Detailed information for compound 48855

Basic information

Technical information
  • TDR Targets ID: 48855
  • Name: 2-[(4-benzoylphenyl)sulfonylmethyl]-5-phenylp entanoic acid
  • MW: 436.52 | Formula: C25H24O5S
  • H donors: 1 H acceptors: 5 LogP: 4.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(CS(=O)(=O)c1ccc(cc1)C(=O)c1ccccc1)CCCc1ccccc1
  • InChi: 1S/C25H24O5S/c26-24(20-11-5-2-6-12-20)21-14-16-23(17-15-21)31(29,30)18-22(25(27)28)13-7-10-19-8-3-1-4-9-19/h1-6,8-9,11-12,14-17,22H,7,10,13,18H2,(H,27,28)
  • InChiKey: CTGVDIGFCHCCJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-benzoylphenyl)sulfonylmethyl]-5-phenyl-pentanoic acid
  • 5-phenyl-2-[[4-(phenylcarbonyl)phenyl]sulfonylmethyl]pentanoic acid
  • 2-[(4-benzoylphenyl)sulfonylmethyl]-5-phenyl-valeric acid
  • 2-[[4-(benzoyl)phenyl]sulfonylmethyl]-5-phenylpentanoic acid
  • 2-[[4-(benzoyl)phenyl]sulfonylmethyl]-5-phenyl-pentanoic acid
  • 2-[[4-(oxo-phenylmethyl)phenyl]sulfonylmethyl]-5-phenylpentanoic acid
  • 2-[[4-(benzoyl)phenyl]sulfonylmethyl]-5-phenyl-valeric acid
  • 5-phenyl-2-[(4-phenylcarbonylphenyl)sulfonylmethyl]pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 8 (neutrophil collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 8 (neutrophil collagenase) 467 aa 467 aa 33.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0926
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Echinococcus multilocularis inhibitor of apoptosis protein 0.0108 0.1366 0.1353
Schistosoma mansoni hypothetical protein 0.0108 0.1366 0.1353
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0067 0.0052
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0141 0.1059
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Plasmodium vivax calpain, putative 0.0021 0.0036 0.0753
Onchocerca volvulus 0.0026 0.0113 0.0191
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0036 0.0021
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0417 0.0403
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0058 0.0328
Schistosoma mansoni lamin 0.0026 0.0113 0.0098
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0298 0.0283
Echinococcus granulosus dnaJ subfamily B 0.0398 0.579 0.5784
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1327 0.1314
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.0328
Schistosoma mansoni ran 0.0021 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0036 0.0021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Echinococcus granulosus tumor protein p63 0.033 0.475 0.4742
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Onchocerca volvulus 0.0066 0.072 0.2311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0272 0.0257
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0417 0.0403
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0417 0.0403
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0036 0.0274
Echinococcus granulosus sodium channel protein 0.0036 0.027 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0897 0.487
Echinococcus granulosus single minded 2 0.0035 0.0247 0.0232
Brugia malayi Peptidase family M13 containing protein 0.0091 0.111 0.341
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1327 1
Schistosoma mansoni hypothetical protein 0.0066 0.0726 0.0712
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0298 1
Brugia malayi Matrixin family protein 0.0095 0.1159 0.3562
Leishmania major hypothetical protein, conserved 0.0037 0.0272 0.2048
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0148 0.0736
Echinococcus multilocularis tumor protein p63 0.033 0.475 0.4742
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1327 0.3097
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0148 0.4713
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0272 0.0784
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1327 1
Loa Loa (eye worm) matrixin family protein 0.0229 0.3211 0.7492
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1327 0.3097
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1327 0.1314
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.1826 0.4261
Onchocerca volvulus 0.0035 0.0247 0.0661
Brugia malayi hypothetical protein 0.0064 0.0692 0.2126
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0141 0.1059
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0987 0.5367
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0272 0.1418
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0298 0.0283
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0987 0.3245
Onchocerca volvulus 0.0066 0.072 0.2311
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0245
Loa Loa (eye worm) hypothetical protein 0.0068 0.0745 0.1738
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1327 0.1314
Echinococcus granulosus importin subunit beta 1 0.0028 0.0141 0.0126
Loa Loa (eye worm) hypothetical protein 0.0115 0.1475 0.344
Brugia malayi POT family protein 0.021 0.2916 0.896
Brugia malayi hypothetical protein 0.0038 0.0298 0.0916
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Schistosoma mansoni hypothetical protein 0.0023 0.0058 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0449 0.0435
Loa Loa (eye worm) hypothetical protein 0.0068 0.0745 0.1738
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Loa Loa (eye worm) hypothetical protein 0.0061 0.0641 0.1496
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Echinococcus multilocularis lamin dm0 0.0026 0.0113 0.0098
