Detailed information for compound 501561

Basic information

Technical information
  • TDR Targets ID: 501561
  • Name: 6-(cyclohexylamino)-9-propylpurine-2-carbonit rile
  • MW: 284.36 | Formula: C15H20N6
  • H donors: 1 H acceptors: 4 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1cnc2c1nc(C#N)nc2NC1CCCCC1
  • InChi: 1S/C15H20N6/c1-2-8-21-10-17-13-14(18-11-6-4-3-5-7-11)19-12(9-16)20-15(13)21/h10-11H,2-8H2,1H3,(H,18,19,20)
  • InChiKey: ZHUNGDQXZYMKSH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 6-(cyclohexylamino)-9-propyl-purine-2-carbonitrile
  • 6-(cyclohexylamino)-9-propyl-2-purinecarbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative References
Homo sapiens cathepsin L Starlite/ChEMBL References
Trypanosoma brucei cysteine peptidase C (CPC) Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 2b cysteine peptidase C (CPC) 340 aa 321 aa 26.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin B-like cysteine proteinase 0.0335 0.4562 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0082 0.2047
Brugia malayi Cytochrome P450 family protein 0.005 0.0449 0.0984
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0082 0.2047
Plasmodium falciparum serine repeat antigen 4 0.0025 0.0082 0.2047
Giardia lamblia Cysteine protease 0.0025 0.0082 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0082 0.2047
Loa Loa (eye worm) ctsf protein 0.0047 0.0399 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0082 0.0276
Loa Loa (eye worm) CYP4Cod1 0.002 0.0011 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0399 0.0875
Echinococcus multilocularis cysteine protease 0.0047 0.0399 0.0399
Brugia malayi Cathepsin L-like precursor 0.0038 0.0271 0.0593
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0082 0.0082
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0011 0.0024
Onchocerca volvulus 0.0047 0.0399 1
Brugia malayi fibroinase precursor 0.0025 0.0082 0.0179
Giardia lamblia Cathepsin B precursor 0.0025 0.0082 0.0276
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0082 0.0276
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0271 0.0271
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0335 0.4562 1
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0593
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0082 0.0082
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Trypanosoma cruzi cysteine proteinase, putative 0.0034 0.0211 0.0461
Echinococcus multilocularis cathepsin L 0.0034 0.0211 0.0211
Echinococcus granulosus cathepsin L cysteine protease 0.0034 0.0211 0.0211
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0211 0.5271
Plasmodium falciparum serine repeat antigen 5 0.0025 0.0082 0.2047
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0025 0.0082 0.2047
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Brugia malayi cathepsin L-like precursor 0.0038 0.0271 0.0593
Trypanosoma cruzi cysteine protease, putative 0.0034 0.0211 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Onchocerca volvulus 0.0047 0.0399 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.4562 0.4562
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0082 0.2047
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0577 0.1951
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Giardia lamblia Cathepsin B precursor 0.0025 0.0082 0.0276
Echinococcus multilocularis cysteine protease 0.0047 0.0399 0.0399
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0399 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0224 0.2957 1
Leishmania major cytochrome p450-like protein 0.002 0.0011 0.0037
Entamoeba histolytica cysteine proteinase 1, putative 0.0034 0.0211 0.5271
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0082 0.0276
Echinococcus granulosus cathepsin b 0.0335 0.4562 0.4562
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0082 0.0082
Onchocerca volvulus 0.0038 0.0271 0.5946
Echinococcus granulosus cathepsin b 0.0335 0.4562 0.4562
Entamoeba histolytica cysteine protease, putative 0.0047 0.0399 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0577 0.0577
Plasmodium vivax vivapain-2 0.0047 0.0399 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Giardia lamblia Encystation-specific protease 0.0025 0.0082 0.0276
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0011 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0399 0.0875
Plasmodium falciparum serine repeat antigen 9 0.0025 0.0082 0.2047
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0399 1
Giardia lamblia Cathepsin B precursor 0.0224 0.2957 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0224 0.2957 1
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Echinococcus multilocularis cathepsin L 0.0025 0.0082 0.0082
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Giardia lamblia Cathepsin B precursor 0.0025 0.0082 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0211 0.0712
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0577 0.1264
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0082 0.0179
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0082 0.0082
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Trypanosoma cruzi cysteine proteinase, putative 0.0034 0.0211 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0025 0.0082 0.0276
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0399 0.0399
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Echinococcus granulosus cysteine protease 0.0034 0.0211 0.0211
