
Onchocerca volvulus		0.0125	0.1921	0.9198
Schistosoma mansoni	hypothetical protein	0.0125	0.1921	0.6574
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0043	0.0474	0.0784
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Onchocerca volvulus		0.0019	0.0059	0.0158
Onchocerca volvulus		0.0019	0.0059	0.0158
Entamoeba histolytica	hypothetical protein	0.0074	0.1014	0.8854
Toxoplasma gondii	microneme protein MIC17A	0.0019	0.0059	0.0066
Onchocerca volvulus		0.0135	0.2087	1
Echinococcus granulosus	heat shock protein 90	0.0032	0.0285	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Onchocerca volvulus	Peroxidasin homolog	0.0053	0.0659	0.3073
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0171	0.2566
Echinococcus multilocularis	slit 2 protein	0.0017	0.0026	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0043	0.0474	0.0474
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0078	0.0078
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0043	0.0474	0.1555
Onchocerca volvulus	Peroxidasin homolog	0.0053	0.0659	0.3073
Trypanosoma cruzi	heat shock protein 90, putative	0.0032	0.0285	0.1405
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0019	0.0059	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0059	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0135	0.2087	0.2079
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0043	0.0474	0.0474
Echinococcus granulosus	notch	0.0017	0.0026	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0023	0.012	0.0111
Entamoeba histolytica	hypothetical protein	0.0074	0.1014	0.8854
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0078	0.0102
Mycobacterium ulcerans	chitinase/cellulase	0.0067	0.0904	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0043	0.0474	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Onchocerca volvulus	Peroxidase homolog	0.0053	0.0659	0.3073
Onchocerca volvulus		0.0019	0.0059	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Toxoplasma gondii	PAN domain-containing protein	0.0019	0.0059	0.0066
Onchocerca volvulus		0.0125	0.1921	0.9198
Plasmodium falciparum	conserved protein, unknown function	0.0125	0.1921	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0043	0.0474	0.1555
Echinococcus granulosus	neural cadherin	0.0017	0.0026	0.0013
Toxoplasma gondii	hypothetical protein	0.0019	0.0059	0.0066
Echinococcus granulosus	delta-like protein 1	0.0017	0.0026	0.0013
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0474	0.0474
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0043	0.0474	0.0784
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0171	0.5
Echinococcus granulosus	heat shock protein	0.0032	0.0285	0.0459
Onchocerca volvulus		0.0053	0.0659	0.3073
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0617	0.205
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0043	0.0474	0.0465
Brugia malayi	Peroxidasin	0.0053	0.0659	0.0659
Brugia malayi	Steroid receptor seven-up type 2	0.0043	0.0474	0.0474
Brugia malayi	P38 map kinase family protein 2	0.0128	0.1973	0.1973
Loa Loa (eye worm)	animal heme peroxidase	0.0053	0.0659	0.0651
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0171	0.2566
Mycobacterium ulcerans	putative regulatory protein	0.0046	0.0537	0.499
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0128	0.1973	1
Brugia malayi	nuclear receptor NHR-67	0.002	0.0078	0.0078
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Brugia malayi	steroid hormone receptor	0.0043	0.0474	0.0474
Schistosoma mansoni	thyroid hormone receptor	0.0043	0.0474	0.1555
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0144	0.0408
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Echinococcus granulosus	fibropellin Ia	0.0017	0.0026	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Onchocerca volvulus	Putative endochitinase	0.0079	0.1108	0.5251
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0119	0.1801	0.1801
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0043	0.0474	0.1555
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0639	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0128	0.1973	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Onchocerca volvulus		0.0019	0.0059	0.0158
Echinococcus multilocularis	neurogenic locus notch protein	0.0017	0.0026	0.0013
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0639	0.125
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0019	0.0059	0.0066
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Brugia malayi	Animal haem peroxidase family protein	0.0053	0.0659	0.0659
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0043	0.0474	0.2175
Loa Loa (eye worm)	hypothetical protein	0.0587	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0078	0.0069
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	GCC2 and GCC3 family protein	0.0017	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0171	0.0823
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0639	0.063
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Brugia malayi	endochitinase	0.0079	0.1108	0.1108
