TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.943 | Formula: C20H25ClN2O2S
H donors: 0 H acceptors: 1 LogP: 3.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)c(cs2)CC(=O)N1CCCCC1CN1CCOCC1
InChi: 1S/C20H25ClN2O2S/c21-16-4-5-19-18(12-16)15(14-26-19)11-20(24)23-6-2-1-3-17(23)13-22-7-9-25-10-8-22/h4-5,12,14,17H,1-3,6-11,13H2
InChiKey: KTAIPWVZLKIKFB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	urotensin 2 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0007	0.01	0.0111
Plasmodium falciparum	thioredoxin reductase	0.0063	0.252	0.2741
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0336	0.0311
Echinococcus multilocularis	allatostatin A receptor	0.0007	0.01	0.0049
Brugia malayi	putative neuropeptide receptor NPR1	0.0007	0.01	0.0044
Treponema pallidum	NADH oxidase	0.0022	0.0747	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0967	0.0916
Toxoplasma gondii	glutamate-cysteine ligase, catalytic subunit domain-containing protein	0.0215	0.9046	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0007	0.01	0.0044
Echinococcus multilocularis	sex peptide receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0007	0.01	0.0044
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0007	0.01	0.0049
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Onchocerca volvulus		0.0007	0.01	0.0049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	Ankyrin	0.0015	0.0431	0.0417
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0367	0.0345
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0007	0.01	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Leishmania major	cytochrome p450-like protein	0.0012	0.0336	0.0311
Echinococcus granulosus	hypothetical protein	0.0007	0.01	0.0049
Echinococcus multilocularis	G protein coupled receptor 139	0.0007	0.01	0.0049
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0007	0.01	0.0049
Echinococcus multilocularis	dro:myosuppressin receptor	0.0007	0.01	0.0049
Echinococcus granulosus	g protein coupled receptor	0.0007	0.01	0.0049
Trichomonas vaginalis	DNA helicase recq, putative	0.0011	0.0297	0.349
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.01	0.0111
Schistosoma mansoni	neuropeptide f receptor 76f	0.0007	0.01	0.0111
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0426	0.0411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0.01	0.0049
Toxoplasma gondii	thioredoxin reductase	0.0063	0.252	0.2786
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0336	0.0311
Echinococcus granulosus	Ankyrin	0.0015	0.0431	0.0417
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0.01	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.01	0.0049
Echinococcus granulosus	lamin	0.0027	0.0967	0.1013
Echinococcus multilocularis	serotonin receptor	0.0007	0.01	0.0049
Giardia lamblia	Sgs1 DNA helicase, putative	0.0009	0.0186	0.0144
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0237	1	1
Echinococcus granulosus	intermediate filament protein	0.0027	0.0967	0.1013
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0007	0.01	0.0111
Onchocerca volvulus		0.0007	0.01	0.0049
Schistosoma mansoni	adenoreceptor	0.0007	0.01	0.0111
Loa Loa (eye worm)	melatonin receptor type 1A	0.0007	0.01	0.0044
Schistosoma mansoni	hypothetical protein	0.0014	0.0426	0.047
Echinococcus granulosus	neuropeptide receptor	0.0007	0.01	0.0049
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0367	0.0345
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0022	0.0747	0.0768
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0336	0.0281
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0.01	0.0049
Echinococcus granulosus	G protein coupled receptor 139	0.0007	0.01	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.01	0.0049
Loa Loa (eye worm)	thioredoxin reductase	0.0063	0.252	0.2478
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0431	0.0476
Echinococcus multilocularis	lamin dm0	0.0027	0.0967	0.1013
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Echinococcus granulosus	neuropeptide s receptor	0.0007	0.01	0.0049
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0426	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.01	0.0111
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Echinococcus multilocularis	fmrfamide receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0967	0.0916
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0007	0.01	0.0044
Trypanosoma cruzi	trypanothione reductase, putative	0.0022	0.0747	0.0768
Onchocerca volvulus		0.0007	0.01	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Onchocerca volvulus		0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0725	0.0744
Brugia malayi	Thioredoxin reductase	0.0063	0.252	0.2478
Echinococcus multilocularis	glutamate cysteine ligase, catalytic subunit	0.0215	0.9046	1
Plasmodium falciparum	glutathione reductase	0.0022	0.0747	0.0768
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0725	0.0673
Schistosoma mansoni	neuropeptide receptor	0.0007	0.01	0.0111
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0725	0.9683
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0186	0.0205
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0.01	0.0049
Brugia malayi	larval opioid receptor	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	neuropeptide receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	glutamate synthase	0.0006	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.01	0.0049
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0007	0.01	0.0049
Trypanosoma cruzi	trypanothione reductase, putative	0.0063	0.252	0.2741
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0022	0.0747	1
Onchocerca volvulus		0.0007	0.01	0.0049
Echinococcus multilocularis	musashi	0.0027	0.0967	0.1013
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0022	0.0747	1
