TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 507.534 | Formula: C24H33N3O9
H donors: 2 H acceptors: 5 LogP: 1.51 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@H](NC(=O)CN1C(=O)CC[C@@H](C1=O)NC(=O)c1cc(OC)c(c(c1)OC)OC)CC(C)C
InChi: 1S/C24H33N3O9/c1-13(2)9-16(24(32)36-6)25-19(28)12-27-20(29)8-7-15(23(27)31)26-22(30)14-10-17(33-3)21(35-5)18(11-14)34-4/h10-11,13,15-16H,7-9,12H2,1-6H3,(H,25,28)(H,26,30)/t15-,16-/m0/s1
InChiKey: HCTDCXATPFTQBT-HOTGVXAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0546	0.4414
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2201	0.3059
Echinococcus multilocularis	lamin	0.008	0.0591	0.0591
Onchocerca volvulus		0.008	0.0591	0.0503
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0497	0.0663
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0378	0.0428
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0128	0.1238	0.2395
Brugia malayi	latrophilin 2 splice variant baaae	0.0137	0.1357	0.2279
Schistosoma mansoni	hypothetical protein	0.0064	0.0378	0.0428
Onchocerca volvulus		0.0076	0.0546	0.0451
Schistosoma mansoni	intermediate filament proteins	0.008	0.0591	0.0669
Mycobacterium leprae	Probable lipase LipE	0.0076	0.0546	1
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0128	0.1238	0.5
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Brugia malayi	Zinc carboxypeptidase family protein	0.0154	0.1575	0.2674
Brugia malayi	Intermediate filament tail domain containing protein	0.008	0.0591	0.089
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0128	0.1238	1
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0497	0.0719
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0546	0.0911
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.0546	0.0618
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.0701	0.8841	0.8841
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.0546	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0572	0.0769
Loa Loa (eye worm)	zinc carboxypeptidase	0.0128	0.1238	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0157	0.0102
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0128	0.1238	0.5
Loa Loa (eye worm)	intermediate filament protein	0.008	0.0591	0.0796
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.0546	0.0911
Schistosoma mansoni	peptidase	0.0128	0.1238	0.14
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0035	0	0.5
Schistosoma mansoni	hypothetical protein	0.0336	0.3988	0.451
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.0546	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Leishmania major	mitochondrial DNA polymerase beta	0.0294	0.3432	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0294	0.3432	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3432	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1357	0.1873
Mycobacterium ulcerans	beta-lactamase	0.0076	0.0546	0.344
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0157	0.0178
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.1379	0.3871
Giardia lamblia	Nuclear ATP/GTP-binding protein	0.0128	0.1238	0.5
Brugia malayi	beta-lactamase family protein	0.0076	0.0546	0.0808
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.0701	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Echinococcus granulosus	cytosolic carboxypeptidase protein 5	0.0128	0.1238	0.14
Echinococcus granulosus	Zinc carboxypeptidase family protein	0.0128	0.1238	0.14
Onchocerca volvulus		0.0076	0.0546	0.0451
Onchocerca volvulus	Cytosolic carboxypeptidase 1 homolog	0.0128	0.1238	0.1247
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.0546	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3432	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.0546	0.0911
Echinococcus granulosus	geminin	0.0336	0.3988	0.451
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0201	0.2201	0.381
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0487	0.5998	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.0546	0.344
Schistosoma mansoni	hypothetical protein	0.0064	0.0378	0.0428
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0378	0.0503
Schistosoma mansoni	hypothetical protein	0.0064	0.0378	0.0428
Trypanosoma brucei	Carboxypeptidase-like protein	0.0128	0.1238	0.3448
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.0496
Brugia malayi	hypothetical protein	0.023	0.2586	0.451
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0043	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0546	0.4414
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0546	0.0618
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0497	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0027