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0572 0.0558
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1327 0.3097
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0058 0.0043
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0058 0.0179
Echinococcus granulosus snurportin 1 0.0299 0.4286 0.4277
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0113
Brugia malayi calpain family protein 1 0.0056 0.0572 0.1757
Echinococcus granulosus calpain 0.0021 0.0036 0.0021
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0206
Onchocerca volvulus 0.0037 0.0272 0.0746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Onchocerca volvulus Matrix metalloproteinase homolog 0.021 0.2922 1
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1327 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Schistosoma mansoni neprilysin 0.0024 0.0077 0.0062
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0068 0.0745 0.1738
Loa Loa (eye worm) hypothetical protein 0.0095 0.1159 0.2704
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0272 0.0257
Brugia malayi Importin beta-1 subunit 0.0028 0.0141 0.0432
Trypanosoma brucei antigen, putative 0.0021 0.0036 0.0274
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0108 0.1366 0.1353
Echinococcus granulosus lamin dm0 0.0026 0.0113 0.0098
Brugia malayi follicle stimulating hormone receptor 0.0228 0.319 0.9802
Brugia malayi Blistered cuticle protein 3 0.0066 0.072 0.2212
Loa Loa (eye worm) hypothetical protein 0.0091 0.111 0.2589
Brugia malayi Matrixin family protein 0.0229 0.3211 0.9867
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0272 0.9075
Loa Loa (eye worm) hypothetical protein 0.0108 0.1366 0.3188
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Brugia malayi Cytochrome P450 family protein 0.0029 0.0153 0.0471
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0272 0.0784
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0058 0.0238
Echinococcus granulosus calpain 5 0.0021 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0897 0.2093
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0052 0.0037
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0058 0.0328
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0449 0.0435
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.579 0.5784
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0344 0.4974 0.4966
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0058 0.0043
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0058 0.0238
Brugia malayi hypothetical protein 0.0159 0.2137 0.6567
Onchocerca volvulus 0.0023 0.0067 0.0033
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0427
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.111 0.341
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0153 0.0358
Echinococcus granulosus inhibitor of apoptosis protein 0.0108 0.1366 0.1353
Loa Loa (eye worm) hypothetical protein 0.0091 0.111 0.2589
Brugia malayi phosphofructokinase 0.0106 0.1327 0.4079
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1327 0.9001
Brugia malayi bZIP transcription factor family protein 0.0082 0.096 0.295
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0436
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0206
Onchocerca volvulus 0.0048 0.0449 0.1366
Trichomonas vaginalis chromobox protein, putative 0.0138 0.1826 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0148 0.5
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0058 0.0179
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0168 0.2285 0.2273
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0524
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0246
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0036 0.0021
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Onchocerca volvulus Deterin homolog 0.0108 0.1366 0.4568
Echinococcus granulosus calpain A 0.0021 0.0036 0.0021
Echinococcus multilocularis calpain 0.0021 0.0036 0.0021
Echinococcus multilocularis calpain A 0.0059 0.0611 0.0597
Toxoplasma gondii ABC1 family protein 0.0037 0.0272 0.2346
Entamoeba histolytica Ran family GTPase 0.0021 0.0027 0.0094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0449 0.1048
Schistosoma mansoni calpain (C02 family) 0.0021 0.0036 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0113 0.0263
Echinococcus granulosus intermediate filament protein 0.0026 0.0113 0.0098
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0155 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Onchocerca volvulus 0.0026 0.0113 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0272 0.1418
Loa Loa (eye worm) beta-lactamase 0.0037 0.0272 0.0634
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.3288 1
Toxoplasma gondii peptidase family M13 protein 0.0091 0.111 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0052 0.0037
Schistosoma mansoni rab6-interacting 0.0038 0.0298 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0436
Schistosoma mansoni hypothetical protein 0.0299 0.4286 0.4277
Echinococcus granulosus chromobox protein 1 0.0138 0.1826 0.1814
Schistosoma mansoni rab6-interacting 0.0038 0.0298 0.0283
Echinococcus granulosus jun protein 0.0082 0.096 0.0946
Loa Loa (eye worm) hypothetical protein 0.0095 0.1159 0.2704
Mycobacterium ulcerans beta-lactamase 0.0037 0.0272 0.1843
Schistosoma mansoni cpg binding protein 0.003 0.0163 0.0148