Entamoeba histolytica	recQ family helicase, putative	0.0011	0.0297	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0022	0.0747	0.0768
Onchocerca volvulus		0.0007	0.01	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0426	0.0371
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.01	0.0049
Onchocerca volvulus		0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0007	0.01	0.0044
Echinococcus granulosus	serotonin receptor	0.0007	0.01	0.0049
Brugia malayi	AKH receptor	0.0007	0.01	0.0044
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0022	0.0747	1
Brugia malayi	neuropeptide F receptor	0.0007	0.01	0.0044
Onchocerca volvulus		0.0007	0.01	0.0049
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0.01	0.0111
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0016	0.0497	0.0444
Schistosoma mansoni	sulfide quinone reductase	0.0006	0.0056	0.0062
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0429	0.0374
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.0336	0.4051
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0016	0.0497	0.0444
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0967	0.1069
Echinococcus multilocularis	neuropeptide receptor A26	0.0007	0.01	0.0049
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0336	0.0281
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.2976	0.3248
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0007	0.01	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0022	0.0747	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0007	0.01	0.0049
Echinococcus granulosus	allatostatin A receptor	0.0007	0.01	0.0049
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0429	0.0374
Echinococcus granulosus	thioredoxin glutathione reductase	0.0063	0.252	0.2741
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0426	0.0411
Plasmodium falciparum	gamma-glutamylcysteine synthetase	0.0215	0.9046	1
Echinococcus multilocularis	g protein coupled receptor	0.0007	0.01	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0007	0.01	0.0111
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0.01	0.0044
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.01	0.0111
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0006	0.0056	0.1895
Echinococcus granulosus	g protein coupled receptor	0.0007	0.01	0.0049
Echinococcus granulosus	7tm_1 domain containing protein	0.0007	0.01	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0022	0.0747	0.2803
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Echinococcus granulosus	glutamate cysteine ligase catalytic subunit	0.0215	0.9046	1
Plasmodium vivax	gamma-glutamylcysteine synthetase, putative	0.0215	0.9046	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0022	0.0747	0.0826
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0.01	0.0049
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0006	0.0056	0.1895
Onchocerca volvulus		0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0022	0.0747	0.0768
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0022	0.0747	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	growth hormone secretagogue receptor	0.0007	0.01	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0.01	0.0049
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0022	0.0747	0.0768
Onchocerca volvulus		0.0007	0.01	0.0049
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0725	0.0673
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0007	0.01	0.0049
Echinococcus granulosus	neuropeptide FF receptor 2	0.0007	0.01	0.0049
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0007	0.01	0.0049
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	ORL1-like opioid receptor	0.0007	0.01	0.0044
Echinococcus multilocularis	lamin	0.0027	0.0967	0.1013
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0006	0.0056	0.1895
Onchocerca volvulus		0.0027	0.0967	0.1013
Loa Loa (eye worm)	glutamate-cysteine ligase	0.0215	0.9046	0.904
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0006	0.0056	0.1895
Echinococcus multilocularis	serotonin receptor	0.0007	0.01	0.0049
Mycobacterium tuberculosis	Probable oxidoreductase	0.0022	0.0747	0.2803
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0426	0.0411
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0022	0.0747	0.0768
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0426	0.0411
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0186	0.0205
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0022	0.0747	0.0768
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	hypothetical protein	0.0007	0.01	0.0111
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0022	0.0747	0.0768
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0967	0.0916
Brugia malayi	Melatonin receptor type 1A	0.0007	0.01	0.0044
Trypanosoma cruzi	gamma-glutamylcysteine synthetase, putative	0.0215	0.9046	1
Onchocerca volvulus		0.0007	0.01	0.0049
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0.01	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0007	0.01	0.0111
Echinococcus granulosus	g protein coupled receptor	0.0007	0.01	0.0049
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0022	0.0747	0.0768
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Echinococcus granulosus	lamin dm0	0.0027	0.0967	0.1013
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0007	0.01	0.0049
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0022	0.0747	0.2803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Echinococcus multilocularis	fmrfamide receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	G protein-coupled receptor F59B2.13	0.0007	0.01	0.0044
Schistosoma mansoni	opsin-like receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.01	0.0049
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0725	0.9683
Schistosoma mansoni	disulfide oxidoreductase	0.0006	0.0056	0.0062