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0082 0.0179
Echinococcus granulosus cathepsin l1 0.0047 0.0399 0.0399
Plasmodium falciparum serine repeat antigen 6 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0399 0.1351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0211 0.0712
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0593
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Trypanosoma brucei cytochrome P450, putative 0.002 0.0011 0.0037
Schistosoma mansoni cathepsin C 0.0025 0.0082 0.0082
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0577 0.0577
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0519 0.1138
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0082 0.2047
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0577 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0082 0.0276
Echinococcus granulosus cathepsin L 0.0034 0.0211 0.0211
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0025 0.0082 0.2047
Loa Loa (eye worm) cysteine protease 0.0047 0.0399 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0399 0.0875
Plasmodium falciparum serine repeat antigen 7 0.0025 0.0082 0.2047
Giardia lamblia Cathepsin B precursor 0.0224 0.2957 1
Onchocerca volvulus 0.0047 0.0399 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0082 0.2047
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0211 0.0461
Plasmodium falciparum serine repeat antigen 2 0.0025 0.0082 0.2047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0011 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0271 0.0915
Loa Loa (eye worm) hypothetical protein 0.0335 0.4562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0211 0.0712
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0011 0.019
Onchocerca volvulus 0.0047 0.0399 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Entamoeba histolytica cysteine proteinase 2 0.0034 0.0211 0.5271
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0335 0.4562 0.4562
Brugia malayi cathepsin L precursor 0.0025 0.0082 0.0179
Plasmodium falciparum serine repeat antigen 1 0.0025 0.0082 0.2047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0034 0.0211 0.0211
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0082 0.2047
Echinococcus granulosus cathepsin L 0.0025 0.0082 0.0082
Plasmodium falciparum serine repeat antigen 8 0.0025 0.0082 0.2047
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0399 0.0875
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0082 0.2047
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0399 0.1351
Toxoplasma gondii cathepsin B 0.0224 0.2957 1
Onchocerca volvulus 0.0047 0.0399 1
Echinococcus granulosus cathepsin l1 0.0038 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Echinococcus multilocularis cathepsin b 0.0335 0.4562 0.4562
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0082 0.0179
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0577 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0082 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0399 0.0399
Echinococcus multilocularis cathepsin b 0.0335 0.4562 0.4562
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0082 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0399 0.0399
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0271 0.0915
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0082 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Brugia malayi Cytochrome P450 family protein 0.002 0.0011 0.0024
Loa Loa (eye worm) cathepsin B 0.0224 0.2957 0.6481
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0025 0.0082 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0082 0.0179
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0082 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0082 0.2047
Loa Loa (eye worm) fibroinase 0.0047 0.0399 0.0875
Plasmodium vivax vivapain-3 0.0034 0.0211 0.5271
Onchocerca volvulus 0.0047 0.0399 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0082 0.0082
Plasmodium vivax vivapain-1 0.0034 0.0211 0.5271
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Giardia lamblia Hypothetical protein 0.0025 0.0082 0.0276
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0082 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0025 0.0082 0.2047
Brugia malayi Cathepsin L-like precursor 0.0038 0.0271 0.0593
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0211 0.5271
Toxoplasma gondii cathepsin CPC1 0.0025 0.0082 0.0276
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0399 1
Plasmodium vivax unspecified product 0.0034 0.0211 0.5271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.4562 0.4562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0224 0.2957 0.2957
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Giardia lamblia Hypothetical protein 0.0025 0.0082 0.0276
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0399 1
Giardia lamblia Cathepsin L precursor 0.0025 0.0082 0.0276
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0399 0.0399
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.4562 0.4562
Giardia lamblia Cysteine protease 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0034 0.0211 0.0211
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0082 0.0179
Giardia lamblia Cathepsin B precursor 0.0025 0.0082 0.0276