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.0124
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0148 0.1218
Echinococcus granulosus RUN 0.0038 0.0298 0.0283
Onchocerca volvulus 0.0037 0.0272 0.0746
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0058 0.0393
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0052 0.0037
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1327 0.1314
Schistosoma mansoni microtubule-associated protein tau 0.0674 1 1
Schistosoma mansoni hypothetical protein 0.0134 0.1764 0.1752
Plasmodium vivax importin-beta 2, putative 0.0028 0.0141 0.4434
Brugia malayi SET domain containing protein 0.0023 0.0067 0.0207
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0068
Trichomonas vaginalis esterase, putative 0.0037 0.0272 0.1418
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0058 0.0179
Brugia malayi PAS domain containing protein 0.0047 0.0435 0.1336
Echinococcus multilocularis snurportin 1 0.0299 0.4286 0.4277
Onchocerca volvulus Peroxidase homolog 0.0066 0.072 0.2311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0449 0.0435
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0148 0.1016
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1327 0.7244
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.4286 1
Schistosoma mansoni hypothetical protein 0.0337 0.4864 0.4857
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.124 0.1226
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0059 0.0245
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.072 0.168
Brugia malayi 6-phosphofructokinase 0.0106 0.1327 0.4079
Brugia malayi hypothetical protein 0.0066 0.072 0.2212
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0272 0.0835
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.0274
Onchocerca volvulus 0.0045 0.0404 0.121
Schistosoma mansoni hypothetical protein 0.0053 0.0516 0.0502
Trichomonas vaginalis chromobox protein, putative 0.0138 0.1826 1
Brugia malayi beta-lactamase family protein 0.0037 0.0272 0.0835
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.096 0.0946
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Schistosoma mansoni lamin 0.0026 0.0113 0.0098
Brugia malayi Ets-domain containing protein 0.0076 0.0879 0.27
Echinococcus granulosus chromobox protein 1 0.0138 0.1826 0.1814
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.111 0.1096
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Plasmodium falciparum importin beta, putative 0.0028 0.0141 0.4434
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0345 0.0805
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Onchocerca volvulus Peroxidasin homolog 0.0066 0.072 0.2311
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0113
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.111 0.1096
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1327 0.7244
Brugia malayi Heterochromatin protein 1 0.0138 0.1826 0.5612
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0551 0.296
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0298 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0108 0.1366 0.1353
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.072 0.168
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0272 0.0784
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0449 0.138
Brugia malayi chromobox protein homolog 3 0.0078 0.0897 0.2757
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0058 0.0238
Loa Loa (eye worm) hypothetical protein 0.0065 0.071 0.1655
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0345 0.033
Mycobacterium tuberculosis Conserved protein 0.0037 0.0272 0.0784
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0015 0.0046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0272 0.1843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0449 0.0435
Echinococcus multilocularis geminin 0.0337 0.4864 0.4857
Echinococcus multilocularis hypothetical protein 0.0021 0.0036 0.0021
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0036 0.027 0.0255
Loa Loa (eye worm) matrixin family protein 0.021 0.2922 0.6817
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0058 0.1522
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0052 0.0037
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1327 0.8775
Echinococcus multilocularis microtubule associated protein 2 0.0674 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.008 0.0601
Schistosoma mansoni importin beta-1 0.0028 0.0141 0.0126
Echinococcus multilocularis chromobox protein 1 0.0138 0.1826 0.1814
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.319 0.7442
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Schistosoma mansoni hypothetical protein 0.0038 0.0298 0.0283
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.111 0.1096
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0272 0.1843
Echinococcus multilocularis sodium channel protein 0.0036 0.027 0.0255
Schistosoma mansoni single-minded 0.0047 0.0435 0.042
Schistosoma mansoni intermediate filament proteins 0.0026 0.0113 0.0098
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0745 0.1738
Echinococcus granulosus lamin 0.0026 0.0113 0.0098
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0141 0.1146
Brugia malayi intermediate filament protein 0.0026 0.0113 0.0347
Onchocerca volvulus 0.0035 0.0247 0.066
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.008 0.0601