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0007	0.01	0.0111
Brugia malayi	intermediate filament protein	0.0027	0.0967	0.0916
Brugia malayi	Dopamine receptor	0.0007	0.01	0.0044
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0006	0.0056	0.0062
Schistosoma mansoni	neuropeptide receptor	0.0007	0.01	0.0111
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0.01	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0007	0.01	0.0049
Brugia malayi	G protein-coupled receptor	0.0007	0.01	0.0044
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0009	0.0186	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	Dopamine receptor protein 1	0.0007	0.01	0.0044
Echinococcus granulosus	fmrfamide receptor	0.0007	0.01	0.0049
Schistosoma mansoni	hypothetical protein	0.0007	0.01	0.0111
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0007	0.01	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0426	0.0371
Brugia malayi	Death domain containing protein	0.0014	0.0426	0.0371
Loa Loa (eye worm)	glutathione reductase	0.0063	0.252	0.2478
Onchocerca volvulus		0.0007	0.01	0.0049
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0022	0.0747	0.2803
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0336	0.0281
Onchocerca volvulus		0.0007	0.01	0.0049
Trypanosoma brucei	trypanothione reductase	0.0063	0.252	0.2741
Onchocerca volvulus		0.0007	0.01	0.0049
Echinococcus granulosus	dro:myosuppressin receptor	0.0007	0.01	0.0049
Trichomonas vaginalis	glutathione reductase, putative	0.0022	0.0747	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	biogenic amine receptor	0.0007	0.01	0.0111
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0532	0.0588
Brugia malayi	glutathione reductase	0.0063	0.252	0.2478
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.042	0.0465
Brugia malayi	G-protein coupled receptor	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Schistosoma mansoni	myosin xvIII	0.0007	0.01	0.0111
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0186	0.0205
Schistosoma mansoni	glutamate synthase	0.0006	0.0056	0.0062
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0006	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0967	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	G-protein coupled receptor	0.0007	0.01	0.0044
Echinococcus multilocularis	somatostatin receptor	0.0007	0.01	0.0049
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0007	0.01	0.0049
Giardia lamblia	Glutamate-cysteine ligase	0.0215	0.9046	1
Schistosoma mansoni	amine GPCR	0.0007	0.01	0.0111
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0.01	0.0049
Trypanosoma brucei	gamma-glutamylcysteine synthetase	0.0215	0.9046	1
Schistosoma mansoni	hypothetical protein	0.0006	0.0056	0.0062
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0.01	0.0049
Leishmania major	gamma-glutamylcysteine synthetase, putative	0.0215	0.9046	1
Brugia malayi	Serotonin receptor	0.0007	0.01	0.0044
Brugia malayi	Dopamine receptor protein 2	0.0007	0.01	0.0044
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0336	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0346	0.0291
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0022	0.0747	0.0768
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0186	0.0144
Echinococcus granulosus	sex peptide receptor	0.0007	0.01	0.0049
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0007	0.01	0.0049
Echinococcus granulosus	neuropeptide receptor A26	0.0007	0.01	0.0049
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0186	0.013
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0.01	0.0049
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0007	0.01	0.0044
Echinococcus granulosus	orexin receptor type 2	0.0007	0.01	0.0049
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0022	0.0747	0.0768
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0.01	0.0049
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0297	0.0268
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.01	0.0111
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0006	0.0056	0.0062
Plasmodium vivax	glutathione reductase, putative	0.0063	0.252	0.2741
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0297	0.0268
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0.01	0.0044
Schistosoma mansoni	lamin	0.0027	0.0967	0.1069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Echinococcus granulosus	somatostatin receptor	0.0007	0.01	0.0049
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0007	0.01	0.0049
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0186	0.0205
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0022	0.0747	0.0826
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0022	0.0747	0.0768
Schistosoma mansoni	opsin-like receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0186	0.0144
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0336	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0063	0.252	0.2741
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0022	0.0747	0.0768
Schistosoma mansoni	amine GPCR	0.0007	0.01	0.0111
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0007	0.01	0.0111
Plasmodium falciparum	glutathione reductase	0.0063	0.252	0.2741
Echinococcus multilocularis	neuropeptide s receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.2976	0.3248
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0186	0.0144
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0022	0.0747	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0431	0.0377
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0.01	0.0044
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0186	0.0144
Echinococcus multilocularis	g-protein coupled receptor	0.0007	0.01	0.0049
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	glutamate synthase	0.0006	0.0056	0.0062
Schistosoma mansoni	amine GPCR	0.0007	0.01	0.0111