Echinococcus granulosus	heat shock protein 90	0.0026	0.0171	0.0262
Onchocerca volvulus		0.0047	0.0546	0.2524
Onchocerca volvulus	Putative endochitinase	0.0079	0.1108	0.5251
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0144	0.0144
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Toxoplasma gondii	hypothetical protein	0.0125	0.1921	0.3869
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0043	0.0474	0.0474
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.1014	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.002	0.0078	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1921	0.1914
Brugia malayi	photoreceptor-specific nuclear receptor	0.0043	0.0474	0.0474
Brugia malayi	ecdysteroid receptor	0.0043	0.0474	0.0474
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0043	0.0474	0.0784
Leishmania major	heat shock protein 83-1	0.0032	0.0285	0.1405
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0024	0.0144	0.0215
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0078	0.0102
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0076	0.1054	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Echinococcus multilocularis	protein jagged 2	0.0017	0.0026	0.0013
Loa Loa (eye worm)	steroid hormone receptor	0.0043	0.0474	0.0465
Brugia malayi	bHLH-PAS transcription factor	0.0046	0.0537	0.0537
Brugia malayi	PAN domain containing protein	0.0019	0.0059	0.0059
Brugia malayi	Cadherin domain containing protein	0.0017	0.0026	0.0026
Schistosoma mansoni	heat shock protein	0.0032	0.0285	0.0898
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0069
Onchocerca volvulus	Neurogenic locus notch homolog	0.0017	0.0028	0.0011
Echinococcus multilocularis	tumor protein p63	0.0348	0.5827	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0059	0.0049
Echinococcus multilocularis	protein jagged 1	0.0017	0.0026	0.0013
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0.0026	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Brugia malayi	Endoplasmin precursor	0.0032	0.0285	0.0285
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0639	1
Loa Loa (eye worm)	cuticular endochitinase	0.0079	0.1108	0.11
Echinococcus granulosus	neurogenic locus notch protein	0.0017	0.0026	0.0013
Giardia lamblia	Grp94/Hsp90	0.0026	0.0171	0.2362
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0144	0.2255	0.385
Brugia malayi	EGF-like domain containing protein	0.0017	0.0026	0.0026
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0128	0.1973	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0617	0.0608
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0085	0.1218	0.2065
Brugia malayi	Animal haem peroxidase family protein	0.0053	0.0659	0.0659
Schistosoma mansoni	endoplasmin	0.0032	0.0285	0.0898
Brugia malayi	heat shock protein 90	0.0032	0.0285	0.0285
Toxoplasma gondii	subtilisin SUB12	0.0019	0.0059	0.0066
Echinococcus multilocularis	fibropellin Ia	0.0017	0.0026	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0144	0.0134
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.012	0.012
Echinococcus multilocularis	FTZ F1 alpha	0.0043	0.0474	0.0784
Echinococcus multilocularis	peroxidasin	0.0053	0.0659	0.1103
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0171	0.2362
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0076	0.1054	0.1782
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0639	0.3206
Onchocerca volvulus	Putative endochitinase	0.0089	0.1275	0.6061
Onchocerca volvulus		0.0067	0.0897	0.4227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0043	0.0474	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0474	0.0465
Echinococcus granulosus	FTZ F1 alpha	0.0043	0.0474	0.0784
Toxoplasma gondii	PAN domain-containing protein	0.0297	0.4925	1
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0639	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0639	0.1067
Echinococcus granulosus	protein jagged 2	0.0017	0.0026	0.0013
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0078	0.018

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 56 %	Cytotoxicity against human HeLa cells assessed as viability at 5 uM after 48 hrs by MTT method relative to control	ChEMBL.	17188868
Activity (functional)	= 56 %	Cytotoxicity against human HeLa cells assessed as viability at 5 uM after 48 hrs by MTT method relative to control	ChEMBL.	17188868
Activity (functional)	= 96 %	Cytotoxicity against human Jurkat cells assessed as viability at 5 uM after 48 hrs by MTT method relative to control	ChEMBL.	17188868
Activity (functional)	= 96 %	Cytotoxicity against human Jurkat cells assessed as viability at 5 uM after 48 hrs by MTT method relative to control	ChEMBL.	17188868
Activity (functional)	= 99 %	Cytotoxicity against human MCF7AZ cells assessed as viability at 5 uM after 48 hrs by MTT method relative to control	ChEMBL.	17188868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 25249025

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 455065