Loa Loa (eye worm) hypothetical protein 0.0095 0.1159 0.2704
Echinococcus multilocularis Chromo domain 0.0023 0.0058 0.0043
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0058 0.0393
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0148 0.4713
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0058 0.0393
Brugia malayi RNA, U transporter 1 0.008 0.093 0.2859
Onchocerca volvulus 0.0061 0.0641 0.2036
Onchocerca volvulus 0.0095 0.1159 0.3845
Loa Loa (eye worm) POT family protein 0.021 0.2916 0.6803
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Echinococcus granulosus Chromobox protein 3 0.0023 0.0058 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Schistosoma mansoni jun-related protein 0.0066 0.0726 0.0712
Schistosoma mansoni chromobox protein 0.0023 0.0058 0.0043
Echinococcus multilocularis chromobox protein 2 0.0023 0.0058 0.0043
Schistosoma mansoni lipoxygenase 0.0168 0.2285 0.2273
Onchocerca volvulus 0.0066 0.072 0.2311
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0987 0.5367
Mycobacterium tuberculosis Conserved protein 0.0037 0.0272 0.0784
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Onchocerca volvulus Peroxidase homolog 0.0066 0.072 0.2311
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0298 0.0283
Brugia malayi calpain family protein 1 0.0056 0.0572 0.1757
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0058 0.0043
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0148 0.5
Mycobacterium tuberculosis Conserved protein 0.0037 0.0272 0.0784
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0324
Brugia malayi hypothetical protein 0.0023 0.0058 0.0179
Schistosoma mansoni loxhd1 0.0038 0.0298 0.0283
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0058 0.1522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0155 0.0771
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0298 0.0695
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Echinococcus granulosus chromobox protein 2 0.0023 0.0058 0.0043
Brugia malayi Animal haem peroxidase family protein 0.0066 0.072 0.2212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0617 0.0603
Brugia malayi hypothetical protein 0.0038 0.0298 0.0916
Loa Loa (eye worm) blistered cuticle protein 3 0.0066 0.072 0.168
Schistosoma mansoni cpg binding protein 0.003 0.0163 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0058 0.1522
Leishmania major hypothetical protein, conserved 0.0024 0.008 0.0601
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.096 0.0946
Loa Loa (eye worm) hypothetical protein 0.0159 0.2137 0.4986
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0115 0.1475 0.4459
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0272 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1327 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0449 0.0435
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.111 0.6966
Brugia malayi Matrixin family protein 0.0095 0.1159 0.3562
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1949 0.4548
Loa Loa (eye worm) hypothetical protein 0.0079 0.0926 0.216
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0272 0.0257
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0417 0.0403
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0272 0.0634
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0052 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0272 0.0784
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1327 1
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0062
Echinococcus multilocularis lamin 0.0026 0.0113 0.0098
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0115 0.1475 0.4531
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0247 0.1675
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0058 0.0043
Onchocerca volvulus 0.0038 0.0298 0.0838
Mycobacterium leprae PROBABLE HYDROLASE 0.0115 0.1475 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0272 0.1418
Schistosoma mansoni peroxidasin 0.0066 0.072 0.0706
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0036 0.027 0.2031
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0058 0.0238
Echinococcus multilocularis chromobox protein 1 0.0138 0.1826 0.1814
Brugia malayi CHD4 protein 0.0024 0.0082 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0058 0.0238
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.0695
Onchocerca volvulus 0.0037 0.0272 0.0746
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0141 0.0126
Onchocerca volvulus 0.0108 0.1366 0.4568
Loa Loa (eye worm) hypothetical protein 0.005 0.0474 0.1107
Loa Loa (eye worm) helicase 0.0023 0.0058 0.0136
Loa Loa (eye worm) hypothetical protein 0.0068 0.0745 0.1738
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1327 1
Echinococcus granulosus peroxidasin 0.0066 0.072 0.0706
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0298 0.0283
Onchocerca volvulus Matrilysin homolog 0.021 0.2922 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0298 0.0283
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.0328
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0108 0.1366 0.1353
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0058 0.0238
Loa Loa (eye worm) fli-1 protein 0.0232 0.3254 0.7592
Brugia malayi Doublecortin family protein 0.0038 0.0298 0.0916
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Loa Loa (eye worm) hypothetical protein 0.0056 0.0572 0.1334