Brugia malayi	GnHR receptor homolog	0.0007	0.01	0.0044
Loa Loa (eye worm)	TYRA-2 protein	0.0007	0.01	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Schistosoma mansoni	sulfide quinone reductase	0.0006	0.0056	0.0062
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0346	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	biogenic amine receptor	0.0007	0.01	0.0111
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0426	0.0371
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0007	0.01	0.0049
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0007	0.01	0.0049
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0007	0.01	0.0049
Schistosoma mansoni	hypothetical protein	0.0007	0.01	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Onchocerca volvulus		0.0007	0.01	0.0049
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0186	0.013
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0006	0.0056	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0184	0.0128
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0022	0.0747	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0007	0.01	0.0111
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0022	0.0747	0.0768
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0426	0.047
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	putative neuropeptide receptor	0.0007	0.01	0.0044
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0007	0.01	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0.01	0.0111
Schistosoma mansoni	hypothetical protein	0.0007	0.01	0.0111
Brugia malayi	RE15519p	0.0007	0.01	0.0044
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0426	0.047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0007	0.01	0.0049
Schistosoma mansoni	opsin-like receptor	0.0007	0.01	0.0111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0022	0.0747	1
Schistosoma mansoni	lamin	0.0027	0.0967	0.1069
Plasmodium falciparum	thioredoxin reductase	0.0022	0.0747	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0367	0.0312
Leishmania major	trypanothione reductase	0.0063	0.252	0.2741
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0.01	0.0049
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0426	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0946	0.0895
Toxoplasma gondii	NADPH-glutathione reductase	0.0022	0.0747	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0539	0.0486
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0022	0.0747	1
Brugia malayi	neuropeptide F receptor	0.0007	0.01	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Onchocerca volvulus		0.0027	0.0967	0.1013
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0022	0.0747	0.0768
Trypanosoma cruzi	gamma-glutamylcysteine synthetase, putative	0.0215	0.9046	1
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0014	0.0428	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	orexin receptor type 2	0.0007	0.01	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0.01	0.0111
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0186	0.013
Echinococcus granulosus	neuropeptide receptor	0.0007	0.01	0.0049
Onchocerca volvulus		0.0007	0.01	0.0049
Onchocerca volvulus		0.0007	0.01	0.0049
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0063	0.252	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0007	0.01	0.0049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0725	0.0744
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0186	0.013
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0006	0.0056	0.1895
Echinococcus granulosus	death domain containing protein	0.0014	0.0426	0.0411
Echinococcus granulosus	7TM GPCR rhodopsin	0.0007	0.01	0.0049
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0006	0.0056	0.1895
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0297	0.0268
Trichomonas vaginalis	mercuric reductase, putative	0.0022	0.0747	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0614	0.062
Schistosoma mansoni	amine GPCR	0.0007	0.01	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0.01	0.0049
Brugia malayi	sulfakinin receptor protein	0.0007	0.01	0.0044
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.01	0.0111
Schistosoma mansoni	histamine h1 receptor	0.0007	0.01	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0007	0.01	0.0111
Brugia malayi	glutamate--cysteine ligase	0.0215	0.9046	0.904
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0336	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0006	0.0056	0.0062
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0007	0.01	0.0044
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	Uncoordinated protein 44	0.0014	0.0426	0.0371
Echinococcus granulosus	g-protein coupled receptor	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Brugia malayi	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0747	0.0768
Toxoplasma gondii	selenide, water dikinase	0.0006	0.0056	0.0062
Brugia malayi	Serotonin receptor	0.0007	0.01	0.0044
Schistosoma mansoni	glutamate-cysteine ligase	0.0215	0.9046	1
Plasmodium vivax	thioredoxin reductase, putative	0.0063	0.252	0.2741
Entamoeba histolytica	thioredoxin reductase, putative	0.0006	0.0056	0.1895
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0.01	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0007	0.01	0.0044
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0.01	0.0111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0.01	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= -5.9	Displacement of [125I]human urotensin 2 from human recombinant urotensin 2 receptor expressed in HEK293 cells	ChEMBL.	18420409
Log Ki (binding)	= 5.9	Displacement of [125I]human urotensin 2 from human recombinant urotensin 2 receptor expressed in HEK293 cells	ChEMBL.	18420409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 508964