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0546	0.4414
Schistosoma mansoni	lamin	0.008	0.0591	0.0669
Echinococcus granulosus	lamin	0.008	0.0591	0.0669
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0378	0.0378
Schistosoma mansoni	hypothetical protein	0.0047	0.0157	0.0178
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.0546	0.0911
Echinococcus granulosus	intermediate filament protein	0.008	0.0591	0.0669
Loa Loa (eye worm)	matrixin family protein	0.0051	0.021	0.026
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0546	0.0911
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0203	0.0358
Onchocerca volvulus		0.0701	0.8841	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Onchocerca volvulus		0.0701	0.8841	1
Onchocerca volvulus		0.0701	0.8841	1
Treponema pallidum	bacterioferrin (TpF1)	0.0035	0	0.5
Schistosoma mansoni	hypothetical protein	0.0336	0.3988	0.451
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0573	0.7138	1
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0128	0.1238	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.008	0.0591	0.0796
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.0546	0.0546
Trypanosoma cruzi	zinc carboxypeptidase, putative	0.0128	0.1238	0.3448
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0497	0.0663
Echinococcus multilocularis	Zinc carboxypeptidase family protein	0.0128	0.1238	0.1238
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.0701	0.8841	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Brugia malayi	Zinc carboxypeptidase family protein	0.0154	0.1575	0.2674
Schistosoma mansoni	hypothetical protein	0.0137	0.1357	0.1535
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.0701	0.8841	1
Toxoplasma gondii	flagellar/basal body protein	0.0128	0.1238	1
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.2586	0.2926
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1575	0.2178
Mycobacterium tuberculosis	Conserved protein	0.0076	0.0546	0.0911
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0201	0.2201	0.381
Brugia malayi	Carboxypeptidase A2 precursor	0.0128	0.1238	0.2062
Schistosoma mansoni	peptidase	0.0128	0.1238	0.14
Toxoplasma gondii	ABC1 family protein	0.0076	0.0546	0.3565
Brugia malayi	RNA binding protein	0.0073	0.0497	0.0719
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0378	0.0496
Brugia malayi	Matrixin family protein	0.0051	0.021	0.0199
Toxoplasma gondii	zinc carboxypeptidase, putative	0.0128	0.1238	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.0546	0.0911
Schistosoma mansoni	hypothetical protein	0.0128	0.1238	0.14
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0242	0.0304
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0497	0.0663
Trichomonas vaginalis	esterase, putative	0.0076	0.0546	0.4414
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14	0.0128	0.1238	0.3448
Brugia malayi	intermediate filament protein	0.008	0.0591	0.089
Echinococcus granulosus	tumor protein p63	0.0364	0.4366	0.4938
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0128	0.1238	0.2395
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.2586	0.2586
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.005	0.0198	0.0224
Mycobacterium ulcerans	hypothetical protein	0.0155	0.1588	1
Echinococcus multilocularis	lamin dm0	0.008	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Echinococcus multilocularis	cytosolic carboxypeptidase protein 5	0.0128	0.1238	0.1238
Onchocerca volvulus		0.0458	0.5613	0.6284
Trypanosoma brucei	metallo-peptidase, Clan MC, Family M14, putative	0.0128	0.1238	0.3448
Brugia malayi	TAR-binding protein	0.0073	0.0497	0.0719
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0378	0.0503
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Loa Loa (eye worm)	hypothetical protein	0.008	0.0591	0.0796
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1379	0.2886
Trypanosoma brucei	metallo-peptidase, Clan MC, Family M14, putative	0.0128	0.1238	0.3448
Loa Loa (eye worm)	beta-lactamase	0.0076	0.0546	0.0732
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0077	0.055	0.055
Loa Loa (eye worm)	hypothetical protein	0.0458	0.5613	0.7856
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0497	0.0562
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0497	0.0562
Echinococcus multilocularis	musashi	0.008	0.0591	0.0591
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.0546	0.0808
Brugia malayi	hypothetical protein	0.0458	0.5613	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.0546	0.344
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0128	0.1238	0.2395