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0058 0.0043
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0572 0.1334
Loa Loa (eye worm) hypothetical protein 0.0091 0.111 0.2589
Schistosoma mansoni ran 0.0021 0.0027 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0103 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0272 0.2048
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0148 0.1218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.0695
Onchocerca volvulus Chorion peroxidase homolog 0.0066 0.072 0.2311
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0272 0.0784
Schistosoma mansoni chromobox protein 0.0138 0.1826 0.1814
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0148 0.1218
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0879 0.205
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0148 1
Schistosoma mansoni hypothetical protein 0.0337 0.4864 0.4857
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0339
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0082 0.0192
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0015 0.0102
Leishmania major importin beta-1 subunit, putative 0.0023 0.0059 0.0448
Echinococcus multilocularis calpain 5 0.0021 0.0036 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0449 0.0435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0263
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0272 0.1418
Trichomonas vaginalis hypothetical protein 0.0023 0.0058 0.0238
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0206
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0745 0.1738
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.1366 0.3188
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0059 0.0448
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Echinococcus granulosus geminin 0.0337 0.4864 0.4857
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.011 0.0524
Schistosoma mansoni chromobox protein 0.0023 0.0058 0.0043
Onchocerca volvulus Matrilysin homolog 0.0095 0.1159 0.3845
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0611 0.0597
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0058 0.1522
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0245
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.0274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Loa Loa (eye worm) matrix metalloproteinase 0.0095 0.1159 0.2704
Brugia malayi peptidase family M13 containing protein 0.0022 0.0052 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0058 0.0238
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0247 0.0232
Loa Loa (eye worm) hypothetical protein 0.0048 0.0449 0.1048
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0148 0.0736
Brugia malayi 6-phosphofructokinase 0.0106 0.1327 0.4079
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0082 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0272 0.1418
Brugia malayi hypoxia-induced factor 1 0.0146 0.1949 0.599
Onchocerca volvulus 0.0134 0.1764 0.5957
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0272 0.0784
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0272 0.2048
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0449 0.0435
Echinococcus granulosus calpain A 0.0059 0.0611 0.0597
Schistosoma mansoni hypothetical protein 0.0398 0.579 0.5784
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0168 0.2285 0.2273
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0272 0.2048
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.1366 0.4198
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.111 0.3344
Mycobacterium ulcerans hydrolase 0.0115 0.1475 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0108 0.1366 0.4198
Brugia malayi Animal haem peroxidase family protein 0.0066 0.072 0.2212
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0328
Schistosoma mansoni gabp alpha 0.0076 0.0879 0.0865
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0272 0.0257
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Brugia malayi Matrixin family protein 0.0095 0.1159 0.3562
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0879 0.0865
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0036 0.0021
Brugia malayi Protein cec-1. 0.0023 0.0058 0.0179
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0108 0.1366 0.1353
Schistosoma mansoni peroxidasin 0.0066 0.072 0.0706
Loa Loa (eye worm) calpain 0.0021 0.0036 0.0085
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0036 0.0274
Brugia malayi beta-lactamase 0.0037 0.0272 0.0835
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1327 0.7244
Brugia malayi Animal haem peroxidase family protein 0.0066 0.072 0.2212
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0059 0.0611 0.0597
Echinococcus multilocularis cpg binding protein 0.003 0.0163 0.0148
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0148 0.1016
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0344 0.4974 0.4966
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0058 0.0179
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1327 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0435 0.042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0015 0.5
Brugia malayi calpain 7 0.0021 0.0036 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0272 0.0634
Loa Loa (eye worm) hypothetical protein 0.0066 0.072 0.168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0015 0.0035