Plasmodium vivax vivapain-2 0.0047 0.0399 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0082 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0399 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0082 0.0179
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0034 0.0211 0.0461
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0224 0.2957 0.6481
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0211 0.5271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0271 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0271 0.0593
Toxoplasma gondii cathepsin CPC2 0.0025 0.0082 0.0276
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0271 0.6776
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Giardia lamblia Cysteine protease 0.0025 0.0082 0.0276
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0082 0.2047
Giardia lamblia Cathepsin L-like protease 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0211 0.0712
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0211 0.0461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0082 0.0082
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0211 0.5271
Plasmodium falciparum cysteine proteinase falcipain 1 0.0034 0.0211 0.5271
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0082 0.2047
Schistosoma mansoni microtubule-associated protein tau 0.0711 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Echinococcus multilocularis microtubule associated protein 2 0.0711 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0399 0.0399
Plasmodium vivax unspecified product 0.0025 0.0082 0.2047
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Toxoplasma gondii cathepsin CPL 0.0047 0.0399 0.1351
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0211 0.0461
Plasmodium falciparum serine repeat antigen 3 0.0025 0.0082 0.2047
Giardia lamblia Cathepsin B precursor 0.0224 0.2957 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0082 0.0082
Giardia lamblia Cathepsin L-like protease 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0399 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0399 0.0399
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0399 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0025 0.0082 0.2047
Entamoeba histolytica cysteine protease, putative 0.0025 0.0082 0.2047
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0399 0.0399
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0399 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0025 0.0082 0.0276
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0399 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0025 0.0082 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0082 0.0276
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0577 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0011 0.0024
Giardia lamblia Cysteine protease 0.0025 0.0082 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0082 0.0276
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0399 0.1351
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0082 0.0082
Leishmania major cathepsin L-like protease 0.0047 0.0399 0.1351
Entamoeba histolytica hypothetical protein 0.0025 0.0082 0.2047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0399 0.1351
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0399 0.0875
Giardia lamblia Cathepsin B precursor 0.0025 0.0082 0.0276
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Onchocerca volvulus 0.0047 0.0399 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0224 0.2957 1
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0449 0.0984
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0399 0.0875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0399 0.1351
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0082 0.0276
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0399 0.0399
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0399 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0082 0.0276
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0593
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0025 0.0082 0.0276
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0082 0.0082
Toxoplasma gondii preprocathepsin c precursor, putative 0.0025 0.0082 0.0276
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0025 0.0082 0.0276
Brugia malayi Cathepsin L-like precursor 0.0047 0.0399 0.0875
Entamoeba histolytica cysteine protease, putative 0.0034 0.0211 0.5271
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0034 0.0211 0.0211

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.53 uM Inhibition of human liver cathepsin L ChEMBL. 18173229
IC50 (binding) = 2.53 uM Inhibition of human liver cathepsin L ChEMBL. 18173229
IC50 (binding) = 8.3 uM Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease ChEMBL. 18173229
IC50 (binding) = 8.3 uM Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease ChEMBL. 18173229
IC50 (functional) = 12 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18173229
IC50 (functional) = 12 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18173229
IC50 (binding) = 19.05 uM Inhibition of human liver cathepsin B ChEMBL. 18173229
IC50 (binding) = 19.05 uM Inhibition of human liver cathepsin B ChEMBL. 18173229

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei ChEMBL23 18173229
Trypanosoma brucei gambiense 18173229

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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