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0497	0.0562
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0378	0.0378
Onchocerca volvulus		0.008	0.0591	0.0503
Loa Loa (eye worm)	hypothetical protein	0.023	0.2586	0.3601
Echinococcus granulosus	cytosolic carboxypeptidase 1	0.0128	0.1238	0.14
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Onchocerca volvulus		0.0047	0.0157	0.0003
Schistosoma mansoni	protease m14 carboxypeptidase	0.0128	0.1238	0.14
Echinococcus granulosus	lamin dm0	0.008	0.0591	0.0669
Onchocerca volvulus		0.0076	0.0546	0.0451
Onchocerca volvulus	Carboxypeptidase D homolog	0.0154	0.1575	0.1635
Echinococcus multilocularis		0.0128	0.1238	0.1238
Brugia malayi	beta-lactamase family protein	0.0076	0.0546	0.0808
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.0546	0.0911
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1379	0.3871
Loa Loa (eye worm)	zinc carboxypeptidase	0.0128	0.1238	0.1704
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0378	0.0428
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0546	0.4414
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0128	0.1238	0.3448
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0546	0.4414
Onchocerca volvulus		0.0128	0.1238	0.1247
Schistosoma mansoni	carboxypeptidase N (M14 family)	0.0128	0.1238	0.14
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0497	0.0562
Loa Loa (eye worm)	zinc carboxypeptidase	0.0128	0.1238	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Loa Loa (eye worm)	matrixin family protein	0.0047	0.0154	0.0181
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0128	0.1238	0.3448
Onchocerca volvulus		0.0701	0.8841	1
Echinococcus multilocularis	geminin	0.0336	0.3988	0.3988
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0378	0.0378
Onchocerca volvulus		0.0128	0.1238	0.1247
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0242	0.0273
Schistosoma mansoni	family M14 non-peptidase homologue (M14 family)	0.0128	0.1238	0.14
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Schistosoma mansoni	hypothetical protein	0.0064	0.0378	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Trypanosoma cruzi	Carboxypeptidase-like protein	0.0128	0.1238	0.3448
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.1588	0.2647
Brugia malayi	beta-lactamase	0.0076	0.0546	0.0808
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0038	0.0045	0.005
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0546	0.1384
Mycobacterium ulcerans	lipase LipD	0.0076	0.0546	0.344
Schistosoma mansoni	peptidase	0.0128	0.1238	0.14
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0546	0.1384
Onchocerca volvulus		0.0053	0.0242	0.0101
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0201	0.2201	0.3059
Echinococcus granulosus	GPCR family 2	0.0064	0.0378	0.0428
Schistosoma mansoni	metallocarboxypeptidase D peptidase unit 2 (M14 family)	0.0128	0.1238	0.14
Schistosoma mansoni	lamin	0.008	0.0591	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1238	0.1704
Mycobacterium ulcerans	hypothetical protein	0.0076	0.0546	0.344
Echinococcus multilocularis	tumor protein p63	0.0364	0.4366	0.4366
Loa Loa (eye worm)	zinc carboxypeptidase	0.0154	0.1575	0.2178
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0546	0.0618
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0546	0.1384
Brugia malayi	Zinc carboxypeptidase family protein	0.0128	0.1238	0.2062
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0546	0.0732
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0497	0.0562
Plasmodium vivax	hypothetical protein, conserved	0.0128	0.1238	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0038	0.0045	0.0045
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.0546	0.0911
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0077	0.055	0.0623
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0128	0.1238	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.8 uM	Inhibition of MMP2 after 30 mins	ChEMBL.	17433673
IC50 (binding)	= 3.8 uM	Inhibition of MMP2 after 30 mins	ChEMBL.	17433673
IC50 (binding)	= 46.2 uM	Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide	ChEMBL.	17433673
IC50 (binding)	= 46.2 uM	Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide	ChEMBL.	17433673
IC50 (binding)	= 46.2 uM	Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins	ChEMBL.	19683842
Ratio IC50 (binding)	= 12.16	Ratio of IC50 for microsomal aminopeptidase to IC50 for MMP2	ChEMBL.	17433673

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL246991

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 455596