Brugia malayi Matrixin family protein 0.0095 0.1159 0.3562
Echinococcus multilocularis peroxidasin 0.0066 0.072 0.0706
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.0274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0611 0.0597
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0082 0.0067
Echinococcus multilocularis musashi 0.0026 0.0113 0.0098
Echinococcus granulosus cpg binding protein 0.003 0.0163 0.0148
Brugia malayi Animal haem peroxidase family protein 0.0066 0.072 0.2212
Onchocerca volvulus Dual oxidase homolog 0.0066 0.072 0.2311
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0058 0.1522
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0113 0.0347
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0113 0.0263
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0058 0.1522
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Brugia malayi Fli-1 protein 0.0232 0.3254 1
Brugia malayi Animal haem peroxidase family protein 0.0066 0.072 0.2212
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0015 0.0113
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0036 0.0021
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0058 0.0043
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0052 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0036 0.0274
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0417 0.0403
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0136
Onchocerca volvulus 0.0038 0.0298 0.0838
Loa Loa (eye worm) hypothetical protein 0.0069 0.0769 0.1795
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1327 0.7244
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0058 0.0238
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0058 0.0328
Onchocerca volvulus Peroxidasin homolog 0.0066 0.072 0.2311
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.072 0.168
Onchocerca volvulus 0.0028 0.0139 0.0282
Schistosoma mansoni ets-related 0.0232 0.3254 0.3244
Echinococcus granulosus Chromo domain 0.0023 0.0058 0.0043
Schistosoma mansoni lipoxygenase 0.0099 0.123 0.1217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0155 0.0771
Loa Loa (eye worm) hypothetical protein 0.0045 0.0404 0.0944
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0551 0.296
Echinococcus multilocularis RUN 0.0038 0.0298 0.0283
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0148 0.4713
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0052 0.0122
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0012
Mycobacterium ulcerans lipase LipD 0.0037 0.0272 0.1843
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.111 0.7525
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0247 0.0759
Onchocerca volvulus 0.0064 0.0692 0.2213
Mycobacterium ulcerans hypothetical protein 0.0037 0.0272 0.1843
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.0328
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1327 0.4009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0113
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0148 0.4713
Schistosoma mansoni chromobox protein 0.0138 0.1826 0.1814
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0036 0.0274
Brugia malayi Ets-domain containing protein 0.0076 0.0879 0.27
Brugia malayi beta-lactamase family protein 0.0037 0.0272 0.0835
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0015 0.0113
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0897 0.293
Brugia malayi Peroxidasin 0.0066 0.072 0.2212
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0077 0.0062
Echinococcus multilocularis jun protein 0.0082 0.096 0.0946
Loa Loa (eye worm) animal heme peroxidase 0.0066 0.072 0.168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0449 0.0435
Brugia malayi Hemopexin family protein 0.0134 0.1764 0.542
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0521 0.4618
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0082 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0897 0.487
Schistosoma mansoni polycystin 1-related 0.0038 0.0298 0.0283
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0036 0.0021
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0095 0.1159 0.1146
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0059 0.0611 0.0597
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0298 0.0283
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0879 0.0865
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0345 0.0805

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 300 nM Inhibition of Matrix metalloproteinase-8 ChEMBL. 11378378
IC50 (binding) = 300 nM Inhibition of Matrix metalloproteinase-8 ChEMBL. 11378378
IC50 (binding) = 400 nM Inhibition of Matrix metalloproteinase-9 ChEMBL. 11378378
IC50 (binding) = 400 nM Inhibition of Matrix metalloproteinase-9 ChEMBL. 11378378
IC50 (binding) = 800 nM Inhibition of Matrix metalloproteinase-2 ChEMBL. 11378378
IC50 (binding) = 800 nM Inhibition of Matrix metalloproteinase-2 ChEMBL. 11378378
IC50 (binding) = 1200 nM Inhibition of Matrix metalloproteinase-3 ChEMBL. 11378378
IC50 (binding) = 1200 nM Inhibition of Matrix metalloproteinase-3 ChEMBL. 11378378
IC50 (binding) = 20000 nM Inhibition of Matrix metalloproteinase-1 ChEMBL. 11378378
IC50 (binding) = 20000 nM Inhibition of Matrix metalloproteinase-1 ChEMBL. 11378